Chang, Tou En Kenneth

​ ​ ​	Title		​:   Clinical Associate Professor
	​Address		​:   Department of Pathology and Laboratory Medicine,     KK Women’s and Children’s Hospital Basement 1,     Children's Tower, 100 Bukit Timah Road, Singapore 229899
	​Email		​:   kenneth.chang.t.e@singhealth.com.sg
	​Current Position		​:   Senior Consultant and Head, Department of Pathology and     Laboratory Medicine, KK Women’s and Children’s Hospital        Vice Chair, Clinical Service Transformation, Pathology     Academic Clinical Programme (ACP)     Visiting Consultant, Division of Forensic Medicine, Applied     Sciences Group, Health Sciences Authority     Director, SingHealth Tissue Repository (STR), SingHealth     Director, Advanced Molecular Pathology Laboratory (AMPL)     @ SingHealth     Clinical Associate Professor, Duke-NUS Medical     School

Research interest:

The Hippo pathway, pathology of childhood cancers, placental pathology.

Selected Publications:

1. Aw SJ, Wang S, Loh AH, Kuick CH, Lian DW, Yong MH, Ling S, Peh GL, Soh SY, Loh AH, Tan PH, Chang KT. Novel karyotypes and cyclin D1 immunoreactivity in clear cell sarcoma of the kidney. Pediatr Dev Pathol. 2015 Jul; 18(4):297-304


2. Loh TJ, Lian DW, Iyer P, Lam JC, Kuick CH, Aung AC, Chang KT. Congenital GATA1-mutated myeloproliferative disorder in trisomy 21 complicated by placental fetal thrombotic vasculopathy. Hum Pathol. 2014 Nov;45(11):2364-7.


3. Chang KT. Examination of the placenta: medico-legal implications. Semin Fetal Neonatal Med. 2014 Oct;19(5):279-84.


4. Shenje LT, Andersen P, Halushka MK, Lui C, Fernandez L, Collin GB, Amat-Alarcon N, Meschino W, Cutz E, Chang K, Yonescu R, Batista DA, Chen Y, Chelko S, Crosson JE, Scheel J, Vricella L, Craig BD, Marosy BA, Mohr DW, Hetrick KN, Romm JM, Scott AF, Valle D, Naggert JK, Kwon C, Doheny KF, Judge DP. Mutations in Alström protein impair terminal differentiation of cardiomyocytes. Nat Commun. 2014 Mar 4;5:3416.


5. Yan B, Kuick CH, Lim M, Venkataraman K, Tennakoon C, Loh E, Lian D, Leong MY, Lakshmanan M, Tergaonkar V, Sung WK, Soh SY, Chang KT. Platform comparison for evaluation of ALK protein immunohistochemical expression, genomic copy number and hotspot mutation status in neuroblastomas. PLoS One. 2014 Sep 4;9(9):e106575.


6. Yan B, Lim M, Zhou L, Kuick CH, Leong MY, Yong KJ, Aung L, Salto-Tellez M, Chang KT. Identification of MET genomic amplification, protein expression and alternative splice isoforms in neuroblastomas. J Clin Pathol. 2013 Nov;66(11):985-91.


7. Chang KT, Keating S, Costa S, Machin G, Kingdom J, Shannon P. Third-trimester stillbirths: correlative neuropathology and placental pathology. Pediatr Dev Pathol. 2011 Sep-Oct;14(5):345-52.


8. Chang KT, Taylor GP, Meschino WS, Kantor PF, Cutz E. Mitogenic cardiomyopathy: a lethal neonatal familial dilated cardiomyopathy characterized by myocyte hyperplasia and proliferation. Hum Pathol. 2010 Jul;41(7):1002-8.


9. Chang KT. Pathological examination of the placenta: raison d'être, clinical relevance and medicolegal utility. Singapore Med J. 2009 Dec;50(12):1123-33. Review.


10. Chang KT, Rajadurai VS, Walford NQ, Hwang WS. Alveolar capillary dysplasia: absence of CD117 immunoreactivity of putative hemangioblast precursor cells. Fetal Pediatr Pathol. 2008;27(3):127-40.