Research Services

Advanced Molecular Pathology Laboratory (AMPL) is a one-stop service for researchers and industry partners providing: 

• Technical support for tissue-based research
• Non-identifiable formalin fixed paraffin embedded tissue sections of different tissue types for control purpose

Core Strengths
To ensure the highest professional standards, AMPL has a team of experienced histopathologists, supported by experienced medical technologists. Researchers will have access to a variety of techniques necessary for human tissue-based research.

AMPL provides a full-range of research services at cost-efficient prices. Services provided include:
 
1. Pathology and Histological Consultation

Consultation with a qualified pathologist supported by a team of pathology associates for:

• Interpretation of histology and immunostaining
• Classification and grading of neoplasms according to standard or protocol-defined criteria
• Selection of material for downstream applications
• Interpretation of histochemical and immunohistochemical (IHC) stains
• Histological techniques, such as tissue processing, cryosectioning, microtomy, standard and special histochemical staining

2. Immunodiagnostics

• Full range of immunodiagnostic techniques ranging from single-label immunostaining to multi-colour immunolabelling techniques
• In-situ-Hybridisation (ISH) assays for detection of viral RNA can also be performed
• AMPL can also evaluate new antibodies for research on cytological specimens, paraffin embedded archival material and tissue microarrays

3. Tissue Microarray Construction

• Construction and stocking of tissue microarrays (TMA) derived from human neoplasm and matched normal tissues.
• All tissue arrays are produced under the supervision of a pathologist, ensuring quality.
   

4. Fluorescence In Situ Hybridisation

• Fluorescence In Situ Hybridisation (FISH)
• Whole chromosome painting with commercial reagents
• Immuno-FISH (FICTION technique), which combines the power of FISH to detect genetic alterations with lineage identification of cells of interest by immunophenotype

5. Nucleic Acid Extraction

• DNA and RNA extraction from frozen tissue using Qiagen EZ1 XL Advanced Machine
• Calculation of the quantity of the extracted samples performed using Caliper DropSense Machine
• Spectrophotometry and gel electrophoresis, quality scoring for RNA and DNA performed using Caliper GX II machine  

The scope of work and service fees depend on the nature of the protocol, the complexity of the procedure and the number of specimens.

For enquiries on AMPL services, please contact [email protected].