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AMR Publications

2021

The place for remdesivir in COVID-19 treatment. Young B, Tan TT, Leo YS. Lancet Infect Dis. 2021 Jan;21(1):20-21. doi: 10.1016/S1473-3099(20)30911-7. Epub 2020 Nov 26. PMID: 33248473

Hypervirulent Klebsiella pneumoniae carriage in polyclinic attendees and national servicemen presenting with diarrhoea. Koh TH, Lee V, Chng J, Cao DYH, Khoo BC, Tan AHJ, Tan PL, Neo FJX, Heng DMW, Ng CG. Ann Acad Med Singap. 2021 Jan;50(1):90-91. doi: 10.47102/annals-acadmedsg.2020323. PMID: 33623964

SARS-CoV-2 viral RNA load dynamics in the nasopharynx of infected children. Kam KQ, Thoon KC, Maiwald M, Chong CY, Soong HY, Loo LH, Tan NWH, Li J, Nadua KD, Yung CF. Epidemiol Infect. 2021 Jan 11;149:e18. doi: 10.1017/S095026882100008X. PMID: 33427152

Comparison of the antimicrobial efficacy of povidone-iodine-alcohol versus chlorhexidine-alcohol for surgical skin preparation on the aerobic and anaerobic skin flora of the shoulder region. Dörfel D, Maiwald M, Daeschlein G, Müller G, Hudek R, Assadian O, Kampf G, Kohlmann T, Harnoss JC, Kramer A. Antimicrob Resist Infect Control. 2021 Jan 22;10(1):17. doi: 10.1186/s13756-020-00874-8. PMID: 33482910

Ceftolozane/Tazobactam Resistance and Mechanisms in Carbapenem-Nonsusceptible Pseudomonas aeruginosa. Teo JQ, Lim JC, Tang CY, Lee SJ, Tan SH, Sim JH, Ong RT, Kwa AL. mSphere. 2021 Jan 27;6(1):e01026-20. doi: 10.1128/mSphere.01026-20. PMID: 33504661

Streptococcus gallolyticus subspecies pasteurianus causing early onset neonatal sepsis complicated by solitary liver abscess in a preterm infant. Geetha O, Cherie C, Natalie TWH, Merchant K, Chien CM, Chandran S. Access Microbiol. 2021 Feb 3;3(3):000200. doi: 10.1099/acmi.0.000200. PMID: 34151155

Cerebral venous thrombosis in a patient with mild COVID-19 infection.nPang YZ, Shafi H, Lee ZC, Ting SKS, De Silva DA.nAnn Acad Med Singap. 2021 Feb;50(2):188-190. doi: 10.47102/annals-acadmedsg.2020435. PMID: 33733266

Sensitive detection of total anti-Spike antibodies and isotype switching in asymptomatic and symptomatic individuals with COVID-19. Goh YS, Chavatte JM, Lim Jieling A, Lee B, Hor PX, Amrun SN, Lee CY, Chee RS, Wang B, Lee CY, Ngoh EZX, Wang CI, Young BE, Tambyah PA, Kalimuddin S, Pada S, Tan SY, Sun LJ, Chen MI, Leo YS, Lye DC, Ng LFP, Lin RTP, Renia L. Cell Rep Med. 2021 Feb 16;2(2):100193. doi: 10.1016/j.xcrm.2021.100193. Epub 2021 Jan 16. PMID: 33495757

Human neutralising antibodies elicited by SARS-CoV-2 non-D614G variants offer cross-protection against the SARS-CoV-2 D614G variant. Lee CY, Amrun SN, Chee RS, Goh YS, Mak TM, Octavia S, Yeo NK, Chang ZW, Tay MZ, Torres-Ruesta A, Carissimo G, Poh CM, Fong SW, Bei W, Lee S, Young BE, Tan SY, Leo YS, Lye DC, Lin RT, Maurer-Stroh S, Lee B, Wang CI, Renia L, Ng LF. Clin Transl Immunology. 2021 Feb 22;10(2):e1241. doi: 10.1002/cti2.1241. PMID: 33628442

Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19. ACTT-2 Study Group Members. N Engl J Med. 2021 Mar 4;384(9):795-807. doi: 10.1056/NEJMoa2031994. Epub 2020 Dec 11. PMID: 33306283

Psychosocial impact of the COVID-19 pandemic on paediatric healthcare workers. Kirk AHP, Chong SL, Kam KQ, Huang W, Ang LSL, Lee JH, Sultana R, Hon KL, Wong JJM. Ann Acad Med Singap. 2021 Mar;50(3):203-211. doi: 10.47102/annals-acadmedsg.2020527. PMID: 33855316

Negative cerebrospinal fluid β-d-glucan levels as an indicator for treatment cessation ahead of biochemical resolution: A case report of Candida glabrata meningitis. Wee LE, Wong CSL, Tan AL, Oh HM. Med Mycol Case Rep. 2021 Mar 5;32:47-49. doi: 10.1016/j.mmcr.2021.03.003. PMID: 33786294

Low incidence of venous thrombosis but high incidence of arterial thrombotic complications among critically ill COVID-19 patients in Singapore. Tan CW, Fan BE, Teo WZY, Tung ML, Shafi H, Christopher D, Zheng S, Peh WM, Chan SSW, Chong VCL, Gallardo CA, Chang CCR, Ling LM, Tan JY, Lee KCH, Phua GC, Cherng BPZ, Low JGH, Ho VK, Prasad V, Wong LJL, Lim CXQ, Chee YL, Ong KH, Lee LH, Ng HJ, Yap ES; Thrombosis Haemostasis Workgroup of Singapore Society of Haematology. Thromb J. 2021 Mar 8;19(1):14. doi: 10.1186/s12959-021-00268-9. PMID: 33685477

Transthoracic colour-encoded M-mode echocardiography demonstrating neonatal atrial flutter. Donceras Nadua K, Xu M, Choo JTL. Arch Dis Child Fetal Neonatal Ed. 2021 Mar;106(2):222. doi: 10.1136/archdischild-2020-319072. Epub 2020 Jun 16. PMID: 32546542

Novel Coronavirus 2019 Transmission Risk in Educational Settings. Yung CF, Kam KQ, Nadua KD, Chong CY, Tan NWH, Li J, Lee KP, Chan YH, Thoon KC, Ng KC. Clin Infect Dis. 2021 Mar 15;72(6):1055-1058. doi: 10.1093/cid/ciaa794. PMID: 32584975

Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation. Chioh FW, Fong SW, Young BE, Wu KX, Siau A, Krishnan S, Chan YH, Carissimo G, Teo LL, Gao F, Tan RS, Zhong L, Koh AS, Tan SY, Tambyah PA, Renia L, Ng LF, Lye DC, Cheung C. Elife. 2021 Mar 23;10:e64909. doi: 10.7554/eLife.64909. PMID: 33752798

Tropheryma whipplei in Feces of Patients with Diarrhea in 3 Locations on Different Continents. Feurle GE, Moos V, Landt O, Corcoran C, Reischl U, Maiwald M. Emerg Infect Dis. 2021 Mar;27(3):932-935. doi: 10.3201/eid2703.200182. PMID: 33622479

Persistent Symptoms and Association With Inflammatory Cytokine Signatures in Recovered Coronavirus Disease 2019 Patients. Ong SWX, Fong SW, Young BE, Chan YH, Lee B, Amrun SN, Chee RS, Yeo NK, Tambyah P, Pada S, Tan SY, Ding Y, Renia L, Leo YS, Ng LFP, Lye DC. Open Forum Infect Dis. 2021 Apr 2;8(6):ofab156. doi: 10.1093/ofid/ofab156. PMID: 34095336

COVID-19, equipoise and observational studies: a reminder of forgotten issues. Yusuf E, Maiwald M. Infection. 2021 Apr;49(2):371-373. doi: 10.1007/s15010-020-01466-9. Epub 2020 Jun 25. PMID: 32588335

Clinical features and predictors of severity in COVID-19 patients with critical illness in Singapore. Puah SH, Young BE, Chia PY, Ho VK, Loh J, Gokhale RS, Tan SY, Sewa DW, Kalimuddin S, Tan CK, Pada SKMS, Cove ME, Chai LYA, Parthasarathy P, Ho BCH, Ng JJ, Ling LM, Abisheganaden JA, Lee VJM, Tan CH, Lin RTP, Leo YS, Lye DC, Yeo TW; Singapore 2019 novel coronavirus outbreak research team. Sci Rep. 2021 Apr 5;11(1):7477. doi: 10.1038/s41598-021-81377-3. PMID: 33820944

Respiratory viral infections in hospitalised paediatric patients in the tropics. Tan KWJ, Yung CF, Maiwald M, Saffari SE, Thoon KC, Chong CY. J Paediatr Child Health. 2021 Apr;57(4):559-565. doi: 10.1111/jpc.15267. Epub 2020 Nov 13. PMID: 33185937

Association of SARS-CoV-2 clades with clinical, inflammatory and virologic outcomes: An observational study. Young BE, Wei WE, Fong SW, Mak TM, Anderson DE, Chan YH, Pung R, Heng CS, Ang LW, Zheng AKE, Lee B, Kalimuddin S, Pada S, Tambyah PA, Parthasarathy P, Tan SY, Sun L, Smith GJ, Lin RTP, Leo YS, Renia L, Wang LF, Ng LF, Maurer-Stroh S, Lye DC, Lee VJ. EBioMedicine. 2021 Apr;66:103319. doi: 10.1016/j.ebiom.2021.103319. Epub 2021 Apr 8. PMID: 33840632

An immunocompetent female with Mycobacterium abscessus cervical lymphadenitis mimicking malignancy. Tan JYQ, Shafi H. Int J Infect Dis. 2021 Apr;105:239-240. doi: 10.1016/j.ijid.2021.02.044. Epub 2021 Feb 15. PMID: 33601034

Virological and serological kinetics of SARS-CoV-2 Delta variant vaccine breakthrough infections: a multicentre cohort study. Chia PY, Ong SWX, Chiew CJ, Ang LW, Chavatte JM, Mak TM, Cui L, Kalimuddin S, Chia WN, Tan CW, Chai LYA, Tan SY, Zheng S, Lin RTP, Wang L, Leo YS, Lee VJ, Lye DC, Young BE. Clin Microbiol Infect. 2022 Apr;28(4):612.e1-612.e7. doi: 10.1016/j.cmi.2021.11.010. Epub 2021 Nov 23. PMID: 34826623

Whole genome sequencing analysis of multidrug-resistant tuberculosis in Singapore, 2006-2018. Chee CBE, Lim LKY, Ong RTH, Sng LH, Hsu LY, Lee VJM, Wang YT. Eur J Clin Microbiol Infect Dis. 2021 May;40(5):1079-1083. doi: 10.1007/s10096-020-04100-6. Epub 2020 Nov 15. PMID: 33190171

Meropenem and piperacillin-tazobactam levels for critical care patients during empiric therapy. Hoo GSR, Chua NG, Ng TM, Lee L, Kwa AL, Ling LM. Ann Acad Med Singap. 2021 May;50(5):447-449. doi: 10.47102/annals-acadmedsg.2020472. PMID: 34100525

Increased detection of pulmonary tuberculosis amongst hospitalised inpatients during the COVID-19 pandemic. Wee LE, Goh KCM, Conceicao EP, Tan JBX, Sng LH, Venkatachalam I. Eur Respir J. 2021 May 20;57(5):2100616. doi: 10.1183/13993003.00616-2021. Print 2021 May. PMID: 34016605

Aortic endograft infection secondary to Burkholderia pseudomallei: A case report and review of the literature. Cheok S, Gan LSC, Chung SJ, Ch'ng JK. J Vasc Surg Cases Innov Tech. 2021 May 21;7(3):421-424. doi: 10.1016/j.jvscit.2021.04.023. PMID: 34278075

A Virus-Specific Immune Rheostat in the Immunome of Patients Recovering From Mild COVID-19. Yeo JG, Leong JY, Tay SH, Nadua KD, Anderson DE, Lim AJM, Ng XW, Poh SL, Guo D, Yaung KN, Kumar P, Wasser M, Hazirah SN, Sutamam N, Chua CJH, Qui M, Foo R, Gamage AM, Yeo KT, Ramakrishna L, Arkachaisri T, Young BE, Lye DC, Wang LF, Chong CY, Tan NWH, Li J, Kam KQ, Ginhoux F, Thoon KC, Chan JKY, Yung CF, Albani S. Front Immunol. 2021 May 25;12:674279. doi: 10.3389/fimmu.2021.674279. PMID: 34113347

Salmonella Renal Abscess in an Immunocompetent Child: Case Report and Literature Review. Poh CWM, Seah XFV, Chong CY, Ganesan I, Maiwald M, Nadua K, Kam KQ, Tan NWH. Glob Pediatr Health. 2021 May 31;8:2333794X211022263. doi: 10.1177/2333794X211022263. PMID: 34104703

Trends in Respiratory Virus Infections During the COVID-19 Pandemic in Singapore, 2020. Wan WY, Thoon KC, Loo LH, Chan KS, Oon LLE, Ramasamy A, Maiwald M. JAMA Netw Open. 2021 Jun 1;4(6):e2115973. doi: 10.1001/jamanetworkopen.2021.15973. PMID: 34181015

Sheathless and high-throughput elasto-inertial bacterial sorting for enhancing molecular diagnosis of bloodstream infection. Lu X, Chow JJM, Koo SH, Jiang B, Tan TY, Yang D, Ai Y. Lab Chip. 2021 Jun 1;21(11):2163-2177. doi: 10.1039/d1lc00085c. PMID: 33899072

Dynamics of SARS-CoV-2 neutralising antibody responses and duration of immunity: a longitudinal study. Chia WN, Zhu F, Ong SWX, Young BE, Fong SW, Le Bert N, Tan CW, Tiu C, Zhang J, Tan SY, Pada S, Chan YH, Tham CYL, Kunasegaran K, Chen MI, Low JGH, Leo YS, Renia L, Bertoletti A, Ng LFP, Lye DC, Wang LF. Lancet Microbe. 2021 Jun;2(6):e240-e249. doi: 10.1016/S2666-5247(21)00025-2. Epub 2021 Mar 23. PMID: 33778792

Incidence of a subsequent carbapenem-resistant Enterobacteriaceae infection after previous colonisation or infection: a prospective cohort study. Tang SSL, Chee E, Teo JQ, Chlebicki MP, Kwa ALH. Int J Antimicrob Agents. 2021 Jun;57(6):106340. doi: 10.1016/j.ijantimicag.2021.106340. Epub 2021 Apr 20. PMID: 33857538

Asymptomatic COVID-19: disease tolerance with efficient anti-viral immunity against SARS-CoV-2. Chan YH, Fong SW, Poh CM, Carissimo G, Yeo NK, Amrun SN, Goh YS, Lim J, Xu W, Chee RS, Torres-Ruesta A, Lee CY, Tay MZ, Chang ZW, Lee WH, Wang B, Tan SY, Kalimuddin S, Young BE, Leo YS, Wang CI, Lee B, Rötzschke O, Lye DC, Renia L, Ng LFP. EMBO Mol Med. 2021 Jun 7;13(6):e14045. doi: 10.15252/emmm.202114045. Epub 2021 May 27. PMID: 33961735

Therapeutic drug monitoring is necessary for patients receiving posaconazole tablet. Zhou PY, Lim TP, Tang SLS, Lim JL, Liew Y, Chua NG, Lim LLC, Lee HLW, Lai OF, Tan TT, Wong GC, Kwa LHA. J Infect. 2021 Jun;82(6):e18-e21. doi: 10.1016/j.jinf.2021.03.021. Epub 2021 Mar 29. PMID: 33794263

Recurrent Tuberculosis Disease in Singapore. Gan SH, KhinMar KW, Ang LW, Lim LKY, Sng LH, Wang YT, Chee CBE. Open Forum Infect Dis. 2021 Jun 27;8(7):ofab340. doi: 10.1093/ofid/ofab340. PMID: 34307732

Differential Cytokine Responses in Hospitalized COVID-19 Patients Limit Efficacy of Remdesivir. Chan YH, Young BE, Fong SW, Ding Y, Goh YS, Chee RS, Tan SY, Kalimuddin S, Tambyah PA, Leo YS, Ng LFP, Lye DC, Renia L. Front Immunol. 2021 Jun 28;12:680188. doi: 10.3389/fimmu.2021.680188. PMID: 34262564

Emerging Role for MAIT Cells in Control of Antimicrobial Resistance. Leeansyah E, Boulouis C, Kwa ALH, Sandberg JK. Trends Microbiol. 2021 Jun;29(6):504-516. doi: 10.1016/j.tim.2020.11.008. Epub 2020 Dec 19. PMID: 33353796

Rapid diagnostic testing for antimicrobial stewardship: Utility in Asia Pacific. Apisarnthanarak A, Kim HB, Moore L, Xiao Y, Singh S, Doi Y, Kwa AL, Sri La Sri Ponnampalavanar S, Cao Q, Kim SW, Lee H, Santanirand P. Infect Control Hosp Epidemiol. 2021 Jul;42(7):864-868. doi: 10.1017/ice.2021.149. Epub 2021 Jun 15. PMID: 34128462

Leclercia adecarboxylata bacteraemia: Clinical features and antibiotic susceptibilities in 2 hospitals in Singapore. Sng ECY, Goh KCM, Tan SH, Tan AL, Oh HML.Ann Acad Med Singap. 2021 Aug;50(8):643-645. doi: 10.47102/annals-acadmedsg.202195. PMID: 34472560

Pharmacokinetics of levetiracetam in neurosurgical ICU patients. Ong CLJ, Goh PSJ, Teo MM, Lim TP, Goh KKK, Ang XY, Lim LJK, Jamaludin NHB, Ang BT, Kwa LHA. J Crit Care. 2021 Aug;64:255-261. doi: 10.1016/j.jcrc.2021.04.013. Epub 2021 Apr 19. PMID: 34051579

Pediatric Kawasaki Disease Trends Prior to and During COVID-19 Outbreak in Singapore. Chong CY, Tan NWH, Yung CF, Nadua K, Kam KQ, Li J, Thoon KC. J Pediatric Infect Dis Soc. 2021 Aug 12:piab047. doi: 10.1093/jpids/piab047. PMID: 34383064

Antibiotic stewardship program (ASP) in palliative care: antibiotics, to give or not to give. Hung KC, Lee LW, Liew YX, Krishna L, Chlebicki MP, Chung SJ, Kwa AL. Eur J Clin Microbiol Infect Dis. 2022 Jan;41(1):29-36. doi: 10.1007/s10096-021-04325-z. Epub 2021 Aug 20. PMID: 34414518

Good hearing outcome in children recovering from non-polio enteroviral meningitis. Choong CT, Lee EY, Tan HKK, Lazaroo D, Tan NWH. J Paediatr Child Health. 2021 Sep;57(9):1438-1441. doi: 10.1111/jpc.15505. Epub 2021 Apr 23. PMID: 33890710

Radiographic features of COVID-19 based on an initial cohort of 96 patients in Singapore. Khoo HWW, Hui TCH, Mohideen SMH, Lee YS, Liew CJY, Kok SSX, Young BE, Ong SWX, Kalimuddin S, Tan SY, Loh J, Chan LP, Poh ACC, Wong SBS, Leo YS, Lye DC, Kaw GJL, Tan CH. Singapore Med J. 2021 Sep;62(9):458-465. doi: 10.11622/smedj.2020142. Epub 2020 Sep 21. PMID: 33047143

Epidemiological analysis in support of hypothesis that D614G virus mutation is a major contributing factor to chemosensory dysfunction in COVID-19 patients. See A, Ko KKK, Toh ST. Eur Arch Otorhinolaryngol. 2021 Sep;278(9):3595-3596. doi: 10.1007/s00405-021-06941-z. Epub 2021 Jun 29. PMID: 34185144

Candida Endophthalmitis Treated Successfully With Isavuconazole: A Case Report. Sng ECY, Tan AL, Zhou PY, Tan TJ, Waduthantri S, Chee SP, Tan BH. Open Forum Infect Dis. 2021 Oct 8;8(12):ofab516. doi: 10.1093/ofid/ofab516. PMID: 34909437

Evaluation of multi-component interventions for prevention of nosocomial pneumonia in older adults: a randomized, controlled trial. Rosario BH, Shafi H, Yii ACA, Tee LY, Ang ASH, Png GK, Ang WST, Lee YQ, Tan PT, Sahu A, Zhou LF, Zheng YL, Slamat RB, Taha AAM. Eur Geriatr Med. 2021 Oct;12(5):1045-1055. doi: 10.1007/s41999-021-00506-3. Epub 2021 Jun 3. PMID: 34081314

Utility and applicability of rapid diagnostic testing in antimicrobial stewardship in Asia Pacific: A Delphi consensus. Apisarnthanarak A, Kim HB, Moore LSP, Xiao Y, Singh S, Doi Y, Kwa AL, Ponnampalavanar SSS, Cao Q, Kim SW, Lee H, Santanirand P. Clin Infect Dis. 2021 Oct 19:ciab910. doi: 10.1093/cid/ciab910. PMID: 34665855

Potent Antiviral and Antimicrobial Polymers as Safe and Effective Disinfectants for the Prevention of Infections. Leong J, Shi D, Tan JPK, Yang C, Yang S, Wang Y, Ngow YS, Kng J, Balakrishnan N, Peng SQ, Yeow CS, Periaswamy B, Venkataraman S, Kwa AL, Liu X, Yao H, Yang YY. Adv Healthc Mater. 2021 Oct 25:e2101898. doi: 10.1002/adhm.202101898. PMID: 34694749

Resistance of SARS-CoV-2 variants to neutralization by convalescent plasma from early COVID-19 outbreak in Singapore. Wang B, Goh YS, Prince T, Ngoh EZX, Salleh SNM, Hor PX, Loh CY, Fong SW, Hartley C, Tan SY, Young BE, Leo YS, Lye DC, Maurer-Stroh S, Ng LFP, Hiscox JA, Renia L, Wang CI. NPJ Vaccines. 2021 Oct 25;6(1):125. doi: 10.1038/s41541-021-00389-2. PMID: 34697298

Will Ceftazidime-Avibactam Replace Polymyxins in Asia? Tan SH, Koomanan N, Chung SJ, Kwa AL. Clin Infect Dis. 2021 Nov 2;73(9):1743-1744. doi: 10.1093/cid/ciab390. PMID: 34009275

Saliva Is Not a Useful Diagnostic Specimen in Children With Coronavirus Disease 2019 (COVID-19). Chong CY, Kam KQ, Li J, Maiwald M, Loo LH, Nadua KD, Tan NWH, Yung CF, Thoon KC. Clin Infect Dis. 2021 Nov 2;73(9):e3144-e3145. doi: 10.1093/cid/ciaa1376. PMID: 32927475

Viral Dynamics and Immune Correlates of Coronavirus Disease 2019 (COVID-19) Severity. Young BE, Ong SWX, Ng LFP, Anderson DE, Chia WN, Chia PY, Ang LW, Mak TM, Kalimuddin S, Chai LYA, Pada S, Tan SY, Sun L, Parthasarathy P, Fong SW, Chan YH, Tan CW, Lee B, Rötzschke O, Ding Y, Tambyah P, Low JGH, Cui L, Barkham T, Lin RTP, Leo YS, Renia L, Wang LF, Lye DC; Singapore 2019 Novel Coronavirus Outbreak Research Team. Clin Infect Dis. 2021 Nov 2;73(9):e2932-e2942. doi: 10.1093/cid/ciaa1280. PMID: 32856707

Rostered Routine Testing: A Necessary Evil? Tan SY, How CH, Poon BH, Tan TY, Siau C. Open Forum Infect Dis. 2021 Nov 3;9(1):ofab549. doi: 10.1093/ofid/ofab549. PMID: 35024370

Acute pericarditis and cardiac tamponade after Covid-19 vaccination. Shen X, Koh MSH, Lim BY, Demo-Os M, Chien JMF, Santosa A, Taha AA. Singapore Med J. 2021 Nov 8. doi: 10.11622/smedj.2021195. PMID: 34749492

Dengue virus infection among renal transplant recipients in Singapore: a 15-year single-centre retrospective review. Tan SSX, Ho QY, Thangaraju S, Tan TT, Kee T, Chung SJ. Singapore Med J. 2021 Nov 8. doi: 10.11622/smedj.2021167. PMID: 34749495

Data-Driven Analysis of COVID-19 Reveals Persistent Immune Abnormalities in Convalescent Severe Individuals. Lim J, Puan KJ, Wang LW, Teng KWW, Loh CY, Tan KP, Carissimo G, Chan YH, Poh CM, Lee CY, Fong SW, Yeo NK, Chee RS, Amrun SN, Chang ZW, Tay MZ, Torres-Ruesta A, Leo Fernandez N, How W, Andiappan AK, Lee W, Duan K, Tan SY, Yan G, Kalimuddin S, Lye DC, Leo YS, Ong SWX, Young BE, Renia L, Ng LFP, Lee B, Rötzschke O. Front Immunol. 2021 Nov 19;12:710217. doi: 10.3389/fimmu.2021.710217. PMID: 34867943

Assessing the predictive performance of population pharmacokinetic models for intravenous polymyxin B in critically ill patients. Hanafin PO, Nation RL, Scheetz MH, Zavascki AP, Sandri AM, Kwa AL, Cherng BPZ, Kubin CJ, Yin MT, Wang J, Li J, Kaye KS, Rao GG. CPT Pharmacometrics Syst Pharmacol. 2021 Dec;10(12):1525-1537. doi: 10.1002/psp4.12720. Epub 2021 Nov 23. PMID: 34811968

Hospital Pharmacists and Antimicrobial Stewardship: A Qualitative Analysis. Wong LH, Tay E, Heng ST, Guo H, Kwa ALH, Ng TM, Chung SJ, Somani J, Lye DCB, Chow A. Antibiotics (Basel). 2021 Nov 24;10(12):1441. doi: 10.3390/antibiotics10121441. PMID: 34943655

Development of a rapid multiplex PCR assay for the detection of common pathogens associated with community-acquired pneumonia. Koo SH, Jiang B, Lim PQ, La MV, Tan TY. Trans R Soc Trop Med Hyg. 2021 Dec 2;115(12):1450-1455. doi: 10.1093/trstmh/trab079. PMID: 34017992

Poor Hygiene as a Risk Factor in the Development of Brain Abscess in Adolescents. Vig PS, Wong JJM, Chong CY, Nguyen TAP, Maiwald M, Tan NWH. J Paediatr Child Health. 2021 Dec;57(12):2043-2045. doi: 10.1111/jpc.15798. Epub 2021 Oct 23. PMID: 34687481

Serotype distribution and incidence of invasive early onset and late onset group B streptococcal disease amongst infants in Singapore. Kam KQ, Thoon KC, Tee WSN, Ang MLT, Tan NWH, Yeo KT, Li J, Chong CY. BMC Infect Dis. 2021 Dec 7;21(1):1221. doi: 10.1186/s12879-021-06891-1. PMID: 34876053

Efficacy of interferon beta-1a plus remdesivir compared with remdesivir alone in hospitalised adults with COVID-19: a double-bind, randomised, placebo-controlled, phase 3 trial.; ACTT-3 study group members. Lancet Respir Med. 2021 Dec;9(12):1365-1376. doi: 10.1016/S2213-2600(21)00384-2. Epub 2021 Oct 18. PMID: 34672949

Genomic characterization of carbapenem-non-susceptible Pseudomonas aeruginosa in Singapore. Teo JQ, Tang CY, Lim JC, Lee SJ, Tan SH, Koh TH, Sim JH, Tan TT, Kwa AL, Ong RT. Emerg Microbes Infect. 2021 Dec;10(1):1706-1716. doi: 10.1080/22221751.2021.1968318. PMID: 34384341

Osteomyelitis in Immunocompromised children and neonates, a case series. Foong B, Wong KPL, Jeyanthi CJ, Li J, Lim KBL, Tan NWH. BMC Pediatr. 2021 Dec 11;21(1):568. doi: 10.1186/s12887-021-03031-1. PMID: 34895166

In vitro Bactericidal Activities of Combination Antibiotic Therapies Against Carbapenem-Resistant Klebsiella pneumoniae With Different Carbapenemases and Sequence Types. Teo JQ, Fauzi N, Ho JJ, Tan SH, Lee SJ, Lim TP, Cai Y, Chang HY, Mohamed Yusoff N, Sim JH, Tan TT, Ong RT, Kwa AL. Front Microbiol. 2021 Dec 13;12:779988. doi: 10.3389/fmicb.2021.779988. PMID: 34970239

A Study of Analytical and Clinical Sensitivity of Aptima SARS-CoV-2 Assay (Hologic) and Proposals of Complementary Tests for SARS-CoV-2 Detection in Low Viral Load Specimens. La MV, Koo SH, Jiang B, Heng YX, Tan TY. Curr Microbiol. 2021 Dec 14;79(1):29. doi: 10.1007/s00284-021-02730-3. PMID: 34905087

High-Throughput Mutagenesis and Cross-Complementation Experiments Reveal Substrate Preference and Critical Residues of the Capsule Transporters in Streptococcus pneumoniae. Chua WZ, Maiwald M, Chew KL, Lin RT, Zheng S, Sham LT. mBio. 2021 Dec 21;12(6):e0261521. doi: 10.1128/mBio.02615-21. Epub 2021 Nov 2. PMID: 34724815

Quantification of Fosfomycin in Combination with Nine Antibiotics in Human Plasma and Cation-Adjusted Mueller-Hinton II Broth via LCMS. Goh KK, Toh WG, Hee DK, Ting EZ, Chua NGS, Zulkifli FIB, Sin LJ, Tan TT, Kwa AL, Lim TP. Antibiotics (Basel). 2022 Jan 2;11(1):54. doi: 10.3390/antibiotics11010054. PMID: 35052932

2020

Quantification of Human MAIT Cell-Mediated Cellular Cytotoxicity and Antimicrobial Activity. Sia WR, Boulouis C, Gulam MY, Kwa ALH, Sandberg JK, Leeansyah E. Methods Mol Biol. 2020;2098:149-165. doi: 10.1007/978-1-0716-0207-2_10. PMID: 31792821.

Taurolidine-citrate lock solution for the prevention of central line-associated bloodstream infection in paediatric haematology-oncology and gastrointestinal failure patients with high baseline central-line associated bloodstream infection rates. Chong CY, Ong RY, Seah VX, Tan NW, Chan MY, Soh SY, Ong C, Lim AS, Thoon KC. J Paediatr Child Health. 2020 Jan;56(1):123-129. doi: 10.1111/jpc.14506. Epub 2019 May 30. PMID: 31145505.

Tuberculosis and Melioidosis at Distinct Sites Occurring Simultaneously. Tan SY. Case Rep Infect Dis. 2020 Jan 3;2020:9818129. doi: 10.1155/2020/9818129. eCollection 2020. PMID: 31984142.

The burden and clinical manifestation of hospitalized influenza among different pediatric age-groups in the tropics. Chong CY, Yung CF, Gan C, Thio ST, Tan NW, Tee NW, Lin C, Lin RT, Thoon KC. Influenza Other Respir Viruses. 2020 Jan;14(1):46-54. doi: 10.1111/irv.12692. Epub 2019 Oct 13. PMID: 31608598.

Comparative genomic analysis of Streptococcus dysgalactiae subspecies dysgalactiae, an occasional cause of zoonotic infection. Koh TH, Binte Abdul Rahman N, Sessions OM. Pathology. 2020 Feb;52(2):262-266. doi: 10.1016/j.pathol.2019.09.016. Epub 2019 Dec 16. PMID: 31859005.

Pediatric Abdominal Tuberculosis in Singapore: A 10-Year Retrospective Series. Wong SA, Lee Meijuan D, Loh SW, Thoon KC, Tan NWH, Chong CY. Glob Pediatr Health. 2020 Feb 5;7:2333794X20903952. doi: 10.1177/2333794X20903952. eCollection 2020. PMID: 32076630.

Determining the Development of Persisters in Extensively Drug-Resistant Acinetobacter baumannii upon Exposure to Polymyxin B-Based Antibiotic Combinations Using Flow Cytometry. Wong FH, Cai Y, Leck H, Lim TP, Teo JQ, Lee W, Koh TH, Tan TT, Tan KW, Kwa AL. Antimicrob Agents Chemother. 2020 Feb 21;64(3):e01712-19. doi: 10.1128/AAC.01712-19. Print 2020 Feb 21. PMID: 31818819.

Kikuchi-Fujimoto disease in children. Selvanathan SN, Suhumaran S, Sahu VK, Chong CY, Tan NWH, Thoon KC. J Paediatr Child Health. 2020 Mar;56(3):389-393. doi: 10.1111/jpc.14628. Epub 2019 Oct 1. PMID: 31576642.

SARS-CoV-2 Infection among Travelers Returning from Wuhan, China. Ng OT, Marimuthu K, Chia PY, Koh V, Chiew CJ, De Wang L, Young BE, Chan M, Vasoo S, Ling LM, Lye DC, Kam KQ, Thoon KC, Kurupatham L, Said Z, Goh E, Low C, Lim SK, Raj P, Oh O, Koh VTJ, Poh C, Mak TM, Cui L, Cook AR, Lin RTP, Leo YS, Lee VJM. N Engl J Med. 2020 Apr 9;382(15):1476-1478. doi: 10.1056/NEJMc2003100. Epub 2020 Mar 12. PMID: 32163698.

COVID-19 and the Risk to Health Care Workers: A Case Report. Ng K, Poon BH, Kiat Puar TH, Shan Quah JL, Loh WJ, Wong YJ, Tan TY, Raghuram J. Ann Intern Med. 2020 Jun 2;172(11):766-767. doi: 10.7326/L20-0175. Epub 2020 Mar 16. PMID: 32176257.

Investigation of three clusters of COVID-19 in Singapore: implications for surveillance and response measures. Pung R, Chiew CJ, Young BE, Chin S, Chen MI, Clapham HE, Cook AR, Maurer-Stroh S, Toh MPHS, Poh C, Low M, Lum J, Koh VTJ, Mak TM, Cui L, Lin RVTP, Heng D, Leo YS, Lye DC, Lee VJM; Singapore 2019 Novel Coronavirus Outbreak Research Team. Lancet. 2020 Mar 28;395(10229):1039-1046. doi: 10.1016/S0140-6736(20)30528-6. Epub 2020 Mar 17. PMID: 32192580.

Acquisition of Plasmid with Carbapenem-Resistance Gene blaKPC2 in Hypervirulent Klebsiella pneumoniae, Singapore. Chen Y, Marimuthu K, Teo J, Venkatachalam I, Cherng BPZ, De Wang L, Prakki SRS, Xu W, Tan YH, Nguyen LC, Koh TH, Ng OT, Gan YH. Emerg Infect Dis. 2020 Mar;26(3):549-559. doi: 10.3201/eid2603.191230. PMID: 32091354.

Environment and Personal Protective Equipment Tests for SARS-CoV-2 in the Isolation Room of an Infant With Infection. Yung CF, Kam KQ, Wong MSY, Maiwald M, Tan YK, Tan BH, Thoon KC. Ann Intern Med. 2020 Aug 4;173(3):240-242. doi: 10.7326/M20-0942. Epub 2020 Apr 1. PMID: 32236490.

Disseminated Mucormycosis Due to Saksenaea vasiformis Complex in an Immunocompetent Adult with Sustained Response to Posaconazole Treatment. Liang En W, Seow Yen T, Ai Ling T, Yen Ee T, Sze Hwa T, Chun AC, Anindita S, Fong R. Mycopathologia. 2020 Jun;185(3):577-581. doi: 10.1007/s11046-020-00443-y. Epub 2020 Apr 11. PMID: 32279162.

Who listens and who doesn't? Factors associated with adherence to antibiotic stewardship intervention in a Singaporean tertiary hospital. Wee LE, Chung SJ, Tang SLS, Liew YX, Tan LY, Cherng PZB, Kwa LHA, Chlebicki MP. J Glob Antimicrob Resist. 2020 Sep;22:391-397. doi: 10.1016/j.jgar.2020.04.006. Epub 2020 Apr 18. PMID: 32311504.

Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore. Young BE, Ong SWX, Kalimuddin S, Low JG, Tan SY, Loh J, Ng OT, Marimuthu K, Ang LW, Mak TM, Lau SK, Anderson DE, Chan KS, Tan TY, Ng TY, Cui L, Said Z, Kurupatham L, Chen MI, Chan M, Vasoo S, Wang LF, Tan BH, Lin RTP, Lee VJM, Leo YS, Lye DC; Singapore 2019 Novel Coronavirus Outbreak Research Team. JAMA. 2020 Apr 21;323(15):1488-1494. doi: 10.1001/jama.2020.3204. PMID: 32125362.

Adapting to a new normal? 5 key operational principles for a radiology service facing the COVID-19 pandemic. Chen RC, Tan TT, Chan LP. Eur Radiol. 2020 Sep;30(9):4964-4967. doi: 10.1007/s00330-020-06862-1. Epub 2020 Apr 23. PMID: 32328761.

The role of self-reported olfactory and gustatory dysfunction as a screening criterion for suspected COVID-19. Wee LE, Chan YFZ, Teo NWY, Cherng BPZ, Thien SY, Wong HM, Wijaya L, Toh ST, Tan TT. Eur Arch Otorhinolaryngol. 2020 Aug;277(8):2389-2390. doi: 10.1007/s00405-020-05999-5. Epub 2020 Apr 24. PMID: 32328771.

Assessment of Proficiency of N95 Mask Donning Among the General Public in Singapore. Yeung W, Ng K, Fong JMN, Sng J, Tai BC, Chia SE. JAMA Netw Open. 2020 May 1;3(5):e209670. doi: 10.1001/jamanetworkopen.2020.9670. PMID: 32432708.

Practical Considerations for Solid Organ Transplantation During the COVID-19 Global Outbreak: The Experience from Singapore. Chung SJ, Tan EK, Kee T, Krishnamoorthy TL, Phua GC, Sewa DW, Ong BH, Tan TE, Sivathasan C, Gan HLV, Goh BKP, Jeyaraj PR, Tan BH. Transplant Direct. 2020 May 8;6(6):e554. doi: 10.1097/TXD.0000000000001002. eCollection 2020 Jun. PMID: 32607420.

Respiratory surveillance wards as a strategy to reduce nosocomial transmission of COVID-19 through early detection: The experience of a tertiary-care hospital in Singapore. Wee LE, Hsieh JYC, Phua GC, Tan Y, Conceicao EP, Wijaya L, Tan TT, Tan BH. Infect Control Hosp Epidemiol. 2020 Jul;41(7):820-825. doi: 10.1017/ice.2020.207. Epub 2020 May 8. PMID: 32381147.

Containment of COVID-19 cases among healthcare workers: The role of surveillance, early detection, and outbreak management. Wee LE, Sim XYJ, Conceicao EP, Aung MK, Goh JQ, Yeo DWT, Gan WH, Chua YY, Wijaya L, Tan TT, Tan BH, Ling ML, Venkatachalam I. Infect Control Hosp Epidemiol. 2020 Jul;41(7):765-771. doi: 10.1017/ice.2020.219. Epub 2020 May 11. PMID: 32391746.

Community-acquired viral respiratory infections amongst hospitalized inpatients during a COVID-19 outbreak in Singapore: co-infection and clinical outcomes. Wee LE, Ko KKK, Ho WQ, Kwek GTC, Tan TT, Wijaya L. J Clin Virol. 2020 Jul;128:104436. doi: 10.1016/j.jcv.2020.104436. Epub 2020 May 19. PMID: 32447256.

Evaluating Potential Deceased Donor Renal Transplant Recipients for Asymptomatic COVID-19. Ho QY, Chung SJ, Low SCS, Chen RC, Teh SP, Chan FZY, Tan BH, Kee TYS. Transplant Direct. 2020 May 22;6(6):e559. doi: 10.1097/TXD.0000000000001010. eCollection 2020 Jun. PMID: 32607425.

Health ethics in COVID-19: no better time for solidarity. Fong JMN, Anantham D. Singapore Med J. 2021 Mar;62(3):155-156. doi: 10.11622/smedj.2020083. Epub 2020 May 27. PMID: 32460454.

Discontinuation of Antibiotics in Patients with Neurological Conditions - A Study on the Impact of an Antimicrobial Stewardship Program (ASP) in a Tertiary Institution. Loo LW, Liew YX, Chlebicki P, Kwa AL. Int J Antimicrob Agents. 2020 Aug;56(2):106038. doi: 10.1016/j.ijantimicag.2020.106038. Epub 2020 May 29. PMID: 32479888.

Initial Experiences of Laboratory Diagnosis of Coronavirus Disease 2019 (COVID-19) in Singapore General Hospital. Chan KS, Ko KK, Koh TH, Ho DW, Chan YF, Tan TT, Oon LL. Ann Acad Med Singap. 2020 Jun;49(6):415-416. PMID: 32712644.

Two linear epitopes on the SARS-CoV-2 spike protein that elicit neutralising antibodies in COVID-19 patients. Poh CM, Carissimo G, Wang B, Amrun SN, Lee CY, Chee RS, Fong SW, Yeo NK, Lee WH, Torres-Ruesta A, Leo YS, Chen MI, Tan SY, Chai LYA, Kalimuddin S, Kheng SSG, Thien SY, Young BE, Lye DC, Hanson BJ, Wang CI, Renia L, Ng LFP. Nat Commun. 2020 Jun 1;11(1):2806. doi: 10.1038/s41467-020-16638-2. PMID: 32483236.

Financial burden and financial aid for medical students in Singapore: a national survey across all three medical schools. Tan YTW, Sayampanathan AA, Chidambaram K, Koh YQ, Fong JMN, Low JI, Ng CL, Tambyah PA. Singapore Med J. 2020 Jun 2. doi: 10.11622/smedj.2020085. Online ahead of print. PMID: 32480436.

Disseminated Bacillus-Calmette-Guérin Infections And Primary Immunodeficiency Disorders In Singapore: A Single Center 15-Year Retrospective Review. Ong RYL, Chan SB, Chew SJ, Liew WK, Thoon KC, Chong CY, Yung CF, Sng LH, Tan AM, Bhattacharyya R, Jamuar SS, Lim JY, Li J, Nadua KD, Kam KQ, Tan NW. Int J Infect Dis. 2020 Aug;97:117-125. doi: 10.1016/j.ijid.2020.05.117. Epub 2020 Jun 2. PMID: 32497805.

Human MAIT cell cytolytic effector proteins synergize to overcome carbapenem resistance in Escherichia coli. Boulouis C, Sia WR, Gulam MY, Teo JQM, Png YT, Phan TK, Mak JYW, Fairlie DP, Poon IKH, Koh TH, Bergman P, Lim CM, Wang LF, Kwa ALH, Sandberg JK, Leeansyah E. PLoS Biol. 2020 Jun 8;18(6):e3000644. doi: 10.1371/journal.pbio.3000644. eCollection 2020 Jun. PMID: 32511236.

Cartography of opportunistic pathogens and antibiotic resistance genes in a tertiary hospital environment. Chng KR, Li C, Bertrand D, Ng AHQ, Kwah JS, Low HM, Tong C, Natrajan M, Zhang MH, Xu L, Ko KKK, Ho EXP, Av-Shalom TV, Teo JWP, Khor CC; MetaSUB Consortium, Chen SL, Mason CE, Ng OT, Marimuthu K, Ang B, Nagarajan N. Nat Med. 2020 Jun;26(6):941-951. doi: 10.1038/s41591-020-0894-4. Epub 2020 Jun 8. PMID: 32514171.

The Diversity of Lipopolysaccharide (O) and Capsular Polysaccharide (K) Antigens of Invasive Klebsiella pneumoniae in a Multi-Country Collection. Choi M, Hegerle N, Nkeze J, Sen S, Jamindar S, Nasrin S, Sen S, Permala-Booth J, Sinclair J, Tapia MD, Johnson JK, Mamadou S, Thaden JT, Fowler VG Jr, Aguilar A, Terán E, Decre D, Morel F, Krogfelt KA, Brauner A, Protonotariou E, Christaki E, Shindo Y, Lin YT, Kwa AL, Shakoor S, Singh-Moodley A, Perovic O, Jacobs J, Lunguya O, Simon R, Cross AS, Tennant SM. Front Microbiol. 2020 Jun 12;11:1249. doi: 10.3389/fmicb.2020.01249. eCollection 2020. PMID: 32595624.

Transthoracic colour-encoded M-mode echocardiography demonstrating neonatal atrial flutter. Donceras Nadua K, Xu M, Choo JTL. Arch Dis Child Fetal Neonatal Ed. 2021 Mar;106(2):222. doi: 10.1136/archdischild-2020-319072. Epub 2020 Jun 16. PMID: 32546542.

The utility of voriconazole therapeutic drug monitoring in a multi-racial cohort in Southeast Asia. Zhou PY, Lim TP, Tang SLS, Liew Y, Chua SGN, Lim LLC, Lee HLW, Tan SX, Lai OF, Tan TT, Wong GC, Kwa LHA. J Glob Antimicrob Resist. 2020 Jun;21:427-433. doi: 10.1016/j.jgar.2019.12.004. Epub 2019 Dec 14. PMID: 31846723.

An unusual case of Scedosporium apiospermum fungaemia in an immunocompetent patient with a left ventricular assist device and an implantable cardiac device. Tan SYL, Chung SJ, Tan TE, Teo L, Tan BH, Tan YE. Access Microbiol. 2020 Jun 25;2(9):acmi000148. doi: 10.1099/acmi.0.000148. eCollection 2020. PMID: 33195980.

COVID-19, equipoise and observational studies: a reminder of forgotten issues. Yusuf E, Maiwald M. Infection. 2021 Apr;49(2):371-373. doi: 10.1007/s15010-020-01466-9. Epub 2020 Jun 25. PMID: 32588335.

Containing COVID-19 outside the isolation ward: The impact of an infection control bundle on environmental contamination and transmission in a cohorted general ward. Wee LEI, Sim XYJ, Conceicao EP, Aung MK, Tan KY, Ko KKK, Wong HM, Wijaya L, Tan BH, Venkatachalam I, Ling ML. Am J Infect Control. 2020 Sep;48(9):1056-1061. doi: 10.1016/j.ajic.2020.06.188. Epub 2020 Jun 26. PMID: 32599101.

Foodborne Klebsiella pneumoniae: Virulence Potential, Antibiotic Resistance, and Risks to Food Safety. Hartantyo SHP, Chau ML, Koh TH, Yap M, Yi T, Cao DYH, GutiÉrrez RA, Ng LC. J Food Prot. 2020 Jul 1;83(7):1096-1103. doi: 10.4315/JFP-19-520. PMID: 31928427.

Kawasaki disease in the COVID-19 era: a distinct clinical phenotype? Kam KQ, Ong JSM, Lee JH. Lancet Child Adolesc Health. 2020 Sep;4(9):642-643. doi:10.1016/S2352-4642(20)30207-8. Epub 2020 Jul 2.PMID: 32622377.

Reduction in healthcare-associated respiratory viral infections during a COVID-19 outbreak.Wee LE, Conceicao EP, Sim XYJ, Ko KKK, Ling ML, Venkatachalam I. Clin Microbiol Infect. 2020 Nov;26(11):1579-1581. doi: 10.1016/j.cmi.2020.06.027. Epub 2020 Jul 3. PMID: 32622953.

Household Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 from Adults to Children. Yung CF, Kam KQ, Chong CY, Nadua KD, Li J, Tan NWH, Ganapathy S, Lee KP, Ng KC, Chan YH, Thoon KC. J Pediatr. 2020 Oct;225:249-251. doi: 10.1016/j.jpeds.2020.07.009. Epub 2020 Jul 4. PMID: 32634405.

Successful containment of horizontal enterovirus infection in a neonatal unit in Singapore through diagnosis by polymerase chain reaction (PCR) and direct sequence analysis. Tan YY, Quek BH, Thoon KC, Maiwald M, Yung CF, Rajadurai VS, Kong JY. J Infect Public Health. 2020 Oct;13(10):1556-1561. doi: 10.1016/j.jiph.2020.06.029. Epub 2020 Jul 9. PMID: 32653481.

Clinical Utility of Buccal Swabs for Severe Acute Respiratory Syndrome Coronavirus 2 Detection in Coronavirus Disease 2019-Infected Children. Kam KQ, Yung CF, Maiwald M, Chong CY, Soong HY, Loo LH, Tan NWH, Li J, Nadua KD, Thoon KC. J Pediatric Infect Dis Soc. 2020 Jul 13;9(3):370-372. doi: 10.1093/jpids/piaa068. PMID: 32463086.

The impact of healthcare associated infections on mortality and length of stay in Singapore-A time-varying analysis. Cai Y, Lo JJ, Venkatachalam I, Kwa AL, Tambyah PA, Hsu LY, Barnett A, Marimuthu K, Graves N. Infect Control Hosp Epidemiol. 2020 Nov;41(11):1315-1320. doi: 10.1017/ice.2020.304. Epub 2020 Jul 15. PMID: 32665057.

Discovery and Genomic Characterization of a 382-Nucleotide Deletion in ORF7b and ORF8 during the Early Evolution of SARS-CoV-2. Su YCF, Anderson DE, Young BE, Linster M, Zhu F, Jayakumar J, Zhuang Y, Kalimuddin S, Low JGH, Tan CW, Chia WN, Mak TM, Octavia S, Chavatte JM, Lee RTC, Pada S, Tan SY, Sun L, Yan GZ, Maurer-Stroh S, Mendenhall IH, Leo YS, Lye DC, Wang LF, Smith GJD. mBio. 2020 Jul 21;11(4):e01610-20. doi: 10.1128/mBio.01610-20. PMID: 32694143.

Genomic Study of bla IMI-Positive Enterobacter cloacae Complex in Singapore over a Five-Year Study Period. Octavia S, Koh TH, Ng OT, Marimuthu K, Venkatachalam I, Lin RTP, Teo JWP. Antimicrob Agents Chemother. 2020 Jul 22;64(8):e00510-20. doi: 10.1128/AAC.00510-20. Print 2020 Jul 22. PMID: 32482676.

Linear B-cell epitopes in the spike and nucleocapsid proteins as markers of SARS-CoV-2 exposure and disease severity. Amrun SN, Lee CY, Lee B, Fong SW, Young BE, Chee RS, Yeo NK, Torres-Ruesta A, Carissimo G, Poh CM, Chang ZW, Tay MZ, Chan YH, Chen MI, Low JG, Tambyah PA, Kalimuddin S, Pada S, Tan SY, Sun LJ, Leo YS, Lye DC, Renia L, Ng LFP. EBioMedicine. 2020 Aug;58:102911. doi: 10.1016/j.ebiom.2020.102911. Epub 2020 Jul 22. PMID: 32711254.

Epidemiologic trends in Kawasaki disease during coronavirus disease-19 in Singapore. Yung CF, Nadua KD, Oh BK, Thoon KC. J Pediatr. 2020 Jul 24;226:314-5. doi: 10.1016/j.jpeds.2020.07.063. Online ahead of print. PMID: 32717229.

Clinical Experience with High-Dose Polymyxin B against Carbapenem-Resistant Gram-Negative Bacterial Infections-A Cohort Study. Cai Y, Leck H, Tan RW, Teo JQ, Lim TP, Lee W, Chlebicki MP, Kwa AL. Antibiotics (Basel). 2020 Jul 27;9(8):451. doi: 10.3390/antibiotics9080451. PMID: 32726974.

A Well Infant With Coronavirus Disease 2019 With High Viral Load. Kam KQ, Yung CF, Cui L, Tzer Pin Lin R, Mak TM, Maiwald M, Li J, Chong CY, Nadua K, Tan NWH, Thoon KC. Clin Infect Dis. 2020 Jul 28;71(15):847-849. doi: 10.1093/cid/ciaa201. PMID: 32112082.

Rapid production of clinical-grade SARS-CoV-2 specific T cells. Leung W, Soh TG, Linn YC, Low JG, Loh J, Chan M, Chng WJ, Koh LP, Poon ML, Ng KP, Kuick CH, Tan TT, Tan LK, Seng MS. Adv Cell Gene Ther. 2020 Jul 31:e101. doi: 10.1002/acg2.101. Online ahead of print. PMID: 32838213.

Diabetic kidney disease in primary care. Fong JMN, Tsang LPM, Kwek JL, Guo W. Singapore Med J. 2020 Aug;61(8):399-405. doi: 10.11622/smedj.2020127. PMID: 32875340.

Comparative Analysis of Symptomatic and Asymptomatic SARS-CoV-2 Infection in Children. Li J, Thoon KC, Chong CY, Maiwald M, Kam KQ, Nadua K, Tan NW, Yung CF. Ann Acad Med Singap. 2020 Aug;49(8):530-537. PMID: 33164022

From Trial to Implementation, Bringing Team-Based Learning Online-Duke-NUS Medical School's Response to the COVID-19 Pandemic. Jumat MR, Wong P, Foo KX, Lee ICJ, Goh SPL, Ganapathy S, Tan TY, Loh AHL, Yeo YC, Chao Y, Cheng LT, Lai SH, Goh SH, Compton S, Hwang NC. Med Sci Educ. 2020 Aug 4:1-6. doi: 10.1007/s40670-020-01039-3. Online ahead of print. PMID: 32837796.

Oral vs Intravenous Antibiotics for Patients With Klebsiella pneumoniae Liver Abscess: A Randomized, Controlled Noninferiority Study. Molton JS, Chan M, Kalimuddin S, Oon J, Young BE, Low JG, Salada BMA, Lee TH, Wijaya L, Fisher DA, Izharuddin E, Koh TH, Teo JWP, Krishnan PU, Tan BP, Woon WWL, Ding Y, Wei Y, Phillips R, Moorakonda R, Yuen KH, Cher BP, Yoong J, Lye DC, Archuleta S. Clin Infect Dis. 2020 Aug 14;71(4):952-959. doi: 10.1093/cid/ciz881. PMID: 31641767.

Effects of a major deletion in the SARS-CoV-2 genome on the severity of infection and the inflammatory response: an observational cohort study. Young BE, Fong SW, Chan YH, Mak TM, Ang LW, Anderson DE, Lee CY, Amrun SN, Lee B, Goh YS, Su YCF, Wei WE, Kalimuddin S, Chai LYA, Pada S, Tan SY, Sun L, Parthasarathy P, Chen YYC, Barkham T, Lin RTP, Maurer-Stroh S, Leo YS, Wang LF, Renia L, Lee VJ, Smith GJD, Lye DC, Ng LFP. Lancet. 2020 Aug 29;396(10251):603-611. doi: 10.1016/S0140-6736(20)31757-8. Epub 2020 Aug 18. PMID: 32822564.

In Vitro Pharmacodynamics of Fosfomycin against Carbapenem-Resistant Enterobacter cloacae and Klebsiella aerogenes. Lim TP, Teo JQ, Goh AW, Tan SX, Koh TH, Lee WH, Cai Y, Tan TT, Kwa AL. Antimicrob Agents Chemother. 2020 Aug 20;64(9):e00536-20. doi: 10.1128/AAC.00536-20. Print 2020 Aug 20. PMID: 32571821.

Genomic analysis of Lactococcus garvieae isolates. Lin YS, Kweh KH, Koh TH, Lau QC, Abdul Rahman NB. Pathology. 2020 Oct;52(6):700-707. doi: 10.1016/j.pathol.2020.06.009. Epub 2020 Aug 20. PMID: 32829891

Subacute thyroiditis associated with COVID-19. Mattar SAM, Koh SJQ, Rama Chandran S, Cherng BPZ. BMJ Case Rep. 2020 Aug 25;13(8):e237336. doi: 10.1136/bcr-2020-237336. PMID: 32843467.

Antimicrobial stewardship programme: a vital resource for hospitals during the global outbreak of coronavirus disease 2019 (COVID-19). Liew Y, Lee WHL, Tan L, Kwa ALH, Thien SY, Cherng BPZ, Chung SJ. Int J Antimicrob Agents. 2020 Nov;56(5):106145. doi: 10.1016/j.ijantimicag.2020.106145. Epub 2020 Aug 27. PMID: 32860880.

Viral dynamics and immune correlates of COVID-19 disease severity. Young BE, Ong SWX, Ng LFP, Anderson DE, Chia WN, Chia PY, Ang LW, Mak TM, Kalimuddin S, Chai LYA, Pada S, Tan SY, Sun L, Parthasarathy P, Fong SW, Chan YH, Tan CW, Lee B, Rötzschke O, Ding Y, Tambyah P, Low JGH, Cui L, Barkham T, Lin RTP, Leo YS, Renia L, Wang LF, Lye DC; Singapore 2019 Novel Coronavirus Outbreak Research team. Clin Infect Dis. 2020 Aug 28:ciaa1280. doi: 10.1093/cid/ciaa1280. Online ahead of print. PMID: 32856707.

Empowerment of nurses in antibiotic stewardship: a social ecological qualitative analysis. Wong LH, Bin Ibrahim MA, Guo H, Kwa ALH, Lum LHW, Ng TM, Chung JS, Somani J, Lye DCB, Chow A. J Hosp Infect. 2020 Nov;106(3):473-482. doi: 10.1016/j.jhin.2020.09.002. Epub 2020 Sep 4. PMID: 32896586

Cohort study to evaluate the effect of vitamin D, magnesium, and vitamin B12 in combination on progression to severe outcomes in older patients with coronavirus (COVID-19). Tan CW, Ho LP, Kalimuddin S, Cherng BPZ, Teh YE, Thien SY, Wong HM, Tern PJW, Chandran M, Chay JWM, Nagarajan C, Sultana R, Low JGH, Ng HJ. Nutrition. 2020 Nov-Dec;79-80:111017. doi: 10.1016/j.nut.2020.111017. Epub 2020 Sep 8. PMID: 33039952.

Saliva is not a useful diagnostic specimen in children with Coronavirus Disease 2019. Chong CY, Kam KQ, Li J, Maiwald M, Loo LH, Nadua KD, Tan NWH, Yung CF, Thoon KC. Clin Infect Dis. 2020 Sep 14:ciaa1376. doi: 10.1093/cid/ciaa1376. Online ahead of print. PMID: 32927475.

Radiographic features of COVID-19 based on an initial cohort of 96 patients in Singapore. Khoo HW, Hui TCH, Haja Mohideen SM, Lee YS, Liew CJY, Kok SSX, Young BE, Ong SWX, Kalimuddin S, Tan SY, Loh J, Chan LP, Poh ACC, Wong SBS, Leo YS, Lye DC, Kaw GJL, Tan CH. Singapore Med J. 2020 Sep 21. doi: 10.11622/smedj.2020142. Online ahead of print. PMID: 33047143.

Construction of a container isolation ward: A rapidly scalable modular approach to expand isolation capacity during the coronavirus disease 2019 (COVID-19) pandemic. Wee LE, Fan EMP, Heng R, Ang SY, Chiang JL, Tan TT, Ling ML, Wijaya L. Infect Control Hosp Epidemiol. 2020 Sep 23:1-3. doi: 10.1017/ice.2020.1222. Online ahead of print. PMID: 32962768.

Elimination of Extracellular Adenosine Triphosphate for the Rapid Prediction of Quantitative Plate Counts in 24 h Time-Kill Studies against Carbapenem-Resistant Gram-Negative Bacteria. Cai Y, Ng JJ, Leck H, Teo JQ, Goh JX, Lee W, Koh TH, Tan TT, Lim TP, Kwa AL. Microorganisms. 2020 Sep 28;8(10):1489. doi: 10.3390/microorganisms8101489. PMID: 32998347.

A comparative study on the clinical features of COVID-19 with non-SARS-CoV-2 respiratory viral infections. Tan JY, Sim XYJ, Wee LE, Chua YY, Cherng BPZ, Ng IM, Conceicao EP, Wong TJ, Yang Y, Aung MK, Ling ML, Venkatachalam I. J Med Virol. 2021 Mar;93(3):1548-1555. doi: 10.1002/jmv.26486. Epub 2020 Sep 29. PMID: 32881022.

Epidemiology of Adenovirus Infections and Outcomes of Cidofovir Treatment in Severely Ill Children. Siew JX, Seah XFV, Chew YR, Thoon KC, Chong CY, Yung CF, Maiwald M, Len Y, Li J, Kam KQ, Nadua K, Tanugroho R, Tan NWH. Pediatr Infect Dis J. 2020 Oct;39(10):907-913. doi: 10.1097/INF.0000000000002726. PMID: 32404785.

Rare Case Of Pott's Disease Caused By Bacillus-Calmette Guérin Vaccine. Mahtani S, Tan JMC, Low SYY, Nolan CP, Ong RYL, Lam JCM, Yeo TH, Sng LH, Chang KTE, Chong CY, Tan NWH. J Paediatr Child Health. 2020 Oct;56(10):1655-1656. doi: 10.1111/jpc.15082. PMID: 33099828.

Cerebral Venous Thrombosis in Patients with COVID-19 Infection: a Case Series and Systematic Review. Tu TM, Goh C, Tan YK, Leow AS, Pang YZ, Chien J, Shafi H, Chan BP, Hui A, Koh J, Tan BY, Umapathi NT, Yeo LL. J Stroke Cerebrovasc Dis. 2020 Dec;29(12):105379. doi: 10.1016/j.jstrokecerebrovasdis.2020.105379. Epub 2020 Oct 6. PMID: 33254369.

Treatment and Outcomes of Infections Caused by Diverse Carbapenemase-Producing Carbapenem-Resistant Enterobacterales. Lim FK, Liew YX, Cai Y, Lee W, Teo JQM, Lay WQ, Chung J, Kwa ALH. Front Cell Infect Microbiol. 2020 Oct 14;10:579462. doi: 10.3389/fcimb.2020.579462. eCollection 2020. PMID: 33178629.

The COVID-19 cohort ward experience: All hands on deck. Tan SY, Chien JMF, Li J, Teo EK, Tee A. Clin Infect Pract. 2020 Oct;7:100047. doi: 10.1016/j.clinpr.2020.100047. Epub 2020 Oct 14. PMID: 33073233.

When to Test for Anti-Interferon-γ Autoantibody? Loh KM, Zhong Y, Lin L, Chan M, Cherng BPZ, Yew HS, Sun H, Lee Dickens BS, Lye DCB, Huang CH, Khoo AL, Chai LYA. Clin Infect Dis. 2020 Oct 23;71(7):e199. doi: 10.1093/cid/ciaa129. PMID: 32052830.

Disentangling etiologies of CNS infections in Singapore using multiple correspondence analysis and random forest.Zellweger RM, Yacoub S, Chan YFZ, Soon D, Shafi H, Ooi ST, Chan M, Jacobson L, Sessions OM, Vincent A, Low JGH, Ooi EE, Wang L, Wijaya L, Tan K; Singapore Neurologic Infections Program (SNIP). Sci Rep. 2020 Oct 26;10(1):18219. doi: 10.1038/s41598-020-75088-4. PMID: 33106525.

Experience of a Tertiary Hospital in Singapore with Management of a Dual Outbreak of COVID-19 and Dengue. Wee LE, Cherng BPZ, Conceicao EP, Goh KC, Wan WY, Ko KKK, Aung MK, Sim XYJ, Wijaya L, Ling ML, Venkatachalam I. Am J Trop Med Hyg. 2020 Nov;103(5):2005-2011. doi: 10.4269/ajtmh.20-0703. PMID: 32996452.

Multiomic analysis and immunoprofiling reveal distinct subtypes of human angiosarcoma. Chan JY, Lim JQ, Yeong J, Ravi V, Guan P, Boot A, Tay TKY, Selvarajan S, Md Nasir ND, Loh JH, Ong CK, Huang D, Tan J, Li Z, Ng CC, Tan TT, Masuzawa M, Sung KW, Farid M, Quek RHH, Tan NC, Teo MCC, Rozen SG, Tan P, Futreal A, Teh BT, Soo KC. J Clin Invest. 2020 Nov 2;130(11):5833-5846. doi: 10.1172/JCI139080. PMID: 33016928.

COVID-19 and Undiagnosed Pre-diabetes or Diabetes Mellitus Among International Migrant Workers in Singapore. Tee LY, Alhamid SM, Tan JL, Oo TD, Chien J, Galinato P, Tan SY, Humaira S, Fong RKC, Puar TH, Loh WJ, Santosa A, Khoo J, Rosario BH. Front Public Health. 2020 Nov 11;8:584249. doi: 10.3389/fpubh.2020.584249. eCollection 2020. PMID: 33262970.

COVID-19 and Undiagnosed Pre-diabetes or Diabetes Mellitus Among International Migrant Workers in Singapore. Tee LY, Alhamid SM, Tan JL, Oo TD, Chien J, Galinato P, Tan SY, Humaira S, Fong RKC, Puar TH, Loh WJ, Santosa A, Khoo J, Rosario BH. Front Public Health. 2020 Nov 11;8:584249. doi: 10.3389/fpubh.2020.584249. eCollection 2020. PMID: 33262970.

Respiratory viral infections in hospitalised paediatric patients in the tropics. Tan KWJ, Yung CF, Maiwald M, Saffari SE, Thoon KC, Chong CY. J Paediatr Child Health. 2021 Apr;57(4):559-565. doi: 10.1111/jpc.15267. Epub 2020 Nov 13. PMID: 33185937

Whole genome sequencing analysis of multidrug-resistant tuberculosis in Singapore, 2006-2018. Chee CBE, Lim LKY, Ong RTH, Sng LH, Hsu LY, Lee VJM, Wang YT. Eur J Clin Microbiol Infect Dis. 2021 May;40(5):1079-1083. doi: 10.1007/s10096-020-04100-6. Epub 2020 Nov 15. PMID: 33190171.

Containment of COVID-19 and reduction in healthcare-associated respiratory viral infections through a multi-tiered infection control strategy. Wee LE, Venkatachalam I, Sim XYJ, Tan KB, Wen R, Tham CK, Gan WH, Ko KKK, Ho WQ, Kwek GTC, Conceicao EP, Sng CYE, Ng XHJ, Ong JY, Chiang JL, Chua YY, Ling ML, Tan TT, Wijaya L. Infect Dis Health. 2021 May;26(2):123-131. doi: 10.1016/j.idh.2020.11.004. Epub 2020 Nov 16. PMID: 33386294.

Enhanced Molecular Diagnosis of Bloodstream Candida Infection with Size-Based Inertial Sorting at Submicron Resolution. Lu X, Chow JJM, Koo SH, Tan TY, Jiang B, Ai Y. Anal Chem. 2020 Dec 1;92(23):15579-15586. doi: 10.1021/acs.analchem.0c03718. Epub 2020 Nov 16. PMID: 33191733.

Performance of Population Pharmacokinetic Models in Predicting Polymyxin B Exposures. Tam VH, Lee LS, Ng TM, Lim TP, Cherng BPZ, Adewusi H, Hee KH, Ding Y, Chung SJ, Ling LM, Chlebicki P, Kwa ALH, Lye DC. Microorganisms. 2020 Nov 18;8(11):1814. doi: 10.3390/microorganisms8111814. PMID: 33217914.

Procalcitonin (PCT)-guided antibiotic stewardship in Asia-Pacific countries: adaptation based on an expert consensus meeting. Lee CC, Kwa ALH, Apisarnthanarak A, Feng JY, Gluck EH, Ito A, Karuniawati A, Periyasamy P, Pratumvinit B, Sharma J, Solante R, Swaminathan S, Tyagi N, Vu DM, Zirpe K, Schuetz P. Clin Chem Lab Med. 2020 Nov 26;58(12):1983-1991. doi: 10.1515/cclm-2019-1122. PMID: 31926074.

The place for remdesivir in COVID-19 treatment. Young B, Tan TT, Leo YS. Lancet Infect Dis. 2021 Jan;21(1):20-21. doi: 10.1016/S1473-3099(20)30911-7. Epub 2020 Nov 26. PMID: 33248473.

MR1-Restricted T Cells with MAIT-like Characteristics Are Functionally Conserved in the Pteropid Bat Pteropus alecto. Leeansyah E, Hey YY, Sia WR, Ng JHJ, Gulam MY, Boulouis C, Zhu F, Ahn M, Mak JYW, Fairlie DP, Kwa ALH, Sandberg JK, Wang LF. iScience. 2020 Nov 28;23(12):101876. doi: 10.1016/j.isci.2020.101876. eCollection 2020 Dec 18. PMID: 33344919.

Intravesical Bacillus Calmette-Guerin and its complications: 12 years of learning experience in a single local institution. Yang X, Toh Q, Huang HH, Sng LH, Tan TT, Ng LG. Singapore Med J. 2020 Dec 2. doi: 10.11622/smedj.2020168. Online ahead of print. PMID: 33264683.

Waitlisted Transplant Candidates' Attitudes and Concerns Toward Transplantation During COVID-19. Tan EK, Koh YX, Kee T, Juhari JB, Tan TE, Sim DKL, Ho AYL, Krishnan L, Tee PS, Krishnamoorthy TL, Goh BKP, Tan BH, Chung SJ, Phua GC, Jeyaraj PR. Ann Transplant. 2020 Dec 8;25:e926992. doi: 10.12659/AOT.926992. PMID: 33289727.

Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19. Kalil AC, Patterson TF, Mehta AK, Tomashek KM, Wolfe CR, Ghazaryan V, Marconi VC, Ruiz-Palacios GM, Hsieh L, Kline S, Tapson V, Iovine NM, Jain MK, Sweeney DA, El Sahly HM, Branche AR, Regalado Pineda J, Lye DC, Sandkovsky U, Luetkemeyer AF, Cohen SH, Finberg RW, Jackson PEH, Taiwo B, Paules CI, Arguinchona H, Erdmann N, Ahuja N, Frank M, Oh MD, Kim ES, Tan SY, Mularski RA, Nielsen H, Ponce PO, Taylor BS, Larson L, Rouphael NG, Saklawi Y, Cantos VD, Ko ER, Engemann JJ, Amin AN, Watanabe M, Billings J, Elie MC, Davey RT, Burgess TH, Ferreira J, Green M, Makowski M, Cardoso A, de Bono S, Bonnett T, Proschan M, Deye GA, Dempsey W, Nayak SU, Dodd LE, Beigel JH; ACTT-2 Study Group Members. N Engl J Med. 2021 Mar 4;384(9):795-807. doi: 10.1056/NEJMoa2031994. Epub 2020 Dec 11. PMID: 33306283.

Efficacy of commercial mouth-rinses on SARS-CoV-2 viral load in saliva: randomized control trial in Singapore. Seneviratne CJ, Balan P, Ko KKK, Udawatte NS, Lai D, Ng DHL, Venkatachalam I, Lim KS, Ling ML, Oon L, Goh BT, Sim XYJ. Infection. 2021 Apr;49(2):305-311. doi: 10.1007/s15010-020-01563-9. Epub 2020 Dec 14. PMID: 33315181.

The accuracy of healthcare worker versus self collected (2-in-1) Oropharyngeal and Bilateral Mid-Turbinate (OPMT) swabs and saliva samples for SARS-CoV-2. Tan SY, Tey HL, Lim ETH, Toh ST, Chan YH, Tan PT, Lee SA, Tan CX, Koh GCH, Tan TY, Siau C. PLoS One. 2020 Dec 16;15(12):e0244417. doi: 10.1371/journal.pone.0244417. eCollection 2020. PMID: 33326503.

Reactivation of BCG inoculation site in a child with febrile exanthema of 3 days duration: an early indicator of incomplete Kawasaki disease. Lim KYY, Chua MC, Tan NWH, Chandran S. BMJ Case Rep. 2020 Dec 17;13(12):e239648. doi: 10.1136/bcr-2020-239648. PMID: 33334773.

Emerging Role for MAIT Cells in Control of Antimicrobial Resistance. Leeansyah E, Boulouis C, Kwa ALH, Sandberg JK. Trends Microbiol. 2021 Jun; 29(6):504-516. doi: 10.1016/j.tim.2020.11.008. Epub 2020 Dec 19. PMID: 33353796.