Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2. Swadling L, Diniz MO, Schmidt NM, Amin OE, Chandran A, Shaw E, Pade C, Gibbons JM, Le Bert N, Tan AT, Jeffery-Smith A, Tan CCS, Tham CYL, Kucykowicz S, Aidoo-Micah G, Rosenheim J, Davies J, Johnson M, Jensen MP, Joy G, McCoy LE, Valdes AM, Chain BM, Goldblatt D, Altmann DM, Boyton RJ, Manisty C, Treibel TA, Moon JC; COVIDsortium Investigators; van Dorp L, Balloux F, McKnight Á, Noursadeghi M, Bertoletti A, Maini MK. Nature. 2022 Jan;601(7891):110-117. doi: 10.1038/s41586-021-04186-8. Epub 2021 Nov 10. PMID: 34758478Implementation of Universal Newborn Screening for Severe Combined Immunodeficiency in Singapore While Continuing Routine Bacille-Calmette-Guerin Vaccination Given at Birth. Chan SB, Zhong Y, Lim SCJ, Poh S, Teh KL, Soh JY, Chong CY, Thoon KC, Seng M, Tan ES, Arkachaisri T, Liew WK. Front Immunol. 2022 Jan 3;12:794221. doi: 10.3389/fimmu.2021.794221. PMID: 35046952Residual SARS-CoV-2 viral antigens detected in GI and hepatic tissues from five recovered patients with COVID-19. Cheung CCL, Goh D, Lim X, Tien TZ, Lim JCT, Lee JN, Tan B, Tay ZEA, Wan WY, Chen EX, Nerurkar SN, Loong S, Cheow PC, Chan CY, Koh YX, Tan TT, Kalimuddin S, Tai WMD, Ng JL, Low JG, Yeong J, Lim KH. Gut. 2022 Jan;71(1):226-229. doi: 10.1136/gutjnl-2021-324280. Epub 2021 Jun 2. PMID: 34083386Deconvoluting virome-wide antibody epitope reactivity profiles. Monaco DR, Kottapalli SV, Breitwieser FP, Anderson DE, Wijaya L, Tan K, Chia WN, Kammers K, Caturegli P, Waugh K, Roederer M, Petri M, Goldman DW, Rewers M, Wang LF, Larman HB. EBioMedicine. 2022 Jan;75:103747. doi: 10.1016/j.ebiom.2021.103747. Epub 2021 Dec 16. PMID: 34922324Immune Immunomodulation in Coronavirus Disease 2019 (COVID-19): Strategic Considerations for Personalized Therapeutic Intervention. Hall MW, Joshi I, Leal L, Ooi EE. Clin Infect Dis. 2022 Jan 7;74(1):144-148. doi: 10.1093/cid/ciaa904. PMID: 32604407HBV-HCC treatment with mRNA electroporated HBV-TCR T cells. Tan AT, Bertoletti A. Immunother Adv. 2021 Dec 24;2(1):ltab026. doi: 10.1093/immadv/ltab026. PMID: 35919490Metabolic Processes Are Differentially Regulated During Wild-Type and Attenuated Dengue Virus Infection in Aedes aegypti. Siriphanitchakorn T, Modahl CM, Kini RM, Ooi EE, Choy MM. Am J Trop Med Hyg. 2022 Jan 10;106(3):900-904. doi: 10.4269/ajtmh.21-0734. PMID: 35008057Neutralizing Activity and SARS-CoV-2 Vaccine mRNA Persistence in Serum and Breastmilk After BNT162b2 Vaccination in Lactating Women. Yeo KT, Chia WN, Tan CW, Ong C, Yeo JG, Zhang J, Poh SL, Lim AJM, Sim KHZ, Sutamam N, Chua CJH, Albani S, Wang LF, Chua MC. Front Immunol. 2022 Jan 11;12:783975. doi: 10.3389/fimmu.2021.783975. PMID: 35087517Utilisation of SARS-CoV-2 rapid antigen assays in screening asymptomatic hospital visitors: mitigating the risk in low-incidence settings. Wee LE, Conceicao EP, Sim JX, Venkatachalam I, Wijaya L. Int J Infect Dis. 2022 Jan;114:132 134. doi: 10.1016/j.ijid.2021.11.011. Epub 2021 Nov 9. PMID: 34767983Exploring the Role of Innate Lymphocytes in the Immune System of Bats and Virus-Host Interactions. Sia WR, Zheng Y, Han F, Chen S, Ma S, Wang LF, Leeansyah E. Viruses. 2022 Jan 14;14(1):150. doi: 10.3390/v14010150. PMID: 35062356Dengue virus infection modifies mosquito blood-feeding behavior to increase transmission to the host. Wei Xiang BW, Saron WAA, Stewart JC, Hain A, Walvekar V, Missé D, Thomas F, Kini RM, Roche B, Claridge-Chang A, St John AL, Pompon J. Proc Natl Acad Sci U S A. 2022 Jan 18;119(3):e2117589119. doi: 10.1073/pnas.2117589119. PMID: 35012987Presence of Recombinant Bat Coronavirus GCCDC1 in Cambodian Bats. Zhu F, Duong V, Lim XF, Hul V, Chawla T, Keatts L, Goldstein T, Hassanin A, Tu VT, Buchy P, Sessions OM, Wang LF, Dussart P, Anderson DE. Viruses. 2022 Jan 18;14(2):176. doi: 10.3390/v14020176. PMID: 35215769Human Nasal Epithelial Cells Sustain Persistent SARS-CoV-2 Infection In Vitro, despite Eliciting a Prolonged Antiviral Response. Gamage AM, Tan KS, Chan WOY, Lew ZZR, Liu J, Tan CW, Rajagopalan D, Lin QXX, Tan LM, Venkatesh PN, Ong YK, Thong M, Lin RTP, Prabhakar S, Wang Y, Wang LF. mBio. 2022 Jan 18;13(1):e0343621. doi: 10.1128/mbio.03436-21. PMID: 35038898Gut Ruminococcaceae levels at baseline correlate with risk of antibiotic-associated diarrhea. Gu X, Sim JXY, Lee WL, Cui L, Chan YFZ, Chang ED, Teh YE, Zhang AN, Armas F, Chandra F, Chen H, Zhao S, Lee Z, Thompson JR, Ooi EE, Low JG, Alm EJ, Kalimuddin S. iScience. 2021 Dec 16;25(1):103644. doi: 10.1016/j.isci.2021.103644. eCollection 2022 Jan 21. PMID: 35005566Editorial: Mast Cells: Bridging Host-Microorganism Interactions. Chacón-Salinas R, Di Nardo A, Abraham SN. Front Immunol. 2022 Jan 31;13:827375. doi: 10.3389/fimmu.2022.827375. PMID: 35173737Postoperative Rather Than Preoperative Neutropenia Is Associated With Early Catheter-related Bloodstream Infections in Newly Diagnosed Pediatric Cancer Patients. Cher WQ, Lee V, Wang R, Cheah SM, Lee YT, Saffari SE, Tan CB, Chong CY, Lam JCM, Loh AHP. Pediatr Infect Dis J. 2022 Feb 1;41(2):133-139. doi: 10.1097/INF.0000000000003315. PMID: 34596627WHO international standard for SARS-CoV-2 antibodies to determine markers of protection. Zhu F, Althaus T, Tan CW, Costantini A, Chia WN, Van Vinh Chau N, Van Tan L, Mattiuzzo G, Rose NJ, Voiglio E, Wang LF. Lancet Microbe. 2022 Feb;3(2):e81-e82. doi: 10.1016/S2666-5247(21)00307-4. Epub 2021 Dec 3. PMID: 34901897Editorial: Viral Infection at the Maternal-Fetal Interface. Rathore APS, Costa VV, St John AL. Front Immunol. 2022 Feb 4;13:828681. doi: 10.3389/fimmu.2022.828681. eCollection 2022. PMID: 35185919Post-hospitalization venous thromboembolism in COVID-19 patients: Evidence against routine post-hospitalization prophylactic anticoagulation. Tan JY, Tan CW, Wong WH, Cheong MA, Lee LH, Kalimuddin S, Low JGH, Ng HJ. Int J Lab Hematol. 2022 Feb;44(1):e4-e7. doi: 10.1111/ijlh.13633. Epub 2021 Jun 19. PMID: 34146452Robust Virus-Specific Adaptive Immunity in COVID-19 Patients with SARS-CoV-2 Δ382 Variant Infection. Fong SW, Yeo NK, Chan YH, Goh YS, Amrun SN, Ang N, Rajapakse MP, Lum J, Foo S, Lee CY, Carissimo G, Chee RS, Torres-Ruesta A, Tay MZ, Chang ZW, Poh CM, Young BE, Tambyah PA, Kalimuddin S, Leo YS, Lye DC, Lee B, Biswas S, Howland SW, Renia L, Ng LFP. J Clin Immunol. 2022 Feb;42(2):214-229. doi: 10.1007/s10875-021-01142-z. Epub 2021 Oct 30. PMID: 34716845Safety and effectiveness of up to 3 years' bulevirtide monotherapy in patients with HDV-related cirrhosis. Loglio A, Ferenci P, Uceda Renteria SC, Tham CYL, Scholtes C, Holzmann H, van Bömmel F, Borghi M, Perbellini R, Rimondi A, Farina E, Trombetta E, Manunta M, Porretti L, Prati D, Ceriotti F, Zoulim F, Bertoletti A, Lampertico P. J Hepatol. 2022 Feb;76(2):464-469. doi: 10.1016/j.jhep.2021.10.012. Epub 2021 Oct 23. PMID: 34699951Cell Strain-Derived Induced Pluripotent Stem Cells as an Isogenic Approach To Investigate Age-Related Host Response to Flaviviral Infection. Bifani AM, Tan HC, Choy MM, Ooi EE. J Virol. 2022 Feb 9;96(3):e0173721. doi: 10.1128/JVI.01737-21. Epub 2021 Dec 1. PMID: 34851147Seroprevalence of Pteropine orthoreovirus in humans remain similar after nearly two decades (2001-2002 vs. 2017) in Tioman Island, Malaysia. Leong WJ, Quek XF, Tan HY, Wong KM, Muhammad HS, Mohamed NA, Wong ST, Abdullah ML, Leong PP, Wang L, Voon K. J Med Virol. 2022 Feb;94(2):771-775. doi: 10.1002/jmv.27422. Epub 2021 Nov 9. PMID: 34708881Differential immunogenicity of homologous versus heterologous boost in Ad26.COV2.S vaccine recipients. Khoo NKH, Lim JME, Gill US, de Alwis R, Tan N, Toh JZN, Abbott JE, Usai C, Ooi EE, Low JGH, Le Bert N, Kennedy PTF, Bertoletti A. Med (N Y). 2022 Feb 11;3(2):104-118.e4. doi: 10.1016/j.medj.2021.12.004. Epub 2022 Jan 19. PMID: 35072129Pediatric COVID-19 Risk Factors in Southeast Asia-Singapore and Malaysia: A Test-Negative Case-Control Study. Wong JJM, Gan CS, Kaushal SH, Chuah SL, Sultana R, Tan NWH, Eg KP, Thoon KC, Lee JH, Yung CF. Am J Trop Med Hyg. 2022 Feb 15;106(4):1113-20. doi: 10.4269/ajtmh.21-1000. PMID: 35168193Differential escape of neutralizing antibodies by SARS-CoV-2 Omicron and pre-emergent sarbecoviruses. Wang LF, Tan CW, Chia WN, Zhu F, Young B, Chantasrisawad N, Hwa SH, Yeoh AY, Lim BL, Yap WC, Pada SK, Tan SY, Jantarabenjakul W, Chen S, Zhang J, Mah YY, Chen V, Chen M, Wacharapluesadee S, Team CK, Putcharoen O, Lye D. Res Sq. 2022 Feb 23:rs.3.rs-1362541. doi: 10.21203/rs.3.rs-1362541/v1. PMID: 35233568Clinical profile of children with parechovirus meningitis in Singapore. Tan JHY, Choong CT, Tee NWS, Chong CY, Thoon KC, Maiwald M, Lee EYX, Tan MSS, Tan NWH. J Neurovirol. 2022 Feb;28(1):46-51. doi: 10.1007/s13365-021-01035-2. Epub 2021 Dec 9. PMID: 34888744A conserved arginine in NS5 binds genomic 3' stem-loop RNA for primer-independent initiation of flavivirus RNA replication. Wang S, Chan KWK, Tan MJA, Flory C, Luo D, Lescar J, Forwood JK, Vasudevan SG. RNA. 2022 Feb;28(2):177-193. doi: 10.1261/rna.078949.121. Epub 2021 Nov 10. PMID: 34759006Use of analgesics/antipyretics in the management of symptoms associated with COVID-19 vaccination. Ooi EE, Dhar A, Petruschke R, Locht C, Buchy P, Low JGH. NPJ Vaccines. 2022 Mar 2;7(1):31. doi: 10.1038/s41541-022-00453-5. PMID: 35236842Medical Student Portfolios: A Systematic Scoping Review. Tan R, Qi Ting JJ, Zhihao Hong D, Sing Lim AJ, Ong YT, Pisupati A, Xin Chong EJ, Chiam M, Inn Lee AS, Shuen Tan LH, Chew Chin AM, Wijaya L, Fong W, Radha Krishna LK. J Med Educ Curric Dev. 2022 Mar 3;9:23821205221076022. doi: 10.1177/23821205221076022. PMID: 35274044Decreased memory B cell frequencies in COVID-19 delta variant vaccine breakthrough infection. Tay MZ, Rouers A, Fong SW, Goh YS, Chan YH, Chang ZW, Xu W, Tan CW, Chia WN, Torres-Ruesta A, Amrun SN, Huang Y, Hor PX, Loh CY, Yeo NK, Wang B, Ngoh EZX, Salleh SNM, Chavatte JM, Lim AJ, Maurer-Stroh S, Wang LF, Lin RVTP, Wang CI, Tan SY, Young BE, Leo YS, Lye DC, Renia L, Ng LF. EMBO Mol Med. 2022 Mar 7;14(3):e15227. doi: 10.15252/emmm.202115227. Epub 2022 Jan 21. PMID: 34994081The Species-Specific 282 Residue in the PB2 Subunit of the Polymerase Regulates RNA Synthesis and Replication of Influenza A Viruses Infecting Bat and Nonbat Hosts. Banerjee S, De A, Kedia N, Bhakta K, Wang LF, Bhattacharjee B, Mondal A. J Virol. 2022 Mar 9;96(5):e0219021. doi: 10.1128/jvi.02190-21. Epub 2022 Jan 19. PMID: 35044213Experimental evidence for a high rate of maternal-fetal transmission of dengue virus in the presence of antibodies in immunocompromised mice. Watanabe S, Chan KWK, Tan NWW, Mahid MBA, Chowdhury A, Chang KTE, Vasudevan SG. EBioMedicine. 2022 Mar;77:103930. doi: 10.1016/j.ebiom.2022.103930. Epub 2022 Mar 13. PMID: 35290828Association of Homologous and Heterologous Vaccine Boosters With COVID-19 Incidence and Severity in Singapore. Tan SHX, Pung R, Wang LF, Lye DC, Ong B, Cook AR, Tan KB. JAMA. 2022 Mar 22;327(12):1181-1182. doi: 10.1001/jama.2022.1922. PMID: 35147657A potential silver lining of delaying the second dose. Martinez DR, Ooi EE. Nat Immunol. 2022 Mar;23(3):349-351. doi: 10.1038/s41590-022-01143-z. PMID: 35190721Solitary leg ulcer in a renal transplant recipient. Tan WH, Koniman R, Tan AL, Wijaya L, Lim KH, Oh CC. JAAD Case Rep. 2022 Mar 31;23:93-95. doi: 10.1016/j.jdcr.2021.12.046. PMID: 35495974Monocytic MDSCs homing to thymus contribute to age-related CD8+ T cell tolerance of HBV. Fang Z, Zhang Y, Zhu Z, Wang C, Hu Y, Peng X, Zhang D, Zhao J, Shi B, Shen Z, Wu M, Xu C, Chen J, Zhou X, Xie Y, Yu H, Zhang X, Li J, Hu Y, Kozlowski M, Bertoletti A, Yuan Z. J Exp Med. 2022 Apr 4;219(4):e20211838. doi: 10.1084/jem.20211838. Epub 2022 Mar 7. PMID: 35254403Immunological alterations after immunotherapy with short lived HBV-TCR T cells associates with long-term treatment response in HBV-HCC. Tan AT, Meng F, Jin J, Zhang JY, Wang SY, Shi L, Shi M, Li Y, Xie Y, Liu LM, Zhou CB, Chua A, Ho ZZ, Luan J, Zhao J, Li J, Wai LE, Koh S, Wang T, Bertoletti A, Wang FS. Hepatol Commun. 2022 Apr;6(4):841-854. doi: 10.1002/hep4.1857. Epub 2021 Dec 21. PMID: 34935312A protocol to assess cellular bioenergetics in flavivirus-infected cells. Low JZH, Yau C, Zhang SLX, Tan HC, Ooi EE, Chan KR. STAR Protoc. 2022 Apr 11;3(2):101297. doi: 10.1016/j.xpro.2022.101297. PMID: 35463466Correspondence on "The Low Yield of SARS-CoV-2 Rapid Antigen Testing in Screening Asymptomatic Hospital Visitors in Low-incidence Settings". Wee LE, Conceicao EP, Sim JX, Venkatachalam I, Wijaya L. Int J Infect Dis. 2022 Apr;117:187-188. doi: 10.1016/j.ijid.2022.01.049. Epub 2022 Jan 27. PMID: 35093529Dynamics of Neutralizing Antibody and T-Cell Responses to SARS-CoV-2 and Variants of Concern after Primary Immunization with CoronaVac and Booster with BNT162b2 or ChAdOx1 in Health Care Workers. Jantarabenjakul W, Sodsai P, Chantasrisawad N, Jitsatja A, Ninwattana S, Thippamom N, Ruenjaiman V, Tan CW, Pradit R, Sophonphan J, Wacharapluesadee S, Wang LF, Puthanakit T, Hirankarn N, Putcharoen O. Vaccines (Basel). 2022 Apr 19;10(5):639. doi: 10.3390/vaccines10050639. PMID: 35632395Post graduate remediation programs in medicine: a scoping review. Cheong CWS, Quah ELY, Chua KZY, Lim WQ, Toh RQE, Chiang CLL, Ng CWH, Lim EG, Teo YH, Kow CS, Vijayprasanth R, Liang ZJ, Tan YKI, Tan JRM, Chiam M, Lee ASI, Ong YT, Chin AMC, Wijaya L, Fong W, Mason S, Krishna LKR. BMC Med Educ. 2022 Apr 20;22(1):294. doi: 10.1186/s12909-022-03278-x. PMID: 35443679.Infectious disease in an era of global change. Baker RE, Mahmud AS, Miller IF, Rajeev M, Rasambainarivo F, Rice BL, Takahashi S, Tatem AJ, Wagner CE, Wang LF, Wesolowski A, Metcalf CJE. Nat Rev Microbiol. 2022 Apr;20(4):193-205. doi: 10.1038/s41579-021-00639-z. Epub 2021 Oct 13. PMID: 34646006Linking sporadic hospital clusters during a community surge of the severe acute respiratory coronavirus virus 2 (SARS-CoV-2) B.1.617.2 delta variant: The utility of whole-genome sequencing. Wee LE, Ko KK, Conceicao EP, Sim JX, Rahman NA, Tan SY, Cao DY, Chan KX, Aung MK, Aung MO, Yong Y, Arora S, How MKB, Tan KY, Lee LC, Tan TT, Wijaya L, Sim JHC, Suphavilai C, Venkatachalam I, Ling ML. Infect Control Hosp Epidemiol. 2022 Apr 27:1-5. doi: 10.1017/ice.2022.106. Online ahead of print. PMID: 35473629Virological and serological kinetics of SARS-CoV-2 Delta variant vaccine breakthrough infections: a multicentre cohort study. Chia PY, Ong SWX, Chiew CJ, Ang LW, Chavatte JM, Mak TM, Cui L, Kalimuddin S, Chia WN, Tan CW, Chai LYA, Tan SY, Zheng S, Lin RTP, Wang LF, Leo YS, Lee VJ, Lye DC, Young BE. Clin Microbiol Infect. 2022 Apr;28(4):612.e1-612.e7. doi: 10.1016/j.cmi.2021.11.010. Epub 2021 Nov 23. PMID: 34826623As Omicron Takes Hold and Other New Variants Arise, COVID-19 Testing Remains the Universally Agreed Tool to Effect Transition From Pandemic to Endemic State. Miller MB, Ooi EE, Rhoads DD, Kulldorff M, Anderson DE, Lee H, Gupta S, Mel K. Front Public Health. 2022 Apr 28;10:883066. doi: 10.3389/fpubh.2022.883066. PMID: 35602143Loquacious modulates flaviviral RNA replication in mosquito cells. Shivaprasad S, Weng KF, Ooi YS, Belk J, Carette JE, Flynn R, Sarnow P. PLoS Pathog. 2022 Apr 28;18(4):e1010163. doi: 10.1371/journal.ppat.1010163. PMID: 35482886COVID-19 vaccination acceptance of healthcare workers in Singapore. Tan KWA, Wijaya L, Lim CT, Gan WH. Ann Acad Med Singap. 2022 May;51(5):304-308. doi: 10.47102/annals-acadmedsg.2021504. PMID: 35658154Phage ImmunoPrecipitation Sequencing (PhIP-Seq): The Promise of High Throughput Serology. Tiu CK, Zhu F, Wang LF, de Alwis R. Pathogens. 2022 May 11;11(5):568. doi: 10.3390/pathogens11050568. PMID: 35631089New perspectives on the origins and heterogeneity of mast cells. St John AL, Rathore APS, Ginhoux F. Nat Rev Immunol. 2023 Jan;23(1):55-68. doi: 10.1038/s41577-022-00731-2. Epub 2022 May 24. PMID: 35610312Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis. Li Y, Wang X, Blau DM, Caballero MT, Feikin DR, Gill CJ, Madhi SA, Omer SB, Simões EAF, Campbell H, Pariente AB, Bardach D, Bassat Q, Casalegno JS, Chakhunashvili G, Crawford N, Danilenko D, Do LAH, Echavarria M, Gentile A, Gordon A, Heikkinen T, Huang QS, Jullien S, Krishnan A, Lopez EL, Markić J, Mira-Iglesias A, Moore HC, Moyes J, Mwananyanda L, Nokes DJ, Noordeen F, Obodai E, Palani N, Romero C, Salimi V, Satav A, Seo E, Shchomak Z, Singleton R, Stolyarov K, Stoszek SK, von Gottberg A, Wurzel D, Yoshida LM, Yung CF, Zar HJ; Respiratory Virus Global Epidemiology Network; Nair H; RESCEU investigators. Lancet. 2022 May 28;399(10340):2047-2064. doi: 10.1016/S0140-6736(22)00478-0. Epub 2022 May 19. PMID: 35598608Adverse effects following anti-COVID-19 vaccination with mRNA-based BNT162b2 are alleviated by altering the route of administration and correlate with baseline enrichment of T and NK cell genes. Syenina A, Gan ES, Toh JZN, de Alwis R, Lin LZ, Tham CYL, Yee JX, Leong YS, Sam H, Cheong C, Teh YE, Wee ILE, Ng DHL, Chan KR, Sim JXY, Kalimuddin S, Ong EZ, Low JG, Ooi EE.PLoS Biol. 2022 May 31;20(5):e3001643. doi: 10.1371/journal.pbio.3001643. PMID: 35639676A country-specific model of COVID-19 vaccination coverage needed for herd immunity in adult only or population wide vaccination programme. Goh FT, Chew YZ, Tam CC, Yung CF, Clapham H. Epidemics. 2022 Jun;39:100581. doi: 10.1016/j.epidem.2022.100581. Epub 2022 May 20. PMID: 35636311Favorable vaccine-induced SARS-CoV-2-specific T cell response profile in patients undergoing immune-modifying therapies. Qui M, Le Bert N, Chan WPW, Tan M, Hang SK, Hariharaputran S, Sim JXY, Low JGH, Ng W, Wan WY, Ang TL, Bertoletti A, Salazar E. J Clin Invest. 2022 Jun 15;132(12):e159500. doi: 10.1172/JCI159500. PMID: 35536644Evaluation of the safety and immunogenicity of different COVID-19 vaccine combinations in healthy individuals: study protocol for a randomized, subject-blinded, controlled phase 3 trial [PRIBIVAC]. Poh XY, Lee IR, Lim C, Teo J, Rao S, Chia PY, Ong SWX, Lee TH, Lin RJH, Ng LFP, Ren EC, Lin RTP, Wang LF, Renia L, Lye DC, Young BE. Trials. 2022 Jun 16;23(1):498. doi: 10.1186/s13063-022-06345-2. PMID: 35710572A Look inside the Replication Dynamics of SARS-CoV-2 in Blyth's Horseshoe Bat (Rhinolophus lepidus) Kidney Cells. Auerswald H, Low DHW, Siegers JY, Ou T, Kol S, In S, Linster M, Su YCF, Mendenhall IH, Duong V, Smith GJD, Karlsson EA. Microbiol Spectr. 2022 Jun 29;10(3):e0044922. doi: 10.1128/spectrum.00449-22. Epub 2022 May 31. PMID: 35638834Emergence of SARS-CoV-2 Spike Mutations during Prolonged Infection in Immunocompromised Hosts. Ko KKK, Yingtaweesittikul H, Tan TT, Wijaya L, Cao DY, Goh SS, Abdul Rahman NB, Chan KXL, Tay HM, Sim JHC, Chan KS, Oon LLE, Nagarajan N, Suphavilai C. Microbiol Spectr. 2022 Jun 29;10(3):e0079122. doi: 10.1128/spectrum.00791-22. Epub 2022 May 11. PMID: 35543562
Establishment of a Captive Cave Nectar Bat (Eonycteris spelaea) Breeding Colony in Singapore. Foo R, Hey YY, Jia Ng JH, Chionh YT, Chia WN, Kong PS, Lee BPY, Kang AEZ, Borthwick SA, Low DHW, Mendenhall IH, Macabe Pena E, Yroy RE, Sern Ng B, Wang LF. J Am Assoc Lab Anim Sci. 2022 Jul 1;61(4):344-352. doi: 10.30802/AALAS-JAALAS-21-000090. Epub 2022 Jun 10. PMID: 35688608
Enhanced BNT162b2 vaccine-induced cellular immunity in anti-CD19 CAR T cell-treated patients. Oh BLZ, Tan N, de Alwis R, Kunasegaran K, Chen Z, Poon M, Chan E, Low JGH, Yeoh AEJ, Bertoletti A, Le Bert N. Blood. 2022 Jul 14;140(2):156-160. doi: 10.1182/blood.2022016166. PMID: 35472242
Early oral stepdown antibiotic therapy versus continuing intravenous therapy for uncomplicated Gram-negative bacteraemia (the INVEST trial): study protocol for a multicentre, randomised controlled, open-label, phase III, non-inferiority trial. Lee IR, Tong SYC, Davis JS, Paterson DL, Syed-Omar SF, Peck KR, Chung DR, Cooke GS, Libau EA, Rahman SBA, Gandhi MP, Shi L, Zheng S, Chaung J, Tan SY, Kalimuddin S, Archuleta S, Lye DC. Trials. 2022 Jul 19;23(1):572. doi: 10.1186/s13063-022-06495-3. PMID: 35854360
Gene Updater: a web tool that autocorrects and updates for Excel misidentified gene names. Koh CWT, Ooi JSG, Joly GLC, Chan KR. Sci Rep. 2022 Jul 26;12(1):12743. doi: 10.1038/s41598-022-17104-3. PMID: 35882976
A Zoonotic Henipavirus in Febrile Patients in China. Zhang XA, Li H, Jiang FC, Zhu F, Zhang YF, Chen JJ, Tan CW, Anderson DE, Fan H, Dong LY, Li C, Zhang PH, Li Y, Ding H, Fang LQ, Wang LF, Liu W. N Engl J Med. 2022 Aug 4;387(5):470-472. doi: 10.1056/NEJMc2202705. PMID: 35921459
The challenges of adopting immunological biomarkers in the management of chronic HBV infection. Bertoletti A. J Hepatol. 2022 Aug;77(2):299-301. doi: 10.1016/j.jhep.2022.03.028. Epub 2022 Apr 7. PMID: 35398461
Editorial overview: Viral pathogenesis. Bertoletti A, Iannacone M. Curr Opin Virol. 2022 Aug;55:101253. doi: 10.1016/j.coviro.2022.101253. Epub 2022 Jul 8. PMID: 35810670.
Lower vaccine-acquired immunity in the elderly population following two-dose BNT162b2 vaccination is alleviated by a third vaccine dose. Renia L, Goh YS, Rouers A, Le Bert N, Chia WN, Chavatte JM, Fong SW, Chang ZW, Zhuo NZ, Tay MZ, Chan YH, Tan CW, Yeo NK, Amrun SN, Huang Y, Wong JXE, Hor PX, Loh CY, Wang B, Ngoh EZX, Salleh SNM, Carissimo G, Dowla S, Lim AJ, Zhang J, Lim JME, Wang CI, Ding Y, Pada S, Sun LJ, Somani J, Lee ES, Ong DLS; SCOPE Cohort Study Group; Leo YS, MacAry PA, Lin RTP, Wang LF, Ren EC, Lye DC, Bertoletti A, Young BE, Ng LFP. Nat Commun. 2022 Aug 8;13(1):4615. doi: 10.1038/s41467-022-32312-1. PMID: 35941158
TMEM41B and VMP1 modulate cellular lipid and energy metabolism for facilitating dengue virus infection. Yousefi M, Lee WS, Yan B, Cui L, Yong CL, Yap X, Tay KSL, Qiao W, Tan D, Nurazmi NI, Linster M, Smith GJD, Lee YH, Carette JE, Ooi EE, Chan KR, Ooi YS. PLoS Pathog. 2022 Aug 8;18(8):e1010763. doi: 10.1371/journal.ppat.1010763. eCollection 2022 Aug. PMID: 35939522
A strategy to assess spillover risk of bat SARS-related coronaviruses in Southeast Asia. Sánchez CA, Li H, Phelps KL, Zambrana-Torrelio C, Wang LF, Zhou P, Shi ZL, Olival KJ, Daszak P. Nat Commun. 2022 Aug 9;13(1):4380. doi: 10.1038/s41467-022-31860-w. PMID: 35945197
Modelling non-linear patterns of time-varying intervention effects on recurrent events in infectious disease prevention studies. Cheung YB, Ma X, Lam KF, Yung CF, Milligan P. J Biopharm Stat. 2022 Aug 10:1-14. doi: 10.1080/10543406.2022.2108826. PMID: 35946934
Lactobacillus crispatus Limits Bladder Uropathogenic E. coli Infection by Triggering a Host Type I Interferon Response. Song CH, Kim YH, Naskar M, Hayes BW, Abraham MA, Noh JH, Suk G, Kim MJ, Cho KS, Shin M, Lee EJ, Abraham SN, Choi HW. Proc Natl Acad Sci U S A. 2022 Aug 16;119(33):e2117904119. doi: 10.1073/pnas.2117904119. Epub 2022 Aug 8. PMID: 35939684
Chronic sequelae complicate convalescence from both dengue and acute viral respiratory illness. Kalimuddin S, Teh YE, Wee LE, Paintal S, Sasisekharan R, Low JG, Sheth SK, Ooi EE. PLoS Negl Trop Dis. 2022 Aug 18;16(8):e0010724. doi: 10.1371/journal.pntd.0010724. eCollection 2022 Aug. PMID: 35981059
Seroprevalence of Pteropine orthoreovirus (PRV) Infection among Outpatients in a Clinic in Rembau, Malaysia. Leong WJ, Voon K, Wong ST, Teng CL, Leong PP, Wang L. Biomed Environ Sci. 2022 Aug 20;35(8):755-759. doi: 10.3967/bes2022.098. PMID: 36127788
Detection of viable SARS-CoV-2 in deep respiratory specimens despite negative nasopharyngeal SARS-CoV-2 RT-PCR: Occult COVID-19 as an unsuspected cause of pulmonary infiltrates in immunocompromised patients. Wee LE, Tan JY, Ko KK, Wan WY, Lai DCM, Oon LLE, Tan-Garcia A, Yeong JPS, Pena AMT, Lim TKH, Conceicao EP, Venkatachalam I, Wijaya L, Tan TT. IDCases. 2022;30:e01611. doi: 10.1016/j.idcr.2022.e01611. Epub 2022 Aug 23. PMID: 36032521
T cell immunity is key to the pandemic endgame: How to measure and monitor it. Schwarz M, Mzoughi S, Lozano-Ojalvo D, Tan AT, Bertoletti A, Guccione E. Curr Res Immunol. 2022;3:215-221. doi: 10.1016/j.crimmu.2022.08.004. Epub 2022 Sep 1. PMID: 36065205
Monitoring human arboviral diseases through wastewater surveillance: Challenges, progress and future opportunities. Lee WL, Gu X, Armas F, Leifels M, Wu F, Chandra F, Chua FJD, Syenina A, Chen H, Cheng D, Ooi EE, Wuertz S, Alm EJ, Thompson J. Water Res. 2022 Sep 1;223:118904. doi: 10.1016/j.watres.2022.118904. Epub 2022 Jul 25. PMID: 36007397
Early seasonal coronavirus seroconversion did not produce cross-protective SARS-CoV-2 antibodies. Wong LSY, Loo EXL, Huang CH, Yap GC, Tay MJY, Chua RXY, Kang AYH, Lu L, Lee BW, Shek LP, Zhang J, Chia WN, Wang LF, Tham EH, Tambyah PA. J Infect. 2023 Jan;86(1):e10-e12. doi: 10.1016/j.jinf.2022.08.032. Epub 2022 Sep 5. PMID: 36067868
High burden of respiratory viral infection-associated mortality among critically ill children. Ravichandran D, Lim JKB, Wee PH, Allen JC, Yung CF, Lee JH, Yeo KT. Ann Acad Med Singap. 2022 Sep;51(9):575-577. doi: 10.47102/annals-acadmedsg.2022168. PMID: 36189702
Identification of Aedes aegypti salivary gland proteins interacting with human immune receptor proteins. Gavor E, Choong YK, Liu Y, Pompon J, Ooi EE, Mok YK, Liu H, Kini RM, Sivaraman J. PLoS Negl Trop Dis. 2022 Sep 7;16(9):e0010743. doi: 10.1371/journal.pntd.0010743. PMID: 36070318
Serological exposure in Bactrian and dromedary camels in Kazakhstan to a MERS or MERS-like coronavirus. Orynbayev MB, Hitch AT, Kerimbayev AA, Nissanova RK, Sultankulova KT, Rystayeva RA, Omarova ZD, Kassenov MM, Tailakova ET, Smith GJD, Mendenhall IH. Transbound Emerg Dis. 2022 Sep;69(5):e1374-e1381. doi: 10.1111/tbed.14468. Epub 2022 Feb 13. PMID: 35106948
High burden of respiratory viral infection-associated mortality among critically ill children. Ravichandran D, Lim JKB, Wee PH, Allen JC, Yung CF, Lee JH, Yeo KT. Ann Acad Med Singap. 2022 Sep;51(9):575-577. doi: 10.47102/annals-acadmedsg.2022168. PMID: 36189702
In vitro vaccine challenge of PBMCs from BNT162b2 anaphylaxis patients reveals HSP90α-NOD2-NLRP3 nexus. Ko HL, Zhuo N, Chang ZW, Santosa A, Kalimuddin S, Lim XR, Tan SY, Lye DC, Toh D, Young BE, Renia L, Lee HY, Ren EC. Allergy. 2023 Jan;78(1):304-307. doi: 10.1111/all.15503. Epub 2022 Sep 10. PMID: 36056775
Case report: Understanding the impact of persistent tissue-localization of SARS-CoV-2 on immune response activity via spatial transcriptomic analysis of two cancer patients with COVID-19 co-morbidity. Lau MC, Yi Y, Goh D, Cheung CCL, Tan B, Lim JCT, Joseph CR, Wee F, Lee JN, Lim X, Lim CJ, Leow WQ, Lee JY, Ng CCY, Bashiri H, Cheow PC, Chan CY, Koh YX, Tan TT, Kalimuddin S, Tai WMD, Ng JL, Low JG, Lim TKH, Liu J, Yeong JPS. Front Immunol. 2022 Sep 12;13:978760. doi: 10.3389/fimmu.2022.978760. PMID: 36172383
Technology-assisted adaptive recruitment strategy for a large nation-wide COVID-19 vaccine immunogenicity study in Brunei. Shim CY, Chan SY, Wei Y, Ghani H, Ahmad L, Sharif H, Alikhan MF, Haji Bagol S, Taib S, Tan CW, Ong XM, Wang LF, Wang Y, Liu AQ, Lim HS, Wong J, Naing L, Cunningham AC. Front Public Health. 2022 Sep 12;10:983571. doi: 10.3389/fpubh.2022.983571. PMID: 36172211
Act Early and at the Right Location: SARS-CoV-2 T Cell Kinetics and Tissue Localization. Bertoletti A, Le Bert N, Tan AT. Int J Mol Sci. 2022 Sep 14;23(18):10679. doi: 10.3390/ijms231810679. PMID: 36142588
Serological cross-reactivity among common flaviviruses. Chan KR, Ismail AA, Thergarajan G, Raju CS, Yam HC, Rishya M, Sekaran SD. Front Cell Infect Microbiol. 2022 Sep 15;12:975398. doi: 10.3389/fcimb.2022.975398. eCollection 2022. PMID: 36189346
Mast cell regranulation requires a metabolic switch involving mTORC1 and a glucose-6-phosphate transporter. Iskarpatyoti JA, Shi J, Abraham MA, Rathore APS, Miao Y, Abraham SN. Cell Rep. 2022 Sep 27;40(13):111346. doi: 10.1016/j.celrep.2022.111346. PMID: 36170813
Effectiveness of primary series and booster vaccination against SARS-CoV-2 infection and hospitalisation among adolescents aged 12-17 years in Singapore: a national cohort study. Chiew CJ, Premikha M, Chong CY, Wei WE, Ong B, Lye DC, Heng D, Lee VJ, Tan KB. Lancet Infect Dis. 2023 Feb;23(2):177-182. doi: 10.1016/S1473-3099(22)00573-4. Epub 2022 Sep 28. PMID: 36182678
RNA Viruses, Pandemics and Anticipatory Preparedness. Garcia-Blanco MA, Ooi EE, Sessions OM. Viruses. 2022 Sep 30;14(10):2176. doi: 10.3390/v14102176. PMID: 36298729
SARS-CoV-2 breakthrough infection in vaccinees induces virus-specific nasal-resident CD8+ and CD4+ T cells of broad specificity. Lim JME, Tan AT, Le Bert N, Hang SK, Low JGH, Bertoletti A. J Exp Med. 2022 Oct 3;219(10):e20220780. doi: 10.1084/jem.20220780. Epub 2022 Aug 16. PMID: 35972472
Clinical characteristics of macrolide-resistant Mycoplasma pneumoniae infections among hospitalised children in Singapore. Li J, Maiwald M, Loo LH, Soong HY, Octavia S, Thoon KC, Chong CY. Ann Acad Med Singap. 2022 Oct;51(10):653-656. doi: 10.47102/annals-acadmedsg.2022213. PMID: 36317577
The human disease gene LYSET is essential for lysosomal enzyme transport and viral infection. Richards CM, Jabs S, Qiao W, Varanese LD, Schweizer M, Mosen PR, Riley NM, Klüssendorf M, Zengel JR, Flynn RA, Rustagi A, Widen JC, Peters CE, Ooi YS, Xie X, Shi PY, Bartenschlager R, Puschnik AS, Bogyo M, Bertozzi CR, Blish CA, Winter D, Nagamine CM, Braulke T, Carette JE. Science. 2022 Oct 7;378(6615):eabn5648. doi: 10.1126/science.abn5648. Epub 2022 Oct 7. PMID: 36074821
SARS-CoV-2-specific T cells in the changing landscape of the COVID-19 pandemic. Bertoletti A, Le Bert N, Tan AT. Immunity. 2022 Oct 11;55(10):1764-1778. doi: 10.1016/j.immuni.2022.08.008. Epub 2022 Aug 18.PMID: 36049482
Targeting the inflammasome in Parkinson's disease. Su Q, Ng WL, Goh SY, Gulam MY, Wang LF, Tan EK, Ahn M, Chao YX. Front Aging Neurosci. 2022 Oct 12;14:957705. doi: 10.3389/fnagi.2022.957705. PMID: 36313019
Spike-specific humoral and cellular immune responses after COVID-19 mRNA vaccination in patients with cirrhosis: A prospective single center study. Iavarone M, Tosetti G, Facchetti F, Topa M, Er JM, Hang SK, Licari D, Lombardi A, D'Ambrosio R, Degasperi E, Loglio A, Oggioni C, Perbellini R, Caccia R, Bandera A, Gori A, Ceriotti F, Scudeller L, Bertoletti A, Lampertico P. Dig Liver Dis. 2023 Feb;55(2):160-168. doi: 10.1016/j.dld.2022.09.010. Epub 2022 Oct 17. PMID: 36266209
Hyperinflammatory Syndrome, Natural Killer Cell Function, and Genetic Polymorphisms in the Pathogenesis of Severe Dengue. Vuong NL, Cheung KW, Periaswamy B, Vi TT, Duyen HTL, Leong YS, Binte Hamis ZN, Gregorova M, Ooi EE, Sessions O, Rivino L, Yacoub S. J Infect Dis. 2022 Oct 17;226(8):1338-1347. doi: 10.1093/infdis/jiac093. PMID: 35267010
IL7RA single nucleotide polymorphisms are associated with the size and function of the MAIT cell population in treated HIV-1 infection. Han F, Gulam MY, Zheng Y, Zulhaimi NS, Sia WR, He D, Ho A, Hadadi L, Liu Z, Qin P, Lobie PE, Kamarulzaman A, Wang LF, Sandberg JK, Lewin SR, Rajasuriar R, Leeansyah E. Front Immunol. 2022 Oct 20;13:985385. doi: 10.3389/fimmu.2022.985385. PMID: 36341446
Priming conditions shape breadth of neutralizing antibody responses to sarbecoviruses. Jia JZ, Tan CW, Cheng SMS, Gu H, Yeoh AYY, Mok CKP, Wang Y, Zhao J, Leung NHL, Cowling BJ, Poon LLM, Hui DSC, Wang L, Peiris M, Valkenburg SA. Nat Commun. 2022 Oct 21;13(1):6285. doi: 10.1038/s41467-022-34038-6. PMID: 36271047
Unique Evolution of Antiviral Tetherin in Bats. Hayward JA, Tachedjian M, Johnson A, Irving AT, Gordon TB, Cui J, Nicolas A, Smith I, Boyd V, Marsh GA, Baker ML, Wang LF, Tachedjian G. J Virol. 2022 Oct 26;96(20):e0115222. doi: 10.1128/jvi.01152-22. Epub 2022 Sep 29. PMID: 36173189
Development and validation of a clinical predictive model for severe and critical pediatric COVID-19 infection. Wong JJM, Abbas Q, Liauw F, Malisie RF, Gan CS, Abid M, Efar P, Gloriana J, Chuah SL, Sultana R, Thoon KC, Yung CF, Lee JH; PACCOVRA Investigators of the PACCMAN research group. PLoS One. 2022 Oct 27;17(10):e0275761. doi: 10.1371/journal.pone.0275761. PMID: 36301941
Analysis of Neutralizing Antibody Levels in Children and Adolescents Up to 16 Months After SARS-CoV-2 Infection. Yung CF, Saffari SE, Mah SYY, Tan NWH, Chia WN, Thoon KC, Wang LF. JAMA Pediatr. 2022 Nov 1;176(11):1142-1143. doi: 10.1001/jamapediatrics.2022.3072. PMID: 36036929
Effectiveness of maternal pertussis vaccination in Singapore: A test-negative case-control study. Chong CY, Tan NW, Yung CF, Li J, Kam KQ, Nadua K, Maiwald M, Sultana R, Thoon KC. Vaccine. 2022 Nov 2;40(46):6570-6574. doi: 10.1016/j.vaccine.2022.09.087. Epub 2022 Oct 8. PMID: 36216649
Robust neutralizing antibody response to SARS-CoV-2 mRNA vaccination in adolescents and young adults with childhood-onset rheumatic diseases. Yeo JG, Chia WN, Teh KL, Book YX, Hoh SF, Gao X, Das L, Zhang J, Sutamam N, Lim AJM, Poh SL, Tay SH, Nay Yaung K, Ong XM, Hazirah SN, Chua CJH, Leong JY, Wang LF, Albani S, Arkachaisri T. Rheumatology (Oxford). 2022 Nov 2;61(11):4472-4481. doi: 10.1093/rheumatology/keac105. PMID: 35199166
Preclinical evaluation of [18F]FDG-PET as a biomarker of lymphoid tissue disease and inflammation in Zika virus infection. Victorio CBL, Ong J, Tham JY, Reolo MJ, Novera W, Msallam R, Watanabe S, Kalimuddin S, Low JG, Vasudevan SG, Chacko AM. Eur J Nucl Med Mol Imaging. 2022 Nov;49(13):4516-4528. doi: 10.1007/s00259-022-05892-9. Epub 2022 Jul 25. PMID: 35876869
Multisystem inflammatory syndrome in children in Singapore. Nadua KD, Chong CY, Kam KQ, Mok YH, Choo JTL, Lam JCM, Li J, Tan NWH, Yung CF, Chan SWB, Teh KL, Das L, Arkachaisri T, Thoon KC. Ann Acad Med Singap. 2022 Nov;51(11):669-676. doi: 10.47102/annals-acadmedsg.202283. PMID: 36453214
Co-circulation of alpha- and beta-coronaviruses in Pteropus vampyrus flying foxes from Indonesia. Ch'ng L, Tsang SM, Ong ZA, Low DHW, Wiantoro S, Smith IL, Simmons NB, Su YCF, Lohman DJ, Smith GJD, Mendenhall IH. Transbound Emerg Dis. 2022 Nov;69(6):3917-3925. doi: 10.1111/tbed.14762. Epub 2022 Dec 2. PMID: 36382687
SARS-CoV-2 Omicron variant emerged under immune selection. Tan CW, Chia WN, Zhu F, Young BE, Chantasrisawad N, Hwa SH, Yeoh AY, Lim BL, Yap WC, Pada SKMS, Tan SY, Jantarabenjakul W, Toh LK, Chen S, Zhang J, Mah YY, Chen VC, Chen MI, Wacharapluesadee S, Sigal A, Putcharoen O, Lye DC, Wang LF. Nat Microbiol. 2022 Nov;7(11):1756-1761. doi: 10.1038/s41564-022-01246-1. Epub 2022 Oct 4. PMID: 36195753
Single-cell transcriptome analysis of the in vivo response to viral infection in the cave nectar bat Eonycteris spelaea. Gamage AM, Chan WOY, Zhu F, Lim YT, Long S, Ahn M, Tan CW, Hiang Foo RJ, Sia WR, Lim XF, He H, Zhai W, Anderson DE, Sobota RM, Dutertre CA, Wang LF. Immunity. 2022 Nov 8;55(11):2187-2205.e5. doi: 10.1016/j.immuni.2022.10.008. PMID: 36351376
Nosocomial RSV-related In-hospital Mortality in Children <5 Years: A Global Case Series. Löwensteyn YN, Willemsen JE, Mazur NI, Scheltema NM, van Haastregt NCJ, Buuren AAAT, van Roessel I, Scheepmaker D, Nair H, van de Ven PM, Bont LJ; on behalf of the RSV GOLD Study Group. Pediatr Infect Dis J. 2023 Jan 1;42(1):1-7. doi: 10.1097/INF.0000000000003747. Epub 2022 Nov 8. PMID: 36476518
SARS-CoV-2 antigen rapid tests and universal screening for COVID-19 Omicron variant among hospitalized children. Kam KQ, Maiwald M, Chong CY, Thoon KC, Nadua KD, Loo LH, Yelen, Tan NWH, Li J, Yung CF. Am J Infect Control. 2022 Nov 9:S0196-6553(22)00784-2. doi: 10.1016/j.ajic.2022.11.002. PMID: 36370867
TSPO expression in a Zika virus murine infection model as an imaging target for acute infection-induced neuroinflammation. Victorio CBL, Msallam R, Novera W, Ong J, Yang TJ, Ganasarajah A, Low J, Watanabe S, Chacko AM. Eur J Nucl Med Mol Imaging. 2023 Feb;50(3):742-755. doi: 10.1007/s00259-022-06019-w. Epub 2022 Nov 9. PMID: 36348095
CryoEM structures of the multimeric secreted NS1, a major factor for dengue hemorrhagic fever. Bo Shu, Justin S G Ooi, Aaron W K Tan, Thiam-Seng Ng, Wanwisa Dejnirattisai, Juthathip Mongkolsapaya, Guntur Fibriansah, Jian Shi, Victor A Kostyuchenko, Gavin R Screaton, Shee-Mei Lok. Nat Commun. 2022 Nov 9;13(1):6756. doi: 10.1038/s41467-022-34415-1. PMID: 36347841
Rapid, scalable assessment of SARS-CoV-2 cellular immunity by whole-blood PCR. Schwarz M, Torre D, Lozano-Ojalvo D, Tan AT, Tabaglio T, Mzoughi S, Sanchez-Tarjuelo R, Le Bert N, Lim JME, Hatem S, Tuballes K, Camara C, Lopez-Granados E, Paz-Artal E, Correa-Rocha R, Ortiz A, Lopez-Hoyos M, Portoles J, Cervera I, Gonzalez-Perez M, Bodega-Mayor I, Conde P, Oteo-Iglesias J, Borobia AM, Carcas AJ, Frías J, Belda-Iniesta C, Ho JSY, Nunez K, Hekmaty S, Mohammed K, Marsiglia WM, Carreño JM, Dar AC, Berin C, Nicoletti G, Della Noce I, Colombo L, Lapucci C, Santoro G, Ferrari M, Nie K, Patel M, Barcessat V, Gnjatic S, Harris J, Sebra R, Merad M, Krammer F, Kim-Schulze S, Marazzi I, Bertoletti A, Ochando J, Guccione E. Nat Biotechnol. 2022 Nov;40(11):1680-1689. doi: 10.1038/s41587-022-01347-6. Epub 2022 Jun 13. PMID: 35697804
A comparative characterization of SARS-CoV-2-specific T cells induced by mRNA or inactive virus COVID-19 vaccines. Lim JME, Hang SK, Hariharaputran S, Chia A, Tan N, Lee ES, Chng E, Lim PL, Young BE, Lye DC, Le Bert N, Bertoletti A, Tan AT. Cell Rep Med. 2022 Nov 15;3(11):100793. doi: 10.1016/j.xcrm.2022.100793. Epub 2022 Oct 6. PMID: 36257326
BNT162b2 mRNA Vaccine-Induced Immune Response in Oral Fluids and Serum. Seneviratne CJ, Balan P, de Alwis R, Udawatte NS, Herath T, Toh JZN, Tin GB, Ooi EE, Hong JLG, Ying JSX. Int Dent J. 2022 Nov 16:S00206539(22)00225-8. doi: 10.1016/j.identj.2022.09.005. PMID: 36402577
Assessing professional identity formation (PIF) amongst medical students in Oncology and Palliative Medicine postings: a SEBA guided scoping review. Teo KJH, Teo MYK, Pisupati A, Ong RSR, Goh CK, Seah CHX, Toh YR, Burla N, Koh NSY, Tay KT, Ong YT, Chiam M, Fong W, Wijaya L, Goh SPL, Krishna LKR. BMC Palliat Care. 2022 Nov 18;21(1):200. doi: 10.1186/s12904-022-01090-4. PMID: 36397067
Biparatopic nanobodies targeting the receptor binding domain efficiently neutralize SARS-CoV-2. Pymm P, Redmond SJ, Dolezal O, Mordant F, Lopez E, Cooney JP, Davidson KC, Haycroft ER, Tan CW, Seneviratna R, Grimley SL, Purcell DFJ, Kent SJ, Wheatley AK, Wang LF, Leis A, Glukhova A, Pellegrini M, Chung AW, Subbarao K, Uldrich AP, Tham WH, Godfrey DI, Gherardin NA. iScience. 2022 Nov 18;25(11):105259. doi: 10.1016/j.isci.2022.105259. Epub 2022 Oct 4. PMID: 36213007
HBV antigens quantity: duration and effect on functional cure. Bertoletti A, Boni C. Gut. 2022 Nov;71(11):2149-2151. doi: 10.1136/gutjnl-2021-326258. Epub 2021 Nov 19. PMID: 34799373
Conserved longitudinal alterations of anti-S-protein IgG subclasses in disease progression in initial ancestral Wuhan and vaccine breakthrough Delta infections. Goh YS, Fong SW, Hor PX, Amrun SN, Lee CY, Young BE, Chia PY, Tambyah PA, Kalimuddin S, Pada S, Tan SY, Sun LJ, Chen MI, Leo YS, Lye DC, Ng LFP, Renia L. Front Microbiol. 2022 Nov 22;13:1043049. doi: 10.3389/fmicb.2022.1043049. PMID: 36483199
Externalities modulate the effectiveness of the Wolbachia release programme. Ooi EE, Wilder-Smith A. Lancet Infect Dis. 2022 Nov;22(11):1518-1519. doi: 10.1016/S1473-3099(22)00497-2. Epub 2022 Sep 28. PMID: 36182681
IL-17D-induced inhibition of DDX5 expression in keratinocytes amplifies IL-36R-mediated skin inflammation. Ni X, Xu Y, Wang W, Kong B, Ouyang J, Chen J, Yan M, Wu Y, Chen Q, Wang X, Li H, Gao X, Guo H, Cui L, Chen Z, Shi Y, Zhu R, Li W, Shi T, Wang LF, Huang J, Dong C, Lai Y. Nat Immunol. 2022 Nov;23(11):1577-1587. doi: 10.1038/s41590-022-01339-3. Epub 2022 Oct 21. PMID: 36271146
Immune gene expression analysis indicates the potential of a self-amplifying Covid-19 mRNA vaccine. Ong EZ, Yee JX, Ooi JSG, Syenina A, de Alwis R, Chen S, Sim JXY, Kalimuddin S, Leong YS, Chan YFZ, Sekulovich R, Sullivan BM, Lindert K, Sullivan SB, Chivukula P, Hughes SG, Low JG, Ooi EE, Chan KR. NPJ Vaccines. 2022 Nov 28;7(1):154. doi: 10.1038/s41541-022-00573-y. PMID: 36443317
The Staphylococcus aureus Network Adaptive Platform Trial Protocol: New Tools for an Old Foe. Tong SYC, Mora J, Bowen AC, Cheng MP, Daneman N, Goodman AL, Heriot GS, Lee TC, Lewis RJ, Lye DC, Mahar RK, Marsh J, McGlothlin A, McQuilten Z, Morpeth SC, Paterson DL, Price DJ, Roberts JA, Robinson JO, van Hal SJ, Walls G, Webb SA, Whiteway L, Yahav D, Davis JS; Staphylococcus aureus Network Adaptive Platform (SNAP) Study Group. Clin Infect Dis. 2022 Nov 30;75(11):2027-2034. doi: 10.1093/cid/ciac476. PMID: 35717634
Multifactorial influences underpinning a decision on COVID-19 vaccination among healthcare workers: a qualitative analysis. Yoon S, Goh H, Matchar D, Sung SC, Lum E, Lam SSW, Low JGH, Chua T, Graves N, Ong ME. Hum Vaccin Immunother. 2022 Nov 30;18(5):2085469. doi: 10.1080/21645515.2022.2085469. Epub 2022 Jun 10. PMID: 35687802
Immunogenicity of COVID-19 vaccines and levels of SARS-CoV-2 neutralising antibody in the Bruneian population: Protocol for a national longitudinal study. Ghani H, Ahmad L, Sharif H, Wong J, Bagol S, Alikhan MF, Taib S, Tan CW, Zhu F, Ong XM, Shim CY, Wang Y, Chan SY, Wei Y, Idris F, Naing L, Wang LF, Cunningham AC. BMJ Open. 2022 Dec 1;12(12):e067020. doi: 10.1136/bmjopen-2022-067020. PMID: 36456015
Comparative neutralisation profile of SARS-CoV-2 omicron subvariants BA.2.75 and BA.5. Tan CW, Lim BL, Young BE, Yeoh AY, Yung CF, Yap WC, Althaus T, Chia WN, Zhu F, Lye DC, Wang LF. Lancet Microbe. 2022 Dec;3(12):e898. doi: 10.1016/S2666-5247(22)00220-8. Epub 2022 Aug 10. PMID: 35963276
Utilization of rapid antigen assays for detection of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) in a low-incidence setting in emergency department triage: Does risk-stratification still matter? Wee LE, Conceicao EP, Sim JX, Venkatachalam I, Wan PW, Zakaria ND, Tan KB, Wijaya L. Infect Control Hosp Epidemiol. 2022 Dec;43(12):1974-1976. doi: 10.1017/ice.2021.407. Epub 2021 Sep 15. PMID: 34523394
Protection from infection or disease? Re-evaluating the broad immunogenicity of inactivated SARS-CoV-2 vaccines. Tan AT, Lim JME, Bertoletti A. Virol Sin. 2022 Dec;37(6):783-785. doi: 10.1016/j.virs.2022.11.002. Epub 2022 Nov 7. PMID: 36356859
A Zika virus-specific IgM elicited in pregnancy exhibits ultrapotent neutralization. Singh T, Hwang KK, Miller AS, Jones RL, Lopez CA, Dulson SJ, Giuberti C, Gladden MA, Miller I, Webster HS, Eudailey JA, Luo K, Von Holle T, Edwards RJ, Valencia S, Burgomaster KE, Zhang S, Mangold JF, Tu JJ, Dennis M, Alam SM, Premkumar L, Dietze R, Pierson TC, Ooi EE, Lazear HM, Kuhn RJ, Permar SR, Bonsignori M. Cell. 2022 Dec 8;185(25):4826-4840.e17. doi: 10.1016/j.cell.2022.10.023. Epub 2022 Nov 18. PMID: 36402135
Engineering antiviral immune-like systems for autonomous virus detection and inhibition in mice. Wang Y, Xu Y, Tan CW, Qiao L, Chia WN, Zhang H, Huang Q, Deng Z, Wang Z, Wang X, Shen X, Liu C, Pei R, Liu Y, Xue S, Kong D, Anderson DE, Cai F, Zhou P, Wang LF, Ye H. Nat Commun. 2022 Dec 9;13(1):7629. doi: 10.1038/s41467-022-35425-9. PMID: 36494373
The establishment of COPD organoids to study host-pathogen interaction reveals enhanced viral fitness of SARS-CoV-2 in bronchi. Chan LLY, Anderson DE, Cheng HS, Ivan FX, Chen S, Kang AEZ, Foo R, Gamage AM, Tiew PY, Koh MS, Lee KCH, Nichol K, Pathinayake PS, Chan YL, Yeo TW, Oliver BG, Wark PAB, Liu L, Tan NS, Wang LF, Chotirmall SH. Nat Commun. 2022 Dec 10;13(1):7635. doi: 10.1038/s41467-022-35253-x. PMID: 36496442
A fast-growing dengue virus mutant reveals a dual role of STING in response to infection. Ng WC, Kwek SS, Sun B, Yousefi M, Ong EZ, Tan HC, Puschnik AS, Chan KR, Ooi YS, Ooi EE. Open Biol. 2022 Dec;12(12):220227. doi: 10.1098/rsob.220227. Epub 2022 Dec 14. PMID: 36514984
A phase I/II randomized, double-blinded, placebo-controlled trial of a self-amplifying Covid-19 mRNA vaccine. Low JG, de Alwis R, Chen S, Kalimuddin S, Leong YS, Mah TKL, Yuen N, Tan HC, Zhang SL, Sim JXY, Chan YFZ, Syenina A, Yee JX, Ong EZ, Sekulovich R, Sullivan BB, Lindert K, Sullivan SM, Chivukula P, Hughes SG, Ooi EE. NPJ Vaccines. 2022 Dec 13;7(1):161. doi: 10.1038/s41541-022-00590-x. PMID: 36513697
Lessons from the pandemic: Responding to emerging zoonotic viral diseases-a Keystone Symposia report. Cable J, Fauci A, Dowling WE, Günther S, Bente DA, Yadav PD, Madoff LC, Wang LF, Arora RK, Van Kerkhove M, Chu MC, Jaenisch T, Epstein JH, Frost SDW, Bausch DG, Hensley LE, Bergeron É, Sitaras I, Gunn MD, Geisbert TW, Muñoz-Fontela C, Krammer F, de Wit E, Nordenfelt P, Saphire EO, Gilbert SC, Corbett KS, Branco LM, Baize S, van Doremalen N, Krieger MA, Clemens SAC, Hesselink R, Hartman D. Ann N Y Acad Sci. 2022 Dec;1518(1):209-225. doi: 10.1111/nyas.14898. Epub 2022 Oct 2. PMID: 36183296
Genomic epidemiology of SARS-CoV-2 in Cambodia, January 2020 to February 2021. Su YCF, Ma JZJ, Ou TP, Pum L, Krang S, Raftery P, Kinzer MH, Bohl J, Ieng V, Kab V, Patel S, Sar B, Ying WF, Jayakumar J, Horm VS, Boukli N, Yann S, Troupin C, Heang V, Garcia-Rivera JA, Sengdoeurn Y, Heng S, Lay S, Chea S, Darapheak C, Savuth C, Khalakdina A, Ly S, Baril L, Manning JE, Simone-Loriere E, Duong V, Dussart P, Sovann L, Smith GJD, Karlsson EA. Virus Evol. 2022 Dec 16;9(1):veac121. doi: 10.1093/ve/veac121. PMID: 36654682
Antibody Response of Heterologous vs Homologous Messenger RNA Vaccine Boosters Against the Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant: Interim Results from the PRIBIVAC Study, a Randomized Clinical Trial. Poh XY, Tan CW, Lee IR, Chavatte JM, Fong SW, Prince T, Hartley C, Yeoh AYY, Rao S, Chia PY, Ong SWX, Lee TH, Sadarangani SP, Lin RJH, Lim C, Teo J, Lim DRX, Chia W, Hiscox JA, Ng LFP, Ren EC, Lin RTP, Renia L, Lye DC, Wang LF, Young BE. Clin Infect Dis. 2022 Dec 19;75(12):2088-2096. doi: 10.1093/cid/ciac345. PMID: 35543372
Current status of silica-based nanoparticles as therapeutics and its potential as therapies against viruses. Tng DJH, Low JGH. Antiviral Res. 2023 Feb;210:105488. doi: 10.1016/j.antiviral.2022.105488. Epub 2022 Dec 22. PMID: 36566118
Clinical and experimental evidence for transplacental vertical transmission of flaviviruses. Watanabe S, Vasudevan SG. Antiviral Res. 2023 Feb;210:105512. doi: 10.1016/j.antiviral.2022.105512. Epub 2022 Dec 23. PMID: 36572192
Perinatal bacterial colonization and neonatal early-onset sepsis: A case-control study. Foo SXY, Lim CSE, de la Puerta R, Visvalingam D, Yung CF, Yeo KT. J Neonatal Perinatal Med. 2022;15(4):813-819. doi: 10.3233/NPM-210978. PMID: 35811543
Meeting report: 34th international conference on antiviral research. Brancale A, Carter K, Delang L, Deval J, Durantel D, Gentry BG, Jordan R, Julander JG, Lo MK, Pérez-Pérez MJ, Schang LM, Seley-Radtke KL, Shi PY, Vasudevan SG, Whitley RJ, Spengler JR. Antivir Chem Chemother. 2022 Jan-Dec;30:20402066221130853. doi: 10.1177/20402066221130853. PMID: 36305015
Therapeutics for flaviviral infections. Bifani AM, Chan KWK, Borrenberghs D, Tan MJA, Phoo WW, Watanabe S, Goethals O, Vasudevan SG, Choy MM. Antiviral Res. 2023 Feb;210:105517. doi: 10.1016/j.antiviral.2022.105517. Epub 2022 Dec 31. PMID: 36592668
Construction and characterization of an infectious clone generated from Chikungunya virus SL11131 strain. Suzuki Y, Tanaka A, Maeda Y, Emi A, Fujioka Y, Sakaguchi S, Vasudevan SG, Kobayashi T, Lim CK, Takasaki T, Wu H, Nakano T. Virology. 2021 Jan 2;552:52-62. doi: 10.1016/j.virol.2020.09.006. Epub 2020 Oct 6. PMID: 33059320
Challenges in prevaccination screening for previous dengue infection. Ooi EE. Lancet Glob Health. 2021 Jan;9(1):e4-e5. doi: 10.1016/S2214-109X(20)30506-4. PMID: 33338458
SARS-CoV-2 viral RNA load dynamics in the nasopharynx of infected children. Kam KQ, Thoon KC, Maiwald M, Chong CY, Soong HY, Loo LH, Tan NWH, Li J, Nadua KD, Yung CF. Epidemiol Infect. 2021 Jan 11;149:e18. doi: 10.1017/S095026882100008X.PMID: 33427152
Sustainable, three-component, one-pot procedure to obtain active anti-flavivirus agents. Felicetti T, Burali MS, Gwee CP, Ki Chan KW, Alonso S, Massari S, Sabatini S, Tabarrini O, Barreca ML, Cecchetti V, Vasudevan SG, Manfroni G. Eur J Med Chem. 2021 Jan 15;210:112992. doi: 10.1016/j.ejmech.2020.112992. Epub 2020 Nov 4. PMID: 33208235
18F-fluorodeoxyglucose positron emission tomography as a window into human dengue pathophysiology. Kalimuddin S, Xie W, Watanabe S, Tham JY, Sam H, Chan KWK, Yap TS, Totman JJ, Chacko AM, Vasudevan SG, Low JG. Antiviral Res. 2021 Jan;185:104991. doi: 10.1016/j.antiviral.2020.104991. Epub 2020 Dec 3. PMID: 33279522
Clinical and laboratory features of hypercoagulability in COVID-19 and other respiratory viral infections amongst predominantly younger adults with few comorbidities. Tan CW, Tan JY, Wong WH, Cheong MA, Ng IM, Conceicao EP, Low JGH, Ng HJ, Lee LH.Sci Rep. 2021 Jan 19;11(1):1793. doi: 10.1038/s41598-021-81166-y.PMID: 33469056
Animals as potential reservoirs for dengue transmission: A systematic review. Gwee SXW, St John AL, Gray GC, Pang J. One Health. 2021 Jan 20;12:100216. doi: 10.1016/j.onehlt.2021.100216. PMID: 33598525
Lessons from the host defences of bats, a unique viral reservoir. Irving AT, Ahn M, Goh G, Anderson DE, Wang LF. Nature. 2021 Jan;589(7842):363-370. doi: 10.1038/s41586-020-03128-0. Epub 2021 Jan 20. PMID: 33473223
SARS-CoV-2 neutralizing antibodies in patients with varying severity of acute COVID-19 illness. Jeewandara C, Jayathilaka D, Gomes L, Wijewickrama A, Narangoda E, Idampitiya D, Guruge D, Wijayamuni R, Manilgama S, Ogg GS, Tan CW, Wang LF, Malavige GN. Sci Rep. 2021 Jan 21;11(1):2062. doi: 10.1038/s41598-021-81629-2. PMID: 33479465
Genetic diversity and expanded host range of astroviruses detected in small mammals in Singapore. Neves ES, Mendenhall IH, Borthwick SA, Su YCF, Smith GJD. One Health. 2021 Jan 24;12:100218. doi: 10.1016/j.onehlt.2021.100218. PMID: 33553564
Genomic Evidence for Sequestration of Influenza A Virus Lineages in Sea Duck Host Species. McBride DS, Lauterbach SE, Li YT, Smith GJD, Killian ML, Nolting JM, Su YCF, Bowman AS. Viruses. 2021 Jan 24;13(2):172. doi: 10.3390/v13020172. PMID: 33498851
Controlling COVID-19 Spread in a Confined, High-Risk Population. Gray GC. JAMA Netw Open. 2021 Feb 1;4(2):e210234. doi: 10.1001/jamanetworkopen.2021.0234. PMID: 33630082
Poor Performance of Masks Secured Using Ear Loops. Yung CF. JAMA Intern Med. 2021 Feb 1;181(2):294. doi: 10.1001/jamainternmed.2020.6393. PMID: 33226399
Positive RT-PCR detected in patients recovered from COVID-19. Tan GSE, Ding Y, Cui L, Mak TM, Mok CK, Kurup A, Parthasarathy P, Chia WN, Wang LF, Lin RTP, Leo YS, Vasoo S. Ann Acad Med Singap. 2021 Feb;50(2):191-194. doi: 10.47102/annals-acadmedsg.2020387. PMID: 33733267
Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients. Tan AT, Linster M, Tan CW, Le Bert N, Chia WN, Kunasegaran K, Zhuang Y, Tham CYL, Chia A, Smith GJD, Young B, Kalimuddin S, Low JGH, Lye D, Wang LF, Bertoletti A. Cell Rep. 2021 Feb 9;34(6):108728. doi: 10.1016/j.celrep.2021.108728. Epub 2021 Jan 21. PMID: 33516277
Evidence for SARS-CoV-2 related coronaviruses circulating in bats and pangolins in Southeast Asia. Wacharapluesadee S, Tan CW, Maneeorn P, Duengkae P, Zhu F, Joyjinda Y, Kaewpom T, Chia WN, Ampoot W, Lim BL, Worachotsueptrakun K, Chen VC, Sirichan N, Ruchisrisarod C, Rodpan A, Noradechanon K, Phaichana T, Jantarat N, Thongnumchaima B, Tu C, Crameri G, Stokes MM, Hemachudha T, Wang LF. Nat Commun. 2021 Feb 9;12(1):972. doi: 10.1038/s41467-021-21240-1. PMID: 33563978
An epidemiological surveillance of hand foot and mouth disease in paediatric patients and in community: A Singapore retrospective cohort study, 2013-2018. Min N, Ong YHB, Han AX, Ho SX, Yen EWP, Ban KHK, Maurer-Stroh S, Chong CY, Chu JJH. PLoS Negl Trop Dis. 2021 Feb 10;15(2):e0008885. doi: 10.1371/journal.pntd.0008885. PMID: 33566802
While We Endure This Pandemic, What New Respiratory Virus Threats Are We Missing? Gray GC, Abdelgadir A. Open Forum Infect Dis. 2021 Feb 12;8(3):ofab078. doi: 10.1093/ofid/ofab078. PMID: 33778092
Early detection of neutralizing antibodies against SARS-CoV-2 in COVID-19 patients in Thailand. Putcharoen O, Wacharapluesadee S, Chia WN, Paitoonpong L, Tan CW, Suwanpimolkul G, Jantarabenjakul W, Ruchisrisarod C, Wanthong P, Sophonphan J, Chariyavilaskul P, Wang LF, Hemachudha T. PLoS One. 2021 Feb 12;16(2):e0246864. doi: 10.1371/journal.pone.0246864. PMID: 33577615
Sensitive detection of total anti-Spike antibodies and isotype switching in asymptomatic and symptomatic individuals with COVID-19. Goh YS, Chavatte JM, Lim Jieling A, Lee B, Hor PX, Amrun SN, Lee CY, Chee RS, Wang B, Lee CY, Ngoh EZX, Wang CI, Young BE, Tambyah PA, Kalimuddin S, Pada S, Tan SY, Sun LJ, Chen MI, Leo YS, Lye DC, Ng LFP, Lin RTP, Renia L. Cell Rep Med. 2021 Feb 16;2(2):100193. doi: 10.1016/j.xcrm.2021.100193. Epub 2021 Jan 16. PMID: 33495757
Characterization of oral virome and microbiome revealed distinctive microbiome disruptions in paediatric patients with hand, foot and mouth disease. Ho SX, Min N, Wong EPY, Chong CY, Chu JJH. NPJ Biofilms Microbiomes. 2021 Feb 19;7(1):19. doi: 10.1038/s41522-021-00190-y. PMID: 33608551
Etiology of febrile respiratory infections in the general adult population in Singapore, 2007-2013. Chen Y, Mah MG, Low JGH, Ooi EE, Su YCF, Moorthy M, Smith GJD, Linster M. Heliyon. 2021 Feb 23;7(2):e06329. doi: 10.1016/j.heliyon.2021.e06329. eCollection 2021 Feb. PMID: 33665466
Antibody affinity versus dengue morphology influences neutralization. Fibriansah G, Lim EXY, Marzinek JK, Ng TS, Tan JL, Huber RG, Lim XN, Chew VSY, Kostyuchenko VA, Shi J, Anand GS, Bond PJ, Crowe JE Jr, Lok SM. PLoS Pathog. 2021 Feb 23;17(2):e1009331. doi: 10.1371/journal.ppat.1009331. PMID: 33621239
Long-Term Humoral Immune Response in Persons with Asymptomatic or Mild SARS-CoV-2 Infection, Vietnam. Mai HK, Trieu NB, Long TH, Thanh HT, Luong ND, Huy LX, Nguyet LA, Man DNH, Anderson DE, Thanh TT, Chau NVV, Thwaites G, Wang LF, Van Tan L, Hung DT. Emerg Infect Dis. 2021 Feb;27(2):663-666. doi: 10.3201/eid2702.204226. PMID: 33496647
The Roles of T cells in Bladder Pathologies. Wu J, Abraham SN. Trends Immunol. 2021 Mar;42(3):248-260. doi: 10.1016/j.it.2021.01.003. Epub 2021 Feb 1. PMID: 33536141
Environmental bioaerosol surveillance as an early warning system for pathogen detection in North Carolina swine farms: A pilot study. Anderson BD, Yondon M, Bailey ES, Duman EK, Simmons RA, Greer AG, Gray GC. Transbound Emerg Dis. 2021 Mar;68(2):361-367. doi: 10.1111/tbed.13683. Epub 2020 Jun 29. PMID: 32535997
Temporal dynamics of the host molecular responses underlying severe COVID-19 progression and disease resolution. Ong EZ, Kalimuddin S, Chia WC, Ooi SH, Koh CW, Tan HC, Zhang SL, Low JG, Ooi EE, Chan KR. EBioMedicine. 2021 Mar;65:103262. doi: 10.1016/j.ebiom.2021.103262. Epub 2021 Mar 7. PMID: 33691247
Expansion of donor-unrestricted MAIT cells with enhanced cytolytic function suitable for TCR redirection. Parrot T, Healy K, Boulouis C, Sobkowiak MJ, Leeansyah E, Aleman S, Bertoletti A, Sällberg Chen M, Sandberg JK. JCI Insight. 2021 Mar 8;6(5):e140074. doi: 10.1172/jci.insight.140074. PMID: 33561009
Local induction of bladder Th1 responses to combat urinary tract infections. Wu J, Bao C, Reinhardt RL, Abraham SN. Proc Natl Acad Sci U S A. 2021 Mar 9;118(10):e2026461118. doi: 10.1073/pnas.2026461118. PMID: 33653961
Validation of self-collected buccal swab and saliva as a diagnostic tool for COVID-19. Ku CW, Shivani D, Kwan JQT, Loy SL, Erwin C, Ko KKK, Ng XW, Oon L, Thoon KC, Kalimuddin S, Chan JKY. Int J Infect Dis. 2021 Mar;104:255-261. doi: 10.1016/j.ijid.2020.12.080. Epub 2021 Jan 2. PMID: 33401035
High prevalence and diversity of Bartonella in small mammals from the biodiverse Western Ghats. Ansil BR, Mendenhall IH, Ramakrishnan U. PLoS Negl Trop Dis. 2021 Mar 11;15(3):e0009178. doi: 10.1371/journal.pntd.0009178. PMID: 33705398
Novel Coronavirus 2019 Transmission Risk in Educational Settings. Yung CF, Kam KQ, Nadua KD, Chong CY, Tan NWH, Li J, Lee KP, Chan YH, Thoon KC, Ng KC. Clin Infect Dis. 2021 Mar 15;72(6):1055-1058. doi: 10.1093/cid/ciaa794.PMID: 32584975
No influenza D virus detected among pigs, northern Vietnam. Farrell AS, Bui VN, Dao TD, Hoang TD, Gray GC. Influenza Other Respir Viruses. 2021 Mar;15(2):315-317. doi: 10.1111/irv.12812. Epub 2020 Sep 21. PMID: 32959521
An evaluation of the InDevR FluChip-8G insight microarray assay in characterizing influenza a viruses. Bailey ES, Wang X, Ma MJ, Wang GL, Gray GC. Trop Dis Travel Med Vaccines. 2021 Mar 17;7(1):8. doi: 10.1186/s40794-021-00133-7. PMID: 33731192
SARS-CoV-2 seroprevalence and transmission risk factors among high-risk close contacts: a retrospective cohort study. Ng OT, Marimuthu K, Koh V, Pang J, Linn KZ, Sun J, De Wang L, Chia WN, Tiu C, Chan M, Ling LM, Vasoo S, Abdad MY, Chia PY, Lee TH, Lin RJ, Sadarangani SP, Chen MI, Said Z, Kurupatham L, Pung R, Wang LF, Cook AR, Leo YS, Lee VJ. Lancet Infect Dis. 2021 Mar;21(3):333-343. doi: 10.1016/S1473 3099(20)30833-1. Epub 2020 Nov 2. PMID: 33152271
A Systematic Scoping Review on Portfolios of Medical Educators. Hong DZ, Lim AJS, Tan R, Ong YT, Pisupati A, Chong EJX, Quek CWN, Lim JY, Ting JJQ, Chiam M, Chin AMC, Lee ASI, Wijaya L, Cook S, Krishna LKR. J Med Educ Curric Dev. 2021 Mar 24;8:23821205211000356. doi: 10.1177/23821205211000356. PMID: 35187262
Applying a One Health Approach in Global Health and Medicine: Enhancing Involvement of Medical Schools and Global Health Centers. Machalaba C, Raufman J, Anyamba A, Berrian AM, Berthe FCJ, Gray GC, Jonas O, Karesh WB, Larsen MH, Laxminarayan R, Madoff LC, Martin K, Mazet JAK, Mumford E, Parker T, Pintea L, Rostal MK, de Castañeda RR, Vora NM, Wannous C, Weiss LM. Ann Glob Health. 2021 Mar 26;87(1):30. doi: 10.5334/aogh.2647. PMID: 33816135
Detection of Tioman Virus in Pteropus vampyrus Near Flores, Indonesia. Tsang SM, Low DHW, Wiantoro S, Smith I, Jayakumar J, Simmons NB, Vijaykrishna D, Lohman DJ, Mendenhall IH. Viruses. 2021 Mar 26;13(4):563. doi: 10.3390/v13040563. PMID: 33810446
Splice-Switching Antisense Oligonucleotides as a Targeted Intrinsic Engineering Tool for Generating Armored Redirected T Cells. Ceccarello E, Tabaglio T, Koh S, Oei V, Teo W, Jonathan OJ, Pavesi A, Chen Q, Bertoletti A, Wee KB, Guccione E. Nucleic Acid Ther. 2021 Apr;31(2):145-154. doi: 10.1089/nat.2020.0905. Epub 2021 Feb 9. PMID: 33567222
Respiratory viral infections in hospitalised paediatric patients in the tropics. Tan KWJ, Yung CF, Maiwald M, Saffari SE, Thoon KC, Chong CY.J Paediatr Child Health. 2021 Apr;57(4):559-565. doi: 10.1111/jpc.15267. Epub 2020 Nov 13.PMID: 33185937
Association of SARS-CoV-2 clades with clinical, inflammatory and virologic outcomes: An observational study. Young BE, Wei WE, Fong SW, Mak TM, Anderson DE, Chan YH, Pung R, Heng CS, Ang LW, Zheng AKE, Lee B, Kalimuddin S, Pada S, Tambyah PA, Parthasarathy P, Tan SY, Sun L, Smith GJ, Lin RTP, Leo YS, Renia L, Wang LF, Ng LF, Maurer-Stroh S, Lye DC, Lee VJ. EBioMedicine. 2021 Apr;66:103319. doi: 10.1016/j.ebiom.2021.103319. Epub 2021 Apr 8. PMID: 33840632
Clinical features and predictors of severity in COVID-19 patients with critical illness in Singapore. Puah SH, Young BE, Chia PY, Ho VK, Loh J, Gokhale RS, Tan SY, Sewa DW, Kalimuddin S, Tan CK, Pada SKMS, Cove ME, Chai LYA, Parthasarathy P, Ho BCH, Ng JJ, Ling LM, Abisheganaden JA, Lee VJM, Tan CH, Lin RTP, Leo YS, Lye DC, Yeo TW; Singapore 2019 novel coronavirus outbreak research team. Sci Rep. 2021 Apr 5;11(1):7477. doi: 10.1038/s41598-021-81377-3. PMID: 33820944
Mitigating Future Respiratory Virus Pandemics: New Threats and Approaches to Consider. Gray GC, Robie ER, Studstill CJ, Nunn CL. Viruses. 2021 Apr 8;13(4):637. doi: 10.3390/v13040637. PMID: 33917745
Hypoxia and viral infectious diseases. Huang R, Huestis M, Gan ES, Ooi EE, Ohh M. JCI Insight. 2021 Apr 8;6(7):e147190. doi: 10.1172/jci.insight.147190. PMID: 33830079
Coding and non-coding roles of MOCCI (C15ORF48) coordinate to regulate host inflammation and immunity. Lee CQE, Kerouanton B, Chothani S, Zhang S, Chen Y, Mantri CK, Hock DH, Lim R, Nadkarni R, Huynh VT, Lim D, Chew WL, Zhong FL, Stroud DA, Schafer S, Tergaonkar V, St John AL, Rackham OJL, Ho L. Nat Commun. 2021 Apr 9;12(1):2130. doi: 10.1038/s41467-021-22397-5. PMID: 33837217
Cefazolin versus ceftriaxone as definitive treatment for Klebsiella pneumoniae bacteraemia: a retrospective multicentre study in Singapore. Lee IR, Thein TL, Ang LW, Ding Y, Lim JJ, Bok CF, Mukherjee S, Titin C, Kalimuddin S, Archuleta S, Lye DC. J Antimicrob Chemother. 2021 Apr 13;76(5):1303-1310. doi: 10.1093/jac/dkab009. PMID: 33501978
Host specificity of Hepatocystis infection in short-nosed fruit bats (Cynopterus brachyotis) in Singapore. Low DHW, Hitch AT, Skiles MM, Borthwick SA, Neves ES, Lim ZX, Lee BPY, Su YCF, Smith GJD, Mendenhall IH. Int J Parasitol Parasites Wildl. 2021 Apr 15;15:35-42. doi: 10.1016/j.ijppaw.2021.04.001. PMID: 33948432
An epidemiological study of Streptococcus suis prevalence among swine at industrial swine farms in Northern Vietnam. Nguyen NTT, Luu YTH, Hoang TD, Nguyen HX, Dao TD, Bui VN, Gray GC. One Health. 2021 Apr 24;13:100254. doi: 10.1016/j.onehlt.2021.100254. PMID: 33997238
Ivermectin Treatment for Cattle Reduced the Survival of Two Malaria Vectors, Anopheles dirus and Anopheles epiroticus, Under Laboratory Conditions in Central Vietnam. Cramer EY, Quang NX, Hertz JC, Van Nguyen D, Quang HH, Mendenhall I, Lover AA. Am J Trop Med Hyg. 2021 Apr 26;104(6):2165-2168. doi: 10.4269/ajtmh.20-1239. PMID: 33901003
Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection. Le Bert N, Clapham HE, Tan AT, Chia WN, Tham CYL, Lim JM, Kunasegaran K, Tan LWL, Dutertre CA, Shankar N, Lim JME, Sun LJ, Zahari M, Tun ZM, Kumar V, Lim BL, Lim SH, Chia A, Tan YJ, Tambyah PA, Kalimuddin S, Lye D, Low JGH, Wang LF, Wan WY, Hsu LY, Bertoletti A, Tam CC. J Exp Med. 2021 May 3;218(5):e20202617. doi: 10.1084/jem.20202617. PMID: 33646265
Phenotypic Divergence of P Proteins of Australian Bat Lyssavirus Lineages Circulating in Microbats and Flying Foxes. Deffrasnes C, Luo MX, Wiltzer-Bach L, David CT, Lieu KG, Wang LF, Jans DA, Marsh GA, Moseley GW. Viruses. 2021 May 4;13(5):831. doi: 10.3390/v13050831. PMID: 34064444
ACE2 receptor usage reveals variation in susceptibility to SARS-CoV and SARS-CoV-2 infection among bat species. Yan H, Jiao H, Liu Q, Zhang Z, Xiong Q, Wang BJ, Wang X, Guo M, Wang LF, Lan K, Chen Y, Zhao H. Nat Ecol Evol. 2021 May;5(5):600-608. doi: 10.1038/s41559-021-01407-1. Epub 2021 Mar 1. PMID: 33649547
Maternal Immunity and Vaccination Influence Disease Severity in Progeny in a Novel Mast Cell-Deficient Mouse Model of Severe Dengue. Mantri CK, Soundarajan G, Saron WAA, Rathore APS, Alonso S, St John AL. Viruses. 2021 May 12;13(5):900. doi: 10.3390/v13050900. PMID: 34066286
Habitat impacts the abundance and network structure within tick (Acari: Ixodidae) communities on tropical small mammals. Kwak ML, Neves ES, Borthwick SA, Smith GJD, Meier R, Mendenhall IH. Ticks Tick Borne Dis. 2021 May;12(3):101654. doi: 10.1016/j.ttbdis.2021.101654. Epub 2021 Jan 19. PMID: 33548598
An NTD supersite of attack. Lok SM. Cell Host Microbe. 2021 May 12;29(5):744-746. doi: 10.1016/j.chom.2021.04.010. PMID: 33984277
Repurposing Ivermectin as an Anti-dengue Drug. Ooi EE. Clin Infect Dis. 2021 May 18;72(10):e594-e595. doi: 10.1093/cid/ciaa1341. PMID: 33124646
Culture, expansion, and flow-cytometry-based functional analysis of pteropid bat MR1-restricted unconventional T cells. Sia WR, Hey YY, Foo R, Wang LF, Leeansyah E. STAR Protoc. 2021 May 18;2(2):100487. doi: 10.1016/j.xpro.2021.100487. PMID: 34041501
Attenuated dengue viruses are genetically more diverse than their respective wild-type parents. Bifani AM, Choy MM, Tan HC, Ooi EE. NPJ Vaccines. 2021 May 20;6(1):76. doi: 10.1038/s41541-021-00340 5. PMID: 34017007
Decoding bat immunity: the need for a coordinated research approach. Wang LF, Gamage AM, Chan WOY, Hiller M, Teeling EC. Nat Rev Immunol. 2021 May;21(5):269-271. doi: 10.1038/s41577-021-00523-0. PMID: 33649605
A systematic scoping review of approaches to teaching and assessing empathy in medicine. Zhou YC, Tan SR, Tan CGH, Ng MSP, Lim KH, Tan LHE, Ong YT, Cheong CWS, Chin AMC, Chiam M, Chia EWY, Lim C, Wijaya L, Chowdhury AR, Kwek JW, Fong W, Somasundaram N, Ong EK, Mason S, Krishna LKR. BMC Med Educ. 2021 May 22;21(1):292. doi: 10.1186/s12909-021-02697-6. PMID: 34020647
A Virus-Specific Immune Rheostat in the Immunome of Patients Recovering From Mild COVID-19. Yeo JG, Leong JY, Tay SH, Nadua KD, Anderson DE, Lim AJM, Ng XW, Poh SL, Guo D, Yaung KN, Kumar P, Wasser M, Hazirah SN, Sutamam N, Chua CJH, Qui M, Foo R, Gamage AM, Yeo KT, Ramakrishna L, Arkachaisri T, Young BE, Lye DC, Wang LF, Chong CY, Tan NWH, Li J, Kam KQ, Ginhoux F, Thoon KC, Chan JKY, Yung CF, Albani S.Front Immunol. 2021 May 25;12:674279. doi: 10.3389/fimmu.2021.674279. PMID: 34113347
Containment of COVID-19 and reduction in healthcare-associated respiratory viral infections through a multi-tiered infection control strategy. Wee LE, Venkatachalam I, Sim XYJ, Tan KB, Wen R, Tham CK, Gan WH, Ko KKK, Ho WQ, Kwek GTC, Conceicao EP, Sng CYE, Ng XHJ, Ong JY, Chiang JL, Chua YY, Ling ML, Tan TT, Wijaya L. Infect Dis Health. 2021 May;26(2):123-131. doi: 10.1016/j.idh.2020.11.004. Epub 2020 Nov 16. PMID: 33386294
TMEM41B is a host factor required for the replication of diverse coronaviruses including SARS-CoV-2. Trimarco JD, Heaton BE, Chaparian RR, Burke KN, Binder RA, Gray GC, Smith CM, Menachery VD, Heaton NS. PLoS Pathog. 2021 May 27;17(5):e1009599. doi: 10.1371/journal.ppat.1009599. PMID: 34043740
Salmonella Renal Abscess in an Immunocompetent Child: Case Report and Literature Review. Poh CWM, Seah XFV, Chong CY, Ganesan I, Maiwald M, Nadua K, Kam KQ, Tan NWH. Glob Pediatr Health. 2021 May 31;8:2333794X211022263. doi: 10.1177/2333794X211022263. PMID: 34104703
Signatures of mast cell activation are associated with severe COVID-19. Tan J, Anderson DE, Rathore APS, O'Neill A, Mantri CK, Saron WAA, Lee C, Cui CW, Kang AEZ, Foo R, Kalimuddin S, Low JG, Ho L, Tambyah P, Burke TW, Woods CW, Chan KR, Karhausen J, John ALS. medRxiv. 2021 Jun 1:2021.05.31.21255594. doi: 10.1101/2021.05.31.21255594.PMID: 34100020
Dynamics of SARS-CoV-2 neutralising antibody responses and duration of immunity: a longitudinal study. Chia WN, Zhu F, Ong SWX, Young BE, Fong SW, Le Bert N, Tan CW, Tiu C, Zhang J, Tan SY, Pada S, Chan YH, Tham CYL, Kunasegaran K, Chen MI, Low JGH, Leo YS, Renia L, Bertoletti A, Ng LFP, Lye DC, Wang LF. Lancet Microbe. 2021 Jun;2(6):e240-e249. doi: 10.1016/S2666-5247(21)00025-2. Epub 2021 Mar 23. PMID: 33778792
A single dose of self-transcribing and replicating RNA-based SARS-CoV-2 vaccine produces protective adaptive immunity in mice. de Alwis R, Gan ES, Chen S, Leong YS, Tan HC, Zhang SL, Yau C, Low JGH, Kalimuddin S, Matsuda D, Allen EC, Hartman P, Park KJ, Alayyoubi M, Bhaskaran H, Dukanovic A, Bao Y, Clemente B, Vega J, Roberts S, Gonzalez JA, Sablad M, Yelin R, Taylor W, Tachikawa K, Parker S, Karmali P, Davis J, Sullivan BM, Sullivan SM, Hughes SG, Chivukula P, Ooi EE. Mol Ther. 2021 Jun 2;29(6):1970-1983. doi: 10.1016/j.ymthe.2021.04.001. Epub 2021 Apr 5. PMID: 33823303.
Antibody sugars are bittersweet. de Alwis R, Ooi EE. Science. 2021 Jun 4;372(6546):1041-1042. doi: 10.1126/science.abj0435. PMID: 34083476
Optimal Dosing of Meropenem in a Small Cohort of Critically Ill Children Receiving Continuous Renal Replacement Therapy. Tan WW, Watt KM, Boakye-Agyeman F, Cohen-Wolkowiez M, Mok YH, Yung CF, Chan YH. J Clin Pharmacol. 2021 Jun;61(6):744-754. doi: 10.1002/jcph.1798. Epub 2021 Jan 12. PMID: 33314163
Asymptomatic COVID-19: disease tolerance with efficient anti-viral immunity against SARS-CoV-2. Chan YH, Fong SW, Poh CM, Carissimo G, Yeo NK, Amrun SN, Goh YS, Lim J, Xu W, Chee RS, Torres-Ruesta A, Lee CY, Tay MZ, Chang ZW, Lee WH, Wang B, Tan SY, Kalimuddin S, Young BE, Leo YS, Wang CI, Lee B, Rötzschke O, Lye DC, Renia L, Ng LFP. EMBO Mol Med. 2021 Jun 7;13(6):e14045. doi: 10.15252/emmm.202114045. Epub 2021 May 27. PMID: 33961735
Immunological and Pathological Landscape of Dengue Serotypes 1-4 Infections in Immune-Competent Mice. Rathore APS, Mantri CK, Tan MW, Shirazi R, Nishida A, Aman SAB, Morrison J, St John AL. Front Immunol. 2021 Jun 8;12:681950. doi: 10.3389/fimmu.2021.681950. PMID: 34168651
Postgraduate ethics training programs: a systematic scoping review. Hong DZ, Goh JL, Ong ZY, Ting JJQ, Wong MK, Wu J, Tan XH, Toh RQE, Chiang CLL, Ng CWH, Ng JCK, Ong YT, Cheong CWS, Tay KT, Tan LHS, Phua GLG, Fong W, Wijaya L, Neo SHS, Lee ASI, Chiam M, Chin AMC, Krishna LKR. BMC Med Educ. 2021 Jun 9;21(1):338. doi: 10.1186/s12909-021-02644-5. PMID: 34107935
Stool metagenome analysis of patients with Klebsiella pneumoniae liver abscess and their domestic partners. Molton JS, Lee IR, Bertrand D, Ding Y, Kalimuddin S, Lye DC, Nagarajan N, Gan YH, Archuleta S. Int J Infect Dis. 2021 Jun;107:1-4. doi: 10.1016/j.ijid.2021.04.012. Epub 2021 Apr 16. PMID: 33862216
Efficacy of Wolbachia-Infected Mosquito Deployments for the Control of Dengue. Utarini A, Indriani C, Ahmad RA, Tantowijoyo W, Arguni E, Ansari MR, Supriyati E, Wardana DS, Meitika Y, Ernesia I, Nurhayati I, Prabowo E, Andari B, Green BR, Hodgson L, Cutcher Z, Rancès E, Ryan PA, O'Neill SL, Dufault SM, Tanamas SK, Jewell NP, Anders KL, Simmons CP; AWED Study Group. N Engl J Med. 2021 Jun 10;384(23):2177-2186. doi: 10.1056/NEJMoa2030243. PMID: 34107180
Human MAIT cells endowed with HBV specificity are cytotoxic and migrate towards HBV-HCC while retaining antimicrobial functions. Healy K, Pavesi A, Parrot T, Sobkowiak MJ, Reinsbach SE, Davanian H, Tan AT, Aleman S, Sandberg JK, Bertoletti A, Sällberg Chen M. JHEP Rep. 2021 Jun 11;3(4):100318. doi: 10.1016/j.jhepr.2021.100318. PMID: 34377970
Early T cell and binding antibody responses are associated with COVID-19 RNA vaccine efficacy onset. Kalimuddin S, Tham CYL, Qui M, de Alwis R, Sim JXY, Lim JME, Tan HC, Syenina A, Zhang SL, Le Bert N, Tan AT, Leong YS, Yee JX, Ong EZ, Ooi EE, Bertoletti A, Low JG. Med (N Y). 2021 Jun 11;2(6):682-688.e4. doi: 10.1016/j.medj.2021.04.003. Epub 2021 Apr 8. PMID: 33851143
Comparative Analysis of Pediatric COVID-19 Infection in Southeast Asia, South Asia, Japan, and China. Wong JJM, Abbas Q, Chuah SL, Malisie RF, Pon KM, Katsuta T, Dang H, Lee PC, Jayashree M, Sultana R, Maha Q, Gan CS, Shimizu N, Xu F, Tang SF, Shi L, Lee JH, Thoon KC, Yung CF; PACCOVRA Investigators of the PACCMAN Research Group. Am J Trop Med Hyg. 2021 Jun 15;105(2):413-420. doi: 10.4269/ajtmh.21-0299. PMID: 34129517
Post-hospitalization venous thromboembolism in COVID-19 patients: Evidence against routine post-hospitalization prophylactic anticoagulation. Tan JY, Tan CW, Wong WH, Cheong MA, Lee LH, Kalimuddin S, Low JGH, Ng HJ.Int J Lab Hematol. 2021 Jun 19:10.1111/ijlh.13633. doi: 10.1111/ijlh.13633. PMID: 34146452
Exploratory analysis to identify the best antigen and the best immune biomarkers to study SARS-CoV-2 infection. Petruccioli E, Najafi Fard S, Navarra A, Petrone L, Vanini V, Cuzzi G, Gualano G, Pierelli L, Bertoletti A, Nicastri E, Palmieri F, Ippolito G, Goletti D. J Transl Med. 2021 Jun 26;19(1):272. doi: 10.1186/s12967-021-02938-8. PMID: 34174875
Differential Cytokine Responses in Hospitalized COVID-19 Patients Limit Efficacy of Remdesivir. Chan YH, Young BE, Fong SW, Ding Y, Goh YS, Chee RS, Tan SY, Kalimuddin S, Tambyah PA, Leo YS, Ng LFP, Lye DC, Renia L. Front Immunol. 2021 Jun 28;12:680188. doi: 10.3389/fimmu.2021.680188. PMID: 34262564
Perceptions of healthcare professionals towards palliative care in internal medicine wards: a cross-sectional survey. Tay J, Compton S, Phua G, Zhuang Q, Neo S, Lee G, Wijaya L, Chiam M, Woong N, Krishna L. BMC Palliat Care. 2021 Jun 30;20(1):101. doi: 10.1186/s12904-021-00787-2. PMID: 34193142
How NS1 Antibodies Prevent Severe Flavivirus Disease. Ooi JSG, Lok SM. Trends Biochem Sci. 2021 Jul;46(7):519-521. doi: 10.1016/j.tibs.2021.03.005. Epub 2021 Apr 22. PMID: 33895084
Feasibility and utility of facemask sampling in the detection of SARS-CoV-2 during an ongoing pandemic. Ng DHL, Sim MY, Huang HH, Sim JXY, Low JGH, Lim JKS.Eur J Clin Microbiol Infect Dis. 2021 Jul 5:1-8. doi: 10.1007/s10096-021-04302-6. PMID: 34224033
Neutralizing Antibodies Titers and Side Effects in Response to BNT162b2 Vaccine in Healthcare Workers with and without Prior SARS-CoV-2 Infection. Morales-Núñez JJ, Muñoz-Valle JF, Meza-López C, Wang LF, Machado Sulbarán AC, Torres-Hernández PC, Bedolla-Barajas M, De la O-Gómez B, Balcázar-Félix P, Hernández-Bello J. Vaccines (Basel). 2021 Jul 5;9(7):742. doi: 10.3390/vaccines9070742. PMID: 34358158
Immunosuppressive Drug-Resistant Armored T-Cell Receptor T Cells for Immune Therapy of HCC in Liver Transplant Patients. Hafezi M, Lin M, Chia A, Chua A, Ho ZZ, Fam R, Tan D, Aw J, Pavesi A, Krishnamoorthy TL, Chow WC, Chen W, Zhang Q, Wai LE, Koh S, Tan AT, Bertoletti A. Hepatology. 2021 Jul;74(1):200-213. doi: 10.1002/hep.31662. Epub 2021 Jun 2. PMID: 33249625
Zoonotic enteric parasites in Mongolian people, animals, and the environment: Using One Health to address shared pathogens. Barnes AN, Davaasuren A, Baasandavga U, Lantos PM, Gonchigoo B, Gray GC. PLoS Negl Trop Dis. 2021 Jul 8;15(7):e0009543. doi: 10.1371/journal.pntd.0009543. PMID: 34237083
An unusual case of dengue fever in aneurysmal subarachnoid haemorrhage: diagnosis and management nuances. Lo YT, Kalimuddin S, Keong NCH, Lie SA. Br J Neurosurg. 2021 Jul 9:1-4. doi: 10.1080/02688697.2021.1946674. PMID: 34240635
Setting the Terms for Zoonotic Diseases: Effective Communication for Research, Conservation, and Public Policy. Shapiro JT, Víquez-R L, Leopardi S, Vicente-Santos A, Mendenhall IH, Frick WF, Kading RC, Medellín RA, Racey P, Kingston T. Viruses. 2021 Jul 13;13(7):1356. doi: 10.3390/v13071356. PMID: 34372562
Live SARS-CoV-2 is difficult to detect in patient aerosols. Robie ER, Abdelgadir A, Binder RA, Gray GC. Influenza Other Respir Viruses. 2021 Jul;15(4):554-557. doi: 10.1111/irv.12860. Epub 2021 May 3. PMID: 33939268.
Effectiveness of Palivizumab Against Respiratory Syncytial Virus Hospitalization Among Preterm Infants in a Setting With Year-Round Circulation. Yeo KT, Yung CF, Khoo PC, Saffari SE, Sng JSP, How MS, Quek BH. J Infect Dis. 2021 Jul 15;224(2):279-287. doi: 10.1093/infdis/jiaa749. PMID: 33274362
Personalized Armored TCR-Redirected T Cell Therapy for Liver/Organ Transplant with Recurrent Cancer. Hafezi M, Tan A, Bertoletti A. Cells. 2021 Jul 22;10(8):1861. doi: 10.3390/cells10081861. PMID: 34440630
Morphological Diversity and Dynamics of Dengue Virus Affecting Antigenicity. Fibriansah G, Lim XN, Lok SM. Viruses. 2021 Jul 24;13(8):1446. doi: 10.3390/v13081446. PMID: 34452312
Influenza A viruses are likely highly prevalent in South African swine farms. El Zowalaty ME, Abdelgadir A, Borkenhagen LK, Ducatez MF, Bailey ES, Gray GC. Transbound Emerg Dis. 2021 Jul 29. doi: 10.1111/tbed.14255. PMID: 34327845
Target product profile for a dengue pre-vaccination screening test. Fongwen N, Wilder-Smith A, Gubler DJ, Ooi EE, T Salvana EM, de Lamballerie X, Olliaro PL, Peeling RW. PLoS Negl Trop Dis. 2021 Jul 29;15(7):e0009557. doi: 10.1371/journal.pntd.0009557. PMID: 34324505
Animal Coronavirus Diseases: Parallels with COVID-19 in Humans. Lin CN, Chan KR, Ooi EE, Chiou MT, Hoang M, Hsueh PR, Ooi PT. Viruses. 2021 Jul 30;13(8):1507. doi: 10.3390/v13081507. PMID: 34452372
Innate immunity in hepatitis B and D virus infection: consequences for viral persistence, inflammation, and T cell recognition. Dandri M, Bertoletti A, Lütgehetmann M. Semin Immunopathol. 2021 Aug;43(4):535-548. doi: 10.1007/s00281-021-00864-x. Epub 2021 May 21. PMID: 34019142
Pseudo-outbreak of adenovirus in bronchoscopy suite. Seidelman JL, Akinboyo IC, Taylor B, Henshaw NG, Abdelgadir A, Gray GC, Smith BA, Lewis SS. Infect Control Hosp Epidemiol. 2021 Aug;42(8):1016-1017. doi: 10.1017/ice.2021.129. Epub 2021 Apr 8. PMID: 33827727
Bat virome research: the past, the present and the future. Tan CW, Yang X, Anderson DE, Wang LF. Curr Opin Virol. 2021 Aug;49:68-80. doi: 10.1016/j.coviro.2021.04.013. Epub 2021 May 27. PMID: 34052731
Meropenem Versus Piperacillin-Tazobactam for Definitive Treatment of Bloodstream Infections Caused by AmpC β-Lactamase-Producing Enterobacter spp, Citrobacter freundii, Morganella morganii, Providencia spp, or Serratia marcescens: A Pilot Multicenter Randomized Controlled Trial (MERINO-2). Stewart AG, Paterson DL, Young B, Lye DC, Davis JS, Schneider K, Yilmaz M, Dinleyici R, Runnegar N, Henderson A, Archuleta S, Kalimuddin S, Forde BM, Chatfield MD, Bauer MJ, Lipman J, Harris-Brown T, Harris PNA; MERINO Trial Investigators and the Australasian Society for Infectious Disease Clinical Research Network (ASID-CRN). Open Forum Infect Dis. 2021 Aug 2;8(8):ofab387. doi: 10.1093/ofid/ofab387. PMID: 34395716
Molecular typing of human adenoviruses among hospitalized patients with respiratory tract infections in a tertiary Hospital in Guangzhou, China between 2017 and 2019. Wang X, Wang D, Umar S, Qin S, Ling Q, Gray GC, Liu Y. BMC Infect Dis. 2021 Aug 3;21(1):748. doi: 10.1186/s12879-021-06412-0. PMID: 34344310
Implementation strategies for the first licensed dengue vaccine: A meeting report. Fongwen N, Delrieu I, Ham LH, Gubler DJ, Durbin A, Ooi EE, Peeling RW, Flasche S, Hartigan-Go K, Clifford S, Martinez CT, de Lamballerie X, Barnighausen T, Wilder-Smith A. Vaccine. 2021 Aug 9;39(34):4759-4765. doi: 10.1016/j.vaccine.2021.06.083. Epub 2021 Jul 10. PMID: 34253416
Cross-tissue single-cell landscape of human monocytes and macrophages in health and disease. Mulder K, Patel AA, Kong WT, Piot C, Halitzki E, Dunsmore G, Khalilnezhad S, Irac SE, Dubuisson A, Chevrier M, Zhang XM, Tam JKC, Lim TKH, Wong RMM, Pai R, Khalil AIS, Chow PKH, Wu SZ, Al-Eryani G, Roden D, Swarbrick A, Chan JKY, Albani S, Derosa L, Zitvogel L, Sharma A, Chen J, Silvin A, Bertoletti A, Blériot C, Dutertre CA, Ginhoux F. Immunity. 2021 Aug 10;54(8):1883-1900.e5. doi: 10.1016/j.immuni.2021.07.007. Epub 2021 Jul 30. PMID: 34331874
Pediatric Kawasaki Disease Trends Prior to and During COVID-19 Outbreak in Singapore. Chong CY, Tan NWH, Yung CF, Nadua K, Kam KQ, Li J, Thoon KC.J Pediatric Infect Dis Soc. 2021 Aug 12:piab047. doi: 10.1093/jpids/piab047. PMID: 34383064
Six Decades of Human Adenovirus Type 4 Infections Reviewed: Increasing Infections Among Civilians Are a Matter of Concern. Coleman KK, Robie ER, Abdelgadir A, Kozhumam AS, Binder RA, Gray GC. Clin Infect Dis. 2021 Aug 16;73(4):740-746. doi: 10.1093/cid/ciab146. PMID: 33693635
Genetic Characterization of Highly Pathogenic Avian Influenza A(H5N8) Virus in Pakistani Live Bird Markets Reveals Rapid Diversification of Clade 2.3.4.4b Viruses. Ali M, Yaqub T, Shahid MF, Wong FY, Mukhtar N, Naeem M, Lam P, Jayakumar J, Smith GJD, Su YCF. Viruses. 2021 Aug 18;13(8):1633. doi: 10.3390/v13081633. PMID: 34452498
Metagenomic characterization of swine slurry in a North American swine farm operation. Ramesh A, Bailey ES, Ahyong V, Langelier C, Phelps M, Neff N, Sit R, Tato C, DeRisi JL, Greer AG, Gray GC. Sci Rep. 2021 Aug 20;11(1):16994. doi: 10.1038/s41598-021-95804-y. PMID: 34417469
Differential effects of the second SARS-CoV-2 mRNA vaccine dose on T cell immunity in naive and COVID-19 recovered individuals. Lozano-Ojalvo D, Camara C, Lopez-Granados E, Nozal P, Del Pino-Molina L, Bravo-Gallego LY, Paz-Artal E, Pion M, Correa-Rocha R, Ortiz A, Lopez-Hoyos M, Iribarren ME, Portoles J, Rojo-Portoles MP, Ojeda G, Cervera I, Gonzalez-Perez M, Bodega-Mayor I, Montes-Casado M, Portoles P, Perez-Olmeda M, Oteo J, Sanchez-Tarjuelo R, Pothula V, Schwarz M, Brahmachary M, Tan AT, Le Bert N, Berin C, Bertoletti A, Guccione E, Ochando J. Cell Rep. 2021 Aug 24;36(8):109570. doi: 10.1016/j.celrep.2021.109570. Epub 2021 Aug 4. PMID: 34390647
Comprehensive mapping of SARS-CoV-2 interactions in vivo reveals functional virus-host interactions. Yang SL, DeFalco L, Anderson DE, Zhang Y, Aw JGA, Lim SY, Lim XN, Tan KY, Zhang T, Chawla T, Su Y, Lezhava A, Merits A, Wang LF, Huber RG, Wan Y. Nat Commun. 2021 Aug 25;12(1):5113. doi: 10.1038/s41467-021-25357-1. PMID: 34433821
Rapid measurement of SARS-CoV-2 spike T cells in whole blood from vaccinated and naturally infected individuals. Tan AT, Lim JM, Le Bert N, Kunasegaran K, Chia A, Qui MD, Tan N, Chia WN, de Alwis R, Ying D, Sim JX, Ooi EE, Wang LF, Chen MI, Young BE, Hsu LY, Low JG, Lye DC, Bertoletti A. J Clin Invest. 2021 Sep 1;131(17):e152379. doi: 10.1172/JCI152379. PMID: 34623327
Construction of a container isolation ward: A rapidly scalable modular approach to expand isolation capacity during the coronavirus disease 2019 (COVID-19) pandemic. Wee LE, Fan EMP, Heng R, Ang SY, Chiang JL, Tan TT, Ling ML, Wijaya L. Infect Control Hosp Epidemiol. 2021 Sep;42(9):1162-1164. doi: 10.1017/ice.2020.1222. Epub 2020 Sep 23. PMID: 32962768
Patient, staff empowerment and hand hygiene bundle improved and sustained hand hygiene in hospital wards. Chong CY, Catahan MA, Lim SH, Jais T, Kaur G, Yin S, de Korne D, Thoon KC, Ng KC.J Paediatr Child Health. 2021 Sep;57(9):1460-1466. doi: 10.1111/jpc.15526. Epub 2021 Apr 28.PMID: 33908109
Radiographic features of COVID-19 based on an initial cohort of 96 patients in Singapore. Khoo HWW, Hui TCH, Mohideen SMH, Lee YS, Liew CJY, Kok SSX, Young BE, Ong SWX, Kalimuddin S, Tan SY, Loh J, Chan LP, Poh ACC, Wong SBS, Leo YS, Lye DC, Kaw GJL, Tan CH. Singapore Med J. 2021 Sep;62(9):458-465. doi: 10.11622/smedj.2020142. Epub 2020 Sep 21. PMID: 33047143
Translation from bats to humans beyond infectious diseases. Ahn M, Wang LF. J Exp Med. 2021 Sep 6;218(9):e20211223. doi: 10.1084/jem.20211223. Epub 2021 Jul 27. PMID: 34313734
Therapeutic vaccine BRII-179 restores HBV-specific immune responses in patients with chronic HBV in a phase Ib/IIa study. Ma H, Lim TH, Leerapun A, Weltman M, Jia J, Lim YS, Tangkijvanich P, Sukeepaisarnjaroen W, Ji Y, Le Bert N, Li D, Zhang Y, Hamatake R, Tan N, Li C, Strasser SI, Ding H, Yoon JH, Stace NH, Ahmed T, Anderson DE, Yan L, Bertoletti A, Zhu Q, Yuen MF. JHEP Rep. 2021 Sep 8;3(6):100361. doi: 10.1016/j.jhepr.2021.100361. PMID: 34661089
Nasal Immunization With Small Molecule Mast Cell Activators Enhance Immunity to Co-Administered Subunit Immunogens. Johnson-Weaver BT, Choi HW, Yang H, Granek JA, Chan C, Abraham SN, Staats HF. Front Immunol. 2021 Sep 10;12:730346. doi: 10.3389/fimmu.2021.730346. PMID: 34566991
A strategy to assess spillover risk of bat SARS-related coronaviruses in Southeast Asia. Sánchez CA, Li H, Phelps KL, Zambrana-Torrelio C, Wang LF, Olival KJ, Daszak P. medRxiv. 2021 Sep 14:2021.09.09.21263359. doi: 10.1101/2021.09.09.21263359. PMID: 34545371
Utilization of rapid antigen assays for detection of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) in a low-incidence setting in emergency department triage: Does risk-stratification still matter? Wee LE, Conceicao EP, Sim JX, Venkatachalam I, Wan PW, Zakaria ND, Tan KB, Wijaya L. Infect Control Hosp Epidemiol. 2021 Sep 15:1-2. doi: 10.1017/ice.2021.407. PMID: 34523394
A mouse model of lethal respiratory dysfunction for SARS-CoV-2 infection. Gan ES, Syenina A, Linster M, Ng B, Zhang SL, Watanabe S, Rajarethinam R, Tan HC, Smith GJ, Ooi EE. Antiviral Res. 2021 Sep;193:105138. doi: 10.1016/j.antiviral.2021.105138. Epub 2021 Jul 8. PMID: 34246735
The effects of aging on host resistance and disease tolerance to SARS-CoV-2 infection. Mok DZL, Chan CYY, Ooi EE, Chan KR. FEBS J. 2021 Sep;288(17):5055-5070. doi: 10.1111/febs.15613. Epub 2020 Nov 17. PMID: 33124149
Orthogonal genome-wide screens of bat cells identify MTHFD1 as a target of broad antiviral therapy. Anderson DE, Cui J, Ye Q, Huang B, Tan Y, Jiang C, Zu W, Gong J, Liu W, Kim SY, Yan BG, Sigmundsson K, Lim XF, Ye F, Niu P, Irving AT, Zhang H, Tang Y, Zhou X, Wang Y, Tan W, Wang LF, Tan X. Proc Natl Acad Sci U S A. 2021 Sep 28;118(39):e2104759118. doi: 10.1073/pnas.2104759118. PMID: 34544865
Know your enemy and know yourself - the case of SARS-CoV-2 host factors. Lee WS, Yousefi M, Yan B, Yong CL, Ooi YS. Curr Opin Virol. 2021 Oct;50:159-170. doi: 10.1016/j.coviro.2021.08.007. Epub 2021 Aug 21. PMID: 34488003
Burnout, anxiety and depression in healthcare workers during the early COVID-19 period in Singapore. Teo I, Sung SC, Cheung YB, Wong WHM, Abu Bakar Aloweni F, Ang HG, Ayre TC, Chai-Lim C, Chen R, Heng AL, Nadarajan GD, Ong MEH, Soh CR, Tan BH, Tan KBK, Tan BS, Tan MH, Tan PH, Tay KXK, Wijaya L, Tan HK. Singapore Med J. 2021 Oct 7. doi: 10.11622/smedj.2021156. PMID: 34617698
Viral genome-based Zika virus transmission dynamics in a paediatric cohort during the 2016 Nicaragua epidemic. Sun H, Binder RA, Dickens B, de Sessions PF, Rabaa MA, Ho EXP, Cook AR, Carrillo FB, Monterrey JC, Kuan G, Balmaseda A, Ooi EE, Harris E, Sessions OM. EBioMedicine. 2021 Oct;72:103596. doi: 10.1016/j.ebiom.2021.103596. Epub 2021 Oct 7. PMID: 34627081
Pan-Sarbecovirus Neutralizing Antibodies in BNT162b2-Immunized SARS-CoV-1 Survivors. Tan CW, Chia WN, Young BE, Zhu F, Lim BL, Sia WR, Thein TL, Chen MI, Leo YS, Lye DC, Wang LF. N Engl J Med. 2021 Oct 7;385(15):1401-1406. doi: 10.1056/NEJMoa2108453. Epub 2021 Aug 18. PMID: 34407341
Absence of SARS-CoV-2 antibodies in pre-pandemic plasma from children and adults in Vietnam. Chau NVV, Nhan LNT, Nguyet LA, Tu NTK, Hong NTT, Man DNH, Ty DTB, Nhu LNT, Yen LM, Khanh TH, Quy DT, Minh NNQ, Ny NTH, Anderson D, Wang LF, van Doorn HR, Hung NT, Thanh TT, Thwaites G, Tan LV; for OUCRU COVID-19 research group. Int J Infect Dis. 2021 Oct;111:127-129. doi: 10.1016/j.ijid.2021.07.072. Epub 2021 Jul 31. PMID: 34339862
A new Hendra virus genotype found in Australian flying foxes. Wang J, Anderson DE, Halpin K, Hong X, Chen H, Walker S, Valdeter S, van der Heide B, Neave MJ, Bingham J, O'Brien D, Eagles D, Wang LF, Williams DT. Virol J. 2021 Oct 13;18(1):197. doi: 10.1186/s12985-021-01652-7. PMID: 34641882
SARS-CoV-2-specific T cells in infection and vaccination. Bertoletti A, Le Bert N, Qui M, Tan AT. Cell Mol Immunol. 2021 Oct;18(10):2307-2312. doi: 10.1038/s41423-021-00743-3. Epub 2021 Sep 1. PMID: 34471260
Healthcare worker stress, anxiety and burnout during the COVID-19 pandemic in Singapore: A 6-month multi-centre prospective study. Teo I, Chay J, Cheung YB, Sung SC, Tewani KG, Yeo LF, Yang GM, Pan FT, Ng JY, Abu Bakar Aloweni F, Ang HG, Ayre TC, Chai-Lim C, Chen RC, Heng AL, Nadarajan GD, Ong MEH, See B, Soh CR, Tan BKK, Tan BS, Tay KXK, Wijaya L, Tan HK. PLoS One. 2021 Oct 22;16(10):e0258866. doi: 10.1371/journal.pone.0258866. PMID: 34679110
Acute acalculous cholecystitis in dengue fever: a case series. Lai YT, Kalimuddin S, Ng HJH, Tay GCA. Singapore Med J. 2021 Oct 24. doi: 10.11622/smedj.2021168. PMID: 34688232
H5Nx Viruses Emerged during the Suppression of H5N1 Virus Populations in Poultry. Li YT, Su YCF, Smith GJD. Microbiol Spectr. 2021 Oct 31;9(2):e0130921. doi: 10.1128/Spectrum.01309-21. Epub 2021 Sep 29. PMID: 34585974
Leptospirosis infections among hospital patients, Sarawak, Malaysia. Hii KC, Robie ER, Saihidi I, Berita A, Alarja NA, Xiu L, Merchant JA, Binder RA, Goh JK, Guernier-Cambert V, Galán D, Gregory MJ, Gray GC. Trop Dis Travel Med Vaccines. 2021 Nov 1;7(1):32. doi: 10.1186/s40794-021-00154-2. PMID: 34719397
Saliva Is Not a Useful Diagnostic Specimen in Children With Coronavirus Disease 2019 (COVID-19). Chong CY, Kam KQ, Li J, Maiwald M, Loo LH, Nadua KD, Tan NWH, Yung CF, Thoon KC. Clin Infect Dis. 2021 Nov 2;73(9):e3144-e3145. doi: 10.1093/cid/ciaa1376.PMID: 32927475
Viral Dynamics and Immune Correlates of Coronavirus Disease 2019 (COVID-19) Severity. Young BE, Ong SWX, Ng LFP, Anderson DE, Chia WN, Chia PY, Ang LW, Mak TM, Kalimuddin S, Chai LYA, Pada S, Tan SY, Sun L, Parthasarathy P, Fong SW, Chan YH, Tan CW, Lee B, Rötzschke O, Ding Y, Tambyah P, Low JGH, Cui L, Barkham T, Lin RTP, Leo YS, Renia L, Wang LF, Lye DC; Singapore 2019 Novel Coronavirus Outbreak Research Team. Clin Infect Dis. 2021 Nov 2;73(9):e2932-e2942. doi: 10.1093/cid/ciaa1280. PMID: 32856707
Chikungunya and Zika Viruses Not Detected Among Patients With Dengue-Like Illness, Sarawak, Malaysia. Robie ER, Zemke JN, Toh TH, Lee JS, Hii KC, Callahan JD, Schoepp RJ, Gray GC. Asia Pac J Public Health. 2021 Nov;33(8):995-996. doi: 10.1177/10105395211007631. Epub 2021 Apr 8. PMID: 33829875
Ancestral sequence reconstruction pinpoints adaptations that enable avian influenza virus transmission in pigs. Su W, Harfoot R, Su YCF, DeBeauchamp J, Joseph U, Jayakumar J, Crumpton JC, Jeevan T, Rubrum A, Franks J, Pascua PNQ, Kackos C, Zhang Y, Zhang M, Ji Y, Bui HT, Jones JC, Kercher L, Krauss S, Pleschka S, Chan MCW, Webster RG, Wu CY, Van Reeth K, Peiris M, WebbVy RJ, Smith GJD, Yen HL. Nat Microbiol. 2021 Nov;6(11):1455-1465. doi: 10.1038/s41564-021-00976-y. Epub 2021 Oct 26. PMID: 34702977
Antibody effector analysis of prime versus prime-boost immunizations with a recombinant measles-vectored chikungunya virus vaccine. Tschismarov R, Zellweger RM, Koh MJ, Leong YS, Low JG, Ooi EE, Mandl CW, Ramsauer K, de Alwis R. JCI Insight. 2021 Nov 8;6(21):e151095. doi: 10.1172/jci.insight.151095. PMID: 34582377
Pre-existing T cell-mediated cross-reactivity to SARS-CoV-2 cannot solely be explained by prior exposure to endemic human coronaviruses. Tan CCS, Owen CJ, Tham CYL, Bertoletti A, van Dorp L, Balloux F. Infect Genet Evol. 2021 Nov;95:105075. doi: 10.1016/j.meegid.2021.105075. Epub 2021 Sep 10. PMID: 34509646
Revisiting dengue virus-mosquito interactions: molecular insights into viral fitness. Siriphanitchakorn T, Kini RM, Ooi EE, Choy MM. J Gen Virol. 2021 Nov;102(11):001693. doi: 10.1099/jgv.0.001693. PMID: 34845981
Quantitative risk assessment of COVID-19 aerosol transmission indoors: a mechanistic stochastic web application. Rocha-Melogno L, Crank K, Bergin MH, Gray GC, Bibby K, Deshusses MA. Environ Technol. 2021 Nov 13:1-12. doi: 10.1080/09593330.2021.1998228. PMID: 34726128
Susceptibility of different cell lines to the novel canine coronavirus CCoV-HuPn-2018. Abdelgadir A, Vlasova AN, Gray GC. Influenza Other Respir Viruses. 2021 Nov;15(6):824-825. doi: 10.1111/irv.12882. Epub 2021 Jul 1. PMID: 34212500
Amidoxime prodrugs convert to potent cell-active multimodal inhibitors of the dengue virus protease. Swarbrick C, Zogali V, Chan KWK, Kiousis D, Gwee CP, Wang S, Lescar J, Luo D, von Itzstein M, Matsoukas MT, Panagiotakopoulos G, Vasudevan SG, Rassias G. Eur J Med Chem. 2021 Nov 15;224:113695. doi: 10.1016/j.ejmech.2021.113695. Epub 2021 Jul 10. PMID: 34298282
HBV antigens quantity: duration and effect on functional cure. Bertoletti A, Boni C. Gut. 2021 Nov 19:gutjnl-2021-326258. doi: 10.1136/gutjnl-2021-326258. PMID: 34799373
Data-Driven Analysis of COVID-19 Reveals Persistent Immune Abnormalities in Convalescent Severe Individuals. Lim J, Puan KJ, Wang LW, Teng KWW, Loh CY, Tan KP, Carissimo G, Chan YH, Poh CM, Lee CY, Fong SW, Yeo NK, Chee RS, Amrun SN, Chang ZW, Tay MZ, Torres-Ruesta A, Leo Fernandez N, How W, Andiappan AK, Lee W, Duan K, Tan SY, Yan G, Kalimuddin S, Lye DC, Leo YS, Ong SWX, Young BE, Renia L, Ng LFP, Lee B, Rötzschke O. Front Immunol. 2021 Nov 19;12:710217. doi: 10.3389/fimmu.2021.710217. PMID: 34867943
Optimal flexibility of the linker region of Zika virus NS5 methyltransferase-polymerase is critical for virus replication. Flory C, Chan KWK, Bifani AM, Choy MMJ, Lescar J, Ooi EE, Tautz N, Vasudevan SG. Antiviral Res. 2021 Nov;195:105194. doi: 10.1016/j.antiviral.2021.105194. Epub 2021 Oct 23. PMID: 34699863
Phylodynamic analysis and spike protein mutations in porcine deltacoronavirus with a new variant introduction in Taiwan. Hsueh FC, Wu CN, Lin MY, Hsu FY, Lin CF, Chang HW, Lin JH, Liu HF, Chiou MT, Chan KR, Lin CN. Virus Evol. 2021 Nov 24;7(2):veab096. doi: 10.1093/ve/veab096. eCollection 2021. PMID: 34858636
A modified Delphi approach to enhance nurturing of professionalism in postgraduate medical education in Singapore. Teo YH, Peh TY, Abdurrahman ABHM, Lee ASI, Chiam M, Fong W, Wijaya L, Krishna LKR. Singapore Med J. 2021 Nov 26. doi: 10.11622/smedj.2021224. PMID: 34823327
Evaluation of a surrogate virus neutralization test for high-throughput serosurveillance of SARS-CoV-2. Mariën J, Michiels J, Heyndrickx L, Nkuba-Ndaye A, Ceulemans A, Bartholomeeusen K, Madinga J, Mbala-Kingebeni P, Vanlerberghe V, Ahuka-Mundeke S, Wang LF, Ariën KK. J Virol Methods. 2021 Nov;297:114228. doi: 10.1016/j.jviromet.2021.114228. Epub 2021 Jul 3. PMID: 34224754
Immunotherapy of HBV-related advanced hepatocellular carcinoma with short-term HBV-specific TCR expressed T cells: results of dose escalation, phase I trial. Meng F, Zhao J, Tan AT, Hu W, Wang SY, Jin J, Wu J, Li Y, Shi L, Fu JL, Yu S, Shen Y, Liu L, Luan J, Shi M, Xie Y, Zhou CB, Wong RW, Lu-En W, Koh S, Bertoletti A, Wang T, Zhang JY, Wang FS. Hepatol Int. 2021 Dec;15(6):1402-1412. doi: 10.1007/s12072-021-10250-2. Epub 2021 Nov 30. PMID: 34850325
Poor Hygiene as a Risk Factor in the Development of Brain Abscess in Adolescents. Vig PS, Wong JJM, Chong CY, Nguyen TAP, Maiwald M, Tan NWH.J Paediatr Child Health. 2021 Dec;57(12):2043-2045. doi: 10.1111/jpc.15798. Epub 2021 Oct 23.PMID: 34687481
Amplified parallel antigen rapid test for point-of-care salivary detection of SARS-CoV-2 with improved sensitivity. Tng DJH, Yin BCY, Cao J, Ko KKK, Goh KCM, Chua DXW, Zhang Y, Chua MLK, Low JGH, Ooi EE, Soo KC. Mikrochim Acta. 2021 Dec 6;189(1):14. doi: 10.1007/s00604-021-05113-4. PMID: 34870771
Structure, function and pharmacology of human itch GPCRs. Cao C, Kang HJ, Singh I, Chen H, Zhang C, Ye W, Hayes BW, Liu J, Gumpper RH, Bender BJ, Slocum ST, Krumm BE, Lansu K, McCorvy JD, Kroeze WK, English JG, DiBerto JF, Olsen RHJ, Huang XP, Zhang S, Liu Y, Kim K, Karpiak J, Jan LY, Abraham SN, Jin J, Shoichet BK, Fay JF, Roth BL. Nature. 2021 Dec;600(7887):170-175. doi: 10.1038/s41586-021-04126-6. Epub 2021 Nov 17. PMID: 34789874
Serotype distribution and incidence of invasive early onset and late onset group B streptococcal disease amongst infants in Singapore. Kam KQ, Thoon KC, Tee WSN, Ang MLT, Tan NWH, Yeo KT, Li J, Chong CY. BMC Infect Dis. 2021 Dec 7;21(1):1221. doi: 10.1186/s12879-021-06891-1. PMID: 34876053
Human antibody C10 neutralizes by diminishing Zika but enhancing dengue virus dynamics. Lim XX, Shu B, Zhang S, Tan AWK, Ng TS, Lim XN, Chew VS, Shi J, Screaton GR, Lok SM, Anand GS. Cell. 2021 Dec 9;184(25):6067-6080.e13. doi: 10.1016/j.cell.2021.11.009. Epub 2021 Nov 30. PMID: 34852238
Widely heterogeneous humoral and cellular immunity after mild SARS-CoV-2 infection in a homogeneous population of healthy young men. Le Bert N, Chia WN, Wan WY, Teo AKJ, Chong SZ, Tan N, Tan DSC, Chia A, Tan IB, Kunasegaran K, Chua QX, Abdad MY, Ng ASH, Vasoo S, Ang JX, Lee MS, Sun L, Fang J, Zhu F, Cook AR, Aw TC, Huang J, Tam C, Lee FS, Clapham H, Goh EJ, Peou MSS, Tan SP, Ong SK, Wang LF, Bertoletti A, Hsu LY, Ong BC. Emerg Microbes Infect. 2021 Dec;10(1):2141-2150. doi: 10.1080/22221751.2021.1999777. PMID: 34709140
In Vitro and In Vivo Stability of P884T, a Mutation that Relocalizes Dengue Virus 2 Non-structural Protein 5. Cheng CX, Alvin Tan MJ, Chan KWK, Watanabe S, Wang S, Choy MM, Manuel M, Victorio CBL, Ong J, Reolo M, Chacko AM, Vasudevan SG. ACS Infect Dis. 2021 Dec 10;7(12):3277-3291. doi: 10.1021/acsinfecdis.1c00441. Epub 2021 Nov 4. PMID: 34735113
Systemic inflammation, innate immunity and pathogenesis after Zika virus infection in cynomolgus macaques are modulated by strain-specificity within the Asian lineage. de Alwis R, Zellweger RM, Chua E, Wang LF, Chawla T, Sessions OM, Marlier D, Connolly JE, von Messling V, Anderson DE. Emerg Microbes Infect. 2021 Dec;10(1):1457-1470. doi: 10.1080/22221751.2021.1943536. PMID: 34120576
A pan-coronavirus RT-PCR assay for rapid viral screening of animal, human, and environmental specimens. Wang X, Xiu L, Binder RA, Toh TH, Lee JS, Ting J, Than ST, Qi W, Coleman KK, Perera D, Ma M, Gray GC. One Health. 2021 Dec;13:100274. doi: 10.1016/j.onehlt.2021.100274. Epub 2021 Jun 6. PMID: 34124332
Dysregulated metabolism underpins Zika-virus-infection-associated impairment in fetal development. Yau C, Low JZH, Gan ES, Kwek SS, Cui L, Tan HC, Mok DZL, Chan CYY, Sessions OM, Watanabe S, Vasudevan SG, Lee YH, Chan KR, Ooi EE. Cell Rep. 2021 Dec 14;37(11):110118. doi: 10.1016/j.celrep.2021.110118. PMID: 34910902
Difference in sensitivity between SARS-CoV-2-specific T cell assays in patients with underlying conditions. Reply. Tan AT, Le Bert N, Bertoletti A. J Clin Invest. 2021 Dec 15;131(24):e155701. doi: 10.1172/JCI155701. PMID: 34907917
Gut Ruminococcaceae levels at baseline correlate with risk of antibiotic-associated diarrhea. Gu X, Sim JXY, Lee WL, Cui L, Chan YFZ, Chang ED, Teh YE, Zhang AN, Armas F, Chandra F, Chen H, Zhao S, Lee Z,Thompson JR, Ooi EE, Low JG, Alm EJ, Kalimuddin S. iScience. 2021 Dec 16;25(1):103644. doi: 10.1016/j.isci.2021.103644. PMID: 35005566.
Inhibitor of growth protein 3 epigenetically silences endogenous retroviral elements and prevents innate immune activation. Song Y, Hou G, Diep J, Ooi YS, Akopyants NS, Beverley SM, Carette JE, Greenberg HB, Ding S. Nucleic Acids Res. 2021 Dec 16;49(22):12706-12715. doi: 10.1093/nar/gkab1070. PMID: 34791430
The potential clinical utility of measuring severe acute respiratory syndrome coronavirus 2-specific T-cell responses. Goletti D, Petrone L, Manissero D, Bertoletti A, Rao S, Ndunda N, Sette A, Nikolayevskyy V. Clin Microbiol Infect. 2021 Dec;27(12):1784-1789. doi: 10.1016/j.cmi.2021.07.005. Epub 2021 Jul 10. PMID: 34256141
Comparative characterization of B cells specific for HBV nucleocapsid and envelope proteins in patients with chronic hepatitis B. Le Bert N, Salimzadeh L, Gill US, Dutertre CA, Facchetti F, Tan A, Hung M, Novikov N, Lampertico P, Fletcher SP, Kennedy PTF, Bertoletti A. J Hepatol. 2020 Jan;72(1):34-44. doi: 10.1016/j.jhep.2019.07.015. Epub 2019 Jul 23. PMID: 31348999.
Taurolidine-citrate lock solution for the prevention of central line-associated bloodstream infection in paediatric haematology-oncology and gastrointestinal failure patients with high baseline central-line associated bloodstream infection rates. Chong CY, Ong RY, Seah VX, Tan NW, Chan MY, Soh SY, Ong C, Lim AS, Thoon KC. J Paediatr Child Health. 2020 Jan;56(1):123-129. doi: 10.1111/jpc.14506. Epub 2019 May 30. PMID: 31145505.
The burden and clinical manifestation of hospitalized influenza among different pediatric age-groups in the tropics. Chong CY, Yung CF, Gan C, Thio ST, Tan NW, Tee NW, Lin C, Lin RT, Thoon KC. Influenza Other Respir Viruses. 2020 Jan;14(1):46-54. doi: 10.1111/irv.12692. Epub 2019 Oct 13. PMID: 31608598.
Divergent evolutionary trajectories of influenza B viruses underlie their contemporaneous epidemic activity.Virk RK, Jayakumar J, Mendenhall IH, Moorthy M, Lam P, Linster M, Lim J, Lin C, Oon LLE, Lee HK, Koay ESC, Vijaykrishna D, Smith GJD, Su YCF. Proc Natl Acad Sci U S A. 2020 Jan 7;117(1):619-628. doi: 10.1073/pnas.1916585116. Epub 2019 Dec 16. PMID: 31843889.
The impact of transfluthrin on the spatial repellency of the primary malaria mosquito vectors in Vietnam: Anopheles dirus and Anopheles minimus. Martin NJ, Nam VS, Lover AA, Phong TV, Tu TC, Mendenhall IH. Malar J. 2020 Jan 6;19(1):9. doi: 10.1186/s12936-019-3092-4. PMID: 31906969.
A humanized mouse model to study mast cells mediated cutaneous adverse drug reactions. Mencarelli A, Gunawan M, Yong KSM, Bist P, Tan WWS, Tan SY, Liu M, Huang EK, Fan Y, Chan JKY, Choi HW, Abraham SN, Chen Q.J Leukoc Biol. 2020 May;107(5):797-807. doi: 10.1002/JLB.3MA1219-210RR. Epub 2020 Jan 10.PMID: 31922289.
Genetic diversity of Anaplasma and Ehrlichia bacteria found in Dermacentor and Ixodes ticks in Mongolia. von Fricken ME, Qurollo BA, Boldbaatar B, Wang YW, Jiang RR, Lkhagvatseren S, Koehler JW, Moore TC, Nymadawa P, Anderson BD, Matulis G, Jiang JF, Gray GC. Ticks Tick Borne Dis. 2020 Jan;11(1):101316. doi: 10.1016/j.ttbdis.2019.101316. Epub 2019 Oct 21. PMID: 31677968.
Genetic diversity of respiratory enteroviruses and rhinoviruses in febrile adults, Singapore, 2007-2013. Linster M, Donato C, Mah MG, Grau ML, Low JG, Ooi EE, Su YCF, Smith GJD, Vijaykrishna D. Influenza Other Respir Viruses. 2020 Jan;14(1):67-71. doi: 10.1111/irv.12662. Epub 2019 Sep 30. PMID: 31568667.
Immunophenotyping monocytes, macrophages and granulocytes in the Pteropodid bat Eonycteris spelaea. Gamage AM, Zhu F, Ahn M, Foo RJH, Hey YY, Low DHW, Mendenhall IH, Dutertre CA, Wang LF. Sci Rep. 2020 Jan 15;10(1):309. doi: 10.1038/s41598-019-57212-1. PMID: 31941952.
To Succeed, One Health Must Win Animal Agriculture's Stronger Collaboration. Gray GC, Mazet JAK. Clin Infect Dis. 2020 Jan 16;70(3):535-537. doi: 10.1093/cid/ciz729. PMID: 31943052.
Subgenomic RNA from Dengue Virus Type 2 Suppresses Replication of Dengue Virus Genomes and Interacts with Virus-Encoded NS3 and NS5 Proteins. Wang S, Chan KWK, Naripogu KB, Swarbrick CMD, Aaskov J, Vasudevan SG. ACS Infect Dis. 2020 Mar 13;6(3):436-446. doi: 10.1021/acsinfecdis.9b00384. Epub 2020 Jan 22. PMID: 31922712.
Discovery of Bat Coronaviruses through Surveillance and Probe Capture-Based Next-Generation Sequencing. Li B, Si HR, Zhu Y, Yang XL, Anderson DE, Shi ZL, Wang LF, Zhou P. mSphere. 2020 Jan 29;5(1):e00807-19. doi: 10.1128/mSphere.00807-19. PMID: 31996413.
Burkholderia pseudomallei Detection among Hospitalized Patients, Sarawak. Choi JY, Hii KC, Bailey ES, Chuang JY, Tang WY, Yuen Wong EK, Ti T, Pau KS, Berita A, Saihidi I, Ting J, Chua TT, Toh TH, AuCoin DP, DeShazer D, Gray GC. Am J Trop Med Hyg. 2020 Feb;102(2):388-391. doi: 10.4269/ajtmh.19 0625. PMID: 31769397.
Adenoviral Infections in Singapore: Should New Antiviral Therapies and Vaccines Be Adopted? Coleman KK, Wong CC, Jayakumar J, Nguyen TT, Wong AWL, Yadana S, Thoon KC, Chan KP, Low JG, Kalimuddin S, Dehghan S, Kang J, Shamsaddini A, Seto D, Su YCF, Gray GC. J Infect Dis. 2020 Feb 3;221(4):566-577. doi: 10.1093/infdis/jiz489. PMID: 31563943.
Accelerated viral dynamics in bat cell lines, with implications for zoonotic emergence. Brook CE, Boots M, Chandran K, Dobson AP, Drosten C, Graham AL, Grenfell BT, Müller MA, Ng M, Wang LF, van Leeuwen A. Elife. 2020 Feb 3;9:e48401. doi: 10.7554/eLife.48401. PMID: 32011232.
Novel mucosal adjuvant, mastoparan-7, improves cocaine vaccine efficacy. St John AL, Choi HW, Walker QD, Blough B, Kuhn CM, Abraham SN, Staats HF. NPJ Vaccines. 2020 Feb 5;5:12. doi: 10.1038/s41541-020-0161-1. eCollection 2020. PMID: 32047657.
Pediatric Abdominal Tuberculosis in Singapore: A 10-Year Retrospective Series. Wong SA, Lee Meijuan D, Loh SW, Thoon KC, Tan NWH, Chong CY. Glob Pediatr Health. 2020 Feb 5;7:2333794X20903952. doi: 10.1177/2333794X20903952. eCollection 2020. PMID: 32076630.
Safety and immunogenicity of a single dose of a tetravalent dengue vaccine with two different serotype-2 potencies in adults in Singapore: A phase 2, double-blind, randomised, controlled trial. Tricou V, Low JG, Oh HM, Leo YS, Kalimuddin S, Wijaya L, Pang J, Ling LM, Lee TH, Brose M, Hutagalung Y, Rauscher M, Borkowski A, Wallace D. Vaccine. 2020 Feb 5;38(6):1513-1519. doi: 10.1016/j.vaccine.2019.11.061. Epub 2019 Dec 13. PMID: 31843269.
Effect of Vancomycin or Daptomycin With vs Without an Antistaphylococcal β-Lactam on Mortality, Bacteremia, Relapse, or Treatment Failure in Patients With MRSA Bacteremia: A Randomized Clinical Trial. Tong SYC, Lye DC, Yahav D, Sud A, Robinson JO, Nelson J, Archuleta S, Roberts MA, Cass A, Paterson DL, Foo H, Paul M, Guy SD, Tramontana AR, Walls GB, McBride S, Bak N, Ghosh N, Rogers BA, Ralph AP, Davies J, Ferguson PE, Dotel R, McKew GL, Gray TJ, Holmes NE, Smith S, Warner MS, Kalimuddin S, Young BE, Runnegar N, Andresen DN, Anagnostou NA, Johnson SA, Chatfield MD, Cheng AC, Fowler VG Jr, Howden BP, Meagher N, Price DJ, van Hal SJ, O'Sullivan MVN, Davis JS; Australasian Society for Infectious Diseases Clinical Research Network. JAMA. 2020 Feb 11;323(6):527-537. doi: 10.1001/jama.2020.0103. PMID: 32044943.
From Hendra to Wuhan: what has been learned in responding to emerging zoonotic viruses. Wang LF, Anderson DE, Mackenzie JS, Merson MH. Lancet. 2020 Feb 22;395(10224):e33-e34. doi: 10.1016/S0140-6736(20)30350-0. Epub 2020 Feb 11. PMID: 32059799.
Early treatment of chronic hepatitis B in children: Everything to play for? Bertoletti A, Gill US, Kennedy PTF. J Hepatol. 2020 Apr;72(4):802-803. doi: 10.1016/j.jhep.2019.12.007. Epub 2020 Feb 14. PMID: 32067804
Capsid protein structure in Zika virus reveals the flavivirus assembly process. Tan TY, Fibriansah G, Kostyuchenko VA, Ng TS, Lim XX, Zhang S, Lim XN, Wang J, Shi J, Morais MC, Corti D, Lok SM. Nat Commun. 2020 Feb 14;11(1):895. doi: 10.1038/s41467-020-14647-9. PMID: 32060358.
Adenovirus 4 and 7 Vaccine: New Body Armor for U.S. Marine Corps Officer Trainees. Gray GC. J Infect Dis. 2020 Feb 18;221(5):685-686. doi: 10.1093/infdis/jiz061. PMID: 30753651.
Zoonotic Diseases from Horses: A Systematic Review. Sack A, Oladunni FS, Gonchigoo B, Chambers TM, Gray GC. Vector Borne Zoonotic Dis. 2020 Jul;20(7):484-495. doi: 10.1089/vbz.2019.2541. Epub 2020 Feb 20. PMID: 32077811.
Cross-Reactive Immunity Among Flaviviruses. Rathore APS, St John AL. Front Immunol. 2020 Feb 26;11:334. doi: 10.3389/fimmu.2020.00334. eCollection 2020. PMID: 32174923. Review.
Kikuchi-Fujimoto disease in children. Selvanathan SN, Suhumaran S, Sahu VK, Chong CY, Tan NWH, Thoon KC. J Paediatr Child Health. 2020 Mar;56(3):389-393. doi: 10.1111/jpc.14628. Epub 2019 Oct 1. PMID: 31576642.
Persistence of H7N9 virus antibody response 2 years after infection. Yao L, Wang GL, Chen LL, Liu C, Duan LJ, Gray GC, Ma MJ. Influenza Other Respir Viruses. 2020 Mar;14(2):210-214. doi: 10.1111/irv.12702. Epub 2019 Dec 19. PMID: 31856341.
Personal level exposure and hazard potential of particulate matter during haze and non-haze periods in Singapore. George S, Chua ML, ZheWei DZ, Das R, Bijin VA, Connolly JE, Lee KP, Yung CF, Teoh OH, Thomas B. Chemosphere. 2020 Mar;243:125401. doi: 10.1016/j.chemosphere.2019.125401. Epub 2019 Nov 18. PMID: 31995870
Positive Selection of a Serine Residue in Bat IRF3 Confers Enhanced Antiviral Protection. Banerjee A, Zhang X, Yip A, Schulz KS, Irving AT, Bowdish D, Golding B, Wang LF, Mossman K. iScience. 2020 Mar 27;23(3):100958. doi: 10.1016/j.isci.2020.100958. Epub 2020 Mar 2. PMID: 32179480.
First sequence of influenza D virus identified in poultry farm bioaerosols in Sarawak, Malaysia. Bailey ES, Fieldhouse JK, Alarja NA, Chen DD, Kovalik ME, Zemke JN, Choi JY, Borkenhagen LK, Toh TH, Lee JSY, Chong KS, Gray GC. Trop Dis Travel Med Vaccines. 2020 Mar 12;6:5. doi: 10.1186/s40794-020 0105-9. eCollection 2020. PMID: 32190346.
Rapid Progression to Acute Respiratory Distress Syndrome: Review of Current Understanding of Critical Illness from COVID-19 Infection. Goh KJ, Choong MC, Cheong EH, Kalimuddin S, Duu Wen S, Phua GC, Chan KS, Haja Mohideen S. Ann Acad Med Singap. 2020 Mar 16;49(3):108-118. PMID: 32200400.
Investigation of three clusters of COVID-19 in Singapore: implications for surveillance and response measures. Pung R, Chiew CJ, Young BE, Chin S, Chen MI, Clapham HE, Cook AR, Maurer-Stroh S, Toh MPHS, Poh C, Low M, Lum J, Koh VTJ, Mak TM, Cui L, Lin RVTP, Heng D, Leo YS, Lye DC, Lee VJM; Singapore 2019 Novel Coronavirus Outbreak Research Team. Lancet. 2020 Mar 28;395(10229):1039-1046. doi: 10.1016/S0140-6736(20)30528-6. Epub 2020 Mar 17. PMID: 32192580.
The temporal RNA virome patterns of a lesser dawn bat (Eonycteris spelaea) colony revealed by deep sequencing. Paskey AC, Ng JHJ, Rice GK, Chia WN, Philipson CW, Foo RJH, Cer RZ, Long KA, Lueder MR, Frey KG, Hamilton T, Mendenhall IH, Smith GJ, Wang LF, Bishop-Lilly KA.Virus Evol. 2020 Mar 18;6(1):veaa017. doi: 10.1093/ve/veaa017. eCollection 2020 Jan. PMID: 33747541.
Platelets trigger perivascular mast cell degranulation to cause inflammatory responses and tissue injury. Karhausen J, Choi HW, Maddipati KR, Mathew JP, Ma Q, Boulaftali Y, Lee RH, Bergmeier W, Abraham SN. Sci Adv. 2020 Mar 18;6(12):eaay6314. doi: 10.1126/sciadv.aay6314. eCollection 2020 Mar. PMID: 32206714.
Pyridobenzothiazolones Exert Potent Anti-Dengue Activity by Hampering Multiple Functions of NS5 Polymerase. Cannalire R, Ki Chan KW, Burali MS, Gwee CP, Wang S, Astolfi A, Massari S, Sabatini S, Tabarrini O, Mastrangelo E, Barreca ML, Cecchetti V, Vasudevan SG, Manfroni G. ACS Med Chem Lett. 2020 Mar 19;11(5):773-782. doi: 10.1021/acsmedchemlett.9b00619. eCollection 2020 May 14. PMID: 32435384.
Assessing Viral Shedding and Infectivity of Tears in Coronavirus Disease 2019 (COVID-19) Patients. Seah IYJ, Anderson DE, Kang AEZ, Wang L, Rao P, Young BE, Lye DC, Agrawal R. Ophthalmology. 2020 Jul;127(7):977-979. doi: 10.1016/j.ophtha.2020.03.026. Epub 2020 Mar 24. PMID: 32291098.
Promoting interdisciplinary research through transversality-an aid to communicating more effectively with health sociologists. Sturgiss EA, Smith GJD. Fam Pract. 2020 Mar 25;37(2):286. doi: 10.1093/fampra/cmaa012. PMID: 32061091.
Acute experimental infection of bats and ferrets with Hendra virus: Insights into the early host response of the reservoir host and susceptible model species. Woon AP, Boyd V, Todd S, Smith I, Klein R, Woodhouse IB, Riddell S, Crameri G, Bingham J, Wang LF, Purcell AW, Middleton D, Baker ML. PLoS Pathog. 2020 Mar 30;16(3):e1008412. doi: 10.1371/journal.ppat.1008412. eCollection 2020 Mar. PMID: 32226041.
Therapeutic strategies for hepatitis B virus infection: towards a cure. Fanning GC, Zoulim F, Hou J, Bertoletti A. Nat Rev Drug Discov. 2020 Apr;19(4):291. doi: 10.1038/s41573-019-0057-9. PMID: 31913354.
Robust dengue virus infection in bat cells and limited innate immune responses coupled with positive serology from bats in IndoMalaya and Australasia. Irving AT, Rozario P, Kong PS, Luko K, Gorman JJ, Hastie ML, Chia WN, Mani S, Lee BP, Smith GJD, Mendenhall IH, Larman HB, Elledge SJ, Wang LF. Cell Mol Life Sci. 2020 Apr;77(8):1607-1622. doi: 10.1007/s00018-019-03242-x. Epub 2019 Jul 27. PMID: 31352533.
Novel de Novo Genome of Cynopterus brachyotis Reveals Evolutionarily Abrupt Shifts in Gene Family Composition across Fruit Bats. Chattopadhyay B, Garg KM, Ray R, Mendenhall IH, Rheindt FE. Genome Biol Evol. 2020 Apr 1;12(4):259-272. doi: 10.1093/gbe/evaa030. PMID: 32068833.
Environment and Personal Protective Equipment Tests for SARS-CoV-2 in the Isolation Room of an Infant With Infection. Yung CF, Kam KQ, Wong MSY, Maiwald M, Tan YK, Tan BH, Thoon KC. Ann Intern Med. 2020 Aug 4;173(3):240-242. doi: 10.7326/M20-0942. Epub 2020 Apr 1. PMID: 32236490.
Japanese encephalitis virus and its mechanisms of neuroinvasion. Hsieh JT, St John AL. PLoS Pathog. 2020 Apr 2;16(4):e1008260. doi: 10.1371/journal.ppat.1008260. eCollection 2020 Apr.PMID: 32240272.
To offer or not to offer: A conundrum on ascertaining whether post-exposure prophylaxis is indicated in occupational exposure of HIV. Aribou ZM, Wijaya L, Hoe GW. Health Sci Rep. 2020 Apr 3;3(2):e152. doi: 10.1002/hsr2.152. eCollection 2020 Jun.PMID: 32258433.
When Can One Vaccinate with a Live Vaccine after Wild-Type Dengue Infection? Guy B, Ooi EE, Ramos-Castañeda J, Thomas SJ. Vaccines (Basel). 2020 Apr 9;8(2):174. doi: 10.3390/vaccines8020174. PMID: 32283639.
Infectious KoRV-related retroviruses circulating in Australian bats. Hayward JA, Tachedjian M, Kohl C, Johnson A, Dearnley M, Jesaveluk B, Langer C, Solymosi PD, Hille G, Nitsche A, Sánchez CA, Werner A, Kontos D, Crameri G, Marsh GA, Baker ML, Poumbourios P, Drummer HE, Holmes EC, Wang LF, Smith I, Tachedjian G. Proc Natl Acad Sci U S A. 2020 Apr 28;117(17):9529-9536. doi: 10.1073/pnas.1915400117. Epub 2020 Apr 13. PMID: 32284399.
Effects of Hepatitis B Surface Antigen on Virus-Specific and Global T Cells in Patients With Chronic Hepatitis B Virus infection. Le Bert N, Gill US, Hong M, Kunasegaran K, Tan DZM, Ahmad R, Cheng Y, Dutertre CA, Heinecke A, Rivino L, Tan A, Hansi NK, Zhang M, Xi S, Chong Y, Pflanz S, Newell EW, Kennedy PTF, Bertoletti A. Gastroenterology. 2020 Aug;159(2):652-664. doi: 10.1053/j.gastro.2020.04.019. Epub 2020 Apr 14. PMID: 32302614.
Impact of immune enhancement on Covid-19 polyclonal hyperimmune globulin therapy and vaccine development. de Alwis R, Chen S, Gan ES, Ooi EE. EBioMedicine. 2020 May;55:102768. doi: 10.1016/j.ebiom.2020.102768. Epub 2020 Apr 16. PMID: 32344202.
Safety, tolerability, pharmacokinetics, and immunogenicity of a human monoclonal antibody targeting the G glycoprotein of henipaviruses in healthy adults: a first-in-human, randomised, controlled, phase 1 study. Playford EG, Munro T, Mahler SM, Elliott S, Gerometta M, Hoger KL, Jones ML, Griffin P, Lynch KD, Carroll H, El Saadi D, Gilmour ME, Hughes B, Hughes K, Huang E, de Bakker C, Klein R, Scher MG, Smith IL, Wang LF, Lambert SB, Dimitrov DS, Gray PP, Broder CC. Lancet Infect Dis. 2020 Apr;20(4):445-454. doi: 10.1016/S1473-3099(19)30634-6. Epub 2020 Feb 3. PMID: 32027842.
Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore.Young BE, Ong SWX, Kalimuddin S, Low JG, Tan SY, Loh J, Ng OT, Marimuthu K, Ang LW, Mak TM, Lau SK, Anderson DE, Chan KS, Tan TY, Ng TY, Cui L, Said Z, Kurupatham L, Chen MI, Chan M, Vasoo S, Wang LF, Tan BH, Lin RTP, Lee VJM, Leo YS, Lye DC; Singapore 2019 Novel Coronavirus Outbreak Research Team. JAMA. 2020 Apr 21;323(15):14881494. doi: 10.1001/jama.2020.3204. PMID: 32125362.
Connecting clusters of COVID-19: an epidemiological and serological investigation. Yong SEF, Anderson DE, Wei WE, Pang J, Chia WN, Tan CW, Teoh YL, Rajendram P, Toh MPHS, Poh C, Koh VTJ, Lum J, Suhaimi NM, Chia PY, Chen MI, Vasoo S, Ong B, Leo YS, Wang L, Lee VJM. Lancet Infect Dis. 2020 Jul;20(7):809-815. doi: 10.1016/S1473-3099(20)30273-5. Epub 2020 Apr 21. PMID: 32330439.
Timeliness of Childhood Vaccination Coverage: the Growing Up in Singapore Towards Healthy Outcomes Study. Loy SL, Cheung YB, Chan JKY, Soh SE, Godfrey KM, Tan KH, Shek LP, Chong YS, Lek N, Yap F, Teoh OH, Yung CF, Thoon KC. Prev Sci. 2020 Apr;21(3):283-292. doi: 10.1007/s11121-019-01078-2. PMID: 31960261.
Bioaerosol Sampling at a Live Animal Market in Kunshan, China: A Noninvasive Approach for Detecting Emergent Viruses. Wang X, Bailey ES, Qi X, Yu H, Bao C, Gray GC. Open Forum Infect Dis. 2020 Apr 22;7(5):ofaa134. doi: 10.1093/ofid/ofaa134. eCollection 2020 May. PMID: 32462044.
The role of self-reported olfactory and gustatory dysfunction as a screening criterion for suspected COVID-19. Wee LE, Chan YFZ, Teo NWY, Cherng BPZ, Thien SY, Wong HM, Wijaya L, Toh ST, Tan TT.Eur Arch Otorhinolaryngol. 2020 Aug;277(8):2389-2390. doi: 10.1007/s00405-020-05999-5. Epub 2020 Apr 24.PMID: 32328771.
A Human Antibody Neutralizes Different Flaviviruses by Using Different Mechanisms. Zhang S, Loy T, Ng TS, Lim XN, Chew SV, Tan TY, Xu M, Kostyuchenko VA, Tukijan F, Shi J, Fink K, Lok SM. Cell Rep. 2020 Apr 28;31(4):107584. doi: 10.1016/j.celrep.2020.107584. PMID: 32348755.
A Dynamic Immune Response Shapes COVID-19 Progression. Ong EZ, Chan YFZ, Leong WY, Lee NMY, Kalimuddin S, Haja Mohideen SM, Chan KS, Tan AT, Bertoletti A, Ooi EE, Low JGH. Cell Host Microbe. 2020 Jun 10;27(6):879-882.e2. doi: 10.1016/j.chom.2020.03.021. Epub 2020 Apr 30.PMID: 32359396.
HBV as a target for CAR or TCR-T cell therapy. Bertoletti A, Tan AT. Curr Opin Immunol. 2020 Oct;66:35-41. doi: 10.1016/j.coi.2020.04.003. Epub 2020 Apr 30. PMID: 32361634 Review.
A RT-PCR assay for the detection of coronaviruses from four genera. Xiu L, Binder RA, Alarja NA, Kochek K, Coleman KK, Than ST, Bailey ES, Bui VN, Toh TH, Erdman DD, Gray GC. J Clin Virol. 2020 Jul;128:104391. doi: 10.1016/j.jcv.2020.104391. Epub 2020 Apr 30. PMID: 32403008.
Ecology of bat flies in Singapore: A study on the diversity, infestation bias and host specificity (Diptera: Nycteribiidae). Lim ZX, Hitch AT, Lee BPY, Low DHW, Neves ES, Borthwick SA, Smith GJD, Mendenhall IH. Int J Parasitol Parasites Wildl. 2020 May 1;12:29-33. doi: 10.1016/j.ijppaw.2020.04.010. eCollection 2020 Aug.PMID: 32420022.
Introducing a novel experimental model of bladder transplantation in mice. Wang J, Wu J, Moris D, Hayes B, Abraham SN, Cendales LC. Am J Transplant. 2020 Dec;20(12):3558-3566. doi: 10.1111/ajt.15912. Epub 2020 May 3. PMID: 32282990.
Challenges of CAR- and TCR-T cell-based therapy for chronic infections. Bertoletti A, Tan AT. J Exp Med. 2020 May 4;217(5):e20191663. doi: 10.1084/jem.20191663.PMID: 32163104. Review.
Critically ill COVID-19 infected patients exhibit increased clot waveform analysis parameters consistent with hypercoagulability.Tan CW, Low JGH, Wong WH, Chua YY, Goh SL, Ng HJ. Am J Hematol. 2020 Jul;95(7):E156-E158. doi: 10.1002/ajh.25822. Epub 2020 May 4. PMID: 32267008.
Positive epistasis between viral polymerase and the 3' untranslated region of its genome reveals the epidemiologic fitness of dengue virus. Syenina A, Vijaykrishna D, Gan ES, Tan HC, Choy MM, Siriphanitchakorn T, Cheng C, Vasudevan SG, Ooi EE. Proc Natl Acad Sci U S A. 2020 May 19;117(20):11038 11047. doi: 10.1073/pnas.1919287117. Epub 2020 May 4. PMID: 32366663.
The Effects of Pre-Existing Antibodies on Live-Attenuated Viral Vaccines. Mok DZL, Chan KR. Viruses. 2020 May 8;12(5):520. doi: 10.3390/v12050520. PMID: 32397218. Review.
Respiratory surveillance wards as a strategy to reduce nosocomial transmission of COVID-19 through early detection: The experience of a tertiary-care hospital in Singapore. Wee LE, Hsieh JYC, Phua GC, Tan Y, Conceicao EP, Wijaya L, Tan TT, Tan BH.Infect Control Hosp Epidemiol. 2020 Jul;41(7):820-825. doi: 10.1017/ice.2020.207. Epub 2020 May 8.PMID: 32381147.
Containment of COVID-19 cases among healthcare workers: The role of surveillance, early detection, and outbreak management. Wee LE, Sim XYJ, Conceicao EP, Aung MK, Goh JQ, Yeo DWT, Gan WH, Chua YY, Wijaya L, Tan TT, Tan BH, Ling ML, Venkatachalam I.Infect Control Hosp Epidemiol. 2020 Jul;41(7):765-771. doi: 10.1017/ice.2020.219. Epub 2020 May 11.PMID: 32391746.
A Non-structural 1 Protein G53D Substitution Attenuates a Clinically Tested Live Dengue Vaccine. Choy MM, Ng DHL, Siriphanitchakorn T, Ng WC, Sundstrom KB, Tan HC, Zhang SL, Chan KWK, Manuel M, Kini RM, Chan KR, Vasudevan SG, Ooi EE. Cell Rep. 2020 May 12;31(6):107617. doi: 10.1016/j.celrep.2020.107617. PMID: 32402284.
The association of obesity and severe dengue: possible pathophysiological mechanisms. Gallagher P, Chan KR, Rivino L, Yacoub S. J Infect. 2020 Jul;81(1):10-16. doi: 10.1016/j.jinf.2020.04.039. Epub 2020 May 12.PMID: 32413364 Review.
Virus detections among patients with severe acute respiratory illness, Northern Vietnam. Le YH, Nguyen KC, Coleman KK, Nguyen TT, Than ST, Phan HH, Nguyen MD, Ngu ND, Phan DT, Hoang PVM, Trieu LP, Bailey ES, Warkentien TE, Gray GC. PLoS One. 2020 May 12;15(5):e0233117. doi: 10.1371/journal.pone.0233117. eCollection 2020. PMID: 32396550.
Detection of Recombinant Rousettus Bat Coronavirus GCCDC1 in Lesser Dawn Bats (Eonycteris spelaea) in Singapore. Paskey AC, Ng JHJ, Rice GK, Chia WN, Philipson CW, Foo RJH, Cer RZ, Long KA, Lueder MR, Lim XF, Frey KG, Hamilton T, Anderson DE, Laing ED, Mendenhall IH, Smith GJ, Wang LF, Bishop-Lilly KA.Viruses. 2020 May 14;12(5):539. doi: 10.3390/v12050539. PMID: 32422932.
Bioaerosol sampling optimization for community exposure assessment in cities with poor sanitation: A one health cross-sectional study. Rocha-Melogno L, Ginn O, Bailey ES, Soria F, Andrade M, Bergin MH, Brown J, Gray GC, Deshusses MA. Sci Total Environ. 2020 Oct 10;738:139495. doi: 10.1016/j.scitotenv.2020.139495. Epub 2020 May 18. PMID: 32425257.
A highly polarized TH2 bladder response to infection promotes epithelial repair at the expense of preventing new infections. Wu J, Hayes BW, Phoenix C, Macias GS, Miao Y, Choi HW, Hughes FM Jr, Todd Purves J, Lee Reinhardt R, Abraham SN. Nat Immunol. 2020 Jun;21(6):671-683. doi: 10.1038/s41590 020-0688-3. Epub 2020 May 18. PMID: 32424366.
Community-acquired viral respiratory infections amongst hospitalized inpatients during a COVID-19 outbreak in Singapore: co-infection and clinical outcomes. Wee LE, Ko KKK, Ho WQ, Kwek GTC, Tan TT, Wijaya L. J Clin Virol. 2020 Jul;128:104436. doi: 10.1016/j.jcv.2020.104436. Epub 2020 May 19.PMID: 32447256.
Distinct Cell Transcriptomic Landscapes Upon Henipavirus Infections. Chen M, Tachedjian M, Marsh GA, Cui J, Wang LF. Front Microbiol. 2020 May 19;11:986. doi: 10.3389/fmicb.2020.00986. eCollection 2020. PMID: 32508793.
Remdesivir for 5 or 10 Days in Patients with Severe Covid-19. Goldman JD, Lye DCB, Hui DS, Marks KM, Bruno R, Montejano R, Spinner CD, Galli M, Ahn MY, Nahass RG, Chen YS, SenGupta D, Hyland RH, Osinusi AO, Cao H, Blair C, Wei X, Gaggar A, Brainard DM, Towner WJ, Muñoz J, Mullane KM, Marty FM, Tashima KT, Diaz G, Subramanian A; GS-US-540-5773 Investigators. N Engl J Med. 2020 Nov 5;383(19):1827-1837. doi:10.1056/NEJMoa2015301. Epub 2020 May 27. PMID: 32459919.
Detection of air and surface contamination by SARS-CoV-2 in hospital rooms of infected patients. Chia PY, Coleman KK, Tan YK, Ong SWX, Gum M, Lau SK, Lim XF, Lim AS, Sutjipto S, Lee PH, Son TT, Young BE, Milton DK, Gray GC, Schuster S, Barkham T, De PP, Vasoo S, Chan M, Ang BSP, Tan BH, Leo YS, Ng OT, Wong MSY, Marimuthu K; Singapore 2019 Novel Coronavirus Outbreak Research Team. Nat Commun. 2020 May 29;11(1):2800. doi: 10.1038/s41467-020-16670-2. PMID: 32472043.
Two linear epitopes on the SARS-CoV-2 spike protein that elicit neutralising antibodies in COVID-19 patients. Poh CM, Carissimo G, Wang B, Amrun SN, Lee CY, Chee RS, Fong SW, Yeo NK, Lee WH, Torres-Ruesta A, Leo YS, Chen MI, Tan SY, Chai LYA, Kalimuddin S, Kheng SSG, Thien SY, Young BE, Lye DC, Hanson BJ, Wang CI, Renia L, Ng LFP. Nat Commun. 2020 Jun 1;11(1):2806. doi: 10.1038/s41467-020-16638-2. PMID: 32483236.
Statistical inference in matched case-control studies of recurrent events. Cheung YB, Ma X, Lam KF, Li J, Yung CF, Milligan P, Mackenzie G. Int J Epidemiol. 2020 Jun 1;49(3):996-1006. doi: 10.1093/ije/dyaa012. PMID: 32125376.
The Extended Polydimensional Immunome Characterization (EPIC) web-based reference and discovery tool for cytometry data. Yeo JG, Wasser M, Kumar P, Pan L, Poh SL, Ally F, Arkachaisri T, Lim AJM, Leong JY, Lai L, Yeo KT, Lee ESC, Chua CJH, Larbi A, Nyunt MSZ, Ng TP, Chiesa S, Gattorno M, Martini A, Paleja BS, Dutertre CA, Chen J, Nay Yaung K, Tang SP, Ng SK, Yung CF, Tan AYJ, Lee SY, Ginhoux F, Albani S. Nat Biotechnol. 2020 Jun;38(6):679-684. doi: 10.1038/s41587-020-0532-1. PMID: 32440006.
Disseminated Bacillus-Calmette-Guérin Infections And Primary Immunodeficiency Disorders In Singapore: A Single Center 15-Year Retrospective Review. Ong RYL, Chan SB, Chew SJ, Liew WK, Thoon KC, Chong CY, Yung CF, Sng LH, Tan AM, Bhattacharyya R, Jamuar SS, Lim JY, Li J, Nadua KD, Kam KQ, Tan NW. Int J Infect Dis. 2020 Aug;97:117-125. doi: 10.1016/j.ijid.2020.05.117. Epub 2020 Jun 2. PMID: 32497805. Review.
Early Insights into Immune Responses during COVID-19. St John AL, Rathore APS. J Immunol. 2020 Aug 1;205(3):555-564. doi: 10.4049/jimmunol.2000526. Epub 2020 Jun 8. PMID: 32513850 Review.
Human MAIT cell cytolytic effector proteins synergize to overcome carbapenem resistance in Escherichia coli. Boulouis C, Sia WR, Gulam MY, Teo JQM, Png YT, Phan TK, Mak JYW, Fairlie DP, Poon IKH, Koh TH, Bergman P, Lim CM, Wang LF, Kwa ALH, Sandberg JK, Leeansyah E. PLoS Biol. 2020 Jun 8;18(6):e3000644. doi: 10.1371/journal.pbio.3000644. eCollection 2020 Jun. PMID: 32511236.
Asymptomatic SARS-CoV-2 infection. Ooi EE, Low JG. Lancet Infect Dis. 2020 Sep;20(9):996-998. doi: 10.1016/S1473-3099(20)30460-6. Epub 2020 Jun 12. PMID: 32539989.
Preventing Dengue Epidemics during the COVID-19 Pandemic. Wilder-Smith A, Tissera H, Ooi EE, Coloma J, Scott TW, Gubler DJ. Am J Trop Med Hyg. 2020 Aug;103(2):570-571. doi: 10.4269/ajtmh.20-0480. Epub 2020 Jun 15. PMID: 32539912.
IFN-α Suppresses Myeloid Cytokine Production, Impairing IL-12 Production and the Ability to Support T-Cell Proliferation. Mehrotra A, D'Angelo JA, Romney-Vanterpool A, Chu T, Bertoletti A, Janssen HLA, Gehring AJ. J Infect Dis. 2020 Jun 16;222(1):148-157. doi: 10.1093/infdis/jiaa064. PMID: 32049318.
Protective and pathogenic roles for mast cells during viral infections. Rathore AP, St John AL. Curr Opin Immunol. 2020 Oct;66:74-81. doi: 10.1016/j.coi.2020.05.003. Epub 2020 Jun 18. PMID: 32563779. Review.
High flavivirus structural plasticity demonstrated by a non-spherical morphological variant. Morrone SR, Chew VSY, Lim XN, Ng TS, Kostyuchenko VA, Zhang S, Wirawan M, Chew PL, Lee J, Tan JL, Wang J, Tan TY, Shi J, Screaton G, Morais MC, Lok SM. Nat Commun. 2020 Jun 19;11(1):3112. doi: 10.1038/s41467-020-16925-y. PMID: 32561757.
The Lancet Commission on dengue and other Aedes-transmitted viral diseases. Wilder-Smith A, Lindsay SW, Scott TW, Ooi EE, Gubler DJ, Das P. Lancet. 2020 Jun 20;395(10241):1890-1891. doi: 10.1016/S0140-6736(20)31375-1. PMID: 32563358.
A feasibility study of conducting surveillance for swine pathogens in slurry from North Carolina swine farms. Bailey ES, Borkenhagen LK, Choi JY, Greer AE, Culhane MR, Gray GC. Sci Rep. 2020 Jun 22;10(1):10059. doi: 10.1038/s41598-020-67313-x. PMID: 32572119.
The atypical presentation of COVID-19 as gastrointestinal disease: key points for primary care. Ong J, Dan YY, Low JG. Br J Gen Pract. 2020 Jun 25;70(696):360-361. doi: 10.3399/bjgp20X710705. Print 2020 Jul. PMID: 32586825.
Containing COVID-19 outside the isolation ward: The impact of an infection control bundle on environmental contamination and transmission in a cohorted general ward. Wee LEI, Sim XYJ, Conceicao EP, Aung MK, Tan KY, Ko KKK, Wong HM, Wijaya L, Tan BH, Venkatachalam I, Ling ML.Am J Infect Control. 2020 Sep;48(9):1056-1061. doi: 10.1016/j.ajic.2020.06.188. Epub 2020 Jun 26.PMID: 32599101.
Environmental bioaerosol surveillance as an early warning system for pathogen detection in North Carolina swine farms: A pilot study. Anderson BD, Yondon M, Bailey ES, Duman EK, Simmons RA, Greer AG, Gray GC. Transbound Emerg Dis. 2021 Mar;68(2):361-367. doi: 10.1111/tbed.13683. Epub 2020 Jun 29. PMID: 32535997.
Co-circulation of both low and highly pathogenic avian influenza H5 viruses in current poultry epidemics in Taiwan. Li YT, Chen CC, Chang AM, Chao DY, Smith GJD. Virus Evol. 2020 Jun 30;6(1):veaa037. doi: 10.1093/ve/veaa037. eCollection 2020 Jan. PMID: 32661493.
Immune modulation in COVID-19: Strategic considerations for personalized therapeutic intervention. Hall MW, Joshi I, Leal L, Ooi EE. Clin Infect Dis. 2020 Jul 1:ciaa904. doi: 10.1093/cid/ciaa904. Online ahead of print. PMID: 32604407.
Coronavirus disease 2019 (COVID-19): an evidence map of medical literature. Liu N, Chee ML, Niu C, Pek PP, Siddiqui FJ, Ansah JP, Matchar DB, Lam SSW, Abdullah HR, Chan A, Malhotra R, Graves N, Koh MS, Yoon S, Ho AFW, Ting DSW, Low JGH, Ong MEH. BMC Med Res Methodol. 2020 Jul 2;20(1):177. doi: 10.1186/s12874-020-01059-y. PMID: 32615936.
Household Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 from Adults to Children.Yung CF, Kam KQ, Chong CY, Nadua KD, Li J, Tan NWH, Ganapathy S, Lee KP, Ng KC, Chan YH, Thoon KC. J Pediatr. 2020 Oct;225:249-251. doi: 10.1016/j.jpeds.2020.07.009. Epub 2020 Jul 4. PMID: 32634405.
Chest Radiographs and CTs in the Era of COVID-19: Indications, Operational Safety Considerations and Alternative Imaging Practices. Chia AQX, Cheng LT, Wijaya L, Png MA, Sim WY, Hong WL, Chen RC.Acad Radiol. 2020 Sep;27(9):1193-1203. doi: 10.1016/j.acra.2020.06.022. Epub 2020 Jul 7.PMID: 32703648.
Nipah@20: Lessons Learned from Another Virus with Pandemic Potential. Gómez Román R, Wang LF, Lee B, Halpin K, de Wit E, Broder CC, Rahman M, Kristiansen P, Saville M. mSphere. 2020 Jul 8;5(4):e00602-20. doi: 10.1128/mSphere.00602-20. PMID: 32641430.
Successful containment of horizontal enterovirus infection in a neonatal unit in Singapore through diagnosis by polymerase chain reaction (PCR) and direct sequence analysis. Tan YY, Quek BH, Thoon KC, Maiwald M, Yung CF, Rajadurai VS, Kong JY. J Infect Public Health. 2020 Oct;13(10):1556-1561. doi: 10.1016/j.jiph.2020.06.029. Epub 2020 Jul 9. PMID: 32653481.
Predictors and Clinical Outcomes of Poor Platelet Recovery in Adult Dengue With Thrombocytopenia: A Multicenter, Prospective Study. Archuleta S, Chia PY, Wei Y, Syed-Omar SF, Low JG, Oh HM, Fisher D, Ponnampalavanar SSL, Wijaya L, Kamarulzaman A, Lum LCS, Tambyah PA, Leo YS, Lye DC.Clin Infect Dis. 2020 Jul 11;71(2):383-389. doi: 10.1093/cid/ciz850.PMID: 31626692.
Clinical Utility of Buccal Swabs for Severe Acute Respiratory Syndrome Coronavirus 2 Detection in Coronavirus Disease 2019-Infected Children. Kam KQ, Yung CF, Maiwald M, Chong CY, Soong HY, Loo LH, Tan NWH, Li J, Nadua KD, Thoon KC. J Pediatric Infect Dis Soc. 2020 Jul 13;9(3):370-372. doi: 10.1093/jpids/piaa068. PMID: 32463086.
SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls. Le Bert N, Tan AT, Kunasegaran K, Tham CYL, Hafezi M, Chia A, Chng MHY, Lin M, Tan N, Linster M, Chia WN, Chen MI, Wang LF, Ooi EE, Kalimuddin S, Tambyah PA, Low JG, Tan YJ, Bertoletti A. Nature. 2020 Aug;584(7821):457-462. doi: 10.1038/s41586-020-2550-z. Epub 2020 Jul 15. PMID: 32668444.
Serum chymase levels correlate with severe dengue warning signs and clinical fluid accumulation in hospitalized pediatric patients. Rathore APS, Senanayake M, Athapathu AS, Gunasena S, Karunaratna I, Leong WY, Lim T, Mantri CK, Wilder-Smith A, St John AL. Sci Rep. 2020 Jul 16;10(1):11856. doi: 10.1038/s41598-020-68844-z. PMID: 32678248.
Risk factors and biomarkers of severe dengue. Rathore AP, Farouk FS, St John AL. Curr Opin Virol. 2020 Aug;43:1-8. doi: 10.1016/j.coviro.2020.06.008. Epub 2020 Jul 17. PMID: 32688269 Review.
Hepatitis Delta Virus Acts as an Immunogenic Adjuvant in Hepatitis B Virus-Infected Hepatocytes. Tham CYL, Kah J, Tan AT, Volz T, Chia A, Giersch K, Ladiges Y, Loglio A, Borghi M, Sureau C, Lampertico P, Lütgehetmann M, Dandri M, Bertoletti A. Cell Rep Med. 2020 Jul 21;1(4):100060. doi:10.1016/j.xcrm.2020.100060. eCollection 2020 Jul 21. PMID: 33205065.
Discovery and Genomic Characterization of a 382-Nucleotide Deletion in ORF7b and ORF8 during the Early Evolution of SARS-CoV-2. Su YCF, Anderson DE, Young BE, Linster M, Zhu F, Jayakumar J, Zhuang Y, Kalimuddin S, Low JGH, Tan CW, Chia WN, Mak TM, Octavia S, Chavatte JM, Lee RTC, Pada S, Tan SY, Sun L, Yan GZ, Maurer-Stroh S, Mendenhall IH, Leo YS, Lye DC, Wang LF, Smith GJD. mBio. 2020 Jul 21;11(4):e01610-20. doi: 10.1128/mBio.01610-20. PMID: 32694143.
Linear B-cell epitopes in the spike and nucleocapsid proteins as markers of SARS-CoV-2 exposure and disease severity. Amrun SN, Lee CY, Lee B, Fong SW, Young BE, Chee RS, Yeo NK, Torres-Ruesta A, Carissimo G, Poh CM, Chang ZW, Tay MZ, Chan YH, Chen MI, Low JG, Tambyah PA, Kalimuddin S, Pada S, Tan SY, Sun LJ, Leo YS, Lye DC, Renia L, Ng LFP. EBioMedicine. 2020 Aug;58:102911. doi: 10.1016/j.ebiom.2020.102911. Epub 2020 Jul 22. PMID: 32711254.
Early Recognition of Coronavirus 2019 Disease (COVID-19) Infection in Surgical Inpatients: The Importance of a Risk-Stratified Approach for Early Testing and Isolation. Wee LE, Sim XYJ, Conceicao EP, Aung MK, Wong HM, Teh YE, Tan KY, Wijaya L, Tan TBH, Ling ML, Venkatachalam I.Surg Infect (Larchmt). 2020 Nov;21(9):760-765. doi: 10.1089/sur.2020.184. Epub 2020 Jul 22.PMID: 32716758.
A SARS-CoV-2 surrogate virus neutralization test based on antibody-mediated blockage of ACE2-spike protein-protein interaction. Tan CW, Chia WN, Qin X, Liu P, Chen MI, Tiu C, Hu Z, Chen VC, Young BE, Sia WR, Tan YJ, Foo R, Yi Y, Lye DC, Anderson DE, Wang LF. Nat Biotechnol. 2020 Sep;38(9):1073-1078. doi: 10.1038/s41587-020-0631-z. Epub 2020 Jul 23. PMID: 32704169.
Sequential immunization induces strong and broad immunity against all four dengue virus serotypes. Hou J, Shrivastava S, Loo HL, Wong LH, Ooi EE, Chen J. NPJ Vaccines. 2020 Jul 24;5:68. doi: 10.1038/s41541-020-00216-0. eCollection 2020. PMID: 32728482.
Epidemiologic trends in Kawasaki disease during coronavirus disease-19 in Singapore. Yung CF, Nadua KD, Oh BK, Thoon KC. J Pediatr. 2020 Jul 24;226:314-5. doi: 10.1016/j.jpeds.2020.07.063. Online ahead of print. PMID: 32717229.
Burden and Cost of Hospitalization for Respiratory Syncytial Virus in Young Children, Singapore. Tam CC, Yeo KT, Tee N, Lin R, Mak TM, Thoon KC, Jit M, Yung CF. Emerg Infect Dis. 2020 Jul;26(7):1489-1496. doi: 10.3201/eid2607.190539. PMID: 32568036.
High Risk of Influenza Virus Infection Among Swine Workers: Examining a Dynamic Cohort in China. Borkenhagen LK, Wang GL, Simmons RA, Bi ZQ, Lu B, Wang XJ, Wang CX, Chen SH, Song SX, Li M, Zhao T, Wu MN, Park LP, Cao WC, Ma MJ, Gray GC. Clin Infect Dis. 2020 Jul 27;71(3):622-629. doi: 10.1093/cid/ciz865. PMID: 31504322.
Oxygen: viral friend or foe? Gan ES, Ooi EE. Virol J. 2020 Jul 27;17(1):115. doi: 10.1186/s12985-020-01374-2. PMID: 32718318.
A memory of eS25 loss drives resistance phenotypes. Johnson AG, Flynn RA, Lapointe CP, Ooi YS, Zhao ML, Richards CM, Qiao W, Yamada SB, Couthouis J, Gitler AD, Carette JE, Puglisi JD. Nucleic Acids Res. 2020 Jul 27;48(13):7279-7297. doi: 10.1093/nar/gkaa444. PMID: 32463448.
A Well Infant With Coronavirus Disease 2019 With High Viral Load. Kam KQ, Yung CF, Cui L, Tzer Pin Lin R, Mak TM, Maiwald M, Li J, Chong CY, Nadua K, Tan NWH, Thoon KC. Clin Infect Dis. 2020 Jul 28;71(15):847-849. doi: 10.1093/cid/ciaa201. PMID: 32112082.
Phase 1 Trial of a Therapeutic Anti-Yellow Fever Virus Human Antibody. Low JG, Ng JHJ, Ong EZ, Kalimuddin S, Wijaya L, Chan YFZ, Ng DHL, Tan HC, Baglody A, Chionh YH, Lee DCP, Budigi Y, Sasisekharan R, Ooi EE. N Engl J Med. 2020 Jul 30;383(5):452-459. doi: 10.1056/NEJMoa2000226. PMID: 32726531.
ELKS1 controls mast cell degranulation by regulating the transcription of Stxbp2 and Syntaxin 4 via Kdm2b stabilization. Lam HY, Arumugam S, Bae HG, Wang CC, Jung S, St John AL, Hong W, Han W, Tergaonkar V. Sci Adv. 2020 Jul 31;6(31):eabb2497. doi: 10.1126/sciadv.abb2497. Print 2020 Jul. PMID: 32937583.
Rapid production of clinical-grade SARS-CoV-2 specific T cells. Leung W, Soh TG, Linn YC, Low JG, Loh J, Chan M, Chng WJ, Koh LP, Poon ML, Ng KP, Kuick CH, Tan TT, Tan LK, Seng MS. Adv Cell Gene Ther. 2020 Jul 31:e101. doi: 10.1002/acg2.101. PMID: 32838213.
Comparative Analysis of Symptomatic and Asymptomatic SARS-CoV-2 Infection in Children. Li J, Thoon KC, Chong CY, Maiwald M, Kam KQ, Nadua K, Tan NW, Yung CF. Ann Acad Med Singap. 2020 Aug;49(8):530-537. PMID: 33164022.
Crystal structures of full length DENV4 NS2B-NS3 reveal the dynamic interaction between NS2B and NS3. Phoo WW, El Sahili A, Zhang Z, Chen MW, Liew CW, Lescar J, Vasudevan SG, Luo D. Antiviral Res. 2020 Oct;182:104900. doi: 10.1016/j.antiviral.2020.104900. Epub 2020 Aug 5. PMID: 32763315.
Panspecies molecular assays detect viral pathogens missed by real-time PCR/reverse-transcriptase PCR among pneumonia patients, Sarawak, Malaysia. Fieldhouse JK, Bailey ES, Toh TH, Hii KC, Mallinson KA, Ting J, Lednicky JA, Berita A, Nguyen TT, Galan D, Than ST, Wong SC, Wong TM, Blair PJ, Gray GC.Trop Dis Travel Med Vaccines. 2020 Aug 12;6:13. doi: 10.1186/s40794-020-00114-2. eCollection 2020. PMID: 32817802.
SARS-CoV-2 neutralizing antibody levels are correlated with severity of COVID-19 pneumonia. Chen W, Zhang J, Qin X, Wang W, Xu M, Wang LF, Xu C, Tang S, Liu P, Zhang L, Liu X, Zhang Y, Yi C, Hu Z, Yi Y. Biomed Pharmacother. 2020 Oct;130:110629. doi: 10.1016/j.biopha.2020.110629. Epub 2020 Aug 13. PMID: 33406577.
Oral vs Intravenous Antibiotics for Patients With Klebsiella pneumoniae Liver Abscess: A Randomized, Controlled Noninferiority Study. Molton JS, Chan M, Kalimuddin S, Oon J, Young BE, Low JG, Salada BMA, Lee TH, Wijaya L, Fisher DA, Izharuddin E, Koh TH, Teo JWP, Krishnan PU, Tan BP, Woon WWL, Ding Y, Wei Y, Phillips R, Moorakonda R, Yuen KH, Cher BP, Yoong J, Lye DC, Archuleta S. Clin Infect Dis. 2020 Aug 14;71(4):952-959. doi: 10.1093/cid/ciz881. PMID: 31641767.
Letter from Singapore: The clinical and research response to COVID-19. Chotirmall SH, Wang LF, Abisheganaden JA. Respirology. 2020 Oct;25(10):1101-1102. doi: 10.1111/resp.13929. Epub 2020 Aug 17. PMID: 32808426.
Effects of a major deletion in the SARS-CoV-2 genome on the severity of infection and the inflammatory response: an observational cohort study. Young BE, Fong SW, Chan YH, Mak TM, Ang LW, Anderson DE, Lee CY, Amrun SN, Lee B, Goh YS, Su YCF, Wei WE, Kalimuddin S, Chai LYA, Pada S, Tan SY, Sun L, Parthasarathy P, Chen YYC, Barkham T, Lin RTP, Maurer-Stroh S, Leo YS, Wang LF, Renia L, Lee VJ, Smith GJD, Lye DC, Ng LFP. Lancet. 2020 Aug 29;396(10251):603-611. doi: 10.1016/S0140-6736(20)31757-8. Epub 2020 Aug 18. PMID: 32822564.
Origin and cross-species transmission of bat coronaviruses in China. Latinne A, Hu B, Olival KJ, Zhu G, Zhang L, Li H, Chmura AA, Field HE, Zambrana-Torrelio C, Epstein JH, Li B, Zhang W, Wang LF, Shi ZL, Daszak P. Nat Commun. 2020 Aug 25;11(1):4235. doi: 10.1038/s41467-020-17687-3. PMID: 32843626.
Viral dynamics and immune correlates of COVID-19 disease severity. Young BE, Ong SWX, Ng LFP, Anderson DE, Chia WN, Chia PY, Ang LW, Mak TM, Kalimuddin S, Chai LYA, Pada S, Tan SY, Sun L, Parthasarathy P, Fong SW, Chan YH, Tan CW, Lee B, Rötzschke O, Ding Y, Tambyah P, Low JGH, Cui L, Barkham T, Lin RTP, Leo YS, Renia L, Wang LF, Lye DC; Singapore 2019 Novel Coronavirus Outbreak Research team. Clin Infect Dis. 2020 Aug 28:ciaa1280. doi: 10.1093/cid/ciaa1280. PMID: 32856707.
Mutations in the cytoplasmic domain of dengue virus NS4A affect virus fitness and interactions with other non-structural proteins. Tan MJA, Brown NG, Chan KWK, Jin JY, Zu Kong SY, Vasudevan SG. J Gen Virol. 2020 Sep;101(9):941-953. doi: 10.1099/jgv.0.001462. PMID: 32589122.
Possibility for reverse zoonotic transmission of SARS-CoV-2 to free-ranging wildlife: A case study of bats. Olival KJ, Cryan PM, Amman BR, Baric RS, Blehert DS, Brook CE, Calisher CH, Castle KT, Coleman JTH, Daszak P, Epstein JH, Field H, Frick WF, Gilbert AT, Hayman DTS, Ip HS, Karesh WB, Johnson CK, Kading RC, Kingston T, Lorch JM, Mendenhall IH, Peel AJ, Phelps KL, Plowright RK, Reeder DM, Reichard JD, Sleeman JM, Streicker DG, Towner JS, Wang LF. PLoS Pathog. 2020 Sep 3;16(9):e1008758. doi: 10.1371/journal.ppat.1008758. eCollection 2020 Sep. PMID: 32881980.
Development and characterization of specific anti-Usutu virus chicken-derived single chain variable fragment antibodies. Schoenenwald AKJ, Gwee CP, Stiasny K, Hermann M, Vasudevan SG, Skern T. Protein Sci. 2020 Nov;29(11):2175-2188. doi: 10.1002/pro.3937. Epub 2020 Sep 4. PMID: 32829514.
Cohort study to evaluate the effect of vitamin D, magnesium, and vitamin B12 in combination on progression to severe outcomes in older patients with coronavirus (COVID-19). Tan CW, Ho LP, Kalimuddin S, Cherng BPZ, Teh YE, Thien SY, Wong HM, Tern PJW, Chandran M, Chay JWM, Nagarajan C, Sultana R, Low JGH, Ng HJ. Nutrition. 2020 Nov-Dec;79-80:111017. doi: 10.1016/j.nut.2020.111017. Epub 2020 Sep 8. PMID: 33039952.
CRISPR-Mediated Base Conversion Allows Discriminatory Depletion of Endogenous T Cell Receptors for Enhanced Synthetic Immunity. Preece R, Pavesi A, Gkazi SA, Stegmann KA, Georgiadis C, Tan ZM, Aw JYJ, Maini MK, Bertoletti A, Qasim W. Mol Ther Methods Clin Dev. 2020 Sep 11;19:149-161. doi: 10.1016/j.omtm.2020.09.002. eCollection 2020 Dec 11. PMID: 33102612.
Saliva is not a useful diagnostic specimen in children with Coronavirus Disease 2019. Chong CY, Kam KQ, Li J, Maiwald M, Loo LH, Nadua KD, Tan NWH, Yung CF, Thoon KC. Clin Infect Dis. 2020 Sep 14:ciaa1376. doi: 10.1093/cid/ciaa1376. Online ahead of print. PMID: 32927475.
A Potent Postentry Restriction to Primate Lentiviruses in a Yinpterochiropteran Bat. Morrison JH, Miller C, Bankers L, Crameri G, Wang LF, Poeschla EM. mBio. 2020 Sep 15;11(5):e01854-20. doi: 10.1128/mBio.01854-20. PMID: 32934084.
An unusual COVID-19 case with over four months of viral shedding in the presence of low neutralizing antibodies: a case report. Chen W, Hu Z, Yi C, Chi Y, Xiong Q, Tan CW, Yi Y, Wang LF. J Biomed Res. 2020 Sep 16;34(6):470-474. doi: 10.7555/JBR.34.20200099. PMID: 33243942.
No influenza D virus detected among pigs, northern Vietnam. Farrell AS, Bui VN, Dao TD, Hoang TD, Gray GC. Influenza Other Respir Viruses. 2021 Mar;15(2):315-317. doi: 10.1111/irv.12812. Epub 2020 Sep 21. PMID: 32959521.
Radiographic features of COVID-19 based on an initial cohort of 96 patients in Singapore. Khoo HW, Hui TCH, Haja Mohideen SM, Lee YS, Liew CJY, Kok SSX, Young BE, Ong SWX, Kalimuddin S, Tan SY, Loh J, Chan LP, Poh ACC, Wong SBS, Leo YS, Lye DC, Kaw GJL, Tan CH. Singapore Med J. 2020 Sep 21. doi: 10.11622/smedj.2020142. PMID: 33047143.
Construction of a container isolation ward: A rapidly scalable modular approach to expand isolation capacity during the coronavirus disease 2019 (COVID-19) pandemic. Wee LE, Fan EMP, Heng R, Ang SY, Chiang JL, Tan TT, Ling ML, Wijaya L.Infect Control Hosp Epidemiol. 2020 Sep 23:1-3. doi: 10.1017/ice.2020.1222. PMID: 32962768.
At the interface: host-pathogen interactions that dictate protection and pathology. St John AL, Morrison TE. Curr Opin Immunol. 2020 Oct;66:iii-v. doi: 10.1016/j.coi.2020.11.004. PMID: 33334435.
Epidemiology of Adenovirus Infections and Outcomes of Cidofovir Treatment in Severely Ill Children. Siew JX, Seah XFV, Chew YR, Thoon KC, Chong CY, Yung CF, Maiwald M, Len Y, Li J, Kam KQ, Nadua K, Tanugroho R, Tan NWH. Pediatr Infect Dis J. 2020 Oct;39(10):907-913. doi: 10.1097/INF.0000000000002726. PMID: 32404785.
Rare Case Of Pott's Disease Caused By Bacillus-Calmette Guérin Vaccine. Mahtani S, Tan JMC, Low SYY, Nolan CP, Ong RYL, Lam JCM, Yeo TH, Sng LH, Chang KTE, Chong CY, Tan NWH. J Paediatr Child Health. 2020 Oct;56(10):1655-1656. doi: 10.1111/jpc.15082. PMID: 33099828.
Are migrant workers in Singapore receiving adequate healthcare? A survey of doctors working in public tertiary healthcare institutions. Ang JW, Koh CJ, Chua BW, Narayanaswamy S, Wijaya L, Chan LG, Soh LL, Goh WL, Vasoo S.Singapore Med J. 2020 Oct;61(10):540-547. doi: 10.11622/smedj.2019101. Epub 2019 Sep 6.PMID: 31489436.
Dengue virus induces PCSK9 expression to alter antiviral responses and disease outcomes. Gan ES, Tan HC, Le DHT, Huynh TT, Wills B, Seidah NG, Ooi EE, Yacoub S. J Clin Invest. 2020 Oct 1;130(10):5223-5234. doi: 10.1172/JCI137536. PMID: 32644974.
Construction and characterization of an infectious clone generated from Chikungunya virus SL11131 strain. Suzuki Y, Tanaka A, Maeda Y, Emi A, Fujioka Y, Sakaguchi S, Vasudevan SG, Kobayashi T, Lim CK, Takasaki T, Wu H, Nakano T. Virology. 2021 Jan 2;552:52-62. doi: 10.1016/j.virol.2020.09.006. Epub 2020 Oct 6. PMID: 33059320.
Live vaccine infection burden elicits adaptive humoral and cellular immunity required to prevent Zika virus infection. Yau C, Gan ES, Kwek SS, Tan HC, Ong EZ, Hamis NZ, Rivino L, Chan KR, Watanabe S, Vasudevan SG, Ooi EE. EBioMedicine. 2020 Nov;61:103028. doi: 10.1016/j.ebiom.2020.103028. Epub 2020 Oct 9. PMID: 33045466.
Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase. Gharbi-Ayachi A, Santhanakrishnan S, Wong YH, Chan KWK, Tan ST, Bates RW, Vasudevan SG, El Sahili A, Lescar J. J Virol. 2020 Oct 14;94(21):e00794-20. doi: 10.1128/JVI.00794-20. Print 2020 Oct 14. PMID: 32796069.
Assessing Professionalism in Medicine - A Scoping Review of Assessment Tools from 1990 to 2018. Tay KT, Ng S, Hee JM, Chia EWY, Vythilingam D, Ong YT, Chiam M, Chin AMC, Fong W, Wijaya L, Toh YP, Mason S, Krishna LKR.J Med Educ Curric Dev. 2020 Oct 16;7:2382120520955159. doi: 10.1177/2382120520955159. eCollection 2020 Jan-Dec.PMID: 33150208.
Structural basis of Chikungunya virus inhibition by monoclonal antibodies. Zhou QF, Fox JM, Earnest JT, Ng TS, Kim AS, Fibriansah G, Kostyuchenko VA, Shi J, Shu B, Diamond MS, Lok SM. Proc Natl Acad Sci U S A. 2020 Nov 3;117(44):27637-27645. doi: 10.1073/pnas.2008051117. Epub 2020 Oct 21. PMID: 33087569.
Disentangling etiologies of CNS infections in Singapore using multiple correspondence analysis and random forest.Zellweger RM, Yacoub S, Chan YFZ, Soon D, Shafi H, Ooi ST, Chan M, Jacobson L, Sessions OM, Vincent A, Low JGH, Ooi EE, Wang L, Wijaya L, Tan K; Singapore Neurologic Infections Program (SNIP).Sci Rep. 2020 Oct 26;10(1):18219. doi: 10.1038/s41598-020-75088-4.PMID: 33106525.
Complementary regulation of caspase-1 and IL-1β reveals additional mechanisms of dampened inflammation in bats. Goh G, Ahn M, Zhu F, Lee LB, Luo D, Irving AT, Wang LF. Proc Natl Acad Sci U S A. 2020 Nov 17;117(46):28939-28949. doi: 10.1073/pnas.2003352117. Epub 2020 Oct 26. PMID: 33106404.
Fetal mast cells mediate postnatal allergic responses dependent on maternal IgE. Msallam R, Balla J, Rathore APS, Kared H, Malleret B, Saron WAA, Liu Z, Hang JW, Dutertre CA, Larbi A, Chan JKY, St John AL, Ginhoux F. Science. 2020 Nov 20;370(6519):941-950. doi: 10.1126/science.aba0864. Epub 2020 Oct 29. PMID: 33122426.
The effects of aging on host resistance and disease tolerance to SARS-CoV-2 infection. Mok DZL, Chan CYY, Ooi EE, Chan KR. FEBS J. 2020 Oct 30. doi: 10.1111/febs.15613. Online ahead of print. PMID: 33124149 Review.
Achimota Pararubulavirus 3: A New Bat-Derived Paramyxovirus of the Genus Pararubulavirus. Baker KS, Tachedjian M, Barr J, Marsh GA, Todd S, Crameri G, Crameri S, Smith I, Holmes CEG, Suu-Ire R, Fernandez-Loras A, Cunningham AA, Wood JLN, Wang LF. Viruses. 2020 Oct 30;12(11):1236. doi: 10.3390/v12111236. PMID: 33143230.
ImmTAV, a New Immunotherapy Targeting the Source of HBV Infection. Bertoletti A. Hepatology. 2020 Nov;72(5):1514-1517. doi: 10.1002/hep.31527. PMID: 32865247.
Pregnancy Outcomes in COVID-19: A Prospective Cohort Study in Singapore. Mattar CN, Kalimuddin S, Sadarangani SP, Tagore S, Thain S, Thoon KC, Hong EY, Kanneganti A, Ku CW, Chan GM, Lee KZ, Yap JJ, Tan SS, Yan B, Young BE, Lye DC, Anderson DE, Yang L, Su LL, Somani J, Tan LK, Choolani MA, Chan JK. Ann Acad Med Singap. 2020 Nov;49(11):857-869. doi: 10.47102/annals-acadmedsg.2020437. PMID: 33381779.
Experience of a Tertiary Hospital in Singapore with Management of a Dual Outbreak of COVID-19 and Dengue. Wee LE, Cherng BPZ, Conceicao EP, Goh KC, Wan WY, Ko KKK, Aung MK, Sim XYJ, Wijaya L, Ling ML, Venkatachalam I.Am J Trop Med Hyg. 2020 Nov;103(5):2005-2011. doi: 10.4269/ajtmh.20-0703.PMID: 32996452.
SARS-CoV-2 seroprevalence and transmission risk factors among high-risk close contacts: a retrospective cohort study. Ng OT, Marimuthu K, Koh V, Pang J, Linn KZ, Sun J, De Wang L, Chia WN, Tiu C, Chan M, Ling LM, Vasoo S, Abdad MY, Chia PY, Lee TH, Lin RJ, Sadarangani SP, Chen MI, Said Z, Kurupatham L, Pung R, Wang LF, Cook AR, Leo YS, Lee VJ. Lancet Infect Dis. 2021 Mar;21(3):333-343. doi: 10.1016/S1473-3099(20)30833-1. Epub 2020 Nov 2. PMID: 33152271.
Nipah virus dynamics in bats and implications for spillover to humans. Epstein JH, Anthony SJ, Islam A, Kilpatrick AM, Ali Khan S, Balkey MD, Ross N, Smith I, Zambrana-Torrelio C, Tao Y, Islam A, Quan PL, Olival KJ, Khan MSU, Gurley ES, Hossein MJ, Field HE, Fielder MD, Briese T, Rahman M, Broder CC, Crameri G, Wang LF, Luby SP, Lipkin WI, Daszak P. Proc Natl Acad Sci U S A. 2020 Nov 17;117(46):29190-29201. doi: 10.1073/pnas.2000429117. Epub 2020 Nov 2. PMID: 33139552.
Interferon Regulatory Factors IRF1 and IRF7 Directly Regulate Gene Expression in Bats in Response to Viral Infection. Irving AT, Zhang Q, Kong PS, Luko K, Rozario P, Wen M, Zhu F, Zhou P, Ng JHJ, Sobota RM, Wang LF. Cell Rep. 2020 Nov 3;33(5):108345. doi: 10.1016/j.celrep.2020.108345. PMID: 33147460.
Vancomycin Exposure and Acute Kidney Injury Outcome: A Snapshot From the CAMERA2 Study. Liu J, Tong SYC, Davis JS, Rhodes NJ, Scheetz MH; CAMERA2 Study Group. Open Forum Infect Dis. 2020 Nov 4;7(12):ofaa538. doi: 10.1093/ofid/ofaa538. eCollection 2020 Dec. PMID: 33335938.
Sustainable, three-component, one-pot procedure to obtain active anti-flavivirus agents. Felicetti T, Burali MS, Gwee CP, Ki Chan KW, Alonso S, Massari S, Sabatini S, Tabarrini O, Barreca ML, Cecchetti V, Vasudevan SG, Manfroni G. Eur J Med Chem. 2021 Jan 15;210:112992. doi: 10.1016/j.ejmech.2020.112992. Epub 2020 Nov 4. PMID: 33208235.
Outbreak of severe acute respiratory infection in Southern Province, Sri Lanka in 2018: a cross-sectional study.Vanderburg S, Wijayaratne G, Danthanarayana N, Jayamaha J, Piyasiri B, Halloluwa C, Sheng T, Amarasena S, Kurukulasooriya R, Nicholson BP, Peiris JSM, Gray GC, Gunasena S, Nagahawatte A, Bodinayake CK, Woods CW, Devasiri V, Tillekeratne LG. BMJ Open. 2020 Nov 6;10(11):e040612. doi: 10.1136/bmjopen-2020-040612. PMID: 33158834.
Environmental and Aerosolized Severe Acute Respiratory Syndrome Coronavirus 2 Among Hospitalized Coronavirus Disease 2019 Patients. Binder RA, Alarja NA, Robie ER, Kochek KE, Xiu L, Rocha-Melogno L, Abdelgadir A, Goli SV, Farrell AS, Coleman KK, Turner AL, Lautredou CC, Lednicky JA, Lee MJ, Polage CR, Simmons RA, Deshusses MA, Anderson BD, Gray GC. J Infect Dis. 2020 Nov 9;222(11):1798-1806. doi: 10.1093/infdis/jiaa575. PMID: 32905595.
Respiratory viral infections in hospitalised paediatric patients in the tropics.Tan KWJ, Yung CF, Maiwald M, Saffari SE, Thoon KC, Chong CY. J Paediatr Child Health. 2021 Apr;57(4):559-565. doi: 10.1111/jpc.15267. Epub 2020 Nov 13. PMID: 33185937.
Containment of COVID-19 and reduction in healthcare-associated respiratory viral infections through a multi-tiered infection control strategy. Wee LE, Venkatachalam I, Sim XYJ, Tan KB, Wen R, Tham CK, Gan WH, Ko KKK, Ho WQ, Kwek GTC, Conceicao EP, Sng CYE, Ng XHJ, Ong JY, Chiang JL, Chua YY, Ling ML, Tan TT, Wijaya L.Infect Dis Health. 2021 May;26(2):123-131. doi: 10.1016/j.idh.2020.11.004. Epub 2020 Nov 16.PMID: 33386294.
Meteorological drivers of respiratory syncytial virus infections in Singapore. Ali ST, Tam CC, Cowling BJ, Yeo KT, Yung CF. Sci Rep. 2020 Nov 24;10(1):20469. doi: 10.1038/s41598-020-76888-4. PMID: 33235232.
MR1-Restricted T Cells with MAIT-like Characteristics Are Functionally Conserved in the Pteropid Bat Pteropus alecto. Leeansyah E, Hey YY, Sia WR, Ng JHJ, Gulam MY, Boulouis C, Zhu F, Ahn M, Mak JYW, Fairlie DP, Kwa ALH, Sandberg JK, Wang LF. iScience. 2020 Nov 28;23(12):101876. doi: 10.1016/j.isci.2020.101876. eCollection 2020 Dec 18. PMID: 33344919.
Immunosuppressive Drug-Resistant Armored T-Cell Receptor T Cells for Immune Therapy of HCC in Liver Transplant Patients. Hafezi M, Lin M, Chia A, Chua A, Ho ZZ, Fam R, Tan D, Aw J, Pavesi A, Krishnamoorthy TL, Chow WC, Chen W, Zhang Q, Wai LE, Koh S, Tan AT, Bertoletti A. Hepatology. 2020 Nov 29. doi: 10.1002/hep.31662. Online ahead of print. PMID: 33249625.
Lack of cross-neutralization by SARS patient sera towards SARS-CoV-2. Anderson DE, Tan CW, Chia WN, Young BE, Linster M, Low JH, Tan YJ, Chen MI, Smith GJD, Leo YS, Lye DC, Wang LF. Emerg Microbes Infect. 2020 Dec;9(1):900-902. doi: 10.1080/22221751.2020.1761267. PMID: 32380903.
Th1-Polarized, Dengue Virus-Activated Human Mast Cells Induce Endothelial Transcriptional Activation and Permeability. Syenina A, Saron WAA, Jagaraj CJ, Bibi S, Arock M, Gubler DJ, Rathore APS, Abraham SN, St John AL.Viruses. 2020 Dec 2;12(12):1379. doi: 10.3390/v12121379. PMID: 33276578.
18F-fluorodeoxyglucose positron emission tomography as a window into human dengue pathophysiology. Kalimuddin S, Xie W, Watanabe S, Tham JY, Sam H, Chan KWK, Yap TS, Totman JJ, Chacko AM, Vasudevan SG, Low JG. Antiviral Res. 2021 Jan;185:104991. doi: 10.1016/j.antiviral.2020.104991. Epub 2020 Dec 3. PMID: 33279522.
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Effectiveness of Palivizumab against Respiratory Syncytial Virus Hospitalization among Preterm Infants in a Setting with Year-round Circulation. Yeo KT, Yung CF, Khoo PC, Saffari SE, Sng JSP, How MS, Quek BH. J Infect Dis. 2020 Dec 4:jiaa749. doi: 10.1093/infdis/jiaa749. Online ahead of print. PMID: 33274362.
Infection of human Nasal Epithelial Cells with SARS-CoV-2 and a 382-nt deletion isolate lacking ORF8 reveals similar viral kinetics and host transcriptional profiles. Gamage AM, Tan KS, Chan WOY, Liu J, Tan CW, Ong YK, Thong M, Andiappan AK, Anderson DE, Wang Y, Wang LF. PLoS Pathog. 2020 Dec 7;16(12):e1009130. doi: 10.1371/journal.ppat.1009130. eCollection 2020 Dec. PMID: 33284849.
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