Dr Tan Aaron Chia-Ken

MBBS, BSc(Med)Hons, PhD, FRACP

Associate Consultant

Clinical Appointments

Associate Consultant Division of Medical Oncology National Cancer Centre Singapore
Associate Consultant NCCS Oncology @ SKH Sengkang General Hospital

Academic Appointments

Instructor, Duke-NUS Medical School

Profile

Dr Aaron is a Medical Oncologist at the National Cancer Centre Singapore (NCCS), having completed his specialty training in Medical Oncology (FRACP) in Sydney, Australia. He also completed a PhD in cancer drug discovery at The University of Sydney in 2011. At NCCS, he completed a fellowship in drug development/early phase trials and lung cancer translational research.

Education

FRACP (Medical Oncology)

Royal Australian College of Physicians (RACP)
2013-2018

University of Sydney
2008-2010

MBBS

University of New South Wales
2004-2011

BSc(Med)Hons

University of New South Wales
2007

Professional Appointments and Committee Memberships

Awards

NMRC CS-IRG New Investigator Grant (NIG; 2023-24)
ASCO Breakthrough Merit Award (2023)
A*STAR Biomedical Engineering Programme (2022-24)
NMRC CS-IRG New Investigator Grant (NIG; 2022-23)
NNCCS Cancer Fund (Research) Pilot Grant (2021-23)
Early Career Education Award, WCLC 2020 (2021)
SingHealth Publish! Award 2021 & 2022
IASLC Fellowship (2018-2020)
ESMO Asia Merit Award (2019)
IASLC Academy Award (2019-2020)
ESMO Translational Research Unit Fellowship (04/2019)
ASCO Merit Award (2018)
RIRDC Top-Up Scholarship (2009-2010)
CSIRO Full Postgraduate Scholarship (2009-2010)
Australian Young Innovators & Scientists Award (2008)

Research Interests

Publications and Research Trials

Tan AC, Tan SH, Ang MK, Tan DSW. First-line ALK inhibitors in treatment-naive advanced ALK rearranged non-small cell lung cancer: systematic review and network meta-analysis. Precis Cancer Med, 2023;6:3.
Tan AC, Pavlakis N. Anti-Angiogenic Therapy in ALK Rearranged Non-Small Cell Lung Cancer (NSCLC). Int J Mol Sci, 2022;23:8863.
Tan AC, Kobayashi K, Saw SPL et al. Immunotherapy with chemotherapy and anti-angiogenic therapy for EGFR mutated NSCLC: challenging the dogma. Expert Rev Anticancer Ther, 2022;Nov 30:1-4.
Tan AC#, Saw SPL#, Chen J et al. Clinical and Genomic Features of HER2 Exon 20 Insertion Mutations and Characterization of HER2 Expression by Immunohistochemistry in East Asian Non-Small-Cell Lung Cancer. JCO Prec Onc, 2022;6:e2200278.
Tan AC, Tan SH, Zhou S et al. Efficacy of targeted therapies for oncogene-driven lung cancer in early single-arm versus late phase randomized clinical trials: A comparative analysis. Cancer Treat Rev, 2022;104:102354.
Tan AC, Tan TJY, Saw SPL et al. Trials without borders-decentralized trials and ensuring access to novel cancer therapies during a global pandemic. ESMO Open, 2022;7:100537.
Tan AC. The Role of Liquid Biopsy in the Diagnostic Testing Algorithm for Advanced Lung Cancer. Onco, 2022;2:181-5.
Tan AC, Tan DSW. Targeted Therapies for Lung Cancer Patients With Oncogenic Driver Molecu-lar Alterations. J Clin Oncol, 2022;40:611-25.
Tan AC, Boggs DH, Lee EQ, Kim MM, Mehta MP, Khasraw M. Clinical Trial Eligibility Criteria and Recently Approved Cancer Therapies for Patients With Brain Metastases. Frontiers in Oncol-ogy, 2022;11:780379.
Lee J#, Tan AC#, Zhou S, Yoon S, Liu S, Masuda K, et al. Clinical Characteristics and Outcomes in Advanced KRAS-Mutated NSCLC: A Multicenter Collaboration in Asia (ATORG-005). JTO Clin Res Rep, 2021;3:100261.
Tan AC. Tumor-Agnostic Biomarkers: Heed Caution, and Why Cell of Origin Still Matters. Onco, 2021;1:95-100.
Seet AOL#, Tan AC#, Tan TJY, Ng MCH, Tai DWM, Lam JYC, Tan GS, Gogna A, Too CW, Tan BS, Takano A, Lim A, Lim TH, Lim ST, Dent RA, Ang MK, Yap YS, Tan IBH, Choo SP, Toh CK, Lim EH, Farid M, Skanderup AJ, Iyer NG, Lim WT, Tan EH, Lim TKH, Tan DSW. In-dividualized Molecular Profiling for Allocation to Clinical Trials Singapore Study—An Asian Ter-tiary Cancer Center Experience. JCO Prec Onc, 2021;5:859-875.
Tan AC, Bagley SJ, Wen PY, Lim M, Platten M, Colman H, Ashley DM, Wick W, Chang SM, Galanis E, Mansouri A, Khagi S, Mehta MP, Heimberger AB, Puduvalli VK, Reardon DA, Sa-hebjam S, Simes J, Antonia SJ, Berry D, Khasraw M. Systematic review of combinations of tar-geted or immunotherapy in advanced solid tumors. J Immunother Cancer, 2021;9:e002459.
Chua KP#, Teng Y#, Tan AC#, Takano A, Alvarez JJS, Nahar R, Rohatgi N, Lai GGY, Aung ZW, Yeong JPS, Lim KH, Naeini MM, Kassam I, Jain A, Tan WL, Gogna A, Too CW, Kanesvaran R, Ng QS, Ang MK, Rajasekaran T, Anantham D, Phua GC, Tan BS, Lee YY, Wang L, Teo ASM, Khng AJ, Lim MJ, Suteja L, Toh CK, Lim WT, Iyer NG, Tam WL, Tan EH, Zhai W, Hillmer AM, Skanderup AJ, Tan DSW. Integrative Profiling of T790M Negative EGFR Mu-tated NSCLC Reveals Pervasive Lineage Transition and Therapeutic Opportunities. Clin Canc Res, 2021;21:5939-5950.
Tan AC, Chan J, Khasraw M. The role for immunotherapy in fusion-driven lung cancer. Expert Rev Anticancer Ther, 2021;21:461-4.
Tan AC, Loh TJ, Kwang XL, Tan GS, Lim KH, Tan DSW. Novel Therapies for Metastatic Non-Small Cell Lung Cancer with MET Exon 14 Alterations: A Spotlight on Capmatinib. Lung Cancer (Auckl), 2021;12:11-20.
Tan AC, Seet AOL, Lai GGY, Lim TH, Lim AST, Tan GS, Takano A, Tai DWM, Tan TJY, Lam JYC, Ng MCH, Tan WL, Ang MK, Kanesvaran R, Ng QS, Jain A, Rajasekaran T, Lim WT, Tan EH, Lim TKH, Tan DSW. Molecular Characterization and Clinical Outcomes in RET-Rearranged NSCLC. J Thorac Oncol, 2020;12:1928-34.
Tan AC, Ashley DM, Lopez GY, Malinzak M, Friedman H, Khasraw M. Management of glioblas-toma – state of the art and future directions. CA Cancer J Clin, 2020;70:299-312.
Tan AC, Ashley DM, Khasraw M. Adapting to a pandemic - conducting oncology trials during the SARS-CoV-2 pandemic. Clin Cancer Res, 2020;26:3100-03.
Tan AC, Lai GGY, Tan GS, Poon SY, Doble B, Lim TH, Aung ZW, Takana A, Tan WL, Ang MK, Tan BS, Devanand A, Too CW, Gogna A, Ong BH, Koh TPT, Kanesvaran R, Ng QS, Jain A, Rajasekaran T, Lim AST, Lim WT, Toh CK, Tan EH, Lim KH, Tan DSW. Utility of incorpo-rating next generation sequencing (NGS) in an Asian non-small cell lung cancer (NSCLC) popula-tion: incremental yield of actionable alterations and cost effectiveness analysis. Lung Cancer, 2020;139:207-15.
Tan AC, Itchins M, Khasraw M. Brain Metastases in Lung Cancers with Emerging Targetable Fu-sion Drivers. Int J Mol Sci, 2020;21:E1416.
Tan AC. Targeting the PI3K/Akt/mTOR pathway in non-small cell lung cancer (NSCLC). Thorac Cancer, 2020;11:511-8.
Anderson KJ#, Tan AC#, Parkinson J, Back M, Kastelan M, Newey A, Brewer J, Wheeler H, Hudson AL, Amin SB, Johnson KJ, Barthel FP, Verhaak RGW, Khasraw M. Molecular and clon-al evolution in recurrent metastatic gliosarcoma. Cold Spring Harb Mol Case Stud, 2020;6:a004671.

Research Trials

ATORG-003: A single-arm, open-label, phase 2 study of dacomitinib with or without dose titration for the first-line treatment of locally advanced or metastatic non-small cell lung cancer in subjects with an epidermal growth factor receptor (EGFR) activation mutation