Iqbal- Jabed

	Title		:   Associate Professor
	Address		:   Department of Anatomical Pathology, Division of     Pathology, Singapore General Hospital Academia,     Diagnostics Tower, Level 10     20 College Road, Singapore 169856
	Email		:   jabed.iqbal@singhealth.com.sg
	Current Position		:   Senior Consultant, Department of Anatomical Pathology,     Singapore General Hospital     Vice Chair, Research, Pathology Academic Clinical     Programme (ACP)     Associate Professor, Duke-NUS Medical School

Research interest:

Dr Iqbal’s research interest is in studying the biomarkers which are integral components of various cellular processes governing the biology of invasive breast cancer. These processes comprise immune response markers including B- and T-lymphocytes, macrophages and dendritic cells as well as other related cellular processes including proliferation and regulation of hypoxia-induced protein translation that are intimately associated with tumour progression. Proper characterization of the immune response mounted against tumours proliferating in a hypoxic environment may provide means to manipulate the immune response in order to restrict the metastatic capability and aggressiveness of breast cancers.

Dr Iqbal has been studying immune response in triple negative breast cancers because of their tendency to mount strong immune responses. Simultaneously, he is studying the role of hypoxia-induced proteins (HIf1) and the proteins regulating this pathway (Sharp1 and Xbp1). Preliminary studies have been done using immunohistochemical techniques and this will be employed for assays in this project. He also intends to use RNA transcript assays to measure response of various immune response genes, hypoxia-induced genes as well as proliferation-related genes. The future objective is to synthesize a gene signature that can stratify triple negative breast cancers in terms of prognosis and therapy response.

Selected Publications:

1. Wong J, Yong WS, Thike AA, Iqbal J, Salahuddin AS, Ho GH, Madhukumar P, Tan BK, Ong KW, Tan PH. False negative rate for intraoperative sentinel lymph node frozen section in patients with breast cancer: a retrospective analysis of patients in a single Asian institution. J Clin Pathol. 2015; 68(7):536-40
2. Matsumoto H, Koo SL, Dent R, Tan PH, Iqbal J. Role of inflammatory infiltrates in triple negative breast cancer. J Clin Pathol. 2015; 68(7):506-10
3. Ahmed SS, Thike AA, Iqbal J, Yong WS, Tan B, Madhukumar P, Ong KW, Ho GH, Wong CY, Tan PH. Sentinel lymph nodes with isolated tumour cells and micrometastases in breast cancer: clinical relevance and prognostic significance. J Clin Pathol. 2014 Mar;67(3):243-50.
4. Thike AA, Yong-Zheng Chong L, Cheok PY, Li HH, Wai-Cheong Yip G, Huat Bay B, Tse GM, Iqbal J, Tan PH. Loss of androgen receptor expression predicts early recurrence in triple-negative and basal-like breast cancer. Mod Pathol. 2014 Mar;27(3):352-60.
5. Thike AA, Iqbal J, Cheok PY, Tse GM, Tan PH. Ductal carcinoma in situ associated with triple negative invasive breast cancer: evidence for a precursor-product relationship. J Clin Pathol. 2013 Aug;66(8):665-70.
6. Iqbal J, Chong PY, Tan PH. Breast cancer stem cells: an update. J Clin Pathol. 2013 Jun;66(6):485-90.
7. Iqbal J, Thike AA, Cheok PY, Tse GM, Tan PH. Insulin growth factor receptor-1 expression and loss of PTEN protein predict early recurrence in triple-negative breast cancer. Histopathology. 2012 Oct;61(4):652-9.
8. Ahmed SS, Iqbal J, Thike AA, Lim AS, Lim TH, Tien SL, Tan PH. HER2/neu revisited: quality and interpretive issues. J Clin Pathol. 2011 Feb;64(2):120-4.
9. Liu W, Iqbal J, Khoury T. Mammary Paget's disease and extra-mammary Paget's disease: two morphologically similar but biologically different diseases. J Cutan Pathol. 2010 Nov;37(11):1145-9.
10. Thike AA, Iqbal J, Cheok PY, Chong AP, Tse GM, Tan B, Tan P, Wong NS, Tan PH. Triple negative breast cancer: outcome correlation with immunohistochemical detection of basal markers. Am J Surg Pathol. 2010 Jul;34(7):956-64.