About SECThe SingHealth Exome Consortium (SEC) is an initiative started by PRISM to consolidate exomes from healthy individuals generated by investigators from SingHealth institutions and their affiliates. Over the last few years, various exome sequencing projects have taken place across SingHealth institutions, with most of them sequencing the exomes of healthy or normal individuals as controls. These exomes, kindly contributed by investigators from various institutions, have been re-analyzed and jointly-genotyped using the GATK (Genome Analysis Tool Kit) Best Practices Workflow. The latest version of the SEC dataset has variants from 1504 normal individuals. This dataset has been used for the following purposes:
There are different levels of access to SEC data:
NOTE: The SEC dataset was generated using GATK v3.8 (Best Practices Workflow), using hs37d5 (hg19) as the reference genome.