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Dr Li Huihua

Dr Li Huihua



Dr Li Huihua started her career as a biostatistician in 2003. With 20 years’ collaborations with variety of clinicians and scientists, Dr Li has extensive experience in study design, sample size estimation for grant application and clinical studies, data analysis using causal inference approaches, and manuscript preparations. Dr Li is also active in research and has published more than 120 peer-reviewed papers. In 2016, she was awarded SingHealth Publish! Award in recognition of her research in Parkinson’s disease. 

Dr Li joined National Dental Centre Singapore in 2020 and is now focusing on dental research, and the linkage between oral health and general health. Her research interest includes meta-analysis, prognostic modelling, trend analysis, Age-Period-Cohort analysis, Causal Inference. ​


  • Master of Science (Sweden) 2003​
  • Doctor of Philosophy (Singapore) 2003
  • Master of Engineering (China) 1998
  • Bachelor of Science (China) 1993

Professional Appointments and Committee Memberships

  • Senior Biostatistician, National Dental Centre Singapore, 2020-Present​
  • Adjunct Assistant Professor, Duke-NUS Medical School, 2011-Present


  • 2016: SingHealth Publish! Award ​
  • 2006-2009: Singapore Millennium Foundation (SMF) Scholar

Research Interests

  • Meta-analysis​
  • Prognostic modelling
  • Trend analysis
  • Age-Period-Cohort analysis
  • Causal Inference

Publications and Research Trials

  • ​Peres MA, Li H, Antunes JLF, Perea LME, Iyer NG, Peres KG. Time trend and Age-Period-Cohort analysis of potentially HPV-related oral and pharyngeal cancer incidence in Singapore between 1968 and 2017. Oral Oncol. Jan 2023;136:106272.
  • Nasution DLI, Furuta M, Li H, et al. Longitudinal association between periodontal condition and glycaemic status in middle-aged adults: A cross-lagged panel analysis. J Clin Periodontol. Mar 19 2023.
  • Sim CPC, Li H, Peres MA. Who to Be Treated: Nomogram Using Self-Reported Periodontal Screening Instrument among English-Speaking Adults in Multi-Ethnic Singapore. J Pers Med. Jun 4 2022;12(6). 
  • Lim SN, Tay KJ, Li H, Tan KBC, Tan K. Prevalence and risk factors of erosive tooth wear among young adults in the Singapore military. Clin Oral Investig. Jun 3 2022. 
  • Sim J, Li H, Hameed S, Ting SKS. Clinical Manifestations of Early-Onset Dementia With Lewy Bodies Compared With Late-Onset Dementia With Lewy Bodies and Early-Onset Alzheimer Disease. JAMA Neurol. Jul 1 2022;79(7):702-709. 
  • Entezami S, Peres KG, Li H, Albarki Z, Hijazi M, Ahmed KE. Tooth wear and socioeconomic status in childhood and adulthood: findings from a systematic review and meta-analysis of observational studies. J Dent. Sep 29 2021:103827. 
  • Balan P, Chong YS, Lin Q, lim TK, Li H, et al. Isobaric tags for relative and absolute quantification (iTRAQ)-based quantitative analysis of the salivary proteome during healthy pregnancy and pregnancy gingivitis. J Clin Periodontol. Oct 3 2021. 
  • Chan LL, Chen R, Li H, et al. The splenial angle: a novel radiological index for idiopathic normal pressure hydrocephalus. Eur Radiol. May 15 2021. 
  • Tseng FS, Deng X, Ong YL, Li H, Tan EK. Multiple System Atrophy (MSA) and smoking: a meta-analysis and mechanistic insights. Aging (Albany NY). Nov 7 2020;12(21):21959-21970. 
  • Li H, Allen JC, Jr., Thumboo J, Tan YK. Receiver operating characteristic analysis of ultrasound joint inflammation in relation to structural damage and disease activity in rheumatoid arthritis. Radiol Med. Oct 2019;124(10):1037-1042. 
  • Kam MLW, Li H, Tan YH, Low SY. Validation of the ILD-GAP Model and a Local Nomogram in a Singaporean Cohort. Respiration. 2019;98(5):383-390. 
  • Deng X, Xiao B, Li H, et al. Four-Year Longitudinal Study of Motor and Non-motor Symptoms in LRRK2-Related Parkinson's Disease. Front Neurol. 2019;10:1379. 
  • Chng TW, Gudi M, Lim SH, Li H, Tan PH. Validation of the Singapore nomogram for outcome prediction in breast phyllodes tumours in a large patient cohort. J Clin Pathol. Feb 2018;71(2):125-128 
  • Li H, Teo YY, Tan EK. Patterns of linkage disequilibrium at PARK16 may explain variances in genetic association studies. Mov Disord 2015; 30: 1335-1342. 
  • Chu YH*, Li H*, Tan HS, et al. Association of ABCB1 and FLT3 Polymorphisms with Toxicities and Survival in Asian Patients Receiving Sunitinib for Renal Cell Carcinoma. PLoS One. 2015;10(8):e0134102. *: co-first author 
  • Li H, Teo YY, Tan EK. Patterns of linkage disequilibrium of LRRK2 across different races: implications for genetic association studies. PLoS One 2013; 8: e75041. 
  • Li H, Ha TC, Tai BC. XRCC1 gene polymorphisms and breast cancer risk in different populations: a meta-analysis. Breast 2009; 18: 183-191. 
  • Li H, Tai BC. RNASEL gene polymorphisms and the risk of prostate cancer: a meta-analysis. Clin Cancer Res 2006; 12: 5713-5719. 
  • Tan MH*, Li H*, Choong CV* et al. The Karakiewicz nomogram is the most useful clinical predictor for survival outcomes in patients with localized renal cell carcinoma. Cancer 2011; 117: 5314-5324. *: co-first author 
  • Kanesvaran R, Li H, Koo KN, Poon D. Analysis of prognostic factors of comprehensive geriatric assessment and development of a clinical scoring system in elderly Asian patients with cancer. J Clin Oncol. Sep 20 2011;29(27):3620-3627. 
  • Tan MH, Kanesvaran R, Li H, et al. Comparison of the UCLA Integrated Staging System and the Leibovich score in survival prediction for patients with nonmetastatic clear cell renal cell carcinoma. Urology. Jun 2010;75(6):1365-1370; 1370.e1361-1363. 
  • Chowbay B, Li H, David M, Cheung YB, Lee EJ. Meta-analysis of the influence of MDR1 C3435T polymorphism on digoxin pharmacokinetics and MDR1 gene expression. Br J Clin Pharmacol. Aug 2005;60(2):159-171.

Research Trials

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