Success Stories

Automated EEG Interpretation Software and Integrated Analysis Platform

Supporting Innovation Through Strategic Partnership: How AMII Funding Enabled a Breakthrough in Seizure Detection. 

Patients frequently develop seizures in theneurological intensive care unit (ICU) due to thehigh prevalence of acute structural brain injuries.Continuous electroencephalogram (EEG) is avaluable tool used to screen for “clinically silent”electrographic seizures - aberrant electrical activitythat disrupts brain function and requires timelytreatment for better patient outcomes.

Yet the current process of analysing these prolonged recordings is laboriousand time-consuming, requiring experienced neurotechnologists orneurologists to manually review hours of data. Existing commercial seizuredetection tools have fallen short of meeting clinical needs in the hospitalsdue to the low detection sensitivity.

Recognising this critical gap, the National Neuroscience Institute (NNI) team, in partnership with Mindsigns Health™, sought totransform seizure detection through artificial intelligence. With support from the Academic Medicine Innovation Institute (AMII) Testbeddingand Adoption Grant (TAG), the team was able to further validate this NeuroBrowser™ —an automated, cloud-based AIenabledseizure detection software— previously co-developed between NNI and Mindsigns Health™, on prolonged EEG acquisitionsat NNI @ Tan Tock Seng Hospital (TTSH) and Singapore General Hospital (SGH).

A Remarkable Achievement

The results speak to the team's innovationand rigorous development approach.NeuroBrowser™ demonstrated superiorseizure detection sensitivity comparedwith commercially available software.Modelling studies are underway, and ifcost-effectiveness of software adoptioninto clinical workflows is demonstrated,this will position NeuroBrowser™ as agame-changing screening tool for rapiddetection of potential seizures in the ICUenvironment, directly impacting the patientcare delivery.

Navigating Challenges with Strategic Support

The journey wasn't without its challenges.Working with Mindsigns Health™ broughtthe agility and innovation typical of startuppartnerships but also required carefulnavigation of risks such as financialuncertainty and dependence on keyindividuals. The team's success stemmedfrom early alignment on goals, maintainingagility throughout development, andensuring continuous post-project innovationto keep the solution clinically relevant.The software has already obtained ISO13485 certification, and a licensingagreement with Mindsigns Health™ isunderway. Looking ahead, the successfuldeployment of NeuroBrowser™ couldfundamentally transform neurological careacross Singapore's healthcare system andbeyond. Following further technicalrefinement and acquisition of necessaryregulatory approvals for clinicaldeployment, the solution would bepositioned for broader adoption acrosspublic hospitals, potentially reducing theburden on specialist neurologists, whilstimproving patient outcomes through earlyseizure detection and timely treatment.

Our sincere thanks to Dr Tan Yee Leng and her team for generously sharing their journeys and insights for this project. It is a strong example of how our funding programmes, in this instance, the Academic Medicine Innovation Institute (AMII) Test-bedding and Adoption Grant (TAG) has supported the teams to transform their ideas into tangible results.

Dr Buddy

A*STAR Institute of High Performance Computing (A*STAR IHPC), Singapore General Hospital and the SingHealth Office for Service Transformation have collaborated to develop Dr Buddy, an innovative remote clinical monitoring solution for SingHealth@Home. This system empowers healthcare teams to deliver enhanced care directly to patients' homes, transforming the traditional healthcare delivery model.

Dr Buddy streamlines remote patient monitoring by enabling healthcare professionals to provide timely interventions and personalised care outside hospital settings. The system enhances both patient outcomes and healthcare worker efficiency by facilitating continuous monitoring and early detection of health changes. This innovative solution makes healthcare more accessible and patient-centric, reducing the need for frequent hospital visits whilst maintaining high standards of clinical care.

The partnership exemplifies how inter-agency collaboration and technological innovation can revolutionise healthcare delivery in Singapore, demonstrating the potential for scalable remote monitoring solutions that can be adapted across different healthcare settings.