There is no known way to prevent most gallbladder cancers. Many of the known risk factors for gallbladder cancer (age, sex, ethnicity, bile duct defects) are beyond one's control.

The following measures may help to lower the risk of developing the condition:

• Maintain a healthy weight.
• Follow a balanced diet that includes plenty of fruits, vegetables and whole grains, and limit or avoid processed meats, sugary drinks and highly processed foods.
• Avoid excessive consumption of fried and fatty foods.
• Avoid excessive consumption of alcohol.
• Avoid unhealthy habits such as smoking.