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HAI Publications


to be updated​


Molecular insights into evolution, mutations and receptor-binding specificity of influenza A and B viruses from outpatients and hospitalized patients in Singapore. Ivan FX, Zhou X, Lau SH, Rashid S, Teo JSM, Lee HK, Koay ES, Chan KP, Leo YS, Chen MIC, Kwoh CK, Chow VT. Int J Infect Dis. 2020 Jan;90:84-96. doi: 10.1016/j.ijid.2019.10.024. Epub 2019 Oct 25. PMID: 31669593.

Taurolidine-citrate lock solution for the prevention of central line-associated bloodstream infection in paediatric haematology-oncology and gastrointestinal failure patients with high baseline central-line associated bloodstream infection rates. Chong CY, Ong RY, Seah VX, Tan NW, Chan MY, Soh SY, Ong C, Lim AS, Thoon KC. J Paediatr Child Health. 2020 Jan;56(1):123-129. doi: 10.1111/jpc.14506. Epub 2019 May 30. PMID: 31145505.

Divergent evolutionary trajectories of influenza B viruses underlie their contemporaneous epidemic activity. Virk RK, Jayakumar J, Mendenhall IH, Moorthy M, Lam P, Linster M, Lim J, Lin C, Oon LLE, Lee HK, Koay ESC, Vijaykrishna D, Smith GJD, Su YCF. Proc Natl Acad Sci U S A. 2020 Jan 7;117(1):619-628. doi: 10.1073/pnas.1916585116. Epub 2019 Dec 16. PMID: 31843889.

Clinicians' challenges in managing patients with invasive fungal diseases in seven Asian countries: An Asia Fungal Working Group (AFWG) Survey. Tan BH, Chakrabarti A, Patel A, Chua MMM, Sun PL, Liu Z, Rotjanapan P, Li R, Wahyuningsih R, Chayakulkeeree M, Chen YC; Asia Fungal Working Group (AFWG). Int J Infect Dis. 2020 Jun;95:471-480. doi: 10.1016/j.ijid.2020.01.007. Epub 2020 Jan 13. PMID: 31945491.

The burden and clinical manifestation of hospitalized influenza among different pediatric age-groups in the tropics. Chong CY, Yung CF, Gan C, Thio ST, Tan NW, Tee NW, Lin C, Lin RT, Thoon KC. Influenza Other Respir Viruses. 2020 Jan;14(1):46-54. doi: 10.1111/irv.12692. Epub 2019 Oct 13. PMID: 31608598.

Cytomegalovirus preventive strategies in lupus nephritis and renal vasculitis treated with immunosuppressants. Tan HZ, Choo JCJ, Tan BH, Mok IYJ, Lim CC. Lupus. 2020 Mar;29(3):351-352. doi: 10.1177/0961203320902532. Epub 2020 Jan 27. PMID: 31986963.

Comparative genomic analysis of Streptococcus dysgalactiae subspecies dysgalactiae, an occasional cause of zoonotic infection. Koh TH, Binte Abdul Rahman N, Sessions OM. Pathology. 2020 Feb;52(2):262-266. doi: 10.1016/j.pathol.2019.09.016. Epub 2019 Dec 16. PMID: 31859005.

Adenoviral Infections in Singapore: Should New Antiviral Therapies and Vaccines Be Adopted? Coleman KK, Wong CC, Jayakumar J, Nguyen TT, Wong AWL, Yadana S, Thoon KC, Chan KP, Low JG, Kalimuddin S, Dehghan S, Kang J, Shamsaddini A, Seto D, Su YCF, Gray GC. J Infect Dis. 2020 Feb 3;221(4):566-577. doi: 10.1093/infdis/jiz489. PMID: 31563943.

Pediatric Abdominal Tuberculosis in Singapore: A 10-Year Retrospective Series. Wong SA, Lee Meijuan D, Loh SW, Thoon KC, Tan NWH, Chong CY. Glob Pediatr Health. 2020 Feb 5;7:2333794X20903952. doi: 10.1177/2333794X20903952. eCollection 2020. PMID: 32076630.

Handrubbing with sprayed alcohol-based hand rub: an alternative method for effective hand hygiene. Tan JBX, de Kraker MEA, Pires D, Soule H, Pittet D. J Hosp Infect. 2020 Apr;104(4):430-434. doi: 10.1016/j.jhin.2020.02.008. Epub 2020 Feb 14. PMID: 32068015.

Determining the Development of Persisters in Extensively Drug-Resistant Acinetobacter baumannii upon Exposure to Polymyxin B-Based Antibiotic Combinations Using Flow Cytometry. Wong FH, Cai Y, Leck H, Lim TP, Teo JQ, Lee W, Koh TH, Tan TT, Tan KW, Kwa AL. Antimicrob Agents Chemother. 2020 Feb 21;64(3):e01712-19. doi: 10.1128/AAC.01712-19. Print 2020 Feb 21. PMID: 31818819.

Old Threat, New Enemy: Is Your Interventional Radiology Service Ready for the Coronavirus Disease 2019? Da Zhuang K, Tan BS, Tan BH, Too CW, Tay KH. Cardiovasc Intervent Radiol. 2020 May;43(5):665-666. doi: 10.1007/s00270-020-02440-6. Epub 2020 Feb 26. PMID: 32103304.

Kikuchi-Fujimoto disease in children. Selvanathan SN, Suhumaran S, Sahu VK, Chong CY, Tan NWH, Thoon KC. J Paediatr Child Health. 2020 Mar;56(3):389-393. doi: 10.1111/jpc.14628. Epub 2019 Oct 1. PMID: 31576642.

Acquisition of Plasmid with Carbapenem-Resistance Gene bla(KPC2) in Hypervirulent Klebsiella pneumoniae, Singapore. Chen Y, Marimuthu K, Teo J, Venkatachalam I, Cherng BPZ, De Wang L, Prakki SRS, Xu W, Tan YH, Nguyen LC, Koh TH, Ng OT, Gan YH. Emerg Infect Dis. 2020 Mar;26(3):549-559. doi: 10.3201/eid2603.191230. PMID: 32091354.

Identification of AbaR4 Acinetobacter baumannii resistance island in clinical isolates of blaOXA-23-positive Proteus mirabilis. Octavia S, Xu W, Ng OT, Marimuthu K, Venkatachalam I, Cheng B, Lin RTP, Teo JWP. J Antimicrob Chemother. 2020 Mar 1;75(3):521-525. doi: 10.1093/jac/dkz472. PMID: 31725155.

Acquisition of Plasmid with Carbapenem-Resistance Gene blaKPC2 in Hypervirulent Klebsiella pneumoniae, Singapore. Chen Y, Marimuthu K, Teo J, Venkatachalam I, Cherng BPZ, De Wang L, Prakki SRS, Xu W, Tan YH, Nguyen LC, Koh TH, Ng OT, Gan YH. Emerg Infect Dis. 2020 Mar;26(3):549-559. doi: 10.3201/eid2603.191230. PMID: 32091354.

Infant botulism in Singapore. Charan N, Wong JJ, Chan WSD, Ho ZJM, Sim HCJ, Loh JP, Foo LY, Octavia S, Ang M, Thoon KC. Singapore Med J. 2020 Mar;61(3):165-166. doi: 10.11622/smedj.2020017. PMID: 32488271.

Personal level exposure and hazard potential of particulate matter during haze and non-haze periods in Singapore. George S, Chua ML, ZheWei DZ, Das R, Bijin VA, Connolly JE, Lee KP, Yung CF, Teoh OH, Thomas B. Chemosphere. 2020 Mar;243:125401. doi: 10.1016/j.chemosphere.2019.125401. Epub 2019 Nov 18. PMID: 31995870

Immunogenicity and safety of a dengue vaccine given as a booster in Singapore: a randomized Phase II, placebo-controlled trial evaluating its effects 5-6 years after completion of the primary series. Park J, Archuleta S, Oh MH, Shek LP, Jin J, Bonaparte M, Fargo C, Bouckenooghe A. Hum Vaccin Immunother. 2020 Mar 3;16(3):523-529. doi: 10.1080/21645515.2019.1661204. Epub 2019 Nov 5. PMID: 31464558.

Déjà Vu or Jamais Vu? How the Severe Acute Respiratory Syndrome Experience Influenced a Singapore Radiology Department's Response to the Coronavirus Disease (COVID-19) Epidemic. Cheng LT, Chan LP, Tan BH, Chen RC, Tay KH, Ling ML, Tan BS. AJR Am J Roentgenol. 2020 Jun;214(6):1206-1210. doi: 10.2214/AJR.20.22927. Epub 2020 Mar 4. PMID: 32130047.

SARS-CoV-2 Infection among Travelers Returning from Wuhan, China. Ng OT, Marimuthu K, Chia PY, Koh V, Chiew CJ, De Wang L, Young BE, Chan M, Vasoo S, Ling LM, Lye DC, Kam KQ, Thoon KC, Kurupatham L, Said Z, Goh E, Low C, Lim SK, Raj P, Oh O, Koh VTJ, Poh C, Mak TM, Cui L, Cook AR, Lin RTP, Leo YS, Lee VJM. N Engl J Med. 2020 Apr 9;382(15):1476-1478. doi: 10.1056/NEJMc2003100. Epub 2020 Mar 12. PMID: 32163698.

Rapid Progression to Acute Respiratory Distress Syndrome: Review of Current Understanding of Critical Illness from COVID-19 Infection. Goh KJ, Choong MC, Cheong EH, Kalimuddin S, Duu Wen S, Phua GC, Chan KS, Haja Mohideen S. Ann Acad Med Singap. 2020 Mar 16;49(3):108-118. PMID: 32200400.

Investigation of three clusters of COVID-19 in Singapore: implications for surveillance and response measures. Pung R, Chiew CJ, Young BE, Chin S, Chen MI, Clapham HE, Cook AR, Maurer-Stroh S, Toh MPHS, Poh C, Low M, Lum J, Koh VTJ, Mak TM, Cui L, Lin RVTP, Heng D, Leo YS, Lye DC, Lee VJM; Singapore 2019 Novel Coronavirus Outbreak Research Team. Lancet. 2020 Mar 28;395(10229):1039-1046. doi: 10.1016/S0140-6736(20)30528-6. Epub 2020 Mar 17. PMID: 32192580.

Critical illness epidemiology and mortality risk in pediatric oncology. Rr P, Tan EEK, Sultana R, Thoon KC, Chan MY, Lee JH, Wong JJ. Pediatr Blood Cancer. 2020 Jun;67(6):e28242. doi: 10.1002/pbc.28242. Epub 2020 Mar 18. PMID: 32187445.

Antimicrobial susceptibility profiles and species distribution of medically relevant Nocardia species: Results from a large tertiary laboratory in Australia. Tan YE, Chen SC, Halliday CL. J Glob Antimicrob Resist. 2020 Mar;20:110-117. doi: 10.1016/j.jgar.2019.06.018. Epub 2019 Aug 7. PMID: 31400449.

Absence of contamination of personal protective equipment (PPE) by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Ong SWX, Tan YK, Sutjipto S, Chia PY, Young BE, Gum M, Lau SK, Chan M, Vasoo S, Mendis S, Toh BK, Leong J, Barkham T, Ang BSP, Tan BH, Leo YS, Marimuthu K, Wong MSY, Ng OT. Infect Control Hosp Epidemiol. 2020 May;41(5):614-616. doi: 10.1017/ice.2020.91. Epub 2020 Mar 26. PMID: 32213231.

Health-related quality of life and its association with outcomes of outpatient parenteral antibiotic therapy. Wee LE, Sundarajoo M, Quah WF, Farhati A, Huang JY, Chua YY. Eur J Clin Microbiol Infect Dis. 2020 Apr;39(4):765-772. doi: 10.1007/s10096-019-03787-6. Epub 2019 Dec 23. PMID: 31873862.

Environment and Personal Protective Equipment Tests for SARS-CoV-2 in the Isolation Room of an Infant With Infection. Yung CF, Kam KQ, Wong MSY, Maiwald M, Tan YK, Tan BH, Thoon KC. Ann Intern Med. 2020 Aug 4;173(3):240-242. doi: 10.7326/M20-0942. Epub 2020 Apr 1. PMID: 32236490.

Management of HIV-positive pregnant women: a Singapore experience. Loh M, Thoon KC, Mathur M, Kathirvel R. Singapore Med J. 2020 Apr 3. doi: 10.11622/smedj.2020048. Online ahead of print. PMID: 32241070.

Minimizing intra-hospital transmission of COVID-19: the role of social distancing. Wee LE, Conceicao EP, Sim XYJ, Aung MK, Tan KY, Wong HM, Wijaya L, Tan BH, Ling ML, Venkatachalam I. J Hosp Infect. 2020 Jun;105(2):113-115. doi: 10.1016/j.jhin.2020.04.016. Epub 2020 Apr 12. PMID: 32294511.

Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore. Young BE, Ong SWX, Kalimuddin S, Low JG, Tan SY, Loh J, Ng OT, Marimuthu K, Ang LW, Mak TM, Lau SK, Anderson DE, Chan KS, Tan TY, Ng TY, Cui L, Said Z, Kurupatham L, Chen MI, Chan M, Vasoo S, Wang LF, Tan BH, Lin RTP, Lee VJM, Leo YS, Lye DC; Singapore 2019 Novel Coronavirus Outbreak Research Team. JAMA. 2020 Apr 21;323(15):1488-1494. doi: 10.1001/jama.2020.3204. PMID: 32125362.

Timeliness of Childhood Vaccination Coverage: the Growing Up in Singapore Towards Healthy Outcomes Study. Loy SL, Cheung YB, Chan JKY, Soh SE, Godfrey KM, Tan KH, Shek LP, Chong YS, Lek N, Yap F, Teoh OH, Yung CF, Thoon KC. Prev Sci. 2020 Apr;21(3):283-292. doi: 10.1007/s11121-019-01078-2. PMID: 31960261.

The role of self-reported olfactory and gustatory dysfunction as a screening criterion for suspected COVID-19. Wee LE, Chan YFZ, Teo NWY, Cherng BPZ, Thien SY, Wong HM, Wijaya L, Toh ST, Tan TT. Eur Arch Otorhinolaryngol. 2020 Aug;277(8):2389-2390. doi: 10.1007/s00405-020-05999-5. Epub 2020 Apr 24. PMID: 32328771.

Interventional Radiology Procedures for COVID-19 Patients: How we Do it. Too CW, Wen DW, Patel A, Abdul Syafiq AR, Liu J, Leong S, Gogna A, Lo RHG, Tashi S, Lee KA, Kumar P, Lie SA, Tay YC, Lee LC, Ling ML, Tan BS, Tay KH. Cardiovasc Intervent Radiol. 2020 Jun;43(6):827-836. doi: 10.1007/s00270-020-02483-9. Epub 2020 Apr 27. PMID: 32342154.

A Dynamic Immune Response Shapes COVID-19 Progression. Ong EZ, Chan YFZ, Leong WY, Lee NMY, Kalimuddin S, Haja Mohideen SM, Chan KS, Tan AT, Bertoletti A, Ooi EE, Low JGH. Cell Host Microbe. 2020 Jun 10;27(6):879-882.e2. doi: 10.1016/j.chom.2020.03.021. Epub 2020 Apr 30. PMID: 32359396.

Critically ill COVID-19 infected patients exhibit increased clot waveform analysis parameters consistent with hypercoagulability. Tan CW, Low JGH, Wong WH, Chua YY, Goh SL, Ng HJ. Am J Hematol. 2020 Jul;95(7):E156-E158. doi: 10.1002/ajh.25822. Epub 2020 May 4. PMID: 32267008.

Practical Considerations for Solid Organ Transplantation During the COVID-19 Global Outbreak: The Experience from Singapore. Chung SJ, Tan EK, Kee T, Krishnamoorthy TL, Phua GC, Sewa DW, Ong BH, Tan TE, Sivathasan C, Gan HLV, Goh BKP, Jeyaraj PR, Tan BH. Transplant Direct. 2020 May 8;6(6):e554. doi: 10.1097/TXD.0000000000001002. eCollection 2020 Jun. PMID: 32607420.

High-immunological risk living donor renal transplant during the COVID-19 outbreak: Uncertainties and ethical dilemmas. Ho QY, Chung SJ, Gan VHL, Ng LG, Tan BH, Kee TYS. Am J Transplant. 2020 Jul;20(7):1949-1951. doi: 10.1111/ajt.15949. Epub 2020 May 8. PMID: 32337825.

Respiratory surveillance wards as a strategy to reduce nosocomial transmission of COVID-19 through early detection: The experience of a tertiary-care hospital in Singapore. Wee LE, Hsieh JYC, Phua GC, Tan Y, Conceicao EP, Wijaya L, Tan TT, Tan BH. Infect Control Hosp Epidemiol. 2020 Jul;41(7):820-825. doi: 10.1017/ice.2020.207. Epub 2020 May 8. PMID: 32381147.

Containment of COVID-19 cases among healthcare workers: The role of surveillance, early detection, and outbreak management. Wee LE, Sim XYJ, Conceicao EP, Aung MK, Goh JQ, Yeo DWT, Gan WH, Chua YY, Wijaya L, Tan TT, Tan BH, Ling ML, Venkatachalam I. Infect Control Hosp Epidemiol. 2020 Jul;41(7):765-771. doi: 10.1017/ice.2020.219. Epub 2020 May 11. PMID: 32391746.

Containing COVID-19 in the Emergency Department: The Role of Improved Case Detection and Segregation of Suspect Cases. Wee LE, Fua TP, Chua YY, Ho AFW, Sim XYJ, Conceicao EP, Venkatachalam I, Tan KB, Tan BH. Acad Emerg Med. 2020 May;27(5):379-387. doi: 10.1111/acem.13984. Epub 2020 May 11. PMID: 32281231.

Evaluating Potential Deceased Donor Renal Transplant Recipients for Asymptomatic COVID-19. Ho QY, Chung SJ, Low SCS, Chen RC, Teh SP, Chan FZY, Tan BH, Kee TYS. Transplant Direct. 2020 May 22;6(6):e559. doi: 10.1097/TXD.0000000000001010. eCollection 2020 Jun. PMID: 32607425.

Surveillance for COVID-19 in Cardiac Inpatients: Containing COVID-19 in a Specialized Cardiac Centre. Wee LE, Ruan W, Sim XYJ, Ng K, Phoon PC, Conceicao EP, Aung MK, Wong AS, Chua TSJ, Venkatachalam I. Can J Cardiol. 2020 Aug;36(8):1327.e3-1327.e4. doi: 10.1016/j.cjca.2020.05.031. Epub 2020 May 29. PMID: 32473301.

Detection of air and surface contamination by SARS-CoV-2 in hospital rooms of infected patients. Chia PY, Coleman KK, Tan YK, Ong SWX, Gum M, Lau SK, Lim XF, Lim AS, Sutjipto S, Lee PH, Son TT, Young BE, Milton DK, Gray GC, Schuster S, Barkham T, De PP, Vasoo S, Chan M, Ang BSP, Tan BH, Leo YS, Ng OT, Wong MSY, Marimuthu K; Singapore 2019 Novel Coronavirus Outbreak Research Team. Nat Commun. 2020 May 29;11(1):2800. doi: 10.1038/s41467-020-16670-2. PMID: 32472043.

Initial Experiences of Laboratory Diagnosis of Coronavirus Disease 2019 (COVID-19) in Singapore General Hospital. Chan KS, Ko KK, Koh TH, Ho DW, Chan YF, Tan TT, Oon LL. Ann Acad Med Singap. 2020 Jun;49(6):415-416. PMID: 32712644.

A retrospective review of tuberculosis exposure among health care workers in a tertiary hospital. Chia SZG, How KBM, Chlebicki MP, Ling ML, Gan WH. Am J Infect Control. 2020 Jun;48(6):650-655. doi: 10.1016/j.ajic.2019.10.014. Epub 2019 Dec 2. PMID: 31806237.

Two linear epitopes on the SARS-CoV-2 spike protein that elicit neutralising antibodies in COVID-19 patients. Poh CM, Carissimo G, Wang B, Amrun SN, Lee CY, Chee RS, Fong SW, Yeo NK, Lee WH, Torres-Ruesta A, Leo YS, Chen MI, Tan SY, Chai LYA, Kalimuddin S, Kheng SSG, Thien SY, Young BE, Lye DC, Hanson BJ, Wang CI, Renia L, Ng LFP. Nat Commun. 2020 Jun 1;11(1):2806. doi: 10.1038/s41467-020-16638-2. PMID: 32483236.

Statistical inference in matched case-control studies of recurrent events. Cheung YB, Ma X, Lam KF, Li J, Yung CF, Milligan P, Mackenzie G. Int J Epidemiol. 2020 Jun 1;49(3):996-1006. doi: 10.1093/ije/dyaa012. PMID: 32125376.

The Extended Polydimensional Immunome Characterization (EPIC) web-based reference and discovery tool for cytometry data. Yeo JG, Wasser M, Kumar P, Pan L, Poh SL, Ally F, Arkachaisri T, Lim AJM, Leong JY, Lai L, Yeo KT, Lee ESC, Chua CJH, Larbi A, Nyunt MSZ, Ng TP, Chiesa S, Gattorno M, Martini A, Paleja BS, Dutertre CA, Chen J, Nay Yaung K, Tang SP, Ng SK, Yung CF, Tan AYJ, Lee SY, Ginhoux F, Albani S. Nat Biotechnol. 2020 Jun;38(6):679-684. doi: 10.1038/s41587-020-0532-1. PMID: 32440006.

Disseminated Bacillus-Calmette-Guérin Infections And Primary Immunodeficiency Disorders In Singapore: A Single Center 15-Year Retrospective Review. Ong RYL, Chan SB, Chew SJ, Liew WK, Thoon KC, Chong CY, Yung CF, Sng LH, Tan AM, Bhattacharyya R, Jamuar SS, Lim JY, Li J, Nadua KD, Kam KQ, Tan NW. Int J Infect Dis. 2020 Aug;97:117-125. doi: 10.1016/j.ijid.2020.05.117. Epub 2020 Jun 2. PMID: 32497805. Review.

Human MAIT cell cytolytic effector proteins synergize to overcome carbapenem resistance in Escherichia coli. Boulouis C, Sia WR, Gulam MY, Teo JQM, Png YT, Phan TK, Mak JYW, Fairlie DP, Poon IKH, Koh TH, Bergman P, Lim CM, Wang LF, Kwa ALH, Sandberg JK, Leeansyah E. PLoS Biol. 2020 Jun 8;18(6):e3000644. doi: 10.1371/journal.pbio.3000644. eCollection 2020 Jun. PMID: 32511236.

Vaccine-associated Rubella - a report of two cases and a review of the literature. Ong SWX, Vasoo S, Sadarangani SP, Cui L, Marimuthu K, Lim PL, Kong JW, Wong JCC, Puong KY, Chan KP. Hum Vaccin Immunother. 2021 Jan 2;17(1):224-227. doi: 10.1080/21645515.2020.1765623. Epub 2020 Jun 12. PMID: 32530771.

Reorganising the emergency department to manage the COVID-19 outbreak. Quah LJJ, Tan BKK, Fua TP, Wee CPJ, Lim CS, Nadarajan G, Zakaria ND, Chan SJ, Wan PW, Teo LT, Chua YY, Wong E, Venkataraman A. Int J Emerg Med. 2020 Jun 17;13(1):32. doi: 10.1186/s12245-020-00294-w. PMID: 32552659.

An unusual case of Scedosporium apiospermum fungaemia in an immunocompetent patient with a left ventricular assist device and an implantable cardiac device. Tan SYL, Chung SJ, Tan TE, Teo L, Tan BH, Tan YE. Access Microbiol. 2020 Jun 25;2(9):acmi000148. doi: 10.1099/acmi.0.000148. eCollection 2020. PMID: 33195980.

Containing COVID-19 outside the isolation ward: The impact of an infection control bundle on environmental contamination and transmission in a cohorted general ward. Wee LEI, Sim XYJ, Conceicao EP, Aung MK, Tan KY, Ko KKK, Wong HM, Wijaya L, Tan BH, Venkatachalam I, Ling ML. Am J Infect Control. 2020 Sep;48(9):1056-1061. doi: 10.1016/j.ajic.2020.06.188. Epub 2020 Jun 26. PMID: 32599101.

Containing COVID-19 in a specialised neurology centre: the risks of presymptomatic transmission. Wee LEI, Thien SY, Singh SR, Ling ML, Venkatachalam I. Neurol Sci. 2020 Aug;41(8):2013-2015. doi: 10.1007/s10072-020-04548-6. Epub 2020 Jun 27. PMID: 32594267.

Foodborne Klebsiella pneumoniae: Virulence Potential, Antibiotic Resistance, and Risks to Food Safety. Hartantyo SHP, Chau ML, Koh TH, Yap M, Yi T, Cao DYH, GutiÉrrez RA, Ng LC. J Food Prot. 2020 Jul 1;83(7):1096-1103. doi: 10.4315/JFP-19-520. PMID: 31928427.

Cross-reaction of Sera from COVID-19 Patients with SARS-CoV Assays. Wan WY, Lim SH, Seng EH. Ann Acad Med Singap. 2020 Jul;49(7):523-526. PMID: 33000119.

Household Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 from Adults to Children.Yung CF, Kam KQ, Chong CY, Nadua KD, Li J, Tan NWH, Ganapathy S, Lee KP, Ng KC, Chan YH, Thoon KC. J Pediatr. 2020 Oct;225:249-251. doi: 10.1016/j.jpeds.2020.07.009. Epub 2020 Jul 4. PMID: 32634405.

Successful containment of horizontal enterovirus infection in a neonatal unit in Singapore through diagnosis by polymerase chain reaction (PCR) and direct sequence analysis. Tan YY, Quek BH, Thoon KC, Maiwald M, Yung CF, Rajadurai VS, Kong JY. J Infect Public Health. 2020 Oct;13(10):1556-1561. doi: 10.1016/j.jiph.2020.06.029. Epub 2020 Jul 9. PMID: 32653481.

Clinical Utility of Buccal Swabs for Severe Acute Respiratory Syndrome Coronavirus 2 Detection in Coronavirus Disease 2019-Infected Children. Kam KQ,Yung CF, Maiwald M, Chong CY, Soong HY, Loo LH, Tan NWH, Li J, Nadua KD, Thoon KC. J Pediatric Infect Dis Soc. 2020 Jul 13;9(3):370-372. doi: 10.1093/jpids/piaa068. PMID: 32463086.

Serratia marcescens in the neonatal intensive care unit: A cluster investigation using molecular methods. Yeo KT, Octavia S, Lim K, Lin C, Lin R, Thoon KC, Tee NWS, Yung CF. J Infect Public Health. 2020 Jul;13(7):1006-1011. doi: 10.1016/j.jiph.2019.12.003. Epub 2019 Dec 26. PMID: 31883745.

Heterozygous missense variant in EIF6 gene: A novel form of Shwachman-Diamond syndrome? Koh AL, Bonnard C, Lim JY, Liew WK, Thoon KC, Thomas T, Ali NAB, Ng AYJ, Tohari S, Phua KB, Venkatesh B, Reversade B, Jamuar SS. Am J Med Genet A. 2020 Sep;182(9):2010-2020. doi: 10.1002/ajmg.a.61758. Epub 2020 Jul 13. PMID: 32657013.

The impact of healthcare associated infections on mortality and length of stay in Singapore-A time-varying analysis. Cai Y, Lo JJ, Venkatachalam I, Kwa AL, Tambyah PA, Hsu LY, Barnett A, Marimuthu K, Graves N. Infect Control Hosp Epidemiol. 2020 Nov;41(11):1315-1320. doi: 10.1017/ice.2020.304. Epub 2020 Jul 15. PMID: 32665057.

Genomic Study of bla (IMI)-Positive Enterobacter cloacae Complex in Singapore over a Five-Year Study Period. Octavia S, Koh TH, Ng OT, Marimuthu K, Venkatachalam I, Lin RTP, Teo JWP. Antimicrob Agents Chemother. 2020 Jul 22;64(8):e00510-20. doi: 10.1128/AAC.00510-20. Print 2020 Jul 22. PMID: 32482676.

Early Recognition of Coronavirus 2019 Disease (COVID-19) Infection in Surgical Inpatients: The Importance of a Risk-Stratified Approach for Early Testing and Isolation. Wee LE, Sim XYJ, Conceicao EP, Aung MK, Wong HM, Teh YE, Tan KY, Wijaya L, Tan TBH, Ling ML, Venkatachalam I. Surg Infect (Larchmt). 2020 Nov;21(9):760-765. doi: 10.1089/sur.2020.184. Epub 2020 Jul 22. PMID: 32716758.

Genomic Study of bla IMI-Positive Enterobacter cloacae Complex in Singapore over a Five-Year Study Period. Octavia S, Koh TH, Ng OT, Marimuthu K, Venkatachalam I, Lin RTP, Teo JWP. Antimicrob Agents Chemother. 2020 Jul 22;64(8):e00510-20. doi: 10.1128/AAC.00510-20. Print 2020 Jul 22. PMID: 32482676.

Epidemiologic trends in Kawasaki disease during coronavirus disease-19 in Singapore. Yung CF, Nadua KD, Oh BK, Thoon KC. J Pediatr. 2020 Jul 24;226:314-5. doi: 10.1016/j.jpeds.2020.07.063. Online ahead of print. PMID: 32717229.

Impact of formulary interventions on the minimum inhibitory concentration of methicillin-resistant Staphylococcus aureus to mupirocin, chlorhexidine, and octenidine in a Singapore tertiary institution. Zheng S, Chung SJ, Sim HCJ, Chlebicka TM, Chan YH, Lim TP, Kwa LHA, Chlebicki MP. Eur J Clin Microbiol Infect Dis. 2020 Dec;39(12):2397-2403. doi: 10.1007/s10096-020-03995-5. Epub 2020 Jul 25. PMID: 32712737.

Burden and Cost of Hospitalization for Respiratory Syncytial Virus in Young Children, Singapore. Tam CC, Yeo KT, Tee N, Lin R, Mak TM, Thoon KC, Jit M, Yung CF. Emerg Infect Dis. 2020 Jul;26(7):1489-1496. doi: 10.3201/eid2607.190539. PMID: 32568036.

A Well Infant With Coronavirus Disease 2019 With High Viral Load. Kam KQ, Yung CF, Cui L, Tzer Pin Lin R, Mak TM, Maiwald M, Li J, Chong CY, Nadua K, Tan NWH, Thoon KC. Clin Infect Dis. 2020 Jul 28;71(15):847-849. doi: 10.1093/cid/ciaa201. PMID: 32112082.

Transmission modes of severe acute respiratory syndrome coronavirus 2 and implications on infection control: a review. Ong SWX, Coleman KK, Chia PY, Thoon KC, Pada S, Venkatachalam I, Fisher D, Tan YK, Tan BH, Ng OT, Ang BSP, Leo YS, Wong MSY, Marimuthu K. Singapore Med J. 2020 Jul 30. doi: 10.11622/smedj.2020114. Online ahead of print. PMID: 32729311.

Comparative Analysis of Symptomatic and Asymptomatic SARS-CoV-2 Infection in Children. Li J, Thoon KC, Chong CY, Maiwald M, Kam KQ, Nadua K, Tan NW, Yung CF. Ann Acad Med Singap. 2020 Aug;49(8):530-537. PMID: 33164022.

Use of medical face masks versus particulate respirators as a component of personal protective equipment for health care workers in the context of the COVID-19 pandemic. Conly J, Seto WH, Pittet D, Holmes A, Chu M, Hunter PR; WHO Infection Prevention and Control Research and Development Expert Group for COVID-19. Antimicrob Resist Infect Control. 2020 Aug 6;9(1):126. doi: 10.1186/s13756-020-00779-6. PMID: 32762735.

Containment of COVID-19 among ancillary healthcare workers: an integral component of infection control. Wee LE, Sim JXY, Conceicao EP, Aung MK, Tan JY, Venkatachalam I. J Hosp Infect. 2020 Oct;106(2):392-396. doi: 10.1016/j.jhin.2020.08.002. Epub 2020 Aug 8. PMID: 32781199.

Oral vs Intravenous Antibiotics for Patients With Klebsiella pneumoniae Liver Abscess: A Randomized, Controlled Noninferiority Study. Molton JS, Chan M, Kalimuddin S, Oon J, Young BE, Low JG, Salada BMA, Lee TH, Wijaya L, Fisher DA, Izharuddin E, Koh TH, Teo JWP, Krishnan PU, Tan BP, Woon WWL, Ding Y, Wei Y, Phillips R, Moorakonda R, Yuen KH, Cher BP, Yoong J, Lye DC, Archuleta S. Clin Infect Dis. 2020 Aug 14;71(4):952-959. doi: 10.1093/cid/ciz881. PMID: 31641767.

Genomic analysis of Lactococcus garvieae isolates. Lin YS, Kweh KH, Koh TH, Lau QC, Abdul Rahman NB. Pathology. 2020 Oct;52(6):700-707. doi: 10.1016/j.pathol.2020.06.009. Epub 2020 Aug 20. PMID: 32829891.

In Vitro Pharmacodynamics of Fosfomycin against Carbapenem-Resistant Enterobacter cloacae and Klebsiella aerogenes. Lim TP, Teo JQ, Goh AW, Tan SX, Koh TH, Lee WH, Cai Y, Tan TT, Kwa AL. Antimicrob Agents Chemother. 2020 Aug 20;64(9):e00536-20. doi: 10.1128/AAC.00536-20. Print 2020 Aug 20. PMID: 32571821.

Hepatitis C virus antigen detection is an appropriate test for screening and early diagnosis of hepatitis C virus infection in at-risk populations and immunocompromised hosts. Kumar R, Chan KP, Ekstrom VSM, Wong JCC, Lim KL, Ng WC, Woo SM, Chan KS, Thangaraju S, Kee TYS, Gan SSW, Foo MWY, Oon LLE, Chow WC. J Med Virol. 2021 Jun;93(6):3738-3743. doi: 10.1002/jmv.26433. Epub 2020 Aug 25. PMID: 32797627.

Antimicrobial stewardship programme: a vital resource for hospitals during the global outbreak of coronavirus disease 2019 (COVID-19). Liew Y, Lee WHL, Tan L, Kwa ALH, Thien SY, Cherng BPZ, Chung SJ. Int J Antimicrob Agents. 2020 Nov;56(5):106145. doi: 10.1016/j.ijantimicag.2020.106145. Epub 2020 Aug 27. PMID: 32860880.

Personal protective equipment protecting healthcare workers in the Chinese epicenter of COVID-19' by Zhao et al. Wee LE, Sim JXY, Conceicao EP, Aung MK, Ng IM, Ling ML. Clin Microbiol Infect. 2020 Dec;26(12):1719-1721. doi: 10.1016/j.cmi.2020.08.040. Epub 2020 Sep 6. PMID: 32898713.

Cohort study to evaluate the effect of vitamin D, magnesium, and vitamin B12 in combination on progression to severe outcomes in older patients with coronavirus (COVID-19). Tan CW, Ho LP, Kalimuddin S, Cherng BPZ, Teh YE, Thien SY, Wong HM, Tern PJW, Chandran M, Chay JWM, Nagarajan C, Sultana R, Low JGH, Ng HJ. Nutrition. 2020 Nov-Dec;79-80:111017. doi: 10.1016/j.nut.2020.111017. Epub 2020 Sep 8. PMID: 33039952.

Saliva is not a useful diagnostic specimen in children with Coronavirus Disease 2019. Chong CY, Kam KQ, Li J, Maiwald M, Loo LH, Nadua KD, Tan NWH, Yung CF, Thoon KC. Clin Infect Dis. 2020 Sep 14:ciaa1376. doi: 10.1093/cid/ciaa1376. Online ahead of print. PMID: 32927475.

Construction of a container isolation ward: A rapidly scalable modular approach to expand isolation capacity during the coronavirus disease 2019 (COVID-19) pandemic. Wee LE, Fan EMP, Heng R, Ang SY, Chiang JL, Tan TT, Ling ML, Wijaya L. Infect Control Hosp Epidemiol. 2020 Sep 23:1-3. doi: 10.1017/ice.2020.1222. Online ahead of print. PMID: 32962768.

Duration of Carbapenemase-Producing Enterobacteriaceae Carriage in Hospital Patients. Mo Y, Hernandez-Koutoucheva A, Musicha P, Bertrand D, Lye D, Ng OT, Fenlon SN, Chen SL, Ling ML, Tang WY, Barkham T, Nagarajan N, Cooper BS, Marimuthu K. Emerg Infect Dis. 2020 Sep;26(9):2182-2185. doi: 10.3201/eid2609.190592. PMID: 32818397.

Clinical utility of Epstein-Barr virus DNA and other liquid biopsy markers in nasopharyngeal carcinoma. Tan R, Phua SKA, Soong YL, Oon LLE, Chan KS, Lucky SS, Mong J, Tan MH, Lim CM. Cancer Commun (Lond). 2020 Nov;40(11):564-585. doi: 10.1002/cac2.12100. Epub 2020 Sep 28. PMID: 32989921.

Elimination of Extracellular Adenosine Triphosphate for the Rapid Prediction of Quantitative Plate Counts in 24 h Time-Kill Studies against Carbapenem-Resistant Gram-Negative Bacteria. Cai Y, Ng JJ, Leck H, Teo JQ, Goh JX, Lee W, Koh TH, Tan TT, Lim TP, Kwa AL. Microorganisms. 2020 Sep 28;8(10):1489. doi: 10.3390/microorganisms8101489. PMID: 32998347.

A comparative study on the clinical features of COVID-19 with non-SARS-CoV-2 respiratory viral infections. Tan JY, Sim XYJ, Wee LE, Chua YY, Cherng BPZ, Ng IM, Conceicao EP, Wong TJ, Yang Y, Aung MK, Ling ML, Venkatachalam I. J Med Virol. 2021 Mar;93(3):1548-1555. doi: 10.1002/jmv.26486. Epub 2020 Sep 29. PMID: 32881022.

Epidemiology of Adenovirus Infections and Outcomes of Cidofovir Treatment in Severely Ill Children. Siew JX, Seah XFV, Chew YR, Thoon KC, Chong CY, Yung CF, Maiwald M, Len Y, Li J, Kam KQ, Nadua K, Tanugroho R, Tan NWH. Pediatr Infect Dis J. 2020 Oct;39(10):907-913. doi: 10.1097/INF.0000000000002726. PMID: 32404785.

Rare Case Of Pott's Disease Caused By Bacillus-Calmette Guérin Vaccine. Mahtani S, Tan JMC, Low SYY, Nolan CP, Ong RYL, Lam JCM, Yeo TH, Sng LH, Chang KTE, Chong CY, Tan NWH. J Paediatr Child Health. 2020 Oct;56(10):1655-1656. doi: 10.1111/jpc.15082. PMID: 33099828.

Environmental contamination in a coronavirus disease 2019 (COVID-19) intensive care unit-What is the risk? Ong SWX, Lee PH, Tan YK, Ling LM, Ho BCH, Ng CG, Wang DL, Tan BH, Leo YS, Ng OT, Wong MSY, Marimuthu K. Infect Control Hosp Epidemiol. 2021 Jun;42(6):669-677. doi: 10.1017/ice.2020.1278. Epub 2020 Oct 21. PMID: 33081858.

Experience of a Tertiary Hospital in Singapore with Management of a Dual Outbreak of COVID-19 and Dengue. Wee LE, Cherng BPZ, Conceicao EP, Goh KC, Wan WY, Ko KKK, Aung MK, Sim XYJ, Wijaya L, Ling ML, Venkatachalam I. Am J Trop Med Hyg. 2020 Nov;103(5):2005-2011. doi: 10.4269/ajtmh.20-0703. PMID: 32996452.

Pregnancy Outcomes in COVID-19: A Prospective Cohort Study in Singapore. Mattar CN, Kalimuddin S, Sadarangani SP, Tagore S, Thain S, Thoon KC, Hong EY, Kanneganti A, Ku CW, Chan GM, Lee KZ, Yap JJ, Tan SS, Yan B, Young BE, Lye DC, Anderson DE, Yang L, Su LL, Somani J, Tan LK, Choolani MA, Chan JK. Ann Acad Med Singap. 2020 Nov;49(11):857-869. doi: 10.47102/annals-acadmedsg.2020437. PMID: 33381779.

Dominant-negative NFKBIA mutation promotes IL-1β production causing hepatic disease with severe immunodeficiency. Tan EE, Hopkins RA, Lim CK, Jamuar SS, Ong C, Thoon KC, Koh MJ, Shin EM, Lian DW, Weerasooriya M, Lee CZ, Soetedjo AAP, Lim CS, Au VB, Chua E, Lee HY, Jones LA, James SS, Kaliaperumal N, Kwok J, Tan ES, Thomas B, Wu LX, Ho L, Fairhurst AM, Ginhoux F, Teo AK, Zhang YL, Ong KH, Yu W, Venkatesh B, Tergaonkar V, Reversade B, Chin KC, Tan AM, Liew WK, Connolly JE. J Clin Invest. 2020 Nov 2;130(11):5817-5832. doi: 10.1172/JCI98882. PMID: 32750042.

Unintended consequences of infection prevention and control measures during COVID-19 pandemic. Wee LEI, Conceicao EP, Tan JY, Magesparan KD, Amin IBM, Ismail BBS, Toh HX, Jin P, Zhang J, Wee EGL, Ong SJM, Lee GLX, Wang AE, How MKB, Tan KY, Lee LC, Phoon PC, Yang Y, Aung MK, Sim XYJ, Venkatachalam I, Ling ML. Am J Infect Control. 2021 Apr;49(4):469-477. doi: 10.1016/j.ajic.2020.10.019. Epub 2020 Nov 4. PMID: 33157180.

Utilizing the electronic health records to create a syndromic staff surveillance system during the COVID-19 outbreak. Sim JXY, Conceicao EP, Wee LE, Aung MK, Wei Seow SY, Yang Teo RC, Goh JQ, Ting Yeo DW, Jyhhan Kuo B, Lim JW, Gan WH, Ling ML, Venkatachalam I. Am J Infect Control. 2021 Jun;49(6):685-689. doi: 10.1016/j.ajic.2020.11.003. Epub 2020 Nov 4. PMID: 33159997.

The impact of visitor restrictions on health care-associated respiratory viral infections during the COVID-19 pandemic: Experience of a tertiary hospital in Singapore. Wee LE, Conceicao EP, Sim JX, Aung MK, Venkatachalam I. Am J Infect Control. 2021 Jan;49(1):134-135. doi: 10.1016/j.ajic.2020.11.006. Epub 2020 Nov 10. PMID: 33186677.

Respiratory viral infections in hospitalised paediatric patients in the tropics.Tan KWJ, Yung CF, Maiwald M, Saffari SE, Thoon KC, Chong CY. J Paediatr Child Health. 2021 Apr;57(4):559-565. doi: 10.1111/jpc.15267. Epub 2020 Nov 13. PMID: 33185937.

Containment of COVID-19 and reduction in healthcare-associated respiratory viral infections through a multi-tiered infection control strategy. Wee LE, Venkatachalam I, Sim XYJ, Tan KB, Wen R, Tham CK, Gan WH, Ko KKK, Ho WQ, Kwek GTC, Conceicao EP, Sng CYE, Ng XHJ, Ong JY, Chiang JL, Chua YY, Ling ML, Tan TT, Wijaya L. Infect Dis Health. 2021 May;26(2):123-131. doi: 10.1016/j.idh.2020.11.004. Epub 2020 Nov 16. PMID: 33386294.

Reduction in heart failure admissions with concomitant respiratory viral infections during the novel coronavirus disease-2019 pandemic: Unintended consequence of public health measures in Singapore. Wee LE, Conceicao EP, Tan JY, Chan LL, Phoon PC, Sim XYJ, Venkatachalam I. J Card Fail. 2021 Jan;27(1):117-119. doi: 10.1016/j.cardfail.2020.11.011. Epub 2020 Nov 21. PMID: 33232821.

Efficacy of β-lactam/β-lactamase inhibitors to treat extended-spectrum beta-lactamase-producing Enterobacterales bacteremia secondary to urinary tract infection in kidney transplant recipients (INCREMENT-SOT Project). Pierrotti LC, Pérez-Nadales E, Fernández-Ruiz M, Gutiérrez-Gutiérrez B, Tan BH, Carratalà J, Oriol I, Paul M, Cohen-Sinai N, López-Medrano F, San-Juan R, Montejo M, Freire MP, Cordero E, David MD, Merino E, Mehta Steinke S, Grossi PA, Cano Á, Seminari EM, Valerio M, Gunseren F, Rana M, Mularoni A, Martín-Dávila P, van Delden C, Hamiyet Demirkaya M, Koçak Tufan Z, Loeches B, Iyer RN, Soldani F, Eriksson BM, Pilmis B, Rizzi M, Coussement J, Clemente WT, Roilides E, Pascual Á, Martínez-Martínez L, Rodríguez-Baño J, Torre-Cisneros J, Aguado JM; Investigators from the REIPI/INCREMENT-SOT Group. Transpl Infect Dis. 2020 Nov 22:e13520. doi: 10.1111/tid.13520. Online ahead of print. PMID: 33222379.

Meteorological drivers of respiratory syncytial virus infections in Singapore. Ali ST, Tam CC, Cowling BJ, Yeo KT, Yung CF. Sci Rep. 2020 Nov 24;10(1):20469. doi: 10.1038/s41598-020-76888-4. PMID: 33235232.

COVID-19 public health measures: a reduction in hospital admissions for COPD exacerbations. Tan JY, Conceicao EP, Wee LE, Sim XYJ, Venkatachalam I. Thorax. 2020 Dec 3:thoraxjnl-2020-216083. doi: 10.1136/thoraxjnl-2020-216083. Online ahead of print. PMID: 33273024.

Effectiveness of Palivizumab against Respiratory Syncytial Virus Hospitalization among Preterm Infants in a Setting with Year-round Circulation. Yeo KT, Yung CF, Khoo PC, Saffari SE, Sng JSP, How MS, Quek BH. J Infect Dis. 2020 Dec 4:jiaa749. doi: 10.1093/infdis/jiaa749. Online ahead of print. PMID: 33274362

Effectiveness of a Mobile-Based Influenza-Like Illness Surveillance System (FluMob) Among Health Care Workers: Longitudinal Study. Lwin MO, Lu J, Sheldenkar A, Panchapakesan C, Tan YR, Yap P, Chen MI, Chow VT, Thoon KC, Yung CF, Ang LW, Ang BS. JMIR Mhealth Uhealth. 2020 Dec 7;8(12):e19712. doi: 10.2196/19712. PMID: 33284126.

Waitlisted Transplant Candidates' Attitudes and Concerns Toward Transplantation During COVID-19. Tan EK, Koh YX, Kee T, Juhari JB, Tan TE, Sim DKL, Ho AYL, Krishnan L, Tee PS, Krishnamoorthy TL, Goh BKP, Tan BH, Chung SJ, Phua GC, Jeyaraj PR. Ann Transplant. 2020 Dec 8;25:e926992. doi: 10.12659/AOT.926992. PMID: 33289727.

Impact of infection prevention precautions on adenoviral infections during the COVID-19 pandemic: experience of a tertiary hospital in Singapore. Wee LE, Conceicao EP, Sim JXY, Aung MK, Venkatachalam I. Infect Control Hosp Epidemiol. 2020 Dec 10:1-9. doi: 10.1017/ice.2020.1365. Online ahead of print. PMID: 33298224.

Efficacy of commercial mouth-rinses on SARS-CoV-2 viral load in saliva: randomized control trial in Singapore. Seneviratne CJ, Balan P, Ko KKK, Udawatte NS, Lai D, Ng DHL, Venkatachalam I, Lim KS, Ling ML, Oon L, Goh BT, Sim XYJ. Infection. 2021 Apr;49(2):305-311. doi: 10.1007/s15010-020-01563-9. Epub 2020 Dec 14. PMID: 33315181.

Chemical disinfection in healthcare settings: critical aspects for the development of global strategies. Exner M, Bhattacharya S, Gebel J, Goroncy-Bermes P, Hartemann P, Heeg P, Ilschner C, Kramer A, Ling ML, Merkens W, Oltmanns P, Pitten F, Rotter M, Schmithausen RM, Sonntag HG, Steinhauer K, Trautmann M. GMS Hyg Infect Control. 2020 Dec 23;15:Doc36. doi: 10.3205/dgkh000371. eCollection 2020. PMID: 33520601.

Impact of COVID-19 on pediatric emergencies and hospitalizations in Singapore. Chong SL, Soo JSL, Allen JC Jr, Ganapathy S, Lee KP, Tyebally A, Yung CF, Thoon KC, Ng YH, Oh JY, Teoh OH, Mok YH, Chan YH. BMC Pediatr. 2020 Dec 23;20(1):562. doi: 10.1186/s12887-020-02469-z. PMID: 33353540.

Universal Face Masking Reduces Respiratory Viral Infections Among Inpatient Very-Low-Birthweight Neonatal Infants. Tong WY, Yung CF, Chiew LC, Chew SB, Ang LD, Thoon KC, Rajadurai VS, Yeo KT. Clin Infect Dis. 2020 Dec 31;71(11):2958-2961. doi: 10.1093/cid/ciaa555. PMID: 32406498