Skip Ribbon Commands
Skip to main content

Cyproterone Acetate + Ethinylestradiol

Drug Class: Commonly Known As: Category:
Contraceptive Estelle-35/35 ED Adult

Cyproterone Acetate + Ethinylestradiol - What is it for

​Estelle™-35 is used for treatment of moderate to severe acne related to androgen-sensitivity, with or without seborrhea or mild forms of hirsutism (excessive hair growth in certain area of face and body), in women of reproductive age. It also provides effective oral contraception in women being treated for the above conditions.

If you are taking Estelle™-35 for the condition above, you must not take any other hormonal contraceptive at the same time.

Cyproterone Acetate + Ethinylestradiol - Side Effects, Precautions, and Contraindications

What side effects can Cyproterone Acetate + Ethinylestradiol cause?

Spotting or bleeding may occur between your periods during the first 1-2 months of taking oral contraceptives. However, if this continues after the second month, consult your doctor.

Other common side effects that you may experience include:

  • Nausea, vomiting, bloating and abdominal cramps. Take the medication after food to minimise gastric side effects.
  • Breast tenderness. Decrease salt intake and drink more water to help your body expel excess water.
  • Headache or migraine. Paracetamol can be taken to manage headaches.
  • Intolerance to contact lenses
  • Weight changes, mood swings. To take the medication at the same time everyday to avoid large hormonal fluctuations.
  • Pigmentation of the skin. Apply sunblock when outdoors and avoid long hours of sun exposure.

Consult your doctor about any symptom that becomes bothersome.​

Using a combined hormonal pill increases a woman’s risk of developing blood clots compared with a woman not taking any combined hormonal pill. The risk of developing blood clot in a vein is highest during the first year a woman uses the pill. Other risk factors of developing blood clots include smoking and obesity. However, blood clot formation is rare and the doctor would have evaluated and weighed its benefits over risks before making the recommendation.

Report to your doctor if you are experiencing any of the following symptoms:

  • Any unusual sudden cough
  • Severe pain in the chest which may reach the left arm
  • Change in your speech, including slurring of words
  • Change in your senses of hearing, smell or taste
  • Breathlessness or difficulty in breathing
  • Unusual, severe or long lasting headache or worsening of migraine
  • Dizziness or fainting
  • Severe pain in your abdomen
  • Severe pain in legs or swelling in either of your legs.
  • Weakness or numbness in any part of your body

Before taking Cyproterone Acetate + Ethinylestradiol, what precautions must I follow?

What food or medicine must I avoid when I take Cyproterone Acetate + Ethinylestradiol?

Cyproterone Acetate + Ethinylestradiol - Dosage and How to Use

How should Cyproterone Acetate + Ethinylestradiol be used?

The tablets should be taken at the same time daily after food. If you are also using it for contraceptive purposes, a barrier method of contraception e.g. condoms, is recommended for the first 7 days the first time you begin taking Estelle™-35.

For the first pack of oral contraceptives, take the first tablet on the ____ day of your menses.

It comes in a 21-day pack: which has 21 active tablets. Your menses should begin during the 7-day tablet-free period. Even if your menses is still ongoing, subsequent pack is to be started after the 7-day tablet free period has elapsed.

What should I do if I miss a dose?

Within 12 hours:
Take the missed pill as soon as remembered, then resume taking the next one at the regular time.

More than 12 hours:

  • Week 1 & 2: Take the missed pill as soon as remembered, even if it means taking 2 pills at the same time. Continue to take pills at your usual time. Use a barrier method for the next 7 days.
  • Week 3: Take the missed pill as soon as remembered, even if it means taking 2 pills at the same time. Continue to take pills at your usual time and start the next pack right away without the 7-day tablet free period. Your menses may not come until the next pack is finished, but there is no need to worry. However, if your menses does not occur after the next pack is finished, you should take a pregnancy test to rule out pregnancy.

If vomiting and diarrhea occurs within 4 hours of taking oral contraceptives, the tablet may not be absorbed. It is considered a missed dose. You should then follow instructions above.

What should I do if I overdose?

Cyproterone Acetate + Ethinylestradiol - Handling and Storage

How should I handle Cyproterone Acetate + Ethinylestradiol safely?

How should I store Cyproterone Acetate + Ethinylestradiol?

Keep away from children;#Keep in a cool, dry place, away from direct sunlight;#

How should I dispose of Cyproterone Acetate + Ethinylestradiol safely?

Cyproterone Acetate + Ethinylestradiol - Additional Information

Updated on Friday, March 31, 2023

This article is contributed by PSS National Medication Information Workgroup PSS National Medication Information Workgroup

The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

Medication Search