Dr Ryan Lee Wai Kheong

Associate Consultant, Dept of Maternal Fetal Medicine, KK Women’s and Children’s Hospital

Research Interests

• Gestational Diabetes Mellitus (GDM)
• Recurrent Implantation Failure
• Endometrial Stem Cells

Research Trials

• The effect of local endometrial injury on women with repeated implantation failure in women undergoing in-vitro fertilization - KKHHEF fund
• The role of endometrial stem cells in women with recurrent implantation failure - National Medical Research Council Seed fund Grant
• Lifestyle interventions to prevent postpartum type 2 diabetes in Asian women with a history of gestational diabetes mellitus
• Integrated glycemic profiling of treatment responses for gestational diabetes mellitus

Potential Future Direction of Research

1. Gestational Diabetes Mellitus (GDM) – Evaluating the potential effectiveness of lifestyle interventions on reducing the rate of conversion from gestational diabetes mellitus (GDM) to type 2 diabetes mellitus among Singaporean women can provide cost-effectiveness and predictive data to implement nationwide interventions and improve the accessibility of disease self-management in women.
2. Recurrent Implantation Failure (RIF) – Elucidating the mechanisms governing improved implantation rates after local endometrial injury; investigating the immune milieu and the role of endometrial stem cells in sub-fertile women undergoing in-vitro fertilization increases the possibility of devising approaches to enhance fertility outcomes which is of national significance.

Achievements:

• 2019: Awarded the best international poster presentation by ASPIRE (Asia Pacific Initiative on Reproduction Congress)

• 2017: NMRC Clinician Scientist seed fund for research into the role of endometrial stem cells in sub-fertile women with recurrent implantation failure

• 2016: NMRC Healthcare Research Scholarship to undertake a Masters of Clinical Investigation (MCI) at NUS

• 2014: KKH Health Endowment Fund to study the role of local endometrial injury in women with recurrent implantation failure