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Research Overview

​The Research Office of Pathology ACP provides administrative support to allow our researchers to focus on research activities with the ultimate aim of improving patient care. Some of the research activities in Pathology ACP are as follows:

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Pathology ACP Pitch-for-Funds Grant

The Pathology ACP Pitch-for-Funds Grant aims to promote laboratory-based research within Pathology ACP especially among junior doctors (residents/ trainees) and junior scientific/ technical staff.

The grant award will allow them to acquire experience in applying for grants, study design, project work, writing papers and presenting their data at an early stage of their career. It may also be used to jump start laboratory studies providing pilot data leading on to external and national grant funding.

We congratulate the following successful awardees and wish them every success in their research endeavours! We would also like to thank their mentors for their invaluable support and guidance!

FY2019 Awardees

Awardees ​Project Details
​Mr Jonathan Lim
Research Officer II, SGH Div of Pathology

Project Title:

Harmonisation study for 4 PD-L1 clones in triple negative breast cancer

Project Duration:
1 Aug 2019 – 31 Jan 2021

Mentor(s):
Prof Tan Puay Hoon
Senior Consultant & Chairman, SGH Div of Pathology

​Dr Shi Ruoyu
Seniro Resident, SGH Dept of Anatomical Pathology

Project Title:

The utility of next-generation sequencing in diagnosis of histopathologically overlapped inflammatory myofibroblastic tumour and IgG4-related disease

Project Duration:
1 Aug 2019 – 31 Jan 2021

Mentor(s):
Dr Angela Takano
Senior Consultant, SGH Dept of Anatomical  
Pathology

A/Prof Kenneth Chang
Senior Consultant & Head, KKH Dept of                
Pathology and Laboratory Medicine               


FY2018 Awardees

Awardees        Project Details

Ms Fiona Liaw
Senior Medical Laboratory Scientist (Clinical), SGH Dept of Molecular Pathology

Project Title:

Enhanced detection of chromosomal abnormalities in B-cell lymphoma neoplasms by conventional cytogenetics using a new mitogen cocktail comprising pokeweed mitogen (PWM), 12-O-tetradecanolyphorbol-3-acetate (TPA), ionophore (I), and CpG Oligonucleotide (DSP) with Interleukin2 (IL2)

Project Duration:

1 Oct 2018 – 31 Mar 2020

Mentor(s):
A/Prof Chuah Thuan Heng Charles
Senior Consultant, SGH Dept of Haematology
Director, SGH Clinical Translational Research

A/Prof Tien Sim Leng
Senior Consultant, SGH Dept of Haematology

A/Prof Alvin Lim
Assistant Director, SGH Dept of Molecular Pathology

Dr Chow Chun Yuen
Resident, SGH Dept of Anatomical Pathology

Project Title:

The utility of ERG and PTEN in diagnosing acinar adenocarcinoma of the prostate in core biopsy specimens and their value in predicting outcome in Singaporean men

Project Duration:
1 Oct 2018 – 31 Mar 2020

Mentor(s):
Prof Tan Puay Hoon
Senior Consultant & Chairman, SGH Div of Pathology

Dr Aye Aye Thike
Senior Medical Laboratory Scientist (Research), SGH Dept of Anatomical Pathology

​Ms Nur Diyana Binte Md Nasir
Research Officer I, SGH Dept of Anatomical Pathology

​Project Title:

Role of intra-tumoural cholesterol metabolism in breast cancer arising in young women

Project Duration:
1 Oct 2018 – 31 Mar 2020

Mentor(s):
Prof Tan Puay Hoon
Senior Consultant & Chairman, SGH Div of Pathology

​Dr Cheng Xiu Fen
Resident, SGH Dept of Anatomical Pathology

Project Title:
Role of Next Generation Sequencing in Detection of Malignancy in Pancreatobiliary Brushings Specimen

Project Duration:
1 Oct 2018 – 31 Mar 2020

Mentor(s):
Dr Sangeeta Mantoo
Senior Consultant, SGH Dept of Anatomical Pathology


FY2017 Awardees

Awardees ​Project Details
Dr Deborah Lai
Medical Officer, SGH Dept of Microbiology

Project Title:
Metabolic changes in host cells during influenza virus infections

Project Duration:
1 Oct 2017 – 31 Mar 2019

Mentor(s):
Dr Chan Kwai Peng
Senior Consultant, SGH Dept of Microbiology

Dr Dominique Seow
Medical Officer, SGH Dept of Anatomical Pathology

Project Title:

Multiplex immunofluorescence approach to study tumour-infiltrating lymphocytes in Triple-Negative Breast Cancer

Project Duration:
1 Oct 2017 – 31 Mar 2019

Mentor(s):
Dr Jabed Iqbal
Senior Consultant, SGH Dept of Anatomical Pathology

Ms Clara Ong
Research Officer I, SGH Dept of Anatomical Pathology

Project Title:

Study of Janus Kinase 2 (JAK2) genomic alterations and potential role as biomarker in Triple Negative Breast Cancer

Project Duration:
1 Oct 2017 – 31 Mar 2019

Mentor(s):
Dr Jabed Iqbal
Senior Consultant, SGH Dept of Anatomical Pathology

A/Prof Alvin Lim
Assistant Director, SGH Dept of Molecular Pathology

Dr Joe Yeong
Senior Research Fellow, SIgN, A*STAR

Ms Marybeth Tan
Medical Laboratory Technologist I, SGH Dept of Microbiology

Project Title:
A study on dengue virus susceptibility to Itraconazole

Project Duration:
1 Oct 2017 – 31 Mar 2019

Mentor(s):
Dr Chan Kwai Peng
Senior Consultant, SGH Dept of Microbiology

Dr Puong Kim Yoong
Senior Medical Laboratory Scientist (Clinical), SGH Dept of Molecular Pathology


FY2016 Awardees

Awardees ​Project Details
Mr Jeffrey Lim
Medical Technologist, SGH Dept of Anatomical Pathology

Project Title:

Multiplex immunofluorescence approach to study tumour infiltrating lymphocytes: A breast cancer paradigm

Project Duration:
1 Jan 2016 – 30 Jun 2017

Mentor(s):
Dr Syed Salahuddin Ahmed
Senior Consultant, SGH Dept of Anatomical Pathology

Prof Tan Puay Hoon
Senior Consultant & Chairman, SGH Div of Pathology

Dr Aye Aye Thike
Senior Medical Laboratory Scientist (Research), SGH Dept of Anatomical Pathology


FY2015 Awardees

Awardees ​Project Details
Dr Soo Kai Ling
Associate Consultant, SGH Dept of Anatomical Pathology

Project Title:

Molecular profiling of Multiple Myeloma (MM) using Cytogenomic Microarray Analysis (CMA) with enriched plasma cell (PCs) populations

Project Duration:
1 Oct 2015 – 30 Sep 2017

Mentor(s):
A/Prof Tony Lim
Senior Consultant & Head, SGH Dept of Anatomical Pathology

A/Prof Alvin Lim
Assistant Director, SGH Dept of Molecular Pathology

Dr Sathish Kumar Gopalakrishnan
Consultant, SGH Dept of Haematology

​Dr Tracy Loh
Resident, SGH Dept of Anatomical Pathology

Project Title:

Using next generation sequencing (NGS) for the detection of genetic alterations on FFPE and its application on detection of common mutations in patients with dual primary malignancies.

Project Duration:
1 Oct 2015 – 30 Sep 2017

Mentor(s):
Dr Ronald Goh
Consultant, SGH Dept of Anatomical Pathology

A/Prof Tony Lim
Senior Consultant & Head, SGH Dept of Anatomical Pathology

​Dr Lim Kok Hing
Registrar, SGH Dept of Anatomical Pathology

Project Title:

Validating a suitable immunocytochemical protocol for the detection of circulating tumour cells

Project Duration:
1 Oct 2015 – 30 Sep 2017

Mentor(s):
A/Prof Tony Lim
Senior Consultant & Head, SGH Dept of Anatomical Pathology

Dr Angela Takano
Senior Consultant, SGH Dept of Anatomical Pathology


FY2014 Awardees

Awardees ​Project Details
Dr Deborah Lai
Resident, SGH Dept of Anatomical Pathology

Project Title:

Role of the reverse Warburg effect in tumorigenesis in Cervical Intra-epithelial Neoplasia

Project Duration:

1 Jul 2014 – 30 Sep 2016

Mentor(s):
Dr Sangeeta Mantoo
Consultant, SGH Dept of Anatomical Pathology

Dr Sophie Bellanger
IMB, A*STAR

Dr Timothy Tay
Resident, SGH Dept of Anatomical Pathology

Project Title:

Pilot study to investigate the accuracy of p16/Ki-67 immunocytochemical dual stain in detecting Cervical Intraepithelial Neoplasia (CIN) when applied to Papanicolou (Pap) cervical smears with atypical squamous cytology

Project Duration:

1 Jul 2014 – 31 Mar 2016

Mentor(s):
Dr Sangeeta Mantoo
Consultant, SGH Dept of Anatomical Pathology

Dr Tan Yen Ee
Associate, SGH Dept of Microbiology

Project Title:
First survey of antibiotic susceptibility of anaerobic bacteria in a large tertiary hospital in Singapore

Project Duration:
1 Jul 2014 – 31 Dec 2015

Mentor(s):
Dr Tan Ai Ling
Senior Consultant, SGH Dept of Microbiology