Yeong, Poh Sheng Joe

	Title		: Associate Professor
	Address		: Department of Microbiology, Division of Pathology, Singapore General HospitalAcademia, Diagnostics Tower, Level 720 College Road, Singapore 169856
	Email		: joe.yeong.p.s@sgh.com.sg
	Current Position		: Senior Principal Medical Laboratory Scientist II (Research), Department of Microbiology, Singapore General Hospital Director, Immunopathology, Pathology Academic Clinical Programme (ACP) Associate Professor, Duke-NUS Medical School

Research interest:

Integrative translational research to combine tumor immunology and pathology (immunopathology), focusing on the application of immune markers in routine clinical practice for diagnosis and prognosis, with emphasis on immunotherapy and precision medicine.
Studying the mechanism of immunotherapy (PD-L1/PD-1) resistance.
Automation, standardization and translation of tissue and cell-based diagnostic test (processing-running/running-analysis).
AI-triaged value-based healthcare and global health in the field of immunopathology

Selected Publications:

Jia G, et al. Spatial immune scoring system predicts hepatocellular carcinoma recurrence. Nature. 2025 Apr;640(8060):1031-1041.
Fincham REA, et al. The interplay between natural killer cells and pancreatic stellate cells in pancreatic ductal adenocarcinoma. Cancer Commun (Lond). 2025 Feb;45(2):172-177.
Periasamy P, et al. Regulation of non-canonical proteins from diverse origins through the nonsense-mediated mRNA decay pathway. Proteomics. 2024 Sep;24(18):e2300361.
Meng J, et al. The Prognostic Value of CD39 as a Marker of Tumor-Specific T Cells in Triple-Negative Breast Cancer in Asian Women. Lab Invest. 2024 Mar;104(3):100303.
Kaya NA, et al. Multimodal molecular landscape of response to Y90-resin microsphere radioembolization followed by nivolumab for advanced hepatocellular carcinoma. J Immunother Cancer. 2023 Aug;11(8):e007106.
Cheung CCL, et al. Residual SARS-CoV-2 viral antigens detected in GI and hepatic tissues from five recovered patients with COVID-19. Gut. 2022 Jan;71(1):226-229
Goh D, et al. Comparison between non-pulmonary and pulmonary immune responses in a HIV decedent who succumbed to COVID-19. Gut. 2022 Jun;71(6):1231-1234.
Yang Y, et al. SC-MEB: spatial clustering with hidden Markov random field using empirical Bayes. Brief Bioinform. 2022 Jan 17;23(1):bbab466.
Lam JH, et al. CD30⁺OX40⁺ Treg is associated with improved overall survival in colorectal cancer. Cancer Immunol Immunother. 2021 Aug;70(8):2353-2365.
Ng HHM, et al. Immunohistochemical scoring of CD38 in the tumor microenvironment predicts responsiveness to anti-PD-1/PD-L1 immunotherapy in hepatocellular carcinoma. J Immunother Cancer. 2020 Aug;8(2):e0009