PRECISE-SG100K Call For Proposals 2026

Background

The PRECISE-SG100K resource is a unique multi-ancestry Asian population cohort dataset comprising ~100,000 Singaporean men and women. The resource provides an opportunity to advance precision medicine and related health research, in Singapore, Asia and the world. 

As part of our first open Call for Proposals in 2024 (CFP 2024), early access to the intermediate data release of 50,000 participants was enabled for Singapore public academic and clinical researchers. The PRECISE-SG100K Scientific Committee selected 37 projects, comprising 9 Flagship Projects and 28 Driver Projects (Details on the projects are available here).

Building on the success of CFP 2024, and in anticipation of releasing baseline data for all ~100,000 participants, PRECISE-SG100K is planning a second Call for Proposals (CFP 2026). Upon launch of this Call, we invite researchers in Singapore to submit proposals that make use of the unique PRECISE-SG100K dataset to advance scientific knowledge and clinical translation.

Funding Details

No funding will be provided through this Call. All approved projects will have access to the standard PRECISE-SG100K Resource linked to Clinical Data. The linked Resource includes:

TRUST (“Trusted Research and Real world-data Utilisation and Sharing Tech” Platform) is a national health-related data governance framework and analytics platform that catalyses health data research and innovation to improve health. It supports public-private partnerships and enables anonymised health-related research and real-world data to be brought together, accessed and used in an expeditious and secure manner.

The linked PRECISE-SG100K Resource will be accessible on the TRUST platform. All data will be pseudonymised. This means that conventional personal identifiers such as date of birth, NRIC, and residential address are removed. This is to preserve the privacy and prevent re-identification of the study participants

Eligibility Criteria

Scope for Proposals

1. The primary focus should be analysis of the PRECISE-SG100K Resource.
2. Research objectives should be focused, ambitious yet achievable.
3. Data use must align with participants' broad consent, which covers research purposes, record linkage, molecular phenotyping, and health-related studies. All data use must also comply with Institutional Review Board approval.
4. External dataset linkages are not currently supported. All approved projects will receive access to the standard linked PRECISE-SG100K Resource.
5. Proposals that seek to generate bulk analysis of the data (e.g. GWAS across a large number of traits) without clear scientific focus are unlikely to be supported.
6. Submitted proposals should not overlap with existing approved projects (refer to PRECISE_SG100K_Flagship_and_Driver_Projects_10Nov2025.pdf)

Project Team

1. Lead Principal Investigator (Lead-PI) – a senior researcher who takes overall responsibility for ensuring the research is completed as described in the proposal.
2. Co-Lead Principal Investigators (Co-Lead PIs) – senior researchers who will help lead the research described. Maximum two Co-Lead PIs.
3. Co-Investigators (Co-Is) – other researchers involved in completion of the research.

One researcher will generally be limited to being Lead-PI for no more than 1 proposal. In addition, Lead-PIs are required to hold a primary appointment in a local publicly funded institution throughout the duration of the project. 

Other Requirements

• There should be no direct or indirect industry partnerships in the applications.
• Proposals should aim to deliver at least 1 major scientific publication within 2 years.
• Approved projects should provide yearly progress reports to the PRECISE-SG100K Scientific Committee.
• Applicants should ensure sufficient funding for their research activities and associated compute costs including analyses on the TRUST platform. No funding will be provided through this Call.
• Where submitted proposals overlap, the PRECISE-SG100K Scientific Committee may encourage the researchers to converge them into a single proposal.

Submission

Step 1: Complete the TRUST Data Request Form

Download and complete the TRUST Data Request Form using the attached cfp2026-tdrform.docx. This form allows you to describe your proposed research activities.

Step 2: Prepare Your Documents

Please prepare the following documents for upload:

• CV of the Principal Investigator
• CV(s) of all Co-Investigator(s), if applicable
• Completed TRUST Data Request Form (from Step 1)

Step 3: Submit Your Application

Please submit completed CFP 2026 application forms via this link (https://form.gov.sg/690dd0103deab4b8f5c6bc46 ) by 14 Feb 2026. Late or incomplete application forms will not be entertained. You will receive a confirmation email once your application has been successfully submitted.

Note:

SingHealth PIs are to please refer to your respective Institutional Research Administrators for guidance on internal deadlines and submission procedures set by your institutions.

Contact person

Please contact the PRECISE-SG100K Secretariat at research@precise.cris.sg.

Additional information

Please refer to the zip file containing the below documents for more information:

• cfp2026-tdrform.docx
• sg100k-sample-evaluation-dataset.zip
• sg100k-datadictionary.xlsx
• PRECISE_SG100K_Flagship_and_Driver_Projects_10Nov2025.pdf

Please refer to the webpage for full details at https://www.npm.sg/call-for-proposals-2026/