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Publications

​From latest to earliest:

The Extended Polydimensional Immunome Characterization (EPIC) web-based reference and discovery tool for cytometry data. Joo Guan Yeo , Martin Wasser , Pavanish Kumar, Lu Pan , Su Li Poh, Fauziah Ally, Thaschawee Arkachaisri , Amanda Jin Mei Lim, Jing Yao Leong , Liyun Lai, Kee Thai Yeo , elene Seck Choon Lee, Camillus Jian Hui Chua, Anis Larbi, Ma Shwe Zin Nyunt, Tze Pin Ng, Sabrina Chiesa, Marco Gattorno, Alberto Martini, Bhairav Suryakant Paleja, Charles-Antoine Dutertre, Jinmiao Chen , Katherine Nay Yaung, Swee Ping Tang, Sue Kheng Ng, Chee Fu Yung, Angela Yun June Tan, Shu Ying Lee, Florent Ginhoux and Salvatore Albani. Nat Biotechnology 38679–684 (2020). 21 May 2020. https://www.nature.com/articles/s41587-020-0532-1

 

High-dimensional immune-profiling in cancer: implications for immunotherapy. Chuah S, Chew V. Journal for ImmunoTherapy of Cancer 2020;8:e000363. 6 Feb 2020. https://jitc.bmj.com/content/8/1/e000363

 

Impact of Viral Etiologies on the Development of Novel Immunotherapy for Hepatocellular Carcinoma. Chun Jye Lim, Valerie Chew. Semin Liver Dis 2020;40:131–142.  Dec 2019. https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0039-3399534


Cross-Species Single-Cell Analysis Reveals Divergence of the Primate Microglia Program. Laufey Geirsdottir, Eyal David, Hadas Keren-Shaul, Assaf Weiner, Stefan Cornelius Bohlen, Jana Neuber,Adam Balic, Amir Giladi, Fadi Sheban, Charles-Antoine Dutertre, Christine Pfeifle, Francesca Peri, Antonella Raffo-Romero, Jacopo Vizioli, Kaspar Matiasek, Christian Scheiwe, Stephan Meckel, Kerstin Ma¨ tz-Rensing, Franziska van der Meer,  Finnbogi Rutur Thormodsson, Christine Stadelmann, Noga Zilkha, Tali Kimchi, Florent Ginhoux, Igor Ulitsky, Daniel Erny, Ido Amit, Marco Prinz. Cell. 179, 1609-1622. 2019 December 12.
https://www.cell.com/cell/retrieve/pii/S0092867419312310?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867419312310%3Fshowall%3Dtrue
 

An immunome perturbation is present in juvenile idiopathic arthritis patients who are in remission and will relapse upon anti-TNFα withdrawal. Jing Yao Leong,  Phyllis Chen,  Joo Guan Yeo, Fauziah Ally, Camillus Chua,  Sharifah Nur Hazirah,  Su Li Poh,  Lu Pan, Liyun Lai, Elene Seck Choon Lee, Loshinidevi D/o Thana Bathi, Thaschawee Arkachaisri, Daniel Lovell,  Salvatore Albani,. Annals of Rheumatic Diseases (ARD). 2019;78:1712-1721. https://ard.bmj.com/content/78/12/1712

Insights into the immuno-pathogenesis of acute respiratory distress syndrome. Judith Ju Ming Wong, Jing Yao Leong, Jan Hau Lee, Salvatore Albani, Joo Guan Yeo. Ann Transl Med 2019;7(19):504.
http://atm.amegroups.com/article/view/29655/25958
 

Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells. Charles-Antoine Dutertre, Etienne Becht, Sergio Erdal Irac, Ahad Khalilnezhad, Vipin Narang, Shabnam Khalilnezhad, Pei Y. Ng, Lucas L. van den Hoogen, Jing Yao Leong, Bernett Lee, Marion Chevrier, Xiao Meng Zhang, Pearly Jean Ai Yong, Geraldine Koh, Josephine Lum, Shanshan Wu Howland, Esther Mok, Jinmiao Chen, Anis Larbi, Henry Kun Kiaang Tan, Tony Kiat Hon Lim, Panagiota Karagianni, Athanasios G. Tzioufas, Benoit Malleret, Joshua Brody, Salvatore Albani, Joel van Roon, Timothy Radstake, Evan W. Newell, Florent Ginhoux. Immunity. P573-589.E8. 2019 September 17.
https://www.cell.com/immunity/fulltext/S1074-7613(19)30334-6?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761319303346%3Fshowall%3Dtrue

Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Non-Alcoholic Steatohepatitis. Widjaja AA, Singh BK, Adami E, Viswanathan S, Dong J, D'Agostino GA, Ng B, Lim WW, Tan J, Paleja BS, Tripathi M, Lim SY, Shekeran SG, Chothani SP, Rabes A, Sombetzki M, Bruinstroop E, Min LP, Sinha RA, Albani S, Yen PM, Schafer S, Cook SA. Gastroenterology. 2019 May 8


Immunomics in Pediatric Rheumatic Diseases. Shi Huan Tay, Yaung Katherne Nay, Jing Yao Leong, Joo Guan Yeo, Arkachairsri Thaschawee, Salvatore Albani. Front. Med. | doi: 10.3389/fmed. 2019.00111


Pro-inflammatory, IL-17 pathways dominate the architecture of the immunome in pediatric refractory epilepsy. Kumar P, Shih DCW, Lim A, Paleja B, Ling S, Li Yun L, Li Poh S, Ngoh A, Arkachaisri T, Yeo JG, Albani S. JCI Insight. 2019 Mar 26;5


Recent advances in our understanding of the pathogenesis of juvenile idiopathic arthritis and their potential clinical implications. Leong JY, Guan YJ, Albani S, Arkachaisri T. Expert Rev Clin Immunol. 2018 Nov;14(11)


Molecular mechanisms of autophagic memory in pathogenic T cells in human arthritis. Kumar P, Yao LJ, Saidin S, Paleja B, van Loosdregt J, Chua C, Arkachaisri T, Consolaro A, Gattorno M, Martini A, Pischel KD, Williams GW, Lotz M, Albani S. J Autoimmun. 2018 Nov;94:90-98.
Multidimensional analyses reveal distinct immune microenvironment in hepatitis B virus-related hepatocellular carcinoma. Lim CJ, Lee YH, Pan L, Lai L, Chua C, Wasser M, Lim TKH, Yeong J, Toh HC, Lee SY, Chan CY, Goh BK, Chung A, Heikenwälder M, Ng IO, Chow P, Albani S, Chew V. Gut. 2018 Jul 3. pii: gutjnl-2018-316510


A systematic approach to the development of a safe live attenuated Zika vaccine. Kwek SS, Watanabe S, Chan KR, Ong EZ, Tan HC, Ng WC, Nguyen MTX, Gan ES, Zhang SL, Chan KWK, Tan JH, Sessions OM, Manuel M, Pompon J, Chua C, Hazirah S, Tryggvason K, Vasudevan SG, Ooi EE. Nat Commun. 2018 Mar 12;9(1):1031


An automated staining protocol for seven-colour immunofluorescence of human tissue sections for diagnostic and prognostic use. Lim JCT, Yeong JPS, Lim CJ, Ong CCH, Wong SC, Chew VSP, Ahmed SS, Tan PH, Iqbal J. Pathology. 2018 Apr;50(3):333-341


Immune activation underlies a sustained clinical response to Yttrium-90 radioembolisation in hepatocellular carcinoma. Chew V, Lee YH, Pan L, Nasir NJM, Lim CJ, Chua C, Lai L, Hazirah SN, Lim TKH, Goh BKP, Chung A, Lo RHG, Ng D, Filarca RLF, Albani S, Chow PKH. Gut. 2019 Feb;68(2):335-346


Early molecular correlates of adverse events following yellow fever vaccination. Chan CY, Chan KR, Chua CJ, Nur Hazirah S, Ghosh S, Ooi EE, Low JG. JCI Insight. 2017 Oct 5;2(19)


Increased autophagy contributes to the inflammatory phenotype of juvenile idiopathic arthritis synovial fluid T cells. Peeters JGC, de Graeff N, Lotz M, Albani S, de Roock S, van Loosdregt J. Rheumatology (Oxford). 2017 Oct 1;56(10):1694-1699


Precision medicine in pediatric rheumatology. Yeo JG, Ng CT, Albani S. Curr Opin Rheumatol. 2017 Sep;29(5):500-505


Human neonatal thymectomy induces altered B-cell responses and autoreactivity. van den Broek T, Madi A, Delemarre EM, Schadenberg AWL, Tesselaar K, Borghans JAM, Nierkens S, Redegeld FA, Otten HG, Rossetti M, Albani S, Sorek R, Cohen IR, Jansen NJG, van Wijk F. Eur J Immunol. 2017 Nov;47(11):1970-1981


Delineation of an immunosuppressive gradient in hepatocellular carcinoma using high-dimensional proteomic and transcriptomic analyses. Chew V, Lai L, Pan L, Lim CJ, Li J, Ong R, Chua C, Leong JY, Lim KH, Toh HC, Lee SY, Chan CY, Goh BKP, Chung A, Chow PKH, Albani S. Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):E5900-E5909


Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2. McGovern N, Shin A, Low G, Low D, Duan K, Yao LJ, Msallam R, Low I, Shadan NB, Sumatoh HR, Soon E, Lum J, Mok E, Hubert S, See P, Kunxiang EH, Lee YH, Janela B, Choolani M, Mattar CNZ, Fan Y, Lim TKH, Chan DKH, Tan KK, Tam JKC, Schuster C, Elbe-Bürger A, Wang XN, Bigley V, Collin M, Haniffa M, Schlitzer A, Poidinger M, Albani S, Larbi A, Newell EW, Chan JKY, Ginhoux F. Nature. 2017 Jun 29;546(7660):662-666


Singlet gating in mass cytometry. Lai L, Yeo JG, Albani S. 2017 July. Cytometry A. 2017 Feb;91(2):170-172

Epipolymorphisms associated with clinical outcome of arthritis affect T-cell activation pathways. Spreafico R, Rossetti M, Whitaker JW, Wang W, Lovell DJ, Albani S. Proc Natl Acad Sci U S A. 2016 Nov 29;113(48)


Increased autophagy in CD4+ T cells of rheumatoid arthritis patients results in T-cell hyperactivation and apoptosis resistance. van Loosdregt J, Rossetti M, Spreafico R, Moshref M, Olmer M, Williams GW, Kumar P, Copeland D, Pischel K, Lotz M, Albani S. Eur J Immunol. 2016 Dec;46(12):2862-2870


Enhancing translational research in paediatric rheumatology through standardization. Yeung RS, Albani S, Feldman BM, Mellins E, Prakken B, Wedderburn LR. Nat Rev Rheumatol. 2016 Nov;12(11):684-690


TCR repertoire sequencing identifies synovial Treg cell clonotypes in the bloodstream during active inflammation in human arthritis. Rossetti M, Spreafico R, Consolaro A, Leong JY, Chua C, Massa M, Saidin S, Magni-Manzoni S, Arkachaisri T, Wallace CA, Gattorno M, Martini A, Lovell DJ, Albani S. Ann Rheum Dis 2017;76:435–441


The role of nuclear factor-kappa B and endoplasmic reticulum stress in hepatitis B viral-induced hepatocellular carcinoma. Yeong J, Chew V. Transl Cancer Res 2016;5(S1):S13-S17


Using a theragnostic approach in Juvenile Idiopathic Arthritis. Leong JY, Albani S. Expert Opinion on Orphan Drugs 2016;Volume 4-Issue 3


Interaction between tumour-infiltrating B cells and T cells controls the progression of hepatocellular carcinoma. Garnelo M, Tan A, Her Z, Yeong J, Lim CJ, Chen J, Lim KH, Weber A, Chow PKH, Chung A, Ooi LL, Toh HC, Heikenwalder M, Ng I, Nardin A, Chen Q, Abastado J, Chew V. Gut. 2017 Feb;66(2):342-351


TLR3 agonist and Sorafenib combinatorial therapy promotes immune activation and controls hepatocellular carcinoma progression. Ho V, Lim TS, Lee J, Steinberg J, Szmyd R, Tham M, Yaligar J, Kaldis P, Abastado JP, Chew V. Oncotarget. 2015 Sep 29;6(29):27252-66


PD-1 expression on dendritic cells suppresses CD8+ T cell function and antitumor immunity. Lim TS, Chew V, Sieow JL, Goh S, Yeong JP, Soon AL, Ricciardi-Castagnoli P. Oncoimmunology. 2015 Aug 31;5(3):e1085146


A CD45-based barcoding approach to multiplex mass-cytometry (CyTOF). Lai LY, Ong R, Li J, Albani S. Cytometry A. 2015 Apr;87(4):369-74


Ex vivo-expanded, but not in vitro-induced, human regulatory T cells are suitable for cell therapy in rheumatological autoimmune diseases thanks to stable FOXP3 demethylation. Rossetti M, Spreafico R, Saidin S, Chua C, Moshref M, Leong JY, Tan YK, Thumboo J, van Loosdregt J, Albani S. J Immunol. 2015 Jan 1; 194(1): 113–124


A circulating reservoir of pathogenic-like CD4+ T cells shares a genetic and phenotypic signature with the inflamed synovial micro-environment. Spreafico R, Rossetti R, van Loosdregt J, Wallace CA, Massad M, Magni-Manzoni S, Gattorno M, Martini A, Lovell DJ and Albani S. Ann Rheum Dis. 2016 Feb;75(2):459-65


A sensitive protocol for FOXP3 epigenetic analysis in scarce human samples. Spreafico R, Rossetti M, van den Broek T, Jansen NJ, Zhang H, Moshref M, Prakken B, van Loosdregt J, van Wijk F, Albani S. Eur J Immunol. 2014 Oct;44(10):3141-3


The eye: A window of opportunity in rheumatoid arthritis? Tong L, Thumboo J, Tan YK, Wong TY, Albani S. Nat Rev Rheumatol. 2014 Sep;10(9):552-60


A115: deep immunophenotyping in the identification of clinically meaningful immune signatures in juvenile idiopathic arthritis. Spreafico R, Rossetti M, Lovell DJ, Albani S. Arthritis & Rheumatology. 2014;Vol.66(S3).
Startups on the menu: Archimedes. Albani S. Nature Biotechnology volume 31, page 1074 (2013)