AM Research Grant | SingHealth Duke-NUS

Projects should aim to demonstrate the utility of precision medicine, where genomic sequencing is coupled to detailed medical phenotyping to discover genetic variants related to disease pathogenesis, clinical outcome, or to achieve a definite molecular diagnosis.

• Studies should emphasize genomic-level sequencing (whole-exome or whole-genome).

• Only proposals where patient samples have already been recruited and where detailed medical and/or outcome information is available will be considered. Trio-designs are encouraged.

List of Awardees

Grant Call 1 (April 2016)
Main PI	Institution	Collaborators	Mentor	Project Title
Ting Tech Wah	KKH	Tan Ene Choo/Angeline Lai/Law Hai Eng (KKH)	Saumya Shekhar Kamuar (KKH)	Understanding the genetics of neurodevelopmental delay
Joanne Ngeow	NCCS	Chan Sock Hoai (NCCS)/ Tony Lim (SGH)	Teh Bin Tean (NCCS)	Molecular Mechanism Involved in Cancer Predisposition
Fan Qiao	SNEC	Wang Chaolong (GIS)/Wong Tien Yin (SNEC)/Gemmy Chueng (SNEC)/Liu Jin (DNUS)	Cheng Ching-Yu (SNEC)	An integrative framework for analyzing functional genetic variants for polypoidal choroidal vasculopathy in Chinese from next generation sequencing

Grant Call 2 (April 2017)
Main PI	Institution	Collaborators	Mentor	Project Title
Iain Tan bee Huat	NCCS	Daniel Tan (NCCS)/ Steve Rozen (Duke-NUS)/ Zhai Wei Wei (GIS)/ Toh Han Chong (NCCS)/ Koo Si-Lin (NCCS)	Patrick Tan (Duke-NUS0	Prospective determination of neo-antigens in cancer patients to facilitate neo-antigen specific immunotherapy options
Adeline Ng Su Lyn	NNI		Tan Eng King (NNI/SGH)	Cognitive Disorders Exome and Genome Sequencing Study (CODEX)

Grant Call 3 (April 2018)
Main PI	Institution	Collaborators	Mentor	Project Title
Marie Janelle Liwanag	KKH	Christina Ong (KKH), Veena Logarajah (KKH), Law Hai Yang (KKH), Caroline Ong Choon Paik (KKH), Lee York Tien (KKH)	Saumya Jamuar (KKH)	Understanding The Genetics Of Chronic Paediatric Gastrointestinal Diseases
Tan Puay Hoon	SGH	Ong Kong Wee (NCCS), Tan Kiat Tee Benita (SGH), Aye Aye Thike (SGH)	Teh Bin Tean (NCCS)	PROGRESSION MODELS OF BREAST FIBROEPITHELIAL LESIONS
Amos Loh	KKH	Steven G Rozen (Duke-NUS), Joanne Ngeow (NCCS), Victor Lee (NUHS), Quah Thuan Chong (NUHS), Kenneth Chang (KKH)	Teh Bin Tean (NCCS)	Understanding the transcriptomic and epigenetic landscape of Wilms tumor as a model of normal renal development and tumorgenesi

Grant 4 (April 2019)
Main PI	Institution	Collaborators	Mentor	Project Title
Joyce Lam	KKH	Stella Zhang (KKH), Lim Weng Khong (Duke-NUS), Law Hai Yang (KKH), Tan Ee Shien (KKH), Ivy Ng (KKH)	Saumya Shekhar Jamuar (KKH)	Understanding genetic modifiers influencing haemoglobin production to identify potential therapeutic pharmaceutical targets
Yeo Joo Guan	KKH	Thaschawee Arkachaisri (KKH)	Salvatore Albani (Translational Immunology Institute, SingHealth Duke-NUS AMC)	Integrative Mapping of CXCR5+ Immune Cells Transcriptomic Network onto Childhood Onset Systemic Lupus Erythematosus (cSLE) Genomic Architecture for Discrimination of Mechanistically Important Genetic Variations
Aung Tin	SERI	Khor Chiea Chuen (GIS), Cheng Ching-Yu (SERI/Duke-NUS)	N.A	Whole exome sequencing of Indian subjects with primary angle closure glaucoma