Assoc Prof Manzolli Leite Fábio Renato

BDS, MSc, PhD

Principal Investigator

Profile

Fábio explores mechanisms linking oral and systemic diseases using approaches, from cell culture to clinical trials and population-based registries. Collectively, his studies moved the oral inflammation field into the acknowledgement of the synergy and accumulation of multiple causes (from local and systemic molecular factors to structural determinants).

His interest lies in exploring why people develop different phenotypes of oral inflammation. His master´s focused on tissue healing, plus clinical training in treating people with diabetes. His Ph.D. investigated common pathways of Crohn´s disease and periodontitis, including a stay at Prof. Richard Darveau´s microbiology laboratory (University of Washington).

He collaborated in studies involving birth cohorts and spent a year at the Australian Research Centre for Population Oral Health, University of Adelaide, to study common causes of systemic and oral inflammation.

Fábio held positions of trust, such as Head of Department, vice-president of an ethics committee, and executive and research steering committee member in Brazil, Denmark and Singapore. He has published over 90 articles and 4 book chapters, deposited patents, supervised over 30 masters and Ph.D. students, and secured multiple research grants. According to ResearchGate, Fabio is among the top 4% in dentistry and periodontology.

Fábio's soft skills training encompasses leadership and communication.

Education

PhD Periodontology (Brazil) 2009
MSc Periodontology (Brazil) 2006
BDS São Paulo State University 2003

Professional Appointments and Committee Memberships

Leader, Singapore Oral Multiomics Initiative, National Dental Research Institute Singapore 2022 - Present
Director, Basic and Translational Research, ORH ACP 2023 - Present
Member, Biosafety Committee, NDCS 2022 - Present
Editorial Board/Associate Editor, Applied Sciences 2020 - Present
Editorial Board/Associate Editor, Frontiers in Oral Health 2020 - Present

Awards

International Academy of Dental Research Travel Award, 2017 & 2013
International Academy of Dental Research Best Poster, 2015 & 2007
Young Investigator Prize from the Federal University of Pelotas, 2010
Brazilian Society of Immunology conference Best Presentation, 2008

Research Interests

Inflammation
Cell Biology
Microbiome
Chronic Diseases
Omics

Publications and Research Trials

Effect of Smoking Exposure on Nonsurgical Periodontal Therapy: 1-Year Follow-up. Leite FRM, Lopez R, Pajaniaye JB, Nascimento GG. J Dent Res. 2023 Mar;3(102):280-6.
The Role of Dyslipidemia in Periodontitis. Bitencourt FV, Nascimento GG, Costa SA, Orrico SRP, Ribeiro CCC, Leite FRM. Nutrients. 2023 Jan 6;2(15)
Salivary cytokine expression after non-surgical periodontal therapy in smokers: 12-month follow-up. Leite FRM, Lopez R, Moller HJ, Nascimento GG. J Periodontol. 2023 Jan 16 (ahead of print)
Chronic oral diseases burden: The confluence of caries and periodontitis throughout life. Costa SA, Ribeiro CCC, Leite FRM, Peres MA, Souza SFC, Nascimento GG. J Clin Periodontol. 2023 Apr;4(50):452-62.
Confounding in observational studies evaluating the association between Alzheimer's disease and periodontal disease: A systematic review. Nascimento GG, Leite FRM, Mesquita CM, Vidigal MTC, Borges GH, Paranhos LR. Heliyon. 2023 Apr;4(9):e15402.
The association between halitosis and chemosensory disorders: A systematic review. Schertel Cassiano L, Leite FRM, Lopez R, Fjaeldstad AW, Nascimento GG. Oral Dis. 2023 Mar;2(29):369-75.
Embracing multi-causation of periodontitis: Why aren't we there yet? Frandsen Lau E, Peterson DE, Leite FRM, Nascimento GG, Robledo-Sierra J, Porat Ben Amy D, Kerr R, Lopez R, Baelum V, Lodi G, Varoni EM. Oral Dis. 2022 May;4(28):1015-21.
Precursors of insulin resistance underlying periodontitis in adolescents aged 17-18 years. Ladeira LLC, Leite FRM, Nascimento GG, Saraiva MDC, Brondani MA, Moreira ARO, Ribeiro CCC. Oral Dis. 2022 Jun 18 (ahead of print)
Impact of public health and higher education policies on the profile of final-year Brazilian dental students: Challenges and future developments. Bitencourt FV, Olsson TO, Lamers JMS, Leite FRM, Nascimento GG, Toassi RFC. Eur J Dent Educ. 2022 Jul 22 (ahead of print)
Cytokine profiles and the dynamic of gingivitis development in humans. Leite FRM, Nascimento GG, Moller HJ, Belibasakis GN, Bostanci N, Smith PC, Lopez R. J Clin Periodontol. 2022 Jan;1(49):67-75.
Sugar intake above international recommendations and oral disease burden: A population-based study. Ladeira LLC, Nascimento GG, Leite FRM, Alves-Costa S, Thomaz E, Alves CMC, Cury JA, Ribeiro CCC. Oral Dis. 2022 Dec 11 (ahead of print)
Dietary vitamin D and calcium and periodontitis: A population-based study. Nascimento GG, Leite FRM, Gonzalez-Chica DA, Peres KG, Peres MA. Front Nutr. 2022 (9):1016763.
Role of occlusal factors on probable bruxism and orofacial pain: Data from the 1982 Pelotas birth cohort study. Boscato N, Nascimento GG, Leite FRM, Horta BL, Svensson P, Demarco FF. J Dent. 2021 Oct;(113):103788.
The association between halitosis and oral-health-related quality of life: A systematic review and meta-analysis. Schertel Cassiano L, Abdullahi F, Leite FRM, Lopez R, Peres MA, Nascimento GG. J Clin Periodontol. 2021 Nov;11(48):1458-69.
Use of air polishing for supra- and subgingival biofilm removal for treatment of residual periodontal pockets and supportive periodontal care: a systematic review. Nascimento GG, Leite FRM, Pennisi PRC, Lopez R, Paranhos LR. Clin Oral Investig. 2021 Mar;3(25):779-95.
The whitening effect of single brushing with blue-covarine containing toothpaste-A randomized controlled trial. Schlafer S, Poulsen PN, Johansen J, Trap L, Leite FRM. J Dent. 2021 Feb;(105):103559.
Influence of Bacterial Profiles in Cytokine and Clinical Features of Endodontic Disease. Martinho FC, Leite FRM, Arruda-Vasconcelos R, Louzada LM, Darveau RP, Gomes B. J Endod. 2021 Aug;8(47):1265-71.
Biological and mechanical characterization of commercial and experimental periodontal surgical dressings. Concei CLD, Cuevas-SuArez CE, Piva E, Lund RG, Leite FRM. Braz Oral Res. 2021 (35):e045.
Effect of Sample Storage Conditions on Measurements of Salivary Cotinine Levels. Leite FRM, Baelum V, Pajaniaye JB, Abildtrup LA, Lopez R. Metabolites. 2020 Sep 8;9(10)
Periodontitis and self-reported halitosis among young adults from the 1982 Pelotas Birth Cohort. Silva MF, Nascimento GG, Leite FRM, Horta BL, Demarco FF. Oral Dis. 2020 May;4(26):843-6.
Treatment of experimental periodontitis with chlorhexidine as adjuvant to scaling and root planing. Prietto NR, Martins TM, Santinoni CDS, Pola NM, Ervolino E, Bielemann AM, Leite FRM. Arch Oral Biol. 2020 Feb;(110):104600.
Collider bias in the association of periodontitis and carotid intima-media thickness. Leite FRM, Nascimento GG, Peres KG, Demarco FF, Horta BL, Peres MA. Community Dent Oral Epidemiol. 2020 Aug;4(48):264-70.
Effects of orthodontic tooth extrusion produced by different techniques, on the periodontal tissues: a histological study in dogs. da Silva VC, de Molon RS, Martins RP, Ribeiro FS, Pontes AEF, Zandim-Barcelos DL, Leite FRM, Benatti Neto C, Marcantonio RAC, Cirelli JA. Arch Oral Biol. 2020 Aug;(116):104768.
Early-predictors of marginal bone loss around morse taper connection implants loaded with single crowns: A prospective longitudinal study. Radaelli MTB, Federizzi L, Nascimento GG, Leite FRM, Boscato N. J Periodontal Res. 2020 Apr;2(55):174-81.
Impact of Smoking Cessation on Periodontitis: A Systematic Review and Meta-analysis of Prospective Longitudinal Observational and Interventional Studies. Leite FRM, Nascimento GG, Baake S, Pedersen LD, Scheutz F, Lopez R. Nicotine Tob Res. 2019 Nov 19;12(21):1600-8.
Is the misinterpretation of association and causation a never-ending story? Leite FRM, Peres MA, Nascimento GG. Aust Dent J. 2019 Jun;2(64):201-2.
Metabolic syndrome and periodontitis: A structural equation modeling approach. Nascimento GG, Leite FRM, Peres KG, Demarco FF, Correa MB, Peres MA. J Periodontol. 2019 Jun;6(90):655-62.
Pattern recognition receptor polymorphisms in early periodontitis. Leite FRM, Enevold C, Bendtzen K, Baelum V, Lopez R. J Periodontol. 2019 Jun;6(90):647-54.
Is there an association between depression and periodontitis? A birth cohort study. Nascimento GG, Gastal MT, Leite FRM, Quevedo LA, Peres KG, Peres MA, Horta BL, Barros FC, Demarco FF. J Clin Periodontol. 2019 Jan;1(46):31-9.
New fluorescence and reflectance analyses to aid dental material detection in human identification. Conceicao LD, Masotti AS, Forgie AH, Leite FRM. Forensic Sci Int. 2019 Dec;(305):110032.
Staining protocols to improve the detection of composite restorations in human identification. Conceicao LD, de Pereira CMP, Forgie AH, Leite FRM. Forensic Sci Int. 2019 Apr;(297):198-203.
Influence of weight gain on the modulation of wound healing following tooth extraction. Furuse C, Almeida AF, Costa SF, Ervolino-Silva AC, Okamoto R, Sumida DH, Matsumoto MA, Leite FRM. Bone. 2018 Sep;(114):226-34.
Exploratory and confirmatory factorial analysis of the OHIP-Edent instrument. Possebon A, Faot F, Machado RMM, Nascimento GG, Leite FRM. Braz Oral Res. 2018 Oct 29;(32):e111.
Epidemiology and Risk Factors of Maxillofacial Injuries in Brazil, a 5-year Retrospective Study. Conceicao LD, da Silveira IA, Nascimento GG, Lund RG, da Silva RHA, Leite FRM. J Maxillofac Oral Surg. 2018 Jun;2(17):169-74.
Effect of Smoking on Periodontitis: A Systematic Review and Meta-regression. Leite FRM, Nascimento GG, Scheutz F, Lopez R. Am J Prev Med. 2018 Jun;6(54):831-41.
Does diabetes increase the risk of periodontitis? A systematic review and meta-regression analysis of longitudinal prospective studies. Nascimento GG, Leite FRM, Vestergaard P, Scheutz F, Lopez R. Acta Diabetol. 2018 Jul;7(55):653-67.
Comparison between inflammation-related markers in peri-implant crevicular fluid and clinical parameters during osseointegration in edentulous jaws. Bielemann AM, Marcello-Machado RM, Leite FRM, Martinho FC, Chagas-Junior OL, Antoninha Del Bel Cury A, Faot F. Clin Oral Investig. 2018 Jan;1(22):531-43.
Estimated prevalence of halitosis: a systematic review and meta-regression analysis. Silva MF, Leite FRM, Ferreira LB, Pola NM, Scannapieco FA, Demarco FF, Nascimento GG. Clin Oral Investig. 2018 Jan;1(22):47-55.
Clinical comparison of the effectiveness of 7- and 14-day intracanal medications in root canal disinfection and inflammatory cytokines. Martinho FC, Gomes CC, Nascimento GG, Gomes APM, Leite FRM. Clin Oral Investig. 2018 Jan;1(22):523-30.
Is periodontitis associated with halitosis? A systematic review and meta-regression analysis. Silva MF, Cademartori MG, Leite FRM, Lopez R, Demarco FF, Nascimento GG. J Clin Periodontol. 2017 Oct;10(44):1003-9.
The split crest technique and dental implants: a systematic review and meta-analysis. Waechter J, Leite FR, Nascimento GG, Carmo Filho LC, Faot F. Int J Oral Maxillofac Surg. 2017 Jan;1(46):116-28.
Periodontitis: from Infection to Inflammation. Nascimento GG, Leite FRM, Scheutz F, López R. Current Oral Health Reports. 2017 December 01;4(4):301-8.
Etiology, diagnosis, and demographic analysis of maxillofacial trauma in elderly persons: A 10-year investigation. Possebon A, Granke G, Faot F, Pinto LR, Leite FRM, Torriani MA. J Craniomaxillofac Surg. 2017 Dec;12(45):1921-6.
Prediction of Periodontitis Occurrence: Influence of Classification and Sociodemographic and General Health Information. Leite FRM, Peres KG, Do LG, Demarco FF, Peres MAA. J Periodontol. 2017 Aug;8(88):731-43.
Comparison between tapered and cylindrical implants in the posterior regions of the mandible: A prospective, randomized, split-mouth clinical trial focusing on implant stability changes during early healing. Waechter J, Madruga MM, Carmo Filho LCD, Leite FRM, Schinestsck AR, Faot F. Clin Implant Dent Relat Res. 2017 Aug;4(19):733-41.
Does periodontal treatment have an effect on clinical and immunological parameters of periodontal disease in obese subjects? A systematic review and meta-analysis. Nascimento GG, Leite FR, Correa MB, Peres MA, Demarco FF. Clin Oral Investig. 2016 May;4(20):639-47.
Comparison of Fusobacterium nucleatum and Porphyromonas gingivalis Lipopolysaccharides Clinically Isolated from Root Canal Infection in the Induction of Pro-Inflammatory Cytokines Secretion. Martinho FC, Leite FR, Nobrega LM, Endo MS, Nascimento GG, Darveau RP, Gomes BP. Braz Dent J. 2016 Mar-Apr;2(27):202-7.
Is there a relationship between obesity and tooth loss and edentulism? A systematic review and meta-analysis. Nascimento GG, Leite FR, Conceicao DA, Ferrua CP, Singh A, Demarco FF. Obes Rev. 2016 Jul;7(17):587-98.
Prevalence of treponema species detected in endodontic infections: systematic review and meta-regression analysis. Leite FR, Nascimento GG, Demarco FF, Gomes BP, Pucci CR, Martinho FC. J Endod. 2015 May;5(41):579-87.
Can peri-implant crevicular fluid assist in the diagnosis of peri-implantitis? A systematic review and meta-analysis. Faot F, Nascimento GG, Bielemann AM, Campao TD, Leite FR, Quirynen M. J Periodontol. 2015 May;5(86):631-45.
Is weight gain associated with the incidence of periodontitis? A systematic review and meta-analysis. Nascimento GG, Leite FR, Do LG, Peres KG, Correa MB, Demarco FF, Peres MA. J Clin Periodontol. 2015 Jun;6(42):495-505.
Proinflammatory Activity of Primarily Infected Endodontic Content against Macrophages after Different Phases of the Root Canal Therapy. Marinho AC, Martinho FC, Leite FR, Nascimento GG, Gomes BP. J Endod. 2015 Jun;6(41):817-23.
Use of Fusidic Acid for Desquamative Gingivitis Treatment: 1-Year Follow-Up. Leite FR, Nascimento GG, Demarco FF, Waechter J, Etges A. Braz Dent J. 2015 Jul-Aug;4(26):422-7.
Endodontic retreatment: clinical comparison of reciprocating systems versus rotary system in disinfecting root canals. Martinho FC, Freitas LF, Nascimento GG, Fernandes AM, Leite FR, Gomes AP, Camoes IC. Clin Oral Investig. 2015 Jul;6(19):1411-7.
Relevance of the myeloid differentiation factor 88 (MyD88) on RANKL, OPG, and nod expressions induced by TLR and IL-1R signaling in bone marrow stromal cells. Leite FR, de Aquino SG, Guimaraes MR, Cirelli JA, Zamboni DS, Silva JS, Junior CR. Inflammation. 2015 Feb;1(38):1-8.
Clinical influence of different intracanal medications on Th1-type and Th2-type cytokine responses in apical periodontitis. Martinho FC, Nascimento GG, Leite FR, Gomes AP, Freitas LF, Camoes IC. J Endod. 2015 Feb;2(41):169-75.
Genotoxic potential of 10% and 16% carbamide peroxide in dental bleaching. Almeida AF, Torre Edo N, Selayaran Mdos S, Leite FR, Demarco FF, Loguercio AD, Etges A. Braz Oral Res. 2015 (29)
Macrophage cell activation with acute apical abscess contents determined by interleukin-1 Beta and tumor necrosis factor alpha production. Sousa EL, Martinho FC, Leite FR, Nascimento GG, Gomes BP. J Endod. 2014 Nov;11(40):1752-7.
Antifungal activity of 3-(heteroaryl-2-ylmethyl)thiazolidinone derivatives. Marques GH, Kunzler A, Bareno VD, Drawanz BB, Mastelloto HG, Leite FR, Nascimento GG, Nascente PS, Siqueira GM, Cunico W. Med Chem. 2014 Jun;4(10):355-60.
Quantification of endotoxins in infected root canals and acute apical abscess exudates: monitoring the effectiveness of root canal procedures in the reduction of endotoxins. Sousa EL, Martinho FC, Nascimento GG, Leite FR, Gomes BP. J Endod. 2014 Feb;2(40):177-81.
Clinical investigation of bacterial species and endotoxin in endodontic infection and evaluation of root canal content activity against macrophages by cytokine production. Martinho FC, Leite FR, Nascimento GG, Cirelli JA, Gomes BP. Clin Oral Investig. 2014 Dec;9(18):2095-102.
A double-blind randomised clinical trial of two techniques for gingival displacement. Sarmento HR, Leite FR, Dantas RV, Ogliari FA, Demarco FF, Faot F. J Oral Rehabil. 2014 Apr;4(41):306-13.
Signaling pathways activation by primary endodontic infectious contents and production of inflammatory mediators. Martinho FC, Leite FR, Chiesa WM, Nascimento GG, Feres M, Gomes BP. J Endod. 2014 Apr;4(40):484-9.
RANKL expression is differentially modulated by TLR2 and TLR4 signaling in fibroblasts and osteoblasts. Leite FRM, Aquino SGd, Guimarães MR, Cirelli JA, Junior CR. Immunology Innovation. 2014 2014;1(2)
Relationship between periodontal disease and obesity: the role of life-course events. Nascimento GG, Leite FR, Correa MB, Horta BL, Peres MA, Demarco FF. Braz Dent J. 2014 2(25):87-9.
Effect of the association between citric acid and EDTA on root surface etching. Manzolli Leite FR, Nascimento GG, Manzolli Leite ER, Leite AA, Cezar Sampaio JE. J Contemp Dent Pract. 2013 Sep 1;5(14):796-800.
Curcumin abrogates LPS-induced pro-inflammatory cytokines in RAW 264.7 macrophages. Evidence for novel mechanisms involving SOCS-1, -3 and p38 MAPK. Guimaraes MR, Leite FR, Spolidorio LC, Kirkwood KL, Rossa C, Jr. Arch Oral Biol. 2013 Oct;10(58):1309-17.
Influence of nicotine and cotinine impregnation on the first step of periodontal regeneration: clot stabilization. Pinto SC, Leite FR, Fontanari LA, Cavassim R, Leite AA, Bandeca MC, Borges AH, Sampaio JE. J Contemp Dent Pract. 2013 Nov 1;6(14):1044-8.
Wound healing of dehiscence defects following different root conditioning modalities: an experimental study in dogs. Zandim DL, Leite FR, da Silva VC, Lopes BM, Spolidorio LC, Sampaio JE. Clin Oral Investig. 2013 Jul;6(17):1585-93.
Are obesity and overweight associated with gingivitis occurrence in Brazilian schoolchildren? Nascimento GG, Seerig LM, Vargas-Ferreira F, Correa FO, Leite FR, Demarco FF. J Clin Periodontol. 2013 Dec;12(40):1072-8.
Interleukins 1beta and 10 expressions in the periimplant crevicular fluid from patients with untreated periimplant disease. Casado PL, Canullo L, de Almeida Filardy A, Granjeiro JM, Barboza EP, Leite Duarte ME. Implant Dent. 2013 Apr;2(22):143-50.
Effect of the association between citric acid and EDTA on root surface etching. Leite FR, Nascimento GG, Leite ER, Leite AA, Sampaio JE. J Contemp Dent Pract. 2013 5(14):5.
Influence of concentration, time and method of application of citric acid and sodium citrate in root conditioning. Cavassim R, Leite FR, Zandim DL, Dantas AA, Rached RS, Sampaio JE. J Appl Oral Sci. 2012 May-Jun;3(20):376-83.
Blood cells attachment after root conditioning and PRP application: an in vitro study. Dantas AA, Fontanari LA, Ishi Ede P, Leite FR, Zandim DL, Rached RS, Sampaio JE. J Contemp Dent Pract. 2012 May 1;3(13):332-8.
Correlation between clinical/radiographic features and inflammatory cytokine networks produced by macrophages stimulated with endodontic content. Martinho FC, Chiesa WM, Leite FR, Cirelli JA, Gomes BP. J Endod. 2012 Jun;6(38):740-5.
Antigenicity of primary endodontic infection against macrophages by the levels of PGE(2) production. Martinho FC, Chiesa WM, Leite FR, Cirelli JA, Gomes BP. J Endod. 2011 May;5(37):602-7.
Antigenic activity of bacterial endodontic contents from primary root canal infection with periapical lesions against macrophage in the release of interleukin-1beta and tumor necrosis factor alpha. Martinho FC, Chiesa WM, Leite FR, Cirelli JA, Gomes BP. J Endod. 2010 Sep;9(36):1467-74.
In vitro evaluation of the effect of dietary acids and toothbrushing on human root dentin permeability. Zandim DL, Leite FR, Sampaio JE. Quintessence Int. 2010 Mar;3(41):257-63.
Smear layer removal for collagen fiber exposure after citric acid conditionings. Cavassim R, Leite FR, Zandim DL, Dantas AA, Sampaio JE. J Contemp Dent Pract. 2010 Dec 1;6(11):E001-8.
Influence of root-surface conditioning with acid and chelating agents on clot stabilization. Leite FR, Sampaio JE, Zandim DL, Dantas AA, Leite ER, Leite AA. Quintessence Int. 2010 Apr;4(41):341-9.
Bioglass associated with leukocyte-poor platelet-rich plasma in the rabbit maxillary sinus: histomorphometric, densitometric, and fractal analysis. Trindade-Suedam IK, de Morais JA, Faeda RS, Leite FR, Tosoni GM, Neto CB, Marcantonio E, Jr., Scaf G. J Oral Implantol. 2010 5(36):333-43.
Signaling pathways associated with the expression of inflammatory mediators activated during the course of two models of experimental periodontitis. Garcia de Aquino S, Manzolli Leite FR, Stach-Machado DR, Francisco da Silva JA, Spolidorio LC, Rossa C, Jr. Life Sci. 2009 May 22;21-22(84):745-54.
Intrusion of teeth with class III furcation: a clinical, histologic and histometric study in dogs. da Silva VC, Cirelli CC, Ribeiro FS, Leite FR, Benatti Neto C, Marcantonio RA, Cirelli JA. J Clin Periodontol. 2008 Sep;9(35):807-16.
Bone regeneration after demineralized bone matrix and castor oil (Ricinus communis) polyurethane implantation. Leite FR, Ramalho LT. J Appl Oral Sci. 2008 Mar-Apr;2(16):122-6.
Avoiding leukocyte contamination and early platelet activation in platelet-rich plasma. Trindade-Suedam IK, Leite FR, de Morais JA, Leite ER, Marcantonio EJ, Leite AA. J Oral Implantol. 2007 6(33):334-9.
Sharpening of periodontal instruments with different sharpening stones and its influence upon root debridement--scanning electronic microscopy assessment. Silva MV, Gomes DA, Leite FR, Sampaio JE, de Toledo BE, Mendes AJ. J Int Acad Periodontol. 2006 Jan;1(8):17-22.
A scanning electron microscopy study of root surface smear layer removal after topical application of EDTA plus a detergent. Sampaio JE, Campos FP, Pilatti GL, Theodoro LH, Leite FR. J Appl Oral Sci. 2005 Sep;3(13):247-52.
Application of the total etching technique or self-etching primers on primary teeth after air abrasion. Leite FR, Capote TS, Zuanon AC. Braz Oral Res. 2005 Jul-Sep;3(19):198-202.
Blood cell attachment to root surfaces treated with EDTA gel. Leite FR, Moreira CS, Theodoro LH, Sampaio JE. Braz Oral Res. 2005 Apr-Jun;2(19):88-92.

Research Trials

Oral microbiome and salivary biomarkers characterisation
Multi-omics of oral biospecimens in population-based cohorts and clinical trials
Exploring the association between oral inflammation and systemic chronic disorders
Explore the effect of biological (proximal), intermediate and structural determinants on the oral microbiome and oral biomarkers
Anti-inflammatory drug discovery