Dr Leung Jason Hongting

BSE, MD, MRCSEd, FRCSEd (CTh), MCI, FAMS

Consultant

Profile

Dr. Jason Leung is a Consultant from the Department of Cardiothoracic Surgery at National Heart Centre Singapore. He graduated with departmental distinction from Duke University (USA) with a Bachelor of Science in Engineering degree, and completed his Doctor of Medicine degree at Duke-NUS Medical School in Singapore. He trained in cardiothoracic surgery under the SingHealth Cardiothoracic Surgery Clinician Scientist Residency Program. He treats patients with cardiac and thoracic disorders.

Aside from clinical and surgical work, he has also studied the topic of chronic graft rejection following lung transplantation while at Duke University, and his research is published in peer-reviewed journals. He received the Pratt Fellowship (Duke University), National Institutes Cancer Research Training Award (Bethesda, USA) and MOHH Clinician Scientist Residency Seed Funding (Singapore) and completed a Masters of Clinical Investigation at the National University of Singapore.

Education

FAMS, 2022
MCI, National University Singapore, 2022
FRCSEd (CTh), 2022
MRCSEd, 2017
MD, Duke-NUS Medical School, 2013
BSE, Duke University 2006

Professional Appointments and Committee Memberships

Consultant, Department of Cardiothoracic Surgery, National Heart Centre Singapore, November 2024 – Present
Associate Consultant, Department of Cardiothoracic Surgery, National Heart Centre Singapore, October 2022 – October 2024
Co-Chairman, EMR Documentation Review Workgroup, National Heart Centre Singapore, October 2022 - Present
Associate in Education (SingHealth)

Awards

Cancer Research Training Award, National Institutes of Health, USA (2006)
Pratt Research Fellow, Duke University, USA (2005-2006)

Research Interests

Lung Cancer
Lung Transplantation
Biomarkers
Cardiac Surgery
Thoracic Surgery

Publications and Research Trials

Use of Midodrine for Treatment of Chylopericardium Following Coronary Artery Bypass Grafting. Chong C, Lizwan M, Leung JH, Chao VTT, Soo IX. JTCVS Techniques (2022) doi: https://doi.org/10.1016/j.xjtc.2022.08.006
Interleukin-11: A Potential Biomarker and Molecular Therapeutic Target in Non-Small Cell Lung Cancer. Jason Hongting Leung, Benjamin Ng, Wei-Wen Lim. Cells. 2022 Jul 21;11(14):2257.
Gastric Malignancy Causing E. Coli Infection of a Frozen Elephant Trunk Stent Graft and the use of Transthoracic Composite muscle Flaps for Graft Salvage. Hui Chai Fong, Victor Tar Toong Chao, Jason Hongting Leung and Bien-Keem Tan. J Cardiothorac Surg Ther. 2021 July; 5(1):95-97
Pulmonary mucormycosis with diaphragm and liver involvement in a patient with haematopoietic stem cell transplant. Jason Hongting Leung, Khong-Yik Chew, Alexander Yaw-Fui Chung, Tina Puay Theng Koh. Interact Cardiovasc Thorac Surg. 2020 Jan 1;30(1):144-145.
Clearance of bile and trypsin in rat lungs following aspiration of human gastric fluid. Jason H Leung, Jui-Chih Chang, Emily Foltz, Sadé M Bell, Cinthia Pi, Sassan Azad, Mary Lou Everett, Zoie E Holzknecht, Nathan L Sanders, William Parker, R Duane Davis, Shaf Keshavjee, Shu S Lin. Exp Lung Res. 2016;42(1):37-43.
The role of soluble and insoluble gastric fluid components in the pathogenesis of obliterative bronchiolitis in rat lung allografts. Jason H Leung, Jui-Chih Chang, Sadé M Bell, Zoie E Holzknecht, Samantha M Thomas, Mary Lou Everett, William Parker, R Duane Davis, Shu S Lin. Transpl Int. 2016 Feb;29(2):253-61
Cromolyn ameliorates acute and chronic injury in a rat lung transplant model. Jui-Chih Chang, Jason Leung, Tao Tang, Zoie E Holzknecht, Matthew G Hartwig, R Duane Davis, William Parker, Soman N Abraham, Shu S Lin. J Heart Lung Transplant. 2014 Jul;33(7):749-57.
In the face of chronic aspiration, prolonged ischemic time exacerbates obliterative bronchiolitis in rat pulmonary allografts. J-C Chang, J H Leung, T Tang, M G Hartwig, Z E Holzknecht, W Parker, R D Davis, S S Lin. Am J Transplant. 2012 Nov;12(11):2930-7.
Chronic aspiration shifts the immune response from adaptive immunity to innate immunity in a murine model of asthma. Kuei-Ying Su, Anitra D Thomas, Jui-Chih Chang, Jason H Leung, Sean M Lee, Zoie E Holzknecht, Mary Lou Everett, W Michael Foster, Monica Kraft, William Parker, R Duane Davis, Shu S Lin. Inflamm Res. 2012 Aug;61(8):863-73.
Gastroesophageal reflux-associated aspiration alters the immune response in asthma. Anitra D Thomas, Kuei-Ying Su, Jui-Chih Chang, Jason H Leung, Sean M Lee, Zoie E Holzknecht, Mary Lou Everett, William Parker, R Duane Davis, Shu S Lin. Surg Endosc. 2010 May;24(5):1066-74.

Abstracts:

Chang JC, Leung JH, Holtzknect ZE, Parker W, Davis RD, Lin SS. The Effects of Gastric Fluid Aspiration as a Function of Age in a Rat Model: Implications for Pulmonary Allotransplantation. American Transplant Congress 2012, June 4 2012, Boston MA.
Ramalingam S, Leung J, Khismatullin DB, Truskey GA. 3D Numerical Simulation of Leukocyte Adhesion in Flow Chambers: Effect of Wall Shear Stress. Biomedical Engineering Society Annual Fall Meeting October 2004

Books & Chapters:

Jonathan Lee, Jason Leung, Mathew Topel. Foot-Action Guitar Strummer (2006). In John D. Enderle, Brooke Hallowell. National Science Foundation 2006 Engineering Senior Design Projects To Aid Persons with Disabilities. Creative Learning Press, Inc. (ISBN 1-931280-08-8)

Research Trials

IL-11 and non-small cell lung cancer: clinical associations and transcriptome analysis. Role as Principle investigator, supported by the Ministry of Health Clinician Scientist Residency Seed Funding (MOH-CSSDFD19OCT-0002)
A pilot feasibility study of detection of IL-11 and other cytokines in the exhaled breath condensate (EBC) and blood of healthy volunteers. Role as Co-investigator.