Tan, Puay Hoon

​ ​ ​	Title		​:   Professor
	​Address		​:   Division of Pathology, Singapore General Hospital     Academia, Diagnostics Tower, Level 7     20 College Road, Singapore 169856
	​Email		​:   tan.puay.hoon@sgh.com.sg
	​Contact No.		​:   6321 4900 (Office), 6222 6826 (Fax)
	​Current Position		:   Senior Consultant and Chairman, Division of Pathology,     Singapore General Hospital     Academic Chair, Pathology Academic Clinical Programme     (ACP)     Professor, Departments of Anatomy and Pathology,     Yong Loo Lin School of Medicine,     National University of Singapore     Professor, Duke-NUS Medical School

Research interest:

Dr Tan has active interests in breast, urologic and renal pathology, and was a Volume Editor of the 2012 WHO Classification of Tumours of the Breast.  She sits on the Editorial Boards of Modern Pathology, Breast Cancer Research, Journal of Clinical Pathology, Pathology, Seminars in Diagnostic Pathology, and Analytical and Quantitative Cytology and Histology. She is Associate Editor of Histopathology and the Singapore Medical Journal. Apart from a busy service largely focused on subspecialty surgical signouts, she and her collaborators are recipients of several research grants related to translational studies of breast and prostate cancer. She is author of more than 400 publications, and participates regularly in regional and international meetings.

Dr Tan’s research interests in breast pathology centre around the classification of fibroepithelial breast lesions and their molecular pathogenesis, triple negative breast cancers, and ductal carcinoma in situ. In urologic pathology, she is engaged in prostate and renal cancer studies and is a contributor to the 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs.

She is the immediate Past-President of the International Society of Breast Pathology, and was Councillor for Asia of the International Society of Urological Pathology (2009 – 2015).

Selected Publications:

1. Cheng CL, Thike AA, Tan SY, Chua PJ, Bay BH, Tan PH. Expression of FGFR1 is an independent prognostic factor in triple-negative breast cancer. Breast Cancer Res Treat. 2015 May;151(1):99-111


2. Tan PH, Schnitt SJ, van de Vijver MJ, Ellis IO, Lakhani SR. Papillary and neuroendocrine breast lesions: the WHO stance. Histopathology. 2015 May;66(6):761-70.


3. Tan WJ, Thike AA, Tan SY, Tse GM, Tan MH, Bay BH, Tan PH. CD117 expression in breast phyllodes tumors correlates with adverse pathologic parameters and reduced survival. Mod Pathol. 2015 Mar;28(3):352-8.


4. Oon ML, Thike AA, Tan SY, Tan PH. Cancer stem cell and epithelial-mesenchymal transition markers predict worse outcome in metaplastic carcinoma of the breast. Breast Cancer Res Treat. 2015 Feb;150(1):31-41.


5. Lim JC, Koh VC, Tan JS, Tan WJ, Thike AA, Tan PH. Prognostic significance of epithelial-mesenchymal transition proteins Twist and Foxc2 in phyllodes tumours of the breast. Breast Cancer Res Treat. 2015 Feb;150(1):19-29.


6. Rakha EA, Tan PH, Varga Z, Tse GM, Shaaban AM, Climent F, van Deurzen CH, Purnell D, Dodwell D, Chan T, Ellis IO. Prognostic factors in metaplastic carcinoma of the breast: a multi-institutional study. Br J Cancer. 2015 Jan 20;112(2):283-9.


7. Choudhury Y, Wei X, Chu YH, Ng LG, Tan HS, Koh V, Thike AA, Poon E, Ng QS, Toh CK, Kanesvaran R, Tan PH, Tan MH. A multigene assay identifying distinct prognostic subtypes of clear cell renal cell carcinoma with differential response to tyrosine kinase inhibition. Eur Urol. 2015 Jan;67(1):17-20.


8. Lim WK, Ong CK, Tan J, Thike AA, Ng CC, Rajasegaran V, Myint SS, Nagarajan S, Nasir ND, McPherson JR, Cutcutache I, Poore G, Tay ST, Ooi WS, Tan VK, Hartman M, Ong KW, Tan BK, Rozen SG, Tan PH, Tan P, Teh BT. Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma. Nat Genet. 2014 Aug;46(8):877-80.


9. Tan WJ, Lai JC, Thike AA, Lim JC, Tan SY, Koh VC, Lim TH, Bay BH, Tan MH, Tan PH. Novel genetic aberrations in breast phyllodes tumours: comparison between prognostically distinct groups. Breast Cancer Res Treat. 2014 Jun;145(3):635-45.


10. Wong FY, Wang F, Chen JJ, Tan CH, Tan PH. Outcomes of low-risk ductal carcinoma in situ in Southeast Asian women treated with breast conservation therapy. Int J Radiat Oncol Biol Phys. 2014 Apr 1;88(5):998-1003.