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In addition to taking a history and examination, your doctor may recommend certain blood tests such as a Full Blood Count, ESR, HLA-B27, and x-rays of the spine and pelvis to support the diagnosis.
HLA-B27 is a known genetic marker for ankylosing spondylitis. However, most HLA-B27 individuals do not have the disease, therefore it is not advisable to have the test if you do not have symptoms of ankylosing spondylitis, even if you have an affected relative.