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Transthyretin Amyloid Cardiomyopathy (ATTR-CM)

Transthyretin Amyloid Cardiomyopathy (ATTR-CM) - ATTR-CM: Causes, Diagnosis, Treatments | SingHealth

Transthyretin Amyloid Cardiomyopathy (ATTR-CM) - Causes and Risk Factors

​ATTR-CM is caused by a deposition of abnormal misshapen proteins on the heart muscles. This protein, called transthyretin, is normally produced by the liver. Its main function is to transport the thyroid hormone and vitamin A in our bloodstream. Due to either genetic mutation or the ageing process, this transport protein can become misshapen. The abnormal proteins can then be deposited in the heart and various organs, resulting in disease.

There are two types of ATTR-CM:

1) Wild type ATTR-CM 

  • Associated with ageing
  • Mostly affecting males over 60 years old 

2) Hereditary ATTR-CM (hATTR-CM) 

  • Caused by a change or “mutation” in our gene
  • Is hereditary or passed down from birth 
  • Affects both males and females, with symptoms beginning as early as 50 years old

Transthyretin Amyloid Cardiomyopathy (ATTR-CM) - Preparing for surgery

Transthyretin Amyloid Cardiomyopathy (ATTR-CM) - Post-surgery care

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