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Ultrasound is the preferred method for characterising ovarian cysts. Features such as solid areas, multiple internal compartments, irregular margins and high velocity blood flow increase the index of suspicion for ovarian cancer.
A blood test for CA125 may be taken if there is concern about malignancy. This blood protein is frequently raised in ovarian cancer, but must be interpreted in conjunction with symptoms and ultrasound findings as it can also be raised in non-cancerous conditions such as endometriosis and fibroids.