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Overview
You are invited to NBD Invited Speaker Seminar (Virtual) on a novel mechano-protective mechanism in axons of central nervous system.
Presenter:Dr Tong Iris WangGroup Leader/Assistant ProfessorShanghaiTech UniversityChina
Abstract:In traumatic brain injury sudden mechanical impacts cause diffuse axonal injury to central neurons. Whether axons can proactively resist mechanical stress remains unknown. Using a new microfluidic device, we found that mild mechanical stress causes a restricted and reversible axonal beading, generated by NM-II-driven radial contraction of the axon cortex, reducing its volume by over 20%. Thus, the elevated Ca2+ waves in the stressed axon are suppressed, preventing further axonal degeneration.
Seminar Details:Date: 10 February 2023, FridayTime: 12:00pm to 1:00pm
Zoom Details:Join Zoom Meeting https://nus-sg.zoom.us/j/82677764900?pwd=Q3R1WWJ3RUVmNWZKajQyZlN3WGNxdz09
Meeting ID: 826 7776 4900 Passcode: 585428
Host:Prof Wang HongyanPrincipal Investigator & Deputy Programme DirectorNeuroscience & Behavioural Disorders ProgrammeDuke-NUS All are welcome. No registration is required.
You are invited to NBD Invited Speaker Seminar (Virtual) on a novel mechano-protective mechanism in axons of central nervous system.
Presenter:
Dr Tong Iris Wang
Group Leader/Assistant Professor
ShanghaiTech University
China
Abstract:
In traumatic brain injury sudden mechanical impacts cause diffuse axonal injury to central neurons. Whether axons can proactively resist mechanical stress remains unknown. Using a new microfluidic device, we found that mild mechanical stress causes a restricted and reversible axonal beading, generated by NM-II-driven radial contraction of the axon cortex, reducing its volume by over 20%. Thus, the elevated Ca2+ waves in the stressed axon are suppressed, preventing further axonal degeneration.
Seminar Details:
Date: 10 February 2023, Friday
Time: 12:00pm to 1:00pm
Zoom Details:
Join Zoom Meeting
https://nus-sg.zoom.us/j/82677764900?pwd=Q3R1WWJ3RUVmNWZKajQyZlN3WGNxdz09
Meeting ID: 826 7776 4900
Passcode: 585428
Host:
Prof Wang Hongyan
Principal Investigator & Deputy Programme Director
Neuroscience & Behavioural Disorders Programme
Duke-NUS
All are welcome. No registration is required.
Event Details
Date & Time
10 Feb 2023, 02:30 pm to 03:30 pmVenue
ZoomAudience
Healthcare Professionals,Community PartnersLanguage
EnglishCost
FreeVenue
Zoom
Current Session
10 Feb 2023
Seminars
A novel mechano-protective mechanism in axons of central nervous system
Free
02:30 pm to 03:30 pm
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