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CAR T-cell Therapy

CAR T-cell Therapy - What is it for

The immune system is made up of a variety of cells and organs that normally protect the body from viruses. Important components of the immune system are blood cells known as T-cells.

T-cells are a type of white blood cells (known as lymphocytes), which have the capacity to recognise and destroy abnormal cells or any cells infected by the virus.

When the body has a new virus or disease, it creates T-cells to fight that specific virus or disease. The body then keeps some in reserve, so that when they come across that virus again, the body can recognise it and attack it immediately.

However, unlike a virus, cancer is our own tissue growing out of control. T-cells have trouble recognising cancer cells as abnormal.

Chimeric antigen receptor (CAR) T-cell therapy is an innovative approach which involves re-programming T-cells so that they recognise and kill cancer cells.

CAR T-cell Therapy - Symptoms

CAR T-cell Therapy - How to prevent?

CAR T-cell Therapy - Causes and Risk Factors

CAR T-cell Therapy - Diagnosis

CAR T-cell Therapy - Treatments

CAR T-cell therapy is potential treatment for:

  • some children and young people up to the age of 25 who have relapsed or not responded to therapy for acute lymphoblastic leukaemia (ALL), and
  • some adults with diffuse large B cell lymphoma, transformed follicular lymphoma, or primary mediastinal B cell lymphoma who have relapsed or not responded to initial treatment.


People with other types of cancer may also have CAR T-cell therapy as part of a clinical trial.


CAR T-cell Therapy - Preparing for surgery

CAR T-cell Therapy - Post-surgery care