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Publications

"Family History Assessment Significantly Enhances Delivery of Precision Medicine in the Genomics Era" BioRxiv, January 30 2020

Yasmin Bylstra, Weng Khong Lim, Sylvia Kam, KoeiWan Tham, R. Ryanne Wu, Jing Xian Teo, Sonia Davila, Jyn Ling Kuan, Sock Hoai Chan, Nicolas Bertin, ChengXi Yang , Steve Rozen, Bin Tean Teh, Khung Keong Yeo, Stuart Alexander Cook, Lori A. Orlando, Saumya Shekhar Jamuar, Geoffrey S. Ginsburg & Patrick Tan.

 

"Large-Scale Whole-Genome Sequencing of Three Diverse Asian Populations in Singapore" Cell, 2019 October 17

Degang Wu, Jinzhuang Dou, Xiaoran Chai, Claire Bellis, Andreas Wilm, Chih Chuan Shih, Wendy Wei Jia Soon, Nicolas Bertin, Clarabelle Bitong Lin, Chiea Chuen Khor, Michael DeGiorgio, Shanshan Cheng, Li Bao, Neerja Karnani, William Ying Khee Hwang, Sonia Davila, Patrick Tan, Asim Shabbir, Angela Moh, Eng-King Tan, Jia Nee Foo, Liuh Ling Goh, Khai Pang Leong, Roger S.Y. Foo Carolyn Su Ping Lam, Arthur Mark Richards, Ching-Yu Cheng, Tin Aung, Tien Yin Wong, Huck Hui Ng, SG10K Consortium, Jianjun Liu & Chaolong Wan

 

"Implementation of genomics in medical practice to deliver precision medicine for an Asian population" NPJ Genomic Medicine, 2019 June 7

Yasmin Bylstra, Sonia Davila, Weng Khong Lim, Ryanne Wu, Jing Xian Teo, Sylvia Kam, Tamra Lysaght, Steve Rozen, Bin Tean Teh, Khung Keong Yeo, Stuart Alexander Cook, Patrick Tan & Saumya Jamuar.

 

"Digital phenotyping by consumer wearables identifies sleep-associated markers of cardiovascular disease risk and biological aging" Communications Biology, 2019 October 4

Jing Xian Teo, Sonia Davila, Chengxi Yang, Chee Jian Pua, Jonathan Yap, Swee Yaw Tan, Anders Sahlén, Calvin Woon-Loong Chin, Bin Tean Teh, Steven G Rozen, Stuart Alexander Cook, Khung Keong Yeo, Patrick Tan & Weng Khong Lim.


"Beyond fitness tracking: The use of consumer grade wearable data from normal volunteers in cardiovascular and lipidomics research" PLoS Biol, 2018 February 27
Weng Khong Lim, Sonia Davila, Jing Xian Teo, Chengxi Yang, Chee Jian Pua, Christopher Blo ̈cker, Jing Quan Lim, Jianhong Ching, Jonathan Jiunn Liang Yap, Swee Yaw Tan, Anders Sahle ́n, Calvin Woon-Loong Chin, Bin Tean Teh, Steven G. Rozen, Stuart Alexander Cook, Khung Keong Yeo & Patrick Tan.

 

"Population Genomics in South East Asia Captures Unexpectedly High Carrier Frequency for Treatable Inherited Disorders" Genet In Med, 2018 July 2

Yasmin Bylstra, Jyn Ling Kuan, Weng Khong Lim, Jaydutt Digambar Bhalshankar, Jing Xian Teo, Sonia Davila, Bin Tean Teh, Steve Rozen, Ene-Choo Tan, Wendy Kein Meng Liew, Khung Keong Yeo, Patrick Tan, The SinGapore Incidental Finding (SGIF) study group, Seang Mei Saw, Ching-Yu Cheng, Stuart Cook, Roger Foo & Saumya Shekhar Jamuar.



"Clinical Relevance of Screening Checklists for Detecting Cancer Predisposition Syndromes in Asian Childhood Tumours"  NPJ Genomic Medicine, 2018 November 15

Sock Hoai Chan, Winston Chew, Nur Diana Ishak, Weng Khong Lim, Shao-Tzu Li, Sheng Hui Tan, Jing Xian Teo, Tarryn Shaw, Kenneth Tou En Chang, Yong Chen, Prasad Iyer, Enrica Ee Kar Tan, Michaela Su-Fern Seng, Mei Yoke Chan, Ah Moy Tan, Sharon Yin Yee Low, Shui Yen Soh, Amos Hong Pheng Loh & Joanne Ngeow.

 

"Germline pathogenic variants in homologous recombination and DNA repair genes in an Asian cohort of young-onset colorectal cancer"  JNCI Cancer Spectrum, 2018 December 10

Ming Ren Toh, Jian Bang Chiang, Siao Ting Chong, Sock Hoai Chan, Nur Diana Binte Ishak, Eliza Courtney, Wei Hao Lee, Syed Muhammad Fahmy Bin Syed Abdillah Al, John Carson Allen Jr, Kiat Hon Lim, Sonia Davila, Patrick Tan, Weng Khong Lim, Iain Bee Huat Tan & Joanne Ngeow.


"Germline Mutations in Cancer Predisposition Genes are Frequent in Sporadic Sarcomas" Scientific Report, 2017 September 6

Sock Hoai Chan , Weng Khong Lim, Nur Diana Binte Ishak, Shao-Tzu Li, Wei Lin Goh, Gek San Tan, Kiat Hon Lim, Melissa Teo, Cedric Ng Chuan Young, Simeen Malik, Mann Hong Tan, Jonathan Yi Hui Teh, Francis Kuok Choon Chin, Sittampalam Kesavan, Sathiyamoorthy Selvarajan, Patrick Tan, Bin Tean Teh, Khee Chee Soo, Mohamad Farid, Richard Quek & Joanne Ngeow.

 

"Experience of Asian males communicating cardiac genetic risk within the family"  Journal of Community Genetics, 2018 January 8

Sylvia Kam, Yasmin Bylstra, Laura Forrest, Ivan Macciocca & Roger Foo.


"Ethical frameworks for obtaining informed consent in tumour profiling: an evidence-based case for Singapore" Human genomics, 2018 December 8

Yasmin Bylstra, Tamra Lysaght, Jyothi Thrivikraman, Sangeetha Watson & Patrick Tan.  


"The draft genome of tropical fruit durian (Durio zibethinus)" Nature Genetics, 2017 October

Bin Tean Teh, Kevin Lim , Chern Han Yong, Cedric Chuan Young Ng, Sushma Ramesh Rao, Vikneswari Rajasegaran, Weng Khong Lim, Choon Kiat Ong , Ki Chan, Vincent Kin Yuen Cheng, Poh Sheng Soh, Sanjay Swarup, Steven G Rozen , Niranjan Nagarajan & Patrick Tan.

"Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma" Cancer Discovery, 2017 June 30

Apinya Jusakul, Ioana Cutcutache, Chern Han Yong, Jing Quan Lim, Mi Ni Huang, Nisha Padmanabhan, Vishwa Nellore, Sarinya Kongpetch, Alvin Wei Tian Ng, Ley Moy Ng, Su Pin Choo, Swe Swe Myint, Raynoo Thanan, Sanjanaa Nagarajan, Weng Khong Lim, Cedric Chuan Young Ng, Arnoud Boot, Mo Liu, Choon Kiat Ong, Vikneswari Rajasegaran, Stefanus Lie, Alvin Soon Tiong Lim, Tse Hui Lim, Jing Tan, Jia Liang Loh, John R. McPherson, Narong Khuntikeo, Vajaraphongsa Bhudhisawasdi, Puangrat Yongvanit, Sopit Wongkham, Yasushi Totoki, Hiromi Nakamura, Yasuhito Arai, Satoshi Yamasaki, Pierce Kah-Hoe Chow, Alexander Yaw Fui Chung, London Lucien Peng Jin Ooi, Kiat Hon Lim, Simona Dima, Dan G, Duda, Irinel Popescu, Philippe Broet, Sen-Yung Hsieh, Ming-Chin Yu, Aldo Scarpa, Jiaming Lai, Di-Xian Luo, André Lopes Carvalho, André Luiz Vettore, Hyungjin Rhee, Young Nyun Park, Ludmill B. Alexandrov, Raluca Gordân, Steven G. Rozen, Tatsuhiro Shibata, Chawalit Pairojkul, Bin Tean Teh & Patrick Tan.

 

"Osteoblast-specific deletion of Hrpt2/Cdc73 results in high bone mass and increased bone turnover" Bone, 2017 April 3

Casey J.Droscha, Cassandra R, Diegel, Nicole J Ethen, Travis A. Burgers, Mitchell J McDonald, Kevin A. Maupin, Agni S. Naidu, Peng Fei Wang, Bin Tin Teh, Bart O. Williams

 

"Epigenomic Promoter Alterations Amplify Gene Isoform and Immunogenic Diversity in Gastric Adenocarcinoma" Cancer Discovery, 2017 March 20

Aditi Qamra, Manjie Xing, Nisha Padmanabhan, Jeffrey Jun Ting Kwok, Shenli Zhang, Chang Xu, Yan Shan Leong, Ai Ping Lee Lim, Qianqao Tang, Wen Fong Ooi, Joyce Suling Lin, Tannistha Nandi, Xiaosai Yao, Xuewen Ong, Minghui Lee, Su Ting Tay, Angie Tan Lay Keng, Erna Gondo Santoso, Cedric Chuan Young Ng, Alvin Ng, Apinya Jusakul, Duane Smoot, Hassan Ashktorab, Sun Young Rha, Khay Guan Yeoh, Wei Peng Yong, Pierce K.H. Chow, Weng Hoong Chan, Hock Soo Ong, Khee Chee Soo, Kyoung-Mee Kim, Wai Keong Wong, Steven G. Rozen, Bin Tean Teh , Dennis Kappei, Jeeyun Lee, John Connolly & Patrick Tan.

 

"Epigenomic profiling of primary gastric adenocarcinoma reveals super-enhancer heterogeneity" Nature Communications, 2016 September 20

Wen Fong Ooi, Manjie Xing, Chang Xu, Xiaosai Yao, Muhammad Khairul Ramlee, Mei Chee Lim, Fan Cao, Kevin Lim, Deepak Babu, Lai-Fong Poon, Joyce Lin Suling, Aditi Qamra, Astrid Irwanto, James Qu Zhengzhong, Tannistha Nandi, Ai Ping Lee-Lim, Yang Sun Chan, Su Ting Tay, Ming Hui Lee, James O.J. Davies, Wai Keong Wong, Khee Chee Soo, Weng Hoong Chan, Hock Soo Ong, Pierce Chow, Chow Yin Wong, Sun Young Rha, Jianjun Liu, Axel M. Hillmer, Jim R. Hughes, Steve Rozen, Bin Tean Teh, Melissa Jane Fullwood, Shang Li & Patrick Tan


"Excessive fatty acid oxidation induces muscle atrophy in cancer cachexia" Nature Medicine, 2016 May 2

Tomoya Fukawa, Benjamin Chua Yan-Jiang, Jason Chua Min-Wen, Elwin Tan Jun-Hao, Dan Huang, Chao-Nan Qian, Pauline Ong, Zhimei Li, Shuwen Chen, Shi Ya Mak, Wan Jun Lim, Hiro-omi Kanayama, Rosmin Elsa Mohan, Ruiqi Rachel Wang, Jiunn Herng Lai, Clarinda Chua, Hock Soo Ong, Ker-Kan Tan, Ying Swan Ho, Iain Beehuat Tan & Bin Tean Teh