A novel mechano-protective mechanism in axons of central nervous system

Presenter:

Dr Tong Iris Wang

Group Leader/Assistant Professor

ShanghaiTech University

China

Abstract:

In traumatic brain injury sudden mechanical impacts cause diffuse axonal injury to central neurons. Whether axons can proactively resist mechanical stress remains unknown. Using a new microfluidic device, we found that mild mechanical stress causes a restricted and reversible axonal beading, generated by NM-II-driven radial contraction of the axon cortex, reducing its volume by over 20%. Thus, the elevated Ca2+ waves in the stressed axon are suppressed, preventing further axonal degeneration.

Seminar Details:

Date:  10 February 2023, Friday

Time: 12:00pm to 1:00pm

Zoom Details:

Join Zoom Meeting 

https://nus-sg.zoom.us/j/82677764900?pwd=Q3R1WWJ3RUVmNWZKajQyZlN3WGNxdz09  

Meeting ID: 826 7776 4900 

Passcode: 585428

Host:

Prof Wang Hongyan

Principal Investigator & Deputy Programme Director

Neuroscience & Behavioural Disorders Programme

Duke-NUS

 

All are welcome. No registration is required.