Title
: Associate Professor
: Senior Consultant, Department of Anatomical Pathology, Singapore General Hospital
Vice Chair, Research, Pathology Academic Clinical Programme (ACP)
Associate Professor, Duke-NUS Medical School
Dr Iqbal’s research interest is in studying the biomarkers which are integral components of various cellular processes governing the biology of invasive breast cancer. These processes comprise immune response markers including B- and T-lymphocytes, macrophages and dendritic cells as well as other related cellular processes including proliferation and regulation of hypoxia-induced protein translation that are intimately associated with tumour progression. Proper characterization of the immune response mounted against tumours proliferating in a hypoxic environment may provide means to manipulate the immune response in order to restrict the metastatic capability and aggressiveness of breast cancers.
Dr Iqbal has been studying immune response in triple negative breast cancers because of their tendency to mount strong immune responses. Simultaneously, he is studying the role of hypoxia-induced proteins (HIf1) and the proteins regulating this pathway (Sharp1 and Xbp1). Preliminary studies have been done using immunohistochemical techniques and this will be employed for assays in this project. He also intends to use RNA transcript assays to measure response of various immune response genes, hypoxia-induced genes as well as proliferation-related genes. The future objective is to synthesize a gene signature that can stratify triple negative breast cancers in terms of prognosis and therapy response.