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Tan Bingyao
Dr Tan Bingyao

PhD

Researcher Interests
  • Ocular imaging
  • Optical instrumentation
  • 3D retinal vasculature
  • Physics-informed generative AI

Research Appointments

Senior Research Fellow

Ocular Imaging Research Group, SERI

Academic Appointments

Assistant Professor

Ophthalmology & Visual Sciences Academic Clinical Programme

About Researcher

Dr Bingyao Tan obtained his PhD in physics from the University of Waterloo in 2017. In 2018, he joined Singapore Eye Research Institute as a researcher under the SERI-NTU Advanced Ocular Engineering (STANCE) programme.

Dr Bingyao Tan’s research lies at the intersection between optical imaging and ophthalmology, with a particular focus on understanding the structure and function of the eye using advanced optical imaging and image processing methods. His collaborations with clinicians at the Singapore National Eye Centre have allowed Dr Bingyao Tan to expand his research beyond biomedical engineering to highly translational studies, including in vivo neuronal function detection, ocular shape analysis, and angiography.

Education & Training

  • PhD (Canada) (2017)
  • BSc (China) (2012)

Professional Appointments & Committee Memberships

  • Member, ARVO (2014 – present)     
  • Member, SPIE (2014 – present)      
  • Visiting researcher, Singapore-MIT Alliance for Research and Technology (2022 – 2023)

Awards

  • Outstanding Young Researcher, Singapore Eye Research Institute (2024)      
  • Knights Templar Eye Foundation Travel Fellowship Award (2024)

Research Interests

  • Ocular imaging
  • Optical instrumentation   
  • 3D retinal vasculature    
  • Physics-informed generative AI

Publications

  1. Tan B*, Li H*, Zhuo Y, Han L, Mupparapu R, Nanni D, Barathi VA, Palanker D, Schmetterer L, Ling T, Light-evoked deformations in rod photoreceptors, pigment epithelium and subretinal space revealed by prolonged and multilayered optoretinography. 2024, Nature Comm, 15(1), 5156.
  2. Tan B, Chua J, Wong D, Liu X, Ismail M, Schmetterer L., Techniques for imaging the choroid and choroidal blood flow in vivo, Exp Eye Res, 2024 Aug 16:110045.
  3. Ahmed TS, Shah J, Zhen YN, Chua J, Wong DW, Nusinovici S, Tan R, Tan G, Schmetterer L and Tan B, 2024. Ocular microvascular complications in diabetic retinopathy: insights from machine learning. BMJ Open Diabetes Res Care, 12(1), p.e003758.
  4. Tan B, Lim NA, Tan R, Gan AT, Chua J, Nusinovici S, Cheung CM, Chakravarthy U, Wong TY, Schmetterer L, Tan G. Combining retinal and choroidal microvascular metrics improves discriminative power for diabetic retinopathy. Br J Ophthalmol. 2023 Jul 1;107(7):993-9. 
  5. Han L*, Tan B*, Hosseinaee Z, Chen LK, Hileeto D, Bizheva K. Line-scanning SD-OCT for in-vivo, non-contact, volumetric, cellular resolution imaging of the human cornea and limbus. Biomed Opt Express. 2022 Jul 1;13(7):4007-20.
  6. Tan B*, McNabb RP*, Zheng F, Sim YC, Yao X, Chua J, Ang M, Hoang QV, Kuo AN, Schmetterer L. Ultrawide field, distortion-corrected ocular shape estimation with MHz optical coherence tomography (OCT). Biomed Opt Express. 2021 Aug 23;12(9):5770-5781.
  7.  Tan B, Chua J, Lin E, Cheng J, Gan A, Yao X, Wong DWK, Sabanayagam C, Wong D, Chan CM, Wong TY, Schmetterer L, Tan GS. Quantitative Microvascular Analysis With Wide-Field Optical Coherence Tomography Angiography in Eyes With Diabetic Retinopathy. JAMA Netw Open. 2020 Jan 3;3(1):e1919469.
  8. Tan B*, Hosseinaee Z*, Han L, Kralj O, Sorbara L, Bizheva K. 250 kHz, 1.5 µm resolution SD-OCT for in-vivo cellular imaging of the human cornea. Biomed Opt Express. 2018 Nov 29;9(12):6569-6583.
  9. Tan B, Mason E, MacLellan B, Bizheva KK. Correlation of visually evoked functional and blood flow changes in the rat retina measured with a combined OCT+ERG system. Invest Ophthalmol Vis Sci. 2017 Mar 1;58(3):1673-1681.

Research Trials

  • Mapping whole-retina vasculature in rodents (2023 – present)
  • Physics-informed generative AI for retinal vasculature synthesis (2023 – present)
  • Optoretinography – in vivo retinal neuronal function detection (2022 – present)
  • Ocular shape analysis using ultrawide, ultrafast optical coherence tomography (2020 – present)