Find out more our AMC and efforts in academic medicine.
Dr Eyleen Goh's general interest is to determine how stem cells in the developing and adult brain can differentiate and develop into new neurons and functionally integrate into the existing circuitry. Using in vitro and in vivo assays established in the lab combining mouse genetics, anti-sense RNA technology, retroviral and lentiviral strategies, CRISPR-mediated KO or point mutations, in utero electroporation, stereotaxic injections, electrophysiology and animal behavior test, Dr Goh's team examines both intrinsic and extrinsic mechanisms responsible for neurogenesis in the developing and matured adult brain, and also studies the associated cognitive functions (Ge and Goh et al., Nature, 2006; Shim et al., Nature Neurosci., 2005; Goh et al., Mol. Brain, 2008; Shivaraj et al., PLOS one, 2012; Ng et al., PLOS one, 2013; Chew et al., Frontiers in Behav. Neurosci., 2015; Ng et al., J. Biol. Chem., 2016).
Dr Goh's team extended their research activities from understanding the fundamentals of neurogenesis to understanding and treatment of neurodevelopmental, neuropsychiatric disorders and dementia using animal models, human embryonic stem cells and patients derived pluripotent stem cells – through deciphering their common mechanisms and signalling pathways.