From latest to earliest:
Artificial intelligence and high-dimensional technologies in the theragnosis of systemic lupus erythematous. Katherine Nay Yaung, Joo Guan Yeo, Pavanish Kumar, Martin Wasser, Marvin Chew, Angelo Ravelli, Annie Hui Nee Law, Thaschawee Arkachaisri, Alberto Martini, David S Pisetsky, Salvatore Albani. The Lancet Rheumatology Volume 5, Issue 3, March 2023, Pages e151-e165. https://doi.org/10.1016/S2665-9913(23)00010-3
New perspectives on the origins and heterogeneity of mast cells. St John AL, Rathore APS, Ginhoux F. Nat Rev Immunol. 2023 Jan;23(1):55-68. https://doi.org/10.1038/s41577-022-00731-2
Compartmentalization and persistence of dominant (regulatory) T cell clones indicates antigen skewing in juvenile idiopathic arthritis. Gerdien Mijnheer, Nila Hendrika Servaas, Jing Yao Leong, Arjan Boltjes, Eric Spierings, Phyllis Chen, Liyun Lai, Alessandra Petrelli, Sebastiaan Vastert, Rob J de Boer, Salvatore Albani, Aridaman Pandit, Femke van Wijk. Elife. 2023 Jan 23;12:e79016. https://doi.org/10.7554/eLife.79016
COVID-19 mRNA vaccine immunogenicity decay and breakthrough illness in adolescents and young adults with childhood-onset rheumatic diseases. Yeo JG, Teh KL, Ni Chia W, Book YX, Hoh SF, Gao X, Das L, Zhang J, Sutamam N, Poh SL, Lim AJM, Tay SH, Nay Yaung K, Ong XM, Leong JY, Wang LF, Albani S, Arkachaisri T. Rheumatology (Oxford). 2023 Jan 20:kead031. https://doi.org/10.1093/rheumatology/kead031
IFNγ-IL-17+ CD8 T cells contribute to immunosuppression and tumor progression in human hepatocellular carcinoma. Yun Hua Lee, Samuel Chuah, Phuong H D Nguyen, Chun Jye Lim, Hannah L H Lai, Martin Wasser, Camillus Chua, Tony K H Lim, Wei Qiang Leow, Tracy Jiezhen Loh, Wei Keat Wan, Yin Huei Pang, Gwyneth Soon, Peng Chung Cheow, Juinn Huar Kam, Shridhar Iyer, Alfred Kow, Glenn K Bonney, Chung Yip Chan, Alexander Chung, Brian K P Goh, Weiwei Zhai, Pierce K H Chow, Salvatore Albani, Haiyan Liu, Valerie Chew. Cancer Letters. 2023 Jan 1;552:215977. https://doi.org/10.1016/j.canlet.2022.215977
A phase I study of an adenoviral vector delivering a MUC1/CD40-ligand fusion protein in patients with advanced adenocarcinoma. Tira J. Tan, W. X. Gladys Ang, Who-Whong Wang, Hui-Shan Chong, Sze Huey Tan, Rachael Cheong, John Whay-Kuang Chia, Nicholas L. Syn, Wai Ho Shuen, Rebecca Ba, Nivashini Kaliaperumal, Bijin Au, Richard Hopkins, Xinhua Li, Aaron C. Tan, Amanda O. L. Seet, John E. Connolly, Thaschawee Arkachaisri, Valerie Chew, Ahmad bin Mohamed Lajam, Dianyan Guo, Marvin Z. W. Chew, MartinWasser, Pavanish Kumar, Salvatore Albani & Han Chong Toh. Nature Communications. 2022 Oct 28;13(1):6453. http://doi.org/10.1038/s41467-022-33834-4
Single-cell transcriptomics and surface epitope detection in human brain epileptic lesions identifies pro-inflammatory signaling. Pavanish Kumar, Amanda Lim, Sharifah Nur Hazirah, Camillus Jian Hui Chua, Adeline Ngoh, Su Li Poh, Tong Hong Yeo, Jocelyn Lim, Simon Ling, Nursyuhadah Binte Sutamam, Enrico Petretto, David Chyi Yeu Low, Li Zeng, Eng-King Tan, Thaschawee Arkachaisri, Joo Guan Yeo, Florent Ginhoux, Derrick Chan, Salvatore Albani. Nature Neuroscience. 2022 Jul;25(7):956-966. https://doi.org/10.1038/s41593-022-01095-5
Response to contamination of isolated mouse Kupffer cells with liver sinusoidal endothelial cells. Iannacone M, Blériot C, Andreata F, Ficht X, Laura C, Garcia-Manteiga JM, Uderhardt S, Ginhoux F. Immunity. 2022 Jul 12;55(7):1141-1142. https://doi.org/10.1016/j.immuni.2022.06.012
Role of adipose tissue macrophages in obesity-related disorders. Chakarov S, Blériot C, Ginhoux F. Journal of Experimental Medicine. 2022 Jul 4;219(7):e20211948. https://doi.org/10.1084/jem.20211948
Toward Molecular Stratification and Precision Medicine in Systemic Sclerosis. Maria Noviani, Vasuki Ranjani Chellamuthu, Salvatore Albani, Andrea Hsiu Ling Low. Frontiers in Medicine. 2022 Jun 30;9:911977. https://doi.org/10.3389/fmed.2022.911977
Infection of lung megakaryocytes and platelets by SARS-CoV-2 anticipate fatal COVID-19. Zhu A, Real F, Capron C, Rosenberg AR, Silvin A, Dunsmore G, Zhu J, Cottoignies-Callamarte A, Massé JM, Moine P, Bessis S, Godement M, Geri G, Chiche JD, Valdebenito S, Belouzard S, Dubuisson J, Lorin de la Grandmaison G, Chevret S, Ginhoux F, Eugenin EA, Annane D, Bordé EC, Bomsel M. Cellular and Molecular Life Sciences. 2022 Jun 16;79(7):365. https://doi.org/10.1007/s00018-022-04318-x
Unravelling the sex-specific diversity and functions of adrenal gland macrophages. Dolfi B, Gallerand A, Firulyova MM, Xu Y, Merlin J, Dumont A, Castiglione A, Vaillant N, Quemener S, Gerke H, Stunault MI, Schrank PR, Kim SH, Zhu A, Ding J, Gilleron J, Magnone V, Barbry P, Dombrowicz D, Duranton C, Wakkach A, Blin-Wakkach C, Becher B, Pagnotta S, Argüello RJ, Rantakari P, Chakarov S, Ginhoux F, Zaitsev K, Kim KW, Yvan-Charvet L, Guinamard RR, Williams JW, Ivanov S. Cell Reports. 2022 Jun 14;39(11):110949. https://doi.org/10.1016/j.celrep.2022.110949
Biology of resident tissue macrophages. Lee CZW, Ginhoux F. Development. 2022 Apr 15;149(8):dev200270. https://doi.org/10.1242/dev.200270
Trajectory of immune evasion and cancer progression in hepatocellular carcinoma. Phuong H. D. Nguyen, Martin Wasser, Chong Teik Tan, Chun Jye Lim, Hannah L. H. Lai, Justine Jia Wen Seow, Ramanuj DasGupta , Cheryl Z. J. Phua, Siming Ma, Jicheng Yang, Sheena D/O Suthen, Wai Leong Tam, Tony K. H. Lim, Joe Yeong, Wei Qiang Leow, Yin Huei Pang, Gwyneth Soon, Tracy Jiezhen Loh, Wei Keat Wan, Chung Yip Chan, Peng Chung Cheow, Han Chong Toh, Alfred Kow, Yock Young Dan, Juinn Huar Kam, Shridhar Iyer, Krishnakumar Madhavan, Alexander Chung, Glenn K. Bonney, Brian K. P. Goh, Naiyang Fu, Victor C. Yu, Weiwei Zhai, Salvatore Albani, Pierce K.H. Chow & Valerie Chew. Nature Communications. (2022)13:1441. https://doi.org/10.1038/s41467-022-29122-w
Pro-inflammatory derangement of the Immuno-Interactome in Heart Failure. Kumar Pavanish, Amanda Lim, Poh Su Li, Sharifah Nur Hazirah, Camillus Jian Hui Chua, Nursyuhadah Binte Sutamam, Thaschawee Arkachaisri, Joo Guan Yeo, Kofidis Theodoros, Vitaly Sorokin, Carolyn Su Ping Lam, Mark Richards and Salvatore Albani. Frontiers in Immunology. March 2022. Volume 13. Article 817514. https://doi.org/10.3389/fimmu.2022.817514
Robust neutralizing antibody response to SARS-CoV-2 mRNA vaccination in adolescents and young adults with childhood-onset rheumatic diseases. Joo Guan Yeo, Wan Ni Chia, Kai Liang Teh, Yun Xin Book, Sook Fun Hoh, Xiaocong Gao, Lena Das, Jinyan Zhang, Nursyuhadah Sutamam, Amanda Jin Mei Lim, Su Li Poh, Shi Huan Tay, Katherine Nay Yaung, Xin Mei Ong, Sharifah Nur Hazirah, Camillus Jian Hui Chua, Jing Yao Leong, Lin-Fa Wang, Salvatore Albani and Thaschawee Arkachaisri. Rheumatology 2022;00:1–10. https://doi.org/10.1093/rheumatology/keac105
Hypoxia-driven immunosuppression by Treg and type-2 conventional dendritic cells in hepatocellular carcinoma. Sheena D/O Suthen, Chun Jye Lim, Phuong H.D. Nguyen, Charles-Antoine Dutertre, Hannah L.H. Lai, Martin Wasser, Camillus Chua, Tony K.H. Lim, Wei Qiang Leow, Tracy Jiezhen Loh, Wei Keat Wan, Yin Huei Pang, Gwyneth Soon, Peng Chung Cheow, Juinn Huar Kam, Shridhar Iyer, Alfred Kow, Wai Leong Tam, Timothy W.H. Shuen, Han Chong Toh, Yock Young Dan, Glenn K. Bonney, Chung Yip Chan, Alexander Chung, Brian K.P. Goh, Weiwei Zhai, Florent Ginhoux, Pierce K.H. Chow, Salvatore Albani, Valerie Chew. Hepatology. 2022;00:1–16. https://doi.org/10.1002/hep.32419
Neutralizing Activity and SARS-CoV-2 Vaccine mRNA Persistence in Serum and Breastmilk After BNT162b2 Vaccination in Lactating Women. Kee Thai Yeo, Wan Ni Chia, Chee Wah Tan, Chengsi Ong, Joo Guan Yeo, Jinyan Zhang, Su Li Poh, Amanda Jin Mei Lim, Kirsten Hui Zhi Sim, Nursyuhadah Sutamam, Camillus Jian Hui Chua, Salvatore Albani, Lin-Fa Wang and Mei Chien Chua. Frontiers in Immunology. January 2022, Volume 12, Article 783975. https://doi.org/10.3389/fimmu.2021.783975
IL11 is elevated in systemic sclerosis and IL11-dependent ERK signalling underlies TGFβ-mediated activation of dermal fibroblasts. Eleonora Adami, Sivakumar Viswanathan, Anissa A Widjaja, Benjamin Ng, Sonia Chothani , Nevin Zhihao, Jessie Tan, Pei Min Lio, Benjamin L George, Umut Altunoglu, Kakaly Ghosh, Bhairav S Paleja, Sebastian Schafer, Bruno Reversade, Salvatore Albani, Andrea Low Hsiu Ling, Steven O'Reilly, Stuart A Cook. Rheumatology, Volume 60, Issue 12, December 2021. https://doi.org/10.1093/rheumatology/keab168
Reply to Over-celling fetal microbial exposure. Archita Mishra, Leong Jing Yao, Martin Wasser, Costerwell Khyriem, Benoit Malleret, Naomi McGovern, Salvatore Albani, Jerry Kok Yen Chan and Florent Ginhoux. Cell 184, November 24, 2021. https://doi.org/10.1016/j.cell.2021.10.028
Immune implication of an autophagy-related prognostic signature in uveal melanoma. Samuel Chuah, Valerie Chew. Biosci Rep (2021) 41 (8): BSR20211098. https://doi.org/10.1042/BSR20211098
Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in Hepatocellular Carcinoma: the PLANET study. Weiwei Zhai, Hannah Lai, Neslihan Arife Kaya, Chen Jianbin, Hechuan Yang, Bingxin Lu, Jia Qi Lim, Siming Ma, Sin Chi Chew, Khi Pin Chua, Jacob Josiah Santiago Alvarez, Pauline Jieqi Chen, Mei Mei Chang, Lingyan Wu, Brian KP Goh, AY-F Chung, Chung Yip Chan, Peng Chung Cheow, Ser Yee Lee, Juinn Huar Kam, AW-C Kow, Shridhar Ganpathi Iyer, Rawisak Chanwat, Jidapa Thammasiri, Boon Koon Yoong, DB-L Ong, Vanessa H de Villa, Rouchelle D Dela Cruz, Tracy Jiezhen Loh, Wei Keat Wan, Zeng Zeng, Anders Jacobsen Skanderup, Yin Huei Pang, Krishnakumar Madhavan, TK-H Lim, Glenn Bonney, Wei Qiang Leow, Valerie Chew, Yock Young Dan, Wai Leong Tam, Han Chong Toh, RS-Y Foo, PK-H Chow. National Science Review (2021). https://doi.org/10.1093/nsr/nwab192
Identification of a Kupffer cell subset capable of reverting the T cell dysfunction induced by hepatocellular priming. Giorgia De Simone, Francesco Andreata, Camille Bleriot, Valeria Fumagalli, Chiara Laura, Jose ì M. Garcia-Manteiga, Pietro Di Lucia, Stefano Gilotto, Xenia Ficht, Federico F. De Ponti, Elisa B. Bono, Leonardo Giustini, Gioia Ambrosi, Marta Mainetti, Paola Zordan, Alexandre P. Be ì ne ì chet, Micol Rava, Svetoslav Chakarov, Federica Moalli, Marc Bajenoff, Luca G. Guidotti, Florent Ginhoux, and Matteo Iannacone. Immunity (2021). https://doi.org/10.1016/j.immuni.2021.05.005
A subset of Kupffer cells regulates metabolism through the expression of CD36. Camille Ble´riot, Emelie Barreby, Garett Dunsmore, Raphaelle Ballaire, Svetoslav Chakarov, Xenia Ficht, Giorgia De Simone, Francesco Andreata, Valeria Fumagalli,5 Wei Guo, Guochen Wan, Gregoire Gessain, Ahad Khalilnezhad, Xiao Meng Zhang, Nicholas Ang, Ping Chen, Cecilia Morgantini, Valerio Azzimato, Wan Ting Kong, Zhaoyuan Liu, Rhea Pai, Josephine Lum, Foo Shihui, Ivy Low,1 Connie Xu, Benoit Malleret, Muhammad Faris Mohd Kairi, Akhila Balachander, Olivier Cexus, Anis Larbi, Bernett Lee, Evan W. Newell, Lai Guan Ng, Wint Wint Phoo, Radoslaw M. Sobota, Ankur Sharma, Shanshan W. Howland, Jinmiao Chen, Marc Bajenoff, Laurent Yvan-Charvet, Nicolas Venteclef, Matteo Iannacone, Myriam Aouadi, and Florent Ginhoux. Immunity (2021). https://doi.org/10.1016/j.immuni.2021.08.006
Cross-tissue single-cell landscape of human monocytes and macrophages in health and disease. Kevin Mulder, Amit Ashok Patel, Wan Ting Kong, Cécile Piot, Evelyn Halitzki, Garett Dunsmore, Shabnam Khalilnezhad, Sergio Erdal Irac, Agathe Dubuisson, Marion Chevrier, Xiao Meng Zhang, John Kit Chung Tam, Tony Kiat Hon Lim, Regina Men Men Wong, Rhea Pai, Ahmed Ibrahim Samir Khalil, Pierce Kah Hoe Chow, Suny Z. Wu, Ghamdan Al-Eryani, Daniel Roden, Alexander Swarbrick, Jerry Kok Yen Chan, Salvatore Albani, Lisa Derosa, Laurence Zitvogel, Ankur Sharma, Jinmiao Chen, Aymeric Silvin, Antonio Bertoletti, Camille Blériot, Charles-Antoine Dutertre, Florent Ginhoux. Immunity. (2021). https://doi.org/10.1016/j.immuni.2021.07.007
Microbial exposure during early human development primes fetal immune cell. Archita Mishra, Ghee Chuan Lai, Leong Jing Yao, Thet Tun Aung, Noam Shental, Aviva Rotter-Maskowitz, Edwin Shepherdson, Gurmit Singh Naranjan Singh, Rhea Pai, Adhika Shanti, Regina Men Men Wong, Andrea Lee, Costerwell Khyriem, Charles Antoine Dutertre, Svetoslav Chakarov, K.G. Srinivasan, Nurhidaya Binte Shadan, Xiao-Meng Zhang, Shabnam Khalilnezhad, Fabien Cottier, Alrina Shin Min Tan, Gillian Low, Phyllis Chen, Yiping Fan, Pei Xiang Hor, Avery Khoo May Lee, Mahesh Choolani, David Vermijlen, Ankur Sharma, Garold Fuks, Ravid Straussman, Norman Pavelka, Benoit Malleret, Naomi McGovern, Salvatore Albani, Jerry Kok Yen Chan and Florent Ginhoux. Cell. 2021 May 25;S0092-8674(21)00574-2. https://www.cell.com/cell/pdf/S0092-8674(21)00574-2.pdf
A Virus-Specific Immune Rheostat in the Immunome of Patients Recovering From Mild COVID-19. Joo Guan Yeo, Jing Yao Leong, Shi Huan Tay, Karen Donceras Nadua, Danielle E. Anderson, Amanda Jin Mei Lim, Xiang Wen Ng, Su Li Poh, Dianyan Guo, Katherine Nay Yaung, Pavanish Kumar, Martin Wasser, Sharifah Nur Hazirah, Nursyuhadah Sutamam, Camillus Jian Hui Chua, Martin Qui, Randy Foo, Akshamal Mihiranga Gamage, Kee Thai Yeo, Lakshmi Ramakrishna, Thaschawee Arkachaisri, Barnaby E. Young, David Chien Lye, Lin-Fa Wang, Chia Yin Chong, Natalie Woon Hui Tan, Jiahui Li, Kai-Qian Kam, Florent Ginhoux, Koh Cheng Thoon, Jerry Kok Yen Chan, Chee Fu Yung and Salvatore Albani. Front Immunol. 2021 May 25;12:674279. https://pubmed.ncbi.nlm.nih.gov/34113347/#affiliation-1
Juvenile Spondyloarthritis: What More Do We Know About HLA-B27, Enthesitis, and New Bone Formation? Shi Huan Tay, Joo Guan Yeo, Jing Yao Leong, Salvatore Albani and Thaschawee Arkachaisri. Front. Med., 20 May 2021. https://www.frontiersin.org/articles/10.3389/fmed.2021.666772/full
MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche. Ningbo Wu, Hongxiang Sun, Xiaoyun Zhao, Yao Zhang, Jianmei Tan, Yuanyuan Qi, Qun Wang, Melissa Ng, Zhaoyuan Liu, Lingjuan He, Xiaoyin Niu, Lei Chen, Zhiduo Liu, Hua-Bing Li, Yi Arial Zeng, Manolis Roulis, Dou Liu, Jinke Cheng, Bin Zhou, Lai Guan Ng, Duowu Zou, Youqiong Ye, Richard A Flavell, Florent Ginhoux, Bing Su. Nature volume 592, pages 606–610 (2021). https://www.nature.com/articles/s41586-021-03283-y
Immunological Hallmarks for Clinical Response to BCG in Bladder Cancer. Chun Jye Lim, Phuong Hoang Diem Nguyen, Martin Wasser, Pavanish Kumar, Yun Hua Lee, Nurul Jannah Mohamed Nasir, Camillus Chua, Liyun Lai, Sharifah Nur Hazirah, Josh Jie Hua Loh, Li Yan Khor, Joe Yeong, Tony Kiat Hon Lim, Alvin Wei Xiang Low, Salvatore Albani, Tsung Wen Chong and Valerie Chew. Front. Immunol., 29 January 2021. https://www.frontiersin.org/articles/10.3389/fimmu.2020.615091/full
Intratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma. Phuong H. D. Nguyen, Siming Ma, Cheryl Z. J. Phua, Neslihan A. Kaya, Hannah L. H. Lai, Chun Jye Lim, Jia Qi Lim, Martin Wasser, Liyun Lai, Wai Leong Tam, Tony K. H. Lim, Wei Keat Wan, Tracy Loh, Wei Qiang Leow, Yin Huei Pang, Chung Yip Chan, Ser Yee Lee, Peng Chung Cheow, Han Chong Toh, Florent Ginhoux, Shridhar Iyer, Alfred W. C. Kow, Yock Young Dan, Alexander Chung, Brian K. P. Goh, Salvatore Albani, Pierce K. H. Chow, Weiwei Zhai & Valerie Chew. NATURE COMMUNICATIONS (2021)12:227. https://www.nature.com/articles/s41467-020-20171-7.pdf
Fetal mast cells mediate postnatal allergic responses dependent on maternal IgE. Rasha Msallam, Jozef Balla, Abhay P. S. Rathore, Hassen Kared, Benoit Mallere, Wilfried A. A. Saron, Zhaoyuan Liu, Jing Wen Hang, Charles Antoine Dutertre, Anis Larbi, Jerry K. Y. Chan, Ashley L. St. John2, Florent Ginhoux. Science 20 Nov 2020: Vol. 370, Issue 6519, pp. 941-950. https://science.sciencemag.org/content/370/6519/941/tab-pdf
Genetic models of human and mouse dendritic cell development and function. Anderson DA 3rd, Dutertre CA, Ginhoux F, Murphy KM. Nature Reviews Immunology volume 21, pages 101–115 (2021). https://www.nature.com/articles/s41577-020-00413-x
Combinatorial Single-Cell Analyses of Granulocyte-Monocyte Progenitor Heterogeneity Reveals an Early Uni-potent Neutrophil Progenitor. Kwok I, Becht E, Xia Y, Ng M, Teh YC, Tan L, Evrard M, Li JLY, Tran HTN, Tan Y, Liu D, Mishra A, Liong KH, Leong K, Zhang Y, Olsson A, Mantri CK, Shyamsunder P, Liu Z, Piot C, Dutertre CA, Cheng H, Bari S, Ang N, Biswas SK, Koeffler HP, Tey HL, Larbi A, Su IH, Lee B, St John A, Chan JKY, Hwang WYK, Chen J, Salomonis N, Chong SZ, Grimes HL, Liu B, Hidalgo A, Newell EW, Cheng T, Ginhoux F, Ng LG. Immunity Volume 53, Issue 2, 18 August 2020, Pages 303-318.e5.https://www.sciencedirect.com/science/article/abs/pii/S1074761320302351
Systemic Sclerosis Perturbs the Architecture of the Immunome. Bhairav Paleja, Andrea Hsiu Ling Low, Pavanish Kumar, Suzan Saidin, Ahmad Lajam, Sharifah Nur Hazirah, Camillus Chua, Lai Li Yun and Salvatore Albani. Front. Immunol., 06 August 2020. https://www.frontiersin.org/articles/10.3389/fimmu.2020.01602/full
Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19. Silvin A, Chapuis N, Dunsmore G, Goubet AG, Dubuisson A, Derosa L, Almire C, Hénon C, Kosmider O, Droin N, Rameau P, Catelain C, Alfaro A, Dussiau C, Friedrich C, Sourdeau E, Marin N, Szwebel TA, Cantin D, Mouthon L, Borderie D, Deloger M, Bredel D, Mouraud S, Drubay D, Andrieu M, Lhonneur AS, Saada V, Stoclin A, Willekens C, Pommeret F, Griscelli F, Ng LG, Zhang Z, Bost P, Amit I, Barlesi F, Marabelle A, Pène F, Gachot B, André F, Zitvogel L, Ginhoux F, Fontenay M, Solary. Cell 182, 1401–1418 September 17, 2020. https://www.cell.com/cell/pdf/S0092-8674(20)30993-4.pdf
Kidney dendritic cells: fundamental biology and functional roles in health and disease. Kurts C, Ginhoux F, Panzer U. Nature Reviews Nephrology volume 16, pages 391–407 (2020). https://www.nature.com/articles/s41581-020-0272-y
Immunohistochemical scoring of CD38 in the tumor microenvironment predicts responsiveness to anti-PD-1/PD-L1 immunotherapy in hepatocellular carcinoma. Harry Ho Man Ng, Ren Yuan Lee, Siting Goh, Isabel Shu Ying Tay, Xinru Lim, Bernett Lee, Valerie Chew, Huihua Li, Benedict Tan, Sherlly Lim, Jeffrey Chun Tatt Lim, Bijin Au, Josh Jie Hua Loh, Sahil Saraf, John Edward Connolly, Tracy Loh, Wei Qiang Leow, Joycelyn Jie Xin Lee, Han Chong Toh, Fabio Malavasi, Ser Yee Lee, Pierce Chow, Evan W Newell, Su Pin Choo, David Tai, Joe Yeong, Tony Kiat Hon Lim. J Immunother Cancer 2020;8:e000987. https://jitc.bmj.com/content/jitc/8/2/e000987.full.pdf
Fibroblast-specific IL11 signaling drives chronic inflammation in murine fibrotic lung disease. Benjamin Ng, Jinrui Dong, Sivakumar Viswanathan, Anissa A. Widjaja2, Bhairav S. Paleja, Eleonora Adami, Nicole S. J. Ko, Mao Wang, Stella Lim, Jessie Tan1, Sonia P. Chothani, Salvatore Albani, Sebastian Schafer, Stuart A. Cook. The FASEB Journal. 2020;34:11802–11815. https://faseb.onlinelibrary.wiley.com/doi/epdf/10.1096/fj.202001045RR
Determinants of Resident Tissue Macrophage Identity and Function. Blériot C, Chakarov S, Ginhoux F. Immunity Volume 52, Issue 6, 16 June 2020, Pages 957-970. https://www.cell.com/immunity/ppt/S1074-7613(20)30230-2.ppt
Deciphering human macrophage development at single-cell resolution. Bian Z, Gong Y, Huang T, Lee CZW, Bian L, Bai Z, Shi H, Zeng Y, Liu C, He J, Zhou J, Li X, Li Z, Ni Y, Ma C, Cui L, Zhang R, Chan JKY, Ng LG, Lan Y, Ginhoux F, Liu B. Nature 2020 Jun;582(7813):571-576. https://www.nature.com/articles/s41586-020-2316-7
Towards the better understanding of myelopoiesis using single-cell technologies. Dress RJ, Liu Z, Ginhoux F. Molecular Immunology Volume 122, June 2020, Pages 186-192. https://www.sciencedirect.com/science/article/abs/pii/S0161589020300584?via%3Dihub
Early Fate Defines Microglia and Non-parenchymal Brain Macrophage Development. Utz SG, See P, Mildenberger W, Thion MS, Silvin A, Lutz M, Ingelfinger F, Rayan NA, Lelios I, Buttgereit A, Asano K, Prabhakar S, Garel S, Becher B, Ginhoux F, Greter M. Cell 181, 557–573, April 30, 2020. https://www.cell.com/action/showPdf?pii=S0092-8674%2820%2930283-X
High-dimensional immune-profiling in cancer: implications for immunotherapy. Chuah S, Chew V. Journal for ImmunoTherapy of Cancer 2020;8:e000363. 6 Feb 2020. https://jitc.bmj.com/content/8/1/e000363
Impact of Viral Etiologies on the Development of Novel Immunotherapy for Hepatocellular Carcinoma. Chun Jye Lim, Valerie Chew. Semin Liver Dis 2020;40:131–142. Dec 2019. https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0039-3399534
Cross-Species Single-Cell Analysis Reveals Divergence of the Primate Microglia Program. Laufey Geirsdottir, Eyal David, Hadas Keren-Shaul, Assaf Weiner, Stefan Cornelius Bohlen, Jana Neuber,Adam Balic, Amir Giladi, Fadi Sheban, Charles-Antoine Dutertre, Christine Pfeifle, Francesca Peri, Antonella Raffo-Romero, Jacopo Vizioli, Kaspar Matiasek, Christian Scheiwe, Stephan Meckel, Kerstin Ma¨ tz-Rensing, Franziska van der Meer, Finnbogi Rutur Thormodsson, Christine Stadelmann, Noga Zilkha, Tali Kimchi, Florent Ginhoux, Igor Ulitsky, Daniel Erny, Ido Amit, Marco Prinz. Cell. 179, 1609-1622. 2019 December 12. https://www.cell.com/cell/retrieve/pii/S0092867419312310?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867419312310%3Fshowall%3Dtrue
An immunome perturbation is present in juvenile idiopathic arthritis patients who are in remission and will relapse upon anti-TNFα withdrawal. Jing Yao Leong, Phyllis Chen, Joo Guan Yeo, Fauziah Ally, Camillus Chua, Sharifah Nur Hazirah, Su Li Poh, Lu Pan, Liyun Lai, Elene Seck Choon Lee, Loshinidevi D/o Thana Bathi, Thaschawee Arkachaisri, Daniel Lovell, Salvatore Albani,. Annals of Rheumatic Diseases (ARD). 2019;78:1712-1721. https://ard.bmj.com/content/78/12/1712
Insights into the immuno-pathogenesis of acute respiratory distress syndrome. Judith Ju Ming Wong, Jing Yao Leong, Jan Hau Lee, Salvatore Albani, Joo Guan Yeo. Ann Transl Med 2019;7(19):504.http://atm.amegroups.com/article/view/29655/25958
Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells. Charles-Antoine Dutertre, Etienne Becht, Sergio Erdal Irac, Ahad Khalilnezhad, Vipin Narang, Shabnam Khalilnezhad, Pei Y. Ng, Lucas L. van den Hoogen, Jing Yao Leong, Bernett Lee, Marion Chevrier, Xiao Meng Zhang, Pearly Jean Ai Yong, Geraldine Koh, Josephine Lum, Shanshan Wu Howland, Esther Mok, Jinmiao Chen, Anis Larbi, Henry Kun Kiaang Tan, Tony Kiat Hon Lim, Panagiota Karagianni, Athanasios G. Tzioufas, Benoit Malleret, Joshua Brody, Salvatore Albani, Joel van Roon, Timothy Radstake, Evan W. Newell, Florent Ginhoux. Immunity. P573-589.E8. 2019 September 17. https://www.cell.com/immunity/fulltext/S1074-7613(19)30334-6?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761319303346%3Fshowall%3Dtrue
Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Non-Alcoholic Steatohepatitis. Widjaja AA, Singh BK, Adami E, Viswanathan S, Dong J, D'Agostino GA, Ng B, Lim WW, Tan J, Paleja BS, Tripathi M, Lim SY, Shekeran SG, Chothani SP, Rabes A, Sombetzki M, Bruinstroop E, Min LP, Sinha RA, Albani S, Yen PM, Schafer S, Cook SA. Gastroenterology. 2019 May 8
Immunomics in Pediatric Rheumatic Diseases. Shi Huan Tay, Yaung Katherne Nay, Jing Yao Leong, Joo Guan Yeo, Arkachairsri Thaschawee, Salvatore Albani. Front. Med. | doi: 10.3389/fmed. 2019.00111
Pro-inflammatory, IL-17 pathways dominate the architecture of the immunome in pediatric refractory epilepsy. Kumar P, Shih DCW, Lim A, Paleja B, Ling S, Li Yun L, Li Poh S, Ngoh A, Arkachaisri T, Yeo JG, Albani S. JCI Insight. 2019 Mar 26;5
Recent advances in our understanding of the pathogenesis of juvenile idiopathic arthritis and their potential clinical implications. Leong JY, Guan YJ, Albani S, Arkachaisri T. Expert Rev Clin Immunol. 2018 Nov;14(11)
Molecular mechanisms of autophagic memory in pathogenic T cells in human arthritis. Kumar P, Yao LJ, Saidin S, Paleja B, van Loosdregt J, Chua C, Arkachaisri T, Consolaro A, Gattorno M, Martini A, Pischel KD, Williams GW, Lotz M, Albani S. J Autoimmun. 2018 Nov;94:90-98.Multidimensional analyses reveal distinct immune microenvironment in hepatitis B virus-related hepatocellular carcinoma. Lim CJ, Lee YH, Pan L, Lai L, Chua C, Wasser M, Lim TKH, Yeong J, Toh HC, Lee SY, Chan CY, Goh BK, Chung A, Heikenwälder M, Ng IO, Chow P, Albani S, Chew V. Gut. 2018 Jul 3. pii: gutjnl-2018-316510
A systematic approach to the development of a safe live attenuated Zika vaccine. Kwek SS, Watanabe S, Chan KR, Ong EZ, Tan HC, Ng WC, Nguyen MTX, Gan ES, Zhang SL, Chan KWK, Tan JH, Sessions OM, Manuel M, Pompon J, Chua C, Hazirah S, Tryggvason K, Vasudevan SG, Ooi EE. Nat Commun. 2018 Mar 12;9(1):1031
An automated staining protocol for seven-colour immunofluorescence of human tissue sections for diagnostic and prognostic use. Lim JCT, Yeong JPS, Lim CJ, Ong CCH, Wong SC, Chew VSP, Ahmed SS, Tan PH, Iqbal J. Pathology. 2018 Apr;50(3):333-341
Immune activation underlies a sustained clinical response to Yttrium-90 radioembolisation in hepatocellular carcinoma. Chew V, Lee YH, Pan L, Nasir NJM, Lim CJ, Chua C, Lai L, Hazirah SN, Lim TKH, Goh BKP, Chung A, Lo RHG, Ng D, Filarca RLF, Albani S, Chow PKH. Gut. 2019 Feb;68(2):335-346
Early molecular correlates of adverse events following yellow fever vaccination. Chan CY, Chan KR, Chua CJ, Nur Hazirah S, Ghosh S, Ooi EE, Low JG. JCI Insight. 2017 Oct 5;2(19)
Increased autophagy contributes to the inflammatory phenotype of juvenile idiopathic arthritis synovial fluid T cells. Peeters JGC, de Graeff N, Lotz M, Albani S, de Roock S, van Loosdregt J. Rheumatology (Oxford). 2017 Oct 1;56(10):1694-1699
Precision medicine in pediatric rheumatology. Yeo JG, Ng CT, Albani S. Curr Opin Rheumatol. 2017 Sep;29(5):500-505
Human neonatal thymectomy induces altered B-cell responses and autoreactivity. van den Broek T, Madi A, Delemarre EM, Schadenberg AWL, Tesselaar K, Borghans JAM, Nierkens S, Redegeld FA, Otten HG, Rossetti M, Albani S, Sorek R, Cohen IR, Jansen NJG, van Wijk F. Eur J Immunol. 2017 Nov;47(11):1970-1981
Delineation of an immunosuppressive gradient in hepatocellular carcinoma using high-dimensional proteomic and transcriptomic analyses. Chew V, Lai L, Pan L, Lim CJ, Li J, Ong R, Chua C, Leong JY, Lim KH, Toh HC, Lee SY, Chan CY, Goh BKP, Chung A, Chow PKH, Albani S. Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):E5900-E5909
Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2. McGovern N, Shin A, Low G, Low D, Duan K, Yao LJ, Msallam R, Low I, Shadan NB, Sumatoh HR, Soon E, Lum J, Mok E, Hubert S, See P, Kunxiang EH, Lee YH, Janela B, Choolani M, Mattar CNZ, Fan Y, Lim TKH, Chan DKH, Tan KK, Tam JKC, Schuster C, Elbe-Bürger A, Wang XN, Bigley V, Collin M, Haniffa M, Schlitzer A, Poidinger M, Albani S, Larbi A, Newell EW, Chan JKY, Ginhoux F. Nature. 2017 Jun 29;546(7660):662-666
Singlet gating in mass cytometry. Lai L, Yeo JG, Albani S. 2017 July. Cytometry A. 2017 Feb;91(2):170-172
Epipolymorphisms associated with clinical outcome of arthritis affect T-cell activation pathways. Spreafico R, Rossetti M, Whitaker JW, Wang W, Lovell DJ, Albani S. Proc Natl Acad Sci U S A. 2016 Nov 29;113(48)
Increased autophagy in CD4+ T cells of rheumatoid arthritis patients results in T-cell hyperactivation and apoptosis resistance. van Loosdregt J, Rossetti M, Spreafico R, Moshref M, Olmer M, Williams GW, Kumar P, Copeland D, Pischel K, Lotz M, Albani S. Eur J Immunol. 2016 Dec;46(12):2862-2870
Enhancing translational research in paediatric rheumatology through standardization. Yeung RS, Albani S, Feldman BM, Mellins E, Prakken B, Wedderburn LR. Nat Rev Rheumatol. 2016 Nov;12(11):684-690
TCR repertoire sequencing identifies synovial Treg cell clonotypes in the bloodstream during active inflammation in human arthritis. Rossetti M, Spreafico R, Consolaro A, Leong JY, Chua C, Massa M, Saidin S, Magni-Manzoni S, Arkachaisri T, Wallace CA, Gattorno M, Martini A, Lovell DJ, Albani S. Ann Rheum Dis 2017;76:435–441
The role of nuclear factor-kappa B and endoplasmic reticulum stress in hepatitis B viral-induced hepatocellular carcinoma. Yeong J, Chew V. Transl Cancer Res 2016;5(S1):S13-S17
Using a theragnostic approach in Juvenile Idiopathic Arthritis. Leong JY, Albani S. Expert Opinion on Orphan Drugs 2016;Volume 4-Issue 3
Interaction between tumour-infiltrating B cells and T cells controls the progression of hepatocellular carcinoma. Garnelo M, Tan A, Her Z, Yeong J, Lim CJ, Chen J, Lim KH, Weber A, Chow PKH, Chung A, Ooi LL, Toh HC, Heikenwalder M, Ng I, Nardin A, Chen Q, Abastado J, Chew V. Gut. 2017 Feb;66(2):342-351
TLR3 agonist and Sorafenib combinatorial therapy promotes immune activation and controls hepatocellular carcinoma progression. Ho V, Lim TS, Lee J, Steinberg J, Szmyd R, Tham M, Yaligar J, Kaldis P, Abastado JP, Chew V. Oncotarget. 2015 Sep 29;6(29):27252-66
PD-1 expression on dendritic cells suppresses CD8+ T cell function and antitumor immunity. Lim TS, Chew V, Sieow JL, Goh S, Yeong JP, Soon AL, Ricciardi-Castagnoli P. Oncoimmunology. 2015 Aug 31;5(3):e1085146
A CD45-based barcoding approach to multiplex mass-cytometry (CyTOF). Lai LY, Ong R, Li J, Albani S. Cytometry A. 2015 Apr;87(4):369-74
Ex vivo-expanded, but not in vitro-induced, human regulatory T cells are suitable for cell therapy in rheumatological autoimmune diseases thanks to stable FOXP3 demethylation. Rossetti M, Spreafico R, Saidin S, Chua C, Moshref M, Leong JY, Tan YK, Thumboo J, van Loosdregt J, Albani S. J Immunol. 2015 Jan 1; 194(1): 113–124
A circulating reservoir of pathogenic-like CD4+ T cells shares a genetic and phenotypic signature with the inflamed synovial micro-environment. Spreafico R, Rossetti R, van Loosdregt J, Wallace CA, Massad M, Magni-Manzoni S, Gattorno M, Martini A, Lovell DJ and Albani S. Ann Rheum Dis. 2016 Feb;75(2):459-65
A sensitive protocol for FOXP3 epigenetic analysis in scarce human samples. Spreafico R, Rossetti M, van den Broek T, Jansen NJ, Zhang H, Moshref M, Prakken B, van Loosdregt J, van Wijk F, Albani S. Eur J Immunol. 2014 Oct;44(10):3141-3
The eye: A window of opportunity in rheumatoid arthritis? Tong L, Thumboo J, Tan YK, Wong TY, Albani S. Nat Rev Rheumatol. 2014 Sep;10(9):552-60
A115: deep immunophenotyping in the identification of clinically meaningful immune signatures in juvenile idiopathic arthritis. Spreafico R, Rossetti M, Lovell DJ, Albani S. Arthritis & Rheumatology. 2014;Vol.66(S3).Startups on the menu: Archimedes. Albani S. Nature Biotechnology volume 31, page 1074 (2013)
