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Cancer of the uterus

Cancer of the Uterus: Overview, symptoms, risk factors, prevention, diagnosis and treatment | KKH

Cancer of the uterus - What is it for

What is Cancer of the Uterus?​

Cancer of the uterus is the 3rd commonest cancer of the female genital tract in Singapore. It usually affects the endometrium (lining of the uterus). If it is found and treated early, the cure rate is very good - it can be over 90% when the disease is at an early stage. The more advanced the disease is, the lower the cure rate. This is why early detection is so important.

Cancer of the uterus - Symptoms

Symptoms of Cancer of the Uterus

​At present, there is no simple way to screen for uterine cancer. The key to finding the disease in an early stage is being alerted to its symptoms which include:

  • Abnormal bleeding which is not according to the usual menstrual pattern
  • Spotting
  • Discharge

The cause of any abnormal bleeding needs to be looked into by your doctor.

Except when combination hormone therapy is being taken, any bleeding or spotting after menopause is abnormal, no matter when amount or colour. Ask your doctor about any bleeding or spotting you have after menopause.

Cancer of the uterus - How to prevent?

Prevention And Early Detection of Cancer of the Uterus

There are several things you can do to lower your risk of uterine cancer and to improve the changes of early detection :

  • Report any abnormal vaginal bleeding promptly to your doctor. Most bleeding is not caused by cancer, but only your doctor can perform the tests needed to diagnose the problem.
  • Get a yearly pelvic examination.
  • Eat a healthy diet. A diet that prevents obesity can help prevent cancer. This means eating foods that are low in fat and cholesterol and high in fibre, such as fruits, vegetables and wholegrain breads and cereals.
  • Do not take chances if you think you have a problem. See your doctor at once. When uterine cancer is found early, the outlook is excellent. Delay in seeking treatment makes this disease much harder to cure.

Cancer of the uterus - Causes and Risk Factors

Who Is At Risk of Cancer of the Uterus?

In Singapore, the majority of uterine cancer is diagnosed after 40 years of age, most commonly between 50 and 70 years old.

Some women have a higher risk of uterine cancer:

  • Women who are obese
  • Women who do not ovulate regularly and often miss periods
  • Women who have late menopause (when menstrual periods end, which is usually around age 50)
  • Women with polycystic ovarian disease (in which the ovaries contain many abnormal cysts)
  • Women with endometrial hyperlasia (abnormal thickening of the endometrium)
  • Women who have had cancer of the ovary, breast or colon
  • Women with a close family member (mother or daughter) with uterine cancer

It is also thought that some women who take oestrogen alone after menopause may be at risk for cancer of the uterus. If oestrogen is given along with another hormone, progesterone, this combination protects against the risk of uterine cancer.

Women who have ever used the most common type of birth control pills, combination (oestrogen plus progesterone) birth control pills, have a reduced risk of uterine cancer. This protection persists for at least 10 years after a woman stops taking the pill.

A woman may have some or all of the risk factors described here and never have uterine cancer. But women at risk should be aware of the symptoms of uterine cancer and discuss their concerns with their doctor. Regular check-ups, including pelvic examinations, are important.

Cancer of the uterus - Diagnosis

Diagnosis of Cancer of the Uterus

​The procedures used to diagnose cancer of the uterus include an endometrial biopsy, in which tissue from the uterus is removed and examined in a laboratory. Sometimes, hysteroscopy may be done. This is a procedure in which the inside of the uterus is examined with an instrument called a hysteroscope, which resembles a thin telescope. Sometimes, the patient may have to have a procedure called dilatation and curettage (D&C) in the hospital. In D&C, the cervix is slightly widened and tissue is gently scraped or suctioned from the lining of the uterus and the cervix for examination in a laboratory.

The Pap smear test, while an important part of a regular check-up, is not a dependable test for uterine cancer. It can detect cancer or pre-cancer of the cervix, but may indicate uterine cancer in about half the cases.

Cancer of the uterus - Treatments

Treatment of Cancer of the Uterus​

If a woman is found to have cancer of the uterus, surgery will be performed to determine the extent of the disease (stage) and how it should be treated. Stage refers to the extent (if any) to which the cancer has spread. The stages range from early to advanced (I through IV). Staging helps your doctor decide what treatment will have the best chance for success.

About 75% of the women diagnosed with uterine cancer have stage I disease. Of these women, 85 - 90% will have no evidence of cancer 5 years or more after treatment. As the cancer becomes more advanced, the chance for a cure decreases.

Most patients have both hysterectomy (removal of the uterus) and salpingo-oophorectomy (removal of the ovaries and fallopian tubes). Tissue from lymph nodes in the pelvic area may also be tested to find out if the cancer has spread. Some cases of uterine cancer may also require radiation therapy after surgery.

If tests show that the cancer has spread or recurred after surgery and radiation therapy, your doctor may recommend additional drug therapy. Progestin (a hormone) therapy or chemotherapy may be used to treat uterine cancer that has spread to other organs.

Cancer of the uterus - Preparing for surgery

Cancer of the uterus - Post-surgery care

Sexuality After Surgery

Women who have had a hysterectomy for cancer are often concerned about how the surgery will affect their sexuality. It is not uncommon for women to ask questions like "When will I be able to have sex again? Will it be painful? Will I feel less of a woman? How will my partner react?" Those women who require radiotherapy or chemotherapy after their hysterectomy may have further questions.

Women will find sex initially uncomfortable as it will take time for the wound to heal. Most doctors will advise refraining from sexual intercourse until the stitching at the top of the vaginal has healed properly - usually about six weeks.

Having a hysterectomy does not mean women lose their femininity although some women may experience these feelings. It can be helpful to talk about your concerns with your partner or someone close to you. You may also wish to discuss any emotional or sexuality concerns with the social worker, nurse or doctor you feel most comfortable talking to.

Ask Us

If you have cancer of the uterus, you may have many fears and concerns. Talk these fears and concerns over with your doctor. Remember that you are not alone. Your doctor and the other people involved in your care will do everything possible to help you get well. Together, you and the members of your healthcare team can work to reduce the chances of further problems and find ways to keep you as healthy as possible.