Thike, Aye Aye

​ ​ ​ ​	Title		​:   Assistant Professor
	​Address		​:   Department of Anatomical Pathology     Singapore General Hospital     Academia, Diagnostics Tower, Level 9     20 College Road, Singapore 169856
	​Email		​:   daw.aye.aye.thike@sgh.com.sg
	​Contact No.		​:   6576 7550 (Office)
	​Current Position		​:   Senior Medical Laboratory Scientist, Department of Anatomical     Pathology, Singapore General Hospital     Assistant Professor, Duke-NUS Medical School

Research interest:

Dr Aye's research interests include triple negative breast cancers, ductal carcinoma in situ (DCIS) of the breast,  phyllodes tumours and metaplastic breast cancers. Her current research activities focus on biomarker discovery in metaplastic carcinoma of the breast, and the role of tumour infiltrating lymphocytes (TILs) in predicting recurrence and progression of DCIS of the breast.

Selected Publications:

1. Thike AA, Tan PH, Ikeda M, Iqbal J. Increased ID4 expression, accompanied by mutant p53 accumulation and loss of BRCA1/2 proteins in triple-negative breast cancer, adversely affects survival. Histopathology. 2016 Apr;68(5):702-12. doi:10.1111/his.12801.Epub 2015 Nov 2. PubMed PMID: 26259780.


2. Tan J, Ong CK, Lim WK, Ng CC, Thike AA, Ng LM, Rajasegaran V, Myint SS, Nagarajan S, Thangaraju S, Dey S, Nasir ND, Wijaya GC, Lim JQ, Huang D, Li Z, Wong BH, Chan JY, McPherson JR, Cutcutache I, Poore G, Tay ST, Tan WJ, Putti TC, Ahmad BS, Iau P, Chan CW, Tang AP, Yong WS, Madhukumar P, Ho GH, Tan VK, Wong CY, Hartman M, Ong KW, Tan BK, Rozan SG, Tan P, Tan PH, Teh BT.Genomic landscapes of breast fibroepithelial tumors. Nat Genet. 2015 Nov;47(11):1341-5. doi: 10.1038/ng.3409. Epub 2015 Oct 5. PubMed PMID: 26437033.


3. Koh VC, Lim JC, Thike AA, Cheok PY, Thu MM, Tan VK, Tan BK, Ong KW, Ho GH, Tan WJ, Tan Y, Salahuddin AS, Busmanis I, Chong AP, Iqbal J, Thilagaratnam S, Wong JS, Tan PH. Characteristics and behavior of screen-detected ductal carcinoma in situ of the breast: comparison with symptomatic patients. Breast Cancer Res Treat. 2015 Jul;125(2):293-304. doi: 10.1007/s10549-015-3472-6. Epub 2015 Jun 16. PubMed PMID:26077641


4. Oon ML, Thike AA, Tan SY, Tan PH. Cancer stem cell and epithelial-mesenchymal transition markers predict worse outcome in metaplastic carcinoma of the breast. Breast Cancer Res Treast. 2015 Feb;150(1):31-41. doi:10.1007/s10549-015-3299-1. Epub 2015 Feb 13. PubMed PMID:25677743.



5. Thike AA, Yong-Zheng Chong L, Cheok PY, Li HH, Wai-Cheong Yip G, Huat Bay B, Tse GM, Iqbal J, Tan PH. Loss of androgen receptor expression predicts early recurrence in triple-negative and basal-like breast cancer. Mod Pathol. 2014 Mar;27(3):352-60. doi:10.1038/modpathol.2013.145.Epub 2013 Aug 9. PubMed PMID: 23929266.




6. Thike AA, Iqbal J, Cheok PY, Tse GM, Tan PH. Ductal carcinoma in situ associated with triple negative invasive breast cancer: evidence for a precursor-product relationship. J Clin Pathol. 2013 Aug;66(8):665-70. doi:10.1136/jclinpath-2012-201428. Epub 2013 Mar 28. PubMed PMID:23539741.




7. Thike AA, Iqbal J, Cheok PY, Chong AP, Tse GM, Tan B, Tan P, Wong NS, Tan PH. Triple negative breast cancer: outcome correlation with immunohistochemical detection of basal markers. AM J Surg Pathol. 2010 Jul;34(7):956-64. doi: 10.1097/PAS.0b013e3181e02f45. PubMed PMID: 20495445.




8. Idirisinghe PK, Thike AA, Cheok PY, Tse GM, Lui PC, Fook-Chong S, Wong NS, Tan PH. Hormone receptor and c-ERBB2 status in distant metastatic and locally recurrent breast cancer. Pathologic correlations and clinical significance. AM J Clin Pathol. 2010 Mar;133(3):416-29. doi: 10.1309/AJCPJ57FLLJRXKPV. PubMed PMID: 20154280.




9. Thike AA, Cheok PY, Jara-Lazaro AR, Tan B, Tan P, Tan PH. Triple-negative breast cancer: clinicopathological characteristics and relationship with basal-like breast cancer. Mod Pathol. 2010 Jan;23(1):123-33. doi: 10.1038/modpathol.2009.145. Epub 2009 Oct 23. PubMed PMID: 19855377.




10. Thike AA, Chng MJ, Fook-Chong S, Tan PH. Immunohistochemical expression of hormone receptors in invasive breast carcinoma: correlation of results of H-score with pathological parameters. Pathology. 2001 Feb;33(1):21-5. PubMed PMID: 11280603.