Clin Asst Prof Looi Wen Shen

MBBS, FRCR (Clinical Oncology)

Visiting Consultant

Profile

Dr Looi Wen Shen obtained his medical degree from Yong Loo Lin School of Medicine, National University of Singapore in 2008, and went on to complete his residency training in National Cancer Centre Singapore, before receiving specialist accreditation in radiation oncology by the Specialist Accreditation Board. After completing the USMLE, he underwent fellowship training in both paediatric and adult proton therapy at the University of Florida Health Proton Therapy Institute for a year. He is an active cancer researcher and his research published in journals such as the International Journal of Radiation Oncology Biology and Physics, and Medical Physics, Pediatric Blood and Cancer, and the Archives of Disease in Childhood. Through his research, he endeavours to decrease the acute and late side effects of radiation in children and adults, and improve their quality of life. He is an associate member of the Children’s Oncology Group (COG) as well as several other professional societies including the American Society for Radiation Oncology (ASTRO), Academy of Medicine, Singapore (AMS), Royal College of Radiology (RCR) (UK), Children's Cancer and Leukaemia Group (CCLG) (UK), and the Paediatric Radiation Oncology Society (PROS).

Education

2020 – 2021 Postdoctoral Fellowship
Paediatric and Adult Proton Fellowship University of Florida Health Proton Therapy Institute
2017 Fellow, Academy of Medicine, Singapore
2017 Postgraduate Diploma
Fellow of the Royal College of Radiology (UK) Clinical Oncology
2013 – 2017 Residency – Radiation Oncology
National Cancer Centre Singapore
2003 – 2008 Bachelor of Medicine, Bachelor of Surgery (M.B.B.S.)
Yong Loo Lin, School of Medicine, National University of Singapore

Certification

2020, Standard Certificate for United States Medical Licencing Examination
Education Commission for Foreign Medical Graduates (ECFMG)
2019, Essential Skills in Medical Education Certificate (ESME)
Association for Medical Education in Europe (AMEE)
2017, Radiation Oncology
Specialist Accreditation Board, Singapore
2008, Medical Practicing Certificate
Singapore Medical Council

Professional Appointments and Committee Memberships

Past and Present Appointments

2021 – Clinical Assistant Professor, Duke-NUS
2021 – Clinical Teacher, Lee Kong Chian, School of Medicine
2020 – 2021 Postdoctoral Fellow, University of Florida, Proton Therapy Institute
2019 – Visiting Consultant, Hematology/Oncology Service, KKH, Singapore.
2019 – 2021 Clinical Instructor at Duke-NUS Medical School
2017 – 2023 Consultant, Radiation Oncology, National Cancer Centre Singapore

Professional Licensure

2008, Practicing Certificate
Singapore Medical Council
2017, Radiation Oncology Specialty Certificate
Specialist Accreditation Board of Singapore
2020 - 2022, Registration for Resident / House Physician
Florida Board of Medicine

Professional Memberships

2021 – Children’s Oncology Group, International Associate Member
2021 – VIVA Asia Brain and Solid Tumour Working Group Member
2020 – American Society for Radiation Oncology
2019 – Paediatric Radiation Oncology Society, Member
2018 – 2019 Singapore Radiological Society, Executive Committee Member
2017 – Royal College of Radiology (Clinical Oncology), Fellow (FRCR)
2017 – 2021 Academy of Medicine, Fellow (FAMS)
2008 – 2014 Singapore Medical Association, Member

Awards

Health Manpower Development Program (HMDP) award, 2019
SAF resuscitation distinction award, 2016

Research Interests

Publications and Research Trials

Tan AJL, Tey ML, Seow WT, Low DCY, Chang KTE, Ng LP, Looi WS, Wong RX, Tan EEK, Low SYY. Intraoperative Fluorescein Sodium in Pediatric Neurosurgery: A Preliminary Case Series from a Singapore Children’s Hospital. NeuroSci. 2023; 4(1):54-64. https://doi.org/10.3390/neurosci4010007
Liu KX, Indelicato DJ, Paulino AC, Looi WS, Catalano PJ, Chintagumpala MM, Gallotto SL, Marcus KJ, Haas-Kogan DA, Tarbell NJ, MacDonald SM, Mahajan A, Yock TI. Multi-institutional Characterization of Outcomes for Pediatric and Young Adult Patients With High-Risk Myxopapillary Ependymoma After Radiation Therapy. Int J Radiat Oncol Biol Phys. 2023 Jul 10:S0360-3016(23)04708-9. doi: 10.1016/j.ijrobp.2023.06.2293. Epub ahead of print. PMID: 37437812.
Lim YG, Tan EE, Looi WS, Wong RX, Chang KT, Low DC, Seow WT, Low SY. Biopsy of paediatric brainstem intrinsic tumours: Experience from a Singapore Children's Hospital. J Clin Neurosci. 2022 Oct 10;106:8-13. doi: 10.1016/j.jocn.2022.09.021. Epub ahead of print. PMID: 36228504.
Hong KT, Han JW, Fuji H, Byun HK, Koh KN, Wong RX, Lee HL, Yoon HI, Lee JH, Phi JH, Kim SK, Kim DS, Lyu CJ, Choi JY, Kang HJ, Chen YW, Lee YY, Im HJ, Ra YS, Do Ahn S, Low SYY, Looi WS, Park HJ, Suh YG, Suh CO, Wang KC, Tan EEK, Wong TT, Kim JY. Outcomes of intracranial non-germinomatous germ cell tumors: a retrospective Asian multinational study on treatment strategies and prognostic factors. J Neurooncol. 2022 Aug 31. doi: 10.1007/s11060-022-04100-w. Epub ahead of print. PMID: 36045266.
Lim JX, Tan EEK, Ng LP, Seow WT, Chang KTE, Wong RX, Looi WS, Low DCY, Low SYY. Monomodality versus Combined Therapy in Optic Pathway Gliomas-20-Year Experience from a Singapore Children's Hospital. Front Surg. 2022 May 2;9:827675. doi: 10.3389/fsurg.2022.827675. PMID: 35586500; PMCID: PMC9108767.
Li Y, Ong WS, Shwe MTT, Yit NLF, Quek SZH, Pang EPP, Looi WS, Nei WL, Wang MLC, Chua MLK, Tan TWK, Chua ET, Ng CT, Tuan JKL. Cardiovascular toxicities of androgen deprivation therapy in Asian men with localized prostate cancer after curative radiotherapy: a registry-based observational study. Cardiooncology. 2022 Mar 14;8(1):4. doi: 10.1186/s40959-022-00131-4. PMID: 35287756.
Koh KN, Wong RX, Lee DE, Han JW, Byun HK, Yoon HI, Kim DS, Lyu CJ, Kang HJ, Hong KT, Lee JH, Kim IH, Phi JH, Kim SK, Wong TT, Lee HL, Lai IC, Kang YM, Ra YS, Ahn SD, Im HJ, Looi WS, Low SYY, Tan EEK, Park HJ, Shin SH, Fuji H, Suh CO, Chen YW, Kim JY. Outcomes of intracranial germinoma-a retrospective multinational Asian study on effect of clinical presentation and differential treatment strategies. Neuro Oncol. 2021 Dec 22:noab295. doi: 10.1093/neuonc/noab295. Epub ahead of print. PMID: 34935949.
Yen Sin Koh, Jason Yongsheng Chan, Wen Shen Looi, Mohamad Farid, N Gopalakrishna Iyer, Ci-An Gerald Tay, Kiattisa Sommat, Ru Xin Wong. Outcomes of head and neck angiosarcoma with different treatment modalities: a 20-year single institutional experience. Precision Cancer Medicine 2022 March.
Valerie Ting Lim, Angelie Cabe Gacasan, Jeffrey Kit Loong Tuan, Terence Wee Kiat Tan, Youquan Li, Wen Long Nei, Wen Shen Looi, Xinying Lin, Hong Qi Tan, Eric Chern-Pin Chua, Eric Pei Ping Pang. Evaluation of inter- and intra-observer variations in prostate gland delineation using CT-alone versus CT/TPUS. Rep Pract Oncol Radiother 2022;27(1):97-103. DOI: 10.5603/RPOR.a2022.0004
Hyperfractionated-Accelerated Reirradiation with Proton Therapy for Radiation-Associated Breast Angiosarcoma. Wen Shen Looi, MBBS, FRCR; Julie A. Bradley, MD; Xiaoying Liang, PhD; Christiana M. Shaw, MD; Mark Leyngold, MD; Raymond B. Mailhot Vega, MD, MPH; Eric D. Brooks, MD; Michael S. Rutenberg, MD, PhD; Lisa R. Spiguel, MD; Fantine Giap, MD; Nancy P. Mendenhall, MD. International Journal of Particle Therapy. https://doi.org/10.14338/IJPT-21-00031.1 2022/1/18
Li Y, Chan Kong Ngai T, Zhou S, Yap Haw Hwong J, Pang Pei Ping E, Ong Li Kuan A, Wang Lian Chek M, Chua Lee Kiang M, Looi WS, Nei WL, Chua ET, On WLK, Tan Wee Kiat T, Yuen Shyi Peng J, Tuan Kit Loong J. A comparative analysis between low-dose-rate brachytherapy and external beam radiation therapy for low- and intermediate-risk prostate cancer in Asian men. Acta Oncol. 2021 Jul 14:1-5. doi: 10.1080/0284186X.2021.1950921. Epub ahead of print. PMID: 34259123.
Looi WS, Indelicato DJ, Rutenberg MS. The Role of Radiation Therapy for Symptomatic Desmoid Tumors. Curr Treat Options Oncol. 2021 Mar 1;22(4):34. doi: 10.1007/s11864-021-00831-6. PMID: 33649873.
Bte Syed Sulaiman N, Kuick CH, Chang KTE, Wan KR, Looi WS, Low DCY, Seow WT, Low SYY. Cytokines in Pediatric Pilocytic Astrocytomas: A Clinico-Pathological Study. NeuroSci. 2021; 2(1):95-108. https://doi.org/10.3390/neurosci2010006
Indelicato DJ, Bates JE, Mailhot Vega RB, Rotondo RL, Hoppe BS, Morris CG, Looi WS, Sandler ES, Aldana PR, Bradley JA. Second tumor risk in children treated with proton therapy. Pediatr Blood Cancer. 2021 Feb 9:e28941. doi: 10.1002/pbc.28941. Epub ahead of print. PMID: 33565257.
Indelicato DJ, Rotondo RL, Mailhot Vega RB, Holtzman AL, Looi WS, Morris CG, Sandler ES, Aldana PR, Bradley JA. Local Control Following Proton Therapy for Pediatric Chordoma. Int J Radiat Oncol Biol Phys. 2020 Nov 27:S0360-3016(20)34591-0. doi: 10.1016/j.ijrobp.2020.11.051. Epub ahead of print. PMID: 33253819.
Looi WS, Indelicato DJ, Mailhot Vega RB, Morris CG, Sandler E, Aldana PR, Bradley JA. Outcomes following limited-volume proton therapy for multifocal spinal myxopapillary ependymoma. Pediatr Blood Cancer. 2020 Nov 23:e28820. doi: 10.1002/pbc.28820. Epub ahead of print. PMID: 33226179.
Low SYY, Bte Syed Sulaiman N, Tan EEK, Ng LP, Kuick CH, Chang KTE, Tang PH, Wong RX, Looi WS, Low DCY, Seow WT. Cerebrospinal fluid cytokines in metastatic group 3 and 4 medulloblastoma. BMC Cancer. 2020 Jun 15;20(1):554. doi: 10.1186/s12885-020-07048-0. PMID: 32539808; PMCID: PMC7296667.
Pang EPP, Knight K, Park SY, Lian W, Master Z, Baird M, Chan JWX, Wang MLC, Tan TWK, Chua MLK, Chua ET, Looi WS, Nei WL, Tuan JKL. Duration-dependent margins for prostate radiotherapy-a practical motion mitigation strategy. Strahlenther Onkol. 2020 Jul;196(7):657-663. doi: 10.1007/s00066-019-01558-y. Epub 2020 Jan 13. PMID: 31932995.
Looi WS, Goh SH, Tan CJ, Yeoh KW, Seng MS. Adolescent with facial swelling. Arch Dis Child Educ Pract Ed. 2019 Oct 22:edpract-2019-317654. doi: 10.1136/archdischild-2019-317654. Epub ahead of print. PMID: 31641021.
Looi WS, Low DCY, Low SYY, Goh SH. Neonatal orbital swelling due to intracranial teratoma. Arch Dis Child Fetal Neonatal Ed. 2019 Jul;104(4):F365. doi: 10.1136/archdischild-2018-316337. Epub 2018 Dec 14. PMID: 30552092.