Regorafenib

• Palms of the hands or soles of the feet may become dry, sore, itchy or numb
• Diarrhea, stomach discomfort, nausea or decreased appetite and weight loss
• High blood pressure
• Some body weakness/fatigue
• Infection
  Maintain hygiene and see the doctor if fever measures above 38°C
• Mouth ulcer or voice changes/hoarseness

Inform your doctor if any of the following occurs:

• Severe ulceration, pain or swelling of the hands or feet
• Signs of unusual bleeding e.g. unexplained bruises or black, sticky stools
• Chest pain/tightness
• Yellowing of the skin or eyes or tea-colored urine
• Severe headache, giddiness, confusion or change in vision
• Severe abdominal pain, nausea, vomiting or fever

 

• Effective birth control measures are recommended for both men and women during treatment and for at least 2 months after stopping treatment. Inform your doctor if pregnancy is intended or suspected.
• Inform your doctor or pharmacist if you have any other medical conditions or if you are taking any other medicines or supplements. Do not self-medicate.
• If you are required to undergo surgery, inform your doctor or dentist that you are taking this medicine. You will most likely be required to stop Regorafenib 2 weeks before surgery.

 

Avoid grapefruit and its juice while you are on this medicine.

Take it once daily at the same time each day for 3 weeks then stop for 1 week. Take the exact number of tablets as instructed by your doctor each time.

Regorafenib should be taken after a low fat meal.

Examples include:

• 2 slides of bread + 1 tablespoon of low-fat margarine + 1 tablespoon of jam + 240mL of skim milk

                                                                                        OR

• 1 cup of cereal + 240mL of skim milk + 1 slice of toast with jam + apple juice + 1 cup of coffee or tea

 

​Take the medicine as soon as you remember. Do not take 2 doses in the same day.

 

If you overdose on this medicine, inform your doctor immediately.

Do not break or crush the tablets.

 

Keep away from children;#Keep in a cool, dry place, away from direct sunlight;#Store at room temperature;#