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Bridging Perspectives in Academic Medicine: Reflections from A/Prof Chang Ching-yi’s Engagements with SingHealth Duke-NUS Pathology ACP

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Published on 20 August 2026

Associate Professor Chang Ching-yi’s first visit to Singapore in July 2026 since her joint appointment with the SingHealth Duke-NUS Pathology Academic Clinical Programme (ACP) in October 2025 was more than an opportunity to connect with collaborators in person - it marked an important milestone in strengthening the research partnership between Duke University and the SingHealth Duke-NUS Academic Medical Centre (AMC).

A/Prof Chang, Associate Research Professor of Pharmacology and Cancer Biology at Duke University, worked closely with Pathology ACP faculty to shape joint research projects, guide experimental design, provide strategic input in developing grant applications and mentor junior clinicians from Pathology ACP.

From engaging with leaders, clinicians, researchers, and trainees across Pathology ACP and the wider AMC to delivering a Research Grand Round on endocrine therapies for breast and prostate cancer and touring research labs across the AMC, the visit fostered meaningful exchanges, built personal connections, and opened new opportunities for collaboration.
 

On Mentorship, Research and Leadership

Looking back, what first drew you to pathology and cancer research? Was there a defining moment that set you on this path?
Ching-yi:

"My first job after college was in a chemotherapy pharmacy, which gave me an early appreciation for the impact of cancer on patients. As I began research later, I was fascinated by the remarkable adaptability of cancer cells, specifically their ability to alter their biology, interact with their environment, and evolve in response to treatment. That scientific curiosity continues to drive my research today."

A key focus of your joint appointment is mentoring junior clinicians and researchers within Pathology ACP. What do you hope they will gain from working with you?
Ching-yi:

"I hope my mentees will learn to ask important questions, think critically, take ownership of their research, and develop into independent investigators. I also wish to impress upon them the importance of scientific rigour and integrity because a scientist's reputation is built on the credibility of their work."

How has your joint appointment shaped your approach to research and leadership?
Ching-yi:

"The opportunity to engage with faculty and trainees from different backgrounds, and especially those with clinical perspectives, has challenged me to think beyond my immediate field. These interactions will not only influence the scientific questions I pursue but also help me grow as a leader by forcing me to think more broadly about building bridges between groups and fostering collaborations between the two institutions."

On the Joint Appointment

What are you looking forward to next in this collaboration between Duke and SingHealth Duke-NUS, specifically Pathology ACP?
Ching-yi:

"I hope that, through the continued exchange of ideas and the deepening of scientific collaborations, we will be able to ask new research questions that neither group would have envisioned independently. Given the highly translational nature of the research in our laboratory and that at ACP, I am particularly excited about the potential to translate our findings into meaningful clinical advances and ultimately improve patient outcomes." 

For Duke faculty who may be considering a joint appointment with our AMC, what has been the most rewarding aspect(s) of your experience?
Ching-yi:

"The most rewarding experience has been becoming part of this vibrant, diverse, and highly collaborative scientific community, where a culture of open idea-sharing and a genuine enthusiasm for collaboration make every interaction intellectually stimulating." 

Highlights of Singapore Trip

You spent two weeks in July engaging with colleagues across Pathology ACP and the wider SingHealth Duke-NUS AMC. Looking back, what stood out most to you?
Ching-yi:

"All aspects of my visit were great, the most memorable was meeting with faculty, staff, and trainees from diverse disciplines in both individual and group settings. I particularly appreciate their openness and candour in sharing not only their exciting scientific discoveries but also the challenges and obstacles they face in their work. Their honesty, enthusiasm, and collaborative spirit left a lasting impression on me."

As this was your first visit to Singapore, what surprised you most, professionally or personally?
Ching-yi:

"I expected Singapore to be highly urbanised, but I was pleasantly surprised to see so much greenery and how walkable it is. I was also genuinely struck by the warmth, hospitality and openness of everyone I met. From conversations about science to discussions about culture and food, there was a sense of ease that made me feel less like a visitor and more like an old friend!"

During your visit, you met with clinicians, researchers, and trainees, and delivered a Research Grand Round. What were some of the most meaningful scientific discussions or ideas that emerged?
Ching-yi:

"I found the opportunity to engage with investigators from diverse backgrounds and learn about local research and training priorities particularly meaningful. These conversations inspired me to think about how broader interdisciplinary collaborations can be incorporated into my own research and how we can leverage our complementary expertise and resources to develop successful joint grant opportunities."

On Collaboration Opportunities

Your visit sparked plans for joint research in breast and prostate cancer. Which areas are you particularly excited to pursue together?
Ching-yi:

"We have already initiated a joint effort to validate one of the promising new targets we recently identified which may play a role in disease progression during endocrine therapy. We are particularly excited to investigate its therapeutic significance in both prostate and breast cancers. I believe by combining our expertise we can accelerate the validation of this pathway and translate our findings to the clinic."

There are also plans to collaborate with Pathology ACP on future ACP and national grant calls. In your experience, what does it take to build an international partnership that lasts?
Ching-yi:

"A few things come to mind: strong personal relationships, shared scientific interest, complementary expertise, mutual benefit, and regular interactions to maintain engagement. I believe we already check many of these boxes, the key now is to remain committed to ensure that the partnership stays productive for the long term."

The joint appointment scheme recognises Duke faculty who possess critical skills and expertise that complement our ACPs and provide mentoring support for our clinician-researchers in the AMC, made possible through partial FTE funding of Duke faculty by the Office of Academic Medicine. For more information, visit this page.